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Polymerase-δ-interacting protein 2 activates the RhoGEF epithelial cell transforming sequence 2 in vascular smooth muscle cells.

Huff LP, Kikuchi DS, Faidley E, Forrester SJ, Tsai MZ, Lassègue B, Griendling KK.

Am J Physiol Cell Physiol. 2019 May 1;316(5):C621-C631. doi: 10.1152/ajpcell.00208.2018. Epub 2019 Feb 6.


Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome.

Forrester SJ, Xu Q, Kikuchi DS, Okwan-Duodu D, Campos AC, Faidley EA, Zhang G, Lassègue B, Sadikot RT, Griendling KK, Hernandes MS.

Clin Sci (Lond). 2019 Jan 25;133(2):321-334. doi: 10.1042/CS20180944. Print 2019 Jan 31.


NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.

Vukelic S, Xu Q, Seidel-Rogol B, Faidley EA, Dikalova AE, Hilenski LL, Jorde U, Poole LB, Lassègue B, Zhang G, Griendling KK.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2423-2434. doi: 10.1161/ATVBAHA.118.311668.


The cofilin phosphatase slingshot homolog 1 restrains angiotensin II-induced vascular hypertrophy and fibrosis in vivo.

Williams HC, Ma J, Weiss D, Lassègue B, Sutliff RL, San Martín A.

Lab Invest. 2019 Mar;99(3):399-410. doi: 10.1038/s41374-018-0116-6. Epub 2018 Oct 5.


Poldip2 knockdown inhibits vascular smooth muscle proliferation and neointima formation by regulating the expression of PCNA and p21.

Datla SR, L Hilenski L, Seidel-Rogol B, Dikalova AE, Harousseau M, Punkova L, Joseph G, Taylor WR, Lassègue B, Griendling KK.

Lab Invest. 2019 Mar;99(3):387-398. doi: 10.1038/s41374-018-0103-y. Epub 2018 Sep 20.


Reply to Bailey et al.: New perspectives on the novel role of the Poldip2/ACSM1 axis in a functional mammalian lipoylation salvage pathway.

Paredes F, Lassègue B, Williams HC, Faidley EA, Benavides GA, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7460-E7461. doi: 10.1073/pnas.1807968115. Epub 2018 Jul 24. No abstract available.


Cyclic Strain and Hypertension Increase Osteopontin Expression in the Aorta.

Caesar C, Lyle AN, Joseph G, Weiss D, Alameddine FMF, Lassègue B, Griendling KK, Taylor WR.

Cell Mol Bioeng. 2017 Apr;10(2):144-152. Epub 2016 Dec 27.


Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain.

Hernandes MS, Lassègue B, Hilenski LL, Adams J, Gao N, Kuan CY, Sun YY, Cheng L, Kikuchi DS, Yepes M, Griendling KK.

J Neuroinflammation. 2018 Feb 17;15(1):45. doi: 10.1186/s12974-017-1032-1.


Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.

Paredes F, Sheldon K, Lassègue B, Williams HC, Faidley EA, Benavides GA, Torres G, Sanhueza-Olivares F, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1789-1794. doi: 10.1073/pnas.1720693115. Epub 2018 Feb 6.


Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4.

Xu Q, Kulkarni AA, Sajith AM, Hussein D, Brown D, Güner OF, Reddy MD, Watkins EB, Lassègue B, Griendling KK, Bowen JP.

Bioorg Med Chem. 2018 Mar 1;26(5):989-998. doi: 10.1016/j.bmc.2017.12.023. Epub 2017 Dec 17.


Polymerase δ-interacting Protein 2: A Multifunctional Protein.

Hernandes MS, Lassègue B, Griendling KK.

J Cardiovasc Pharmacol. 2017 Jun;69(6):335-342. doi: 10.1097/FJC.0000000000000465. Review.


NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis.

Di Marco E, Gray SP, Kennedy K, Szyndralewiez C, Lyle AN, Lassègue B, Griendling KK, Cooper ME, Schmidt HHHW, Jandeleit-Dahm KAM.

Free Radic Biol Med. 2016 Aug;97:556-567. doi: 10.1016/j.freeradbiomed.2016.07.013. Epub 2016 Jul 19.


Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells.

Fujii M, Amanso A, Abrahão TB, Lassègue B, Griendling KK.

J Mol Cell Cardiol. 2016 Mar;92:21-9. doi: 10.1016/j.yjmcc.2016.01.016. Epub 2016 Jan 19.


Hic-5 Mediates TGFβ-Induced Adhesion in Vascular Smooth Muscle Cells by a Nox4-Dependent Mechanism.

Fernandez I, Martin-Garrido A, Zhou DW, Clempus RE, Seidel-Rogol B, Valdivia A, Lassègue B, García AJ, Griendling KK, San Martin A.

Arterioscler Thromb Vasc Biol. 2015 May;35(5):1198-206. doi: 10.1161/ATVBAHA.114.305185. Epub 2015 Mar 26.


Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization.

Datla SR, McGrail DJ, Vukelic S, Huff LP, Lyle AN, Pounkova L, Lee M, Seidel-Rogol B, Khalil MK, Hilenski LL, Terada LS, Dawson MR, Lassègue B, Griendling KK.

Am J Physiol Heart Circ Physiol. 2014 Oct 1;307(7):H945-57. doi: 10.1152/ajpheart.00918.2013. Epub 2014 Jul 25.


Polymerase δ-interacting protein 2 promotes postischemic neovascularization of the mouse hindlimb.

Amanso AM, Lassègue B, Joseph G, Landázuri N, Long JS, Weiss D, Taylor WR, Griendling KK.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1548-55. doi: 10.1161/ATVBAHA.114.303873. Epub 2014 May 22.


Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts.

Brown DI, Lassègue B, Lee M, Zafari R, Long JS, Saavedra HI, Griendling KK.

PLoS One. 2014 May 5;9(5):e96657. doi: 10.1371/journal.pone.0096657. eCollection 2014.


Hydrogen peroxide regulates osteopontin expression through activation of transcriptional and translational pathways.

Lyle AN, Remus EW, Fan AE, Lassègue B, Walter GA, Kiyosue A, Griendling KK, Taylor WR.

J Biol Chem. 2014 Jan 3;289(1):275-85. doi: 10.1074/jbc.M113.489641. Epub 2013 Nov 18.


Transforming growth factor β inhibits platelet derived growth factor-induced vascular smooth muscle cell proliferation via Akt-independent, Smad-mediated cyclin D1 downregulation.

Martin-Garrido A, Williams HC, Lee M, Seidel-Rogol B, Ci X, Dong JT, Lassègue B, Martín AS, Griendling KK.

PLoS One. 2013 Nov 13;8(11):e79657. doi: 10.1371/journal.pone.0079657. eCollection 2013.


Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension.

Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L, Lassègue B, Griendling KK, Harrison DG, Dikalova AE.

Antioxid Redox Signal. 2014 Jan 10;20(2):281-94. doi: 10.1089/ars.2012.4918. Epub 2013 Oct 30.


Coronary heart disease alters intercellular communication by modifying microparticle-mediated microRNA transport.

Finn NA, Eapen D, Manocha P, Al Kassem H, Lassegue B, Ghasemzadeh N, Quyyumi A, Searles CD.

FEBS Lett. 2013 Nov 1;587(21):3456-63. doi: 10.1016/j.febslet.2013.08.034. Epub 2013 Sep 13.


Polymerase delta interacting protein 2 sustains vascular structure and function.

Sutliff RL, Hilenski LL, Amanso AM, Parastatidis I, Dikalova AE, Hansen L, Datla SR, Long JS, El-Ali AM, Joseph G, Gleason RL Jr, Taylor WR, Hart CM, Griendling KK, Lassègue B.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2154-61. doi: 10.1161/ATVBAHA.113.301913. Epub 2013 Jul 3. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):e132.


The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice.

Koga M, Engberding N, Dikalova AE, Chang KH, Seidel-Rogol B, Long JS, Lassègue B, Jo H, Griendling KK.

Am J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H747-55. doi: 10.1152/ajpheart.00825.2012. Epub 2013 Jun 28.


Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure.

Blanco RR, Austin H, Vest RN 3rd, Valadri R, Li W, Lassegue B, Song Q, London B, Dudley SC, Bloom HL, Searles CD, Zafari AM.

J Card Fail. 2012 Sep;18(9):717-23. doi: 10.1016/j.cardfail.2012.06.531. Epub 2012 Aug 9.


Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells.

Williams HC, San Martín A, Adamo CM, Seidel-Rogol B, Pounkova L, Datla SR, Lassègue B, Bear JE, Griendling K.

Circ Res. 2012 Jun 22;111(1):56-65. doi: 10.1161/CIRCRESAHA.111.255745. Epub 2012 May 22.


Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system.

Lassègue B, San Martín A, Griendling KK.

Circ Res. 2012 May 11;110(10):1364-90. doi: 10.1161/CIRCRESAHA.111.243972. Review.


Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK.

Hitomi H, Mehta PK, Taniyama Y, Lassègue B, Seidel-Rogol B, San Martin A, Griendling KK.

Am J Physiol Cell Physiol. 2011 Dec;301(6):C1415-22. doi: 10.1152/ajpcell.00017.2011. Epub 2011 Sep 7.


Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells.

Maheswaranathan M, Gole HK, Fernandez I, Lassègue B, Griendling KK, San Martín A.

J Biol Chem. 2011 Oct 14;286(41):35430-7. doi: 10.1074/jbc.M111.268284. Epub 2011 Aug 20.


NADPH oxidase 4 mediates TGF-β-induced smooth muscle α-actin via p38MAPK and serum response factor.

Martin-Garrido A, Brown DI, Lyle AN, Dikalova A, Seidel-Rogol B, Lassègue B, San Martín A, Griendling KK.

Free Radic Biol Med. 2011 Jan 15;50(2):354-62. doi: 10.1016/j.freeradbiomed.2010.11.007. Epub 2010 Nov 11.


NADPH oxidases: functions and pathologies in the vasculature.

Lassègue B, Griendling KK.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):653-61. doi: 10.1161/ATVBAHA.108.181610. Epub 2009 Nov 12. Review.


The C242T CYBA polymorphism as a major determinant of NADPH oxidase activity in patients with cardiovascular disease.

Mehranpour P, Wang SS, Blanco RR, Li W, Song Q, Lassègue B, Dikalov SI, Austin H, Zafari AM.

Cardiovasc Hematol Agents Med Chem. 2009 Jul;7(3):251-9.


Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells.

Lyle AN, Deshpande NN, Taniyama Y, Seidel-Rogol B, Pounkova L, Du P, Papaharalambus C, Lassègue B, Griendling KK.

Circ Res. 2009 Jul 31;105(3):249-59. doi: 10.1161/CIRCRESAHA.109.193722. Epub 2009 Jul 2.


Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation.

Lee MY, San Martin A, Mehta PK, Dikalova AE, Garrido AM, Datla SR, Lyons E, Krause KH, Banfi B, Lambeth JD, Lassègue B, Griendling KK.

Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):480-7. doi: 10.1161/ATVBAHA.108.181925. Epub 2009 Jan 15.


Insulin-like growth factor-1 receptor expression masks the antiinflammatory and glucose uptake capacity of insulin in vascular smooth muscle cells.

Engberding N, San Martín A, Martin-Garrido A, Koga M, Pounkova L, Lyons E, Lassègue B, Griendling KK.

Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):408-15. doi: 10.1161/ATVBAHA.108.181727. Epub 2009 Jan 2.


Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells.

Jay DB, Papaharalambus CA, Seidel-Rogol B, Dikalova AE, Lassègue B, Griendling KK.

Free Radic Biol Med. 2008 Aug 1;45(3):329-35. doi: 10.1016/j.freeradbiomed.2008.04.024. Epub 2008 Apr 26.


Dual regulation of cofilin activity by LIM kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells.

San Martín A, Lee MY, Williams HC, Mizuno K, Lassègue B, Griendling KK.

Circ Res. 2008 Feb 29;102(4):432-8. Epub 2007 Dec 20.


How does the chloride/proton antiporter ClC-3 control NADPH oxidase?

Lassègue B.

Circ Res. 2007 Sep 28;101(7):648-50. No abstract available.


Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation.

Szöcs K, Lassègue B, Wenzel P, Wendt M, Daiber A, Oelze M, Meinertz T, Münzel T, Baldus S.

J Mol Cell Cardiol. 2007 Jun;42(6):1111-8. Epub 2007 Mar 30.


Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes.

San Martín A, Du P, Dikalova A, Lassègue B, Aleman M, Góngora MC, Brown K, Joseph G, Harrison DG, Taylor WR, Jo H, Griendling KK.

Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2073-82. Epub 2007 Jan 19.


Mycophenolic acid is a new Nox2 inhibitor.

Lassègue B, Griendling KK.

Hypertension. 2007 Jan;49(1):25-6. Epub 2006 Nov 13. No abstract available.


Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype.

Clempus RE, Sorescu D, Dikalova AE, Pounkova L, Jo P, Sorescu GP, Schmidt HH, Lassègue B, Griendling KK.

Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):42-8. Epub 2006 Nov 2. Erratum in: Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):e8. Schmidt, Harald H H [added].


Nox is playing with a full deck in vascular smooth muscle, a commentary on "Noxa1 is a central component of the smooth muscle NADPH oxidase in mice".

Lassègue B, Griendling KK.

Free Radic Biol Med. 2006 Jul 15;41(2):185-7. Epub 2006 May 6. No abstract available.


Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase.

Rouhanizadeh M, Hwang J, Clempus RE, Marcu L, Lassègue B, Sevanian A, Hsiai TK.

Free Radic Biol Med. 2005 Dec 1;39(11):1512-22. Epub 2005 Aug 10.


Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice.

Dikalova A, Clempus R, Lassègue B, Cheng G, McCoy J, Dikalov S, San Martin A, Lyle A, Weber DS, Weiss D, Taylor WR, Schmidt HH, Owens GK, Lambeth JD, Griendling KK.

Circulation. 2005 Oct 25;112(17):2668-76. Epub 2005 Oct 17.


Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.

Wendt MC, Daiber A, Kleschyov AL, Mülsch A, Sydow K, Schulz E, Chen K, Keaney JF Jr, Lassègue B, Walter U, Griendling KK, Münzel T.

Free Radic Biol Med. 2005 Aug 1;39(3):381-91. Epub 2005 Apr 7.


Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production.

Hwang J, Kleinhenz DJ, Lassègue B, Griendling KK, Dikalov S, Hart CM.

Am J Physiol Cell Physiol. 2005 Apr;288(4):C899-905. Epub 2004 Dec 8.


Functional association of nox1 with p22phox in vascular smooth muscle cells.

Hanna IR, Hilenski LL, Dikalova A, Taniyama Y, Dikalov S, Lyle A, Quinn MT, Lassègue B, Griendling KK.

Free Radic Biol Med. 2004 Nov 15;37(10):1542-9.


Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase.

Sorescu GP, Song H, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassègue B, Griendling KK, Jo H.

Circ Res. 2004 Oct 15;95(8):773-9. Epub 2004 Sep 23.


Reactive oxygen species in hypertension; An update.

Lassègue B, Griendling KK.

Am J Hypertens. 2004 Sep;17(9):852-60. Review.


Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation.

Hwang J, Ing MH, Salazar A, Lassègue B, Griendling K, Navab M, Sevanian A, Hsiai TK.

Circ Res. 2003 Dec 12;93(12):1225-32. Epub 2003 Oct 30.

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