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Items: 1 to 50 of 88

1.

The combination of neoantigen quality and T lymphocyte infiltrates identifies glioblastomas with the longest survival.

Zhang J, Caruso FP, Sa JK, Justesen S, Nam DH, Sims P, Ceccarelli M, Lasorella A, Iavarone A.

Commun Biol. 2019 Apr 23;2:135. doi: 10.1038/s42003-019-0369-7. eCollection 2019.

2.

De novo gene signature identification from single-cell RNA-seq with hierarchical Poisson factorization.

Levitin HM, Yuan J, Cheng YL, Ruiz FJ, Bush EC, Bruce JN, Canoll P, Iavarone A, Lasorella A, Blei DM, Sims PA.

Mol Syst Biol. 2019 Feb 22;15(2):e8557. doi: 10.15252/msb.20188557.

3.

The molecular landscape of glioma in patients with Neurofibromatosis 1.

D'Angelo F, Ceccarelli M, Tala, Garofano L, Zhang J, Frattini V, Caruso FP, Lewis G, Alfaro KD, Bauchet L, Berzero G, Cachia D, Cangiano M, Capelle L, de Groot J, DiMeco F, Ducray F, Farah W, Finocchiaro G, Goutagny S, Kamiya-Matsuoka C, Lavarino C, Loiseau H, Lorgis V, Marras CE, McCutcheon I, Nam DH, Ronchi S, Saletti V, Seizeur R, Slopis J, Suñol M, Vandenbos F, Varlet P, Vidaud D, Watts C, Tabar V, Reuss DE, Kim SK, Meyronet D, Mokhtari K, Salvador H, Bhat KP, Eoli M, Sanson M, Lasorella A, Iavarone A.

Nat Med. 2019 Jan;25(1):176-187. doi: 10.1038/s41591-018-0263-8. Epub 2018 Dec 10.

PMID:
30531922
4.

Standardization of CTC AR-V7 PCR assay and evaluation of its role in castration resistant prostate cancer progression.

Tommasi S, Pilato B, Carella C, Lasorella A, Danza K, Vallini I, De Summa S, Naglieri E.

Prostate. 2019 Jan;79(1):54-61. doi: 10.1002/pros.23710. Epub 2018 Aug 23.

PMID:
30141201
5.

Single-cell transcriptome analysis of lineage diversity in high-grade glioma.

Yuan J, Levitin HM, Frattini V, Bush EC, Boyett DM, Samanamud J, Ceccarelli M, Dovas A, Zanazzi G, Canoll P, Bruce JN, Lasorella A, Iavarone A, Sims PA.

Genome Med. 2018 Jul 24;10(1):57. doi: 10.1186/s13073-018-0567-9.

6.

A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas.

Rosenberg S, Simeonova I, Bielle F, Verreault M, Bance B, Le Roux I, Daniau M, Nadaradjane A, Gleize V, Paris S, Marie Y, Giry M, Polivka M, Figarella-Branger D, Aubriot-Lorton MH, Villa C, Vasiljevic A, Lechapt-Zalcman E, Kalamarides M, Sharif A, Mokhtari K, Pagnotta SM, Iavarone A, Lasorella A, Huillard E, Sanson M.

Nat Commun. 2018 Jun 18;9(1):2371. doi: 10.1038/s41467-018-04622-w.

7.

Transcription factor ID2 prevents E proteins from enforcing a naïve T lymphocyte gene program during NK cell development.

Zook EC, Li ZY, Xu Y, de Pooter RF, Verykokakis M, Beaulieu A, Lasorella A, Maienschein-Cline M, Sun JC, Sigvardsson M, Kee BL.

Sci Immunol. 2018 Apr 27;3(22). pii: eaao2139. doi: 10.1126/sciimmunol.aao2139.

PMID:
29703840
8.

Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.

Rajbhandari P, Lopez G, Capdevila C, Salvatori B, Yu J, Rodriguez-Barrueco R, Martinez D, Yarmarkovich M, Weichert-Leahey N, Abraham BJ, Alvarez MJ, Iyer A, Harenza JL, Oldridge D, De Preter K, Koster J, Asgharzadeh S, Seeger RC, Wei JS, Khan J, Vandesompele J, Mestdagh P, Versteeg R, Look AT, Young RA, Iavarone A, Lasorella A, Silva JM, Maris JM, Califano A.

Cancer Discov. 2018 May;8(5):582-599. doi: 10.1158/2159-8290.CD-16-0861. Epub 2018 Mar 6.

9.

RGBM: regularized gradient boosting machines for identification of the transcriptional regulators of discrete glioma subtypes.

Mall R, Cerulo L, Garofano L, Frattini V, Kunji K, Bensmail H, Sabedot TS, Noushmehr H, Lasorella A, Iavarone A, Ceccarelli M.

Nucleic Acids Res. 2018 Apr 20;46(7):e39. doi: 10.1093/nar/gky015.

10.

A metabolic function of FGFR3-TACC3 gene fusions in cancer.

Frattini V, Pagnotta SM, Tala, Fan JJ, Russo MV, Lee SB, Garofano L, Zhang J, Shi P, Lewis G, Sanson H, Frederick V, Castano AM, Cerulo L, Rolland DCM, Mall R, Mokhtari K, Elenitoba-Johnson KSJ, Sanson M, Huang X, Ceccarelli M, Lasorella A, Iavarone A.

Nature. 2018 Jan 11;553(7687):222-227. doi: 10.1038/nature25171. Epub 2018 Jan 3.

11.

Novel SEC61G-EGFR Fusion Gene in Pediatric Ependymomas Discovered by Clonal Expansion of Stem Cells in Absence of Exogenous Mitogens.

Servidei T, Meco D, Muto V, Bruselles A, Ciolfi A, Trivieri N, Lucchini M, Morosetti R, Mirabella M, Martini M, Caldarelli M, Lasorella A, Tartaglia M, Riccardi R.

Cancer Res. 2017 Nov 1;77(21):5860-5872. doi: 10.1158/0008-5472.CAN-17-0790.

12.

Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features.

Bielle F, Di Stefano AL, Meyronet D, Picca A, Villa C, Bernier M, Schmitt Y, Giry M, Rousseau A, Figarella-Branger D, Maurage CA, Uro-Coste E, Lasorella A, Iavarone A, Sanson M, Mokhtari K.

Brain Pathol. 2018 Sep;28(5):674-683. doi: 10.1111/bpa.12563. Epub 2017 Nov 21.

PMID:
28976058
13.

Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response.

Fok KL, Bose R, Sheng K, Chang CW, Katz-Egorov M, Culty M, Su S, Yang M, Ruan YC, Chan HC, Iavarone A, Lasorella A, Cencic R, Pelletier J, Nagano M, Xu W, Wing SS.

Endocrinology. 2017 Nov 1;158(11):4000-4016. doi: 10.1210/en.2017-00396.

PMID:
28938460
14.

Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.

Yang D, Sun B, Zhang X, Cheng D, Yu X, Yan L, Li L, An S, Jiang H, Lasorella A, Iavarone A, Zhang S, Zou F, Zhao X.

Cancer Res. 2017 Sep 15;77(18):4773-4784. doi: 10.1158/0008-5472.CAN-16-2597. Epub 2017 Jul 7.

15.

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.

Myant KB, Cammareri P, Hodder MC, Wills J, Von Kriegsheim A, Győrffy B, Rashid M, Polo S, Maspero E, Vaughan L, Gurung B, Barry E, Malliri A, Camargo F, Adams DJ, Iavarone A, Lasorella A, Sansom OJ.

EMBO Mol Med. 2017 Feb;9(2):181-197. doi: 10.15252/emmm.201606684.

16.

FGFR-TACC gene fusions in human glioma.

Lasorella A, Sanson M, Iavarone A.

Neuro Oncol. 2017 Apr 1;19(4):475-483. doi: 10.1093/neuonc/now240. Review.

17.

The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells.

King B, Boccalatte F, Moran-Crusio K, Wolf E, Wang J, Kayembe C, Lazaris C, Yu X, Aranda-Orgilles B, Lasorella A, Aifantis I.

Nat Immunol. 2016 Nov;17(11):1312-1321. doi: 10.1038/ni.3559. Epub 2016 Sep 26.

18.

Clonal evolution of glioblastoma under therapy.

Wang J, Cazzato E, Ladewig E, Frattini V, Rosenbloom DI, Zairis S, Abate F, Liu Z, Elliott O, Shin YJ, Lee JK, Lee IH, Park WY, Eoli M, Blumberg AJ, Lasorella A, Nam DH, Finocchiaro G, Iavarone A, Rabadan R.

Nat Genet. 2016 Jul;48(7):768-76. doi: 10.1038/ng.3590. Epub 2016 Jun 6.

19.

Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation.

Shaw LA, Bélanger S, Omilusik KD, Cho S, Scott-Browne JP, Nance JP, Goulding J, Lasorella A, Lu LF, Crotty S, Goldrath AW.

Nat Immunol. 2016 Jul;17(7):834-43. doi: 10.1038/ni.3461. Epub 2016 May 23.

20.

Id2 regulates hyporesponsive invariant natural killer T cells.

Stradner MH, Cheung KP, Lasorella A, Goldrath AW, D'Cruz LM.

Immunol Cell Biol. 2016 Aug;94(7):640-5. doi: 10.1038/icb.2016.19. Epub 2016 Feb 16.

21.

An ID2-dependent mechanism for VHL inactivation in cancer.

Lee SB, Frattini V, Bansal M, Castano AM, Sherman D, Hutchinson K, Bruce JN, Califano A, Liu G, Cardozo T, Iavarone A, Lasorella A.

Nature. 2016 Jan 14;529(7585):172-7. doi: 10.1038/nature16475. Epub 2016 Jan 6.

22.

Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota.

Guo X, Liang Y, Zhang Y, Lasorella A, Kee BL, Fu YX.

Immunity. 2015 Apr 21;42(4):731-43. doi: 10.1016/j.immuni.2015.03.012.

23.

Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma.

Di Stefano AL, Fucci A, Frattini V, Labussiere M, Mokhtari K, Zoppoli P, Marie Y, Bruno A, Boisselier B, Giry M, Savatovsky J, Touat M, Belaid H, Kamoun A, Idbaih A, Houillier C, Luo FR, Soria JC, Tabernero J, Eoli M, Paterra R, Yip S, Petrecca K, Chan JA, Finocchiaro G, Lasorella A, Sanson M, Iavarone A.

Clin Cancer Res. 2015 Jul 15;21(14):3307-17. doi: 10.1158/1078-0432.CCR-14-2199. Epub 2015 Jan 21.

24.

Pegasus: a comprehensive annotation and prediction tool for detection of driver gene fusions in cancer.

Abate F, Zairis S, Ficarra E, Acquaviva A, Wiggins CH, Frattini V, Lasorella A, Iavarone A, Inghirami G, Rabadan R.

BMC Syst Biol. 2014 Sep 4;8:97. doi: 10.1186/s12918-014-0097-z.

25.

ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2.

Ghosh HS, Ceribelli M, Matos I, Lazarovici A, Bussemaker HJ, Lasorella A, Hiebert SW, Liu K, Staudt LM, Reizis B.

J Exp Med. 2014 Jul 28;211(8):1623-35. doi: 10.1084/jem.20132121. Epub 2014 Jun 30.

26.

Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.

Forget A, Bihannic L, Cigna SM, Lefevre C, Remke M, Barnat M, Dodier S, Shirvani H, Mercier A, Mensah A, Garcia M, Humbert S, Taylor MD, Lasorella A, Ayrault O.

Dev Cell. 2014 Jun 23;29(6):649-61. doi: 10.1016/j.devcel.2014.05.014.

27.

Myc and differentiation: going against the current.

Iavarone A, Lasorella A.

EMBO Rep. 2014 Apr;15(4):324-5. doi: 10.1002/embr.201438509. Epub 2014 Mar 10. No abstract available.

28.

The ID proteins: master regulators of cancer stem cells and tumour aggressiveness.

Lasorella A, Benezra R, Iavarone A.

Nat Rev Cancer. 2014 Feb;14(2):77-91. doi: 10.1038/nrc3638. Epub 2014 Jan 20. Review.

PMID:
24442143
29.

Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development.

Verykokakis M, Krishnamoorthy V, Iavarone A, Lasorella A, Sigvardsson M, Kee BL.

J Immunol. 2013 Dec 15;191(12):5973-83. doi: 10.4049/jimmunol.1301521. Epub 2013 Nov 15.

30.

The integrated landscape of driver genomic alterations in glioblastoma.

Frattini V, Trifonov V, Chan JM, Castano A, Lia M, Abate F, Keir ST, Ji AX, Zoppoli P, Niola F, Danussi C, Dolgalev I, Porrati P, Pellegatta S, Heguy A, Gupta G, Pisapia DJ, Canoll P, Bruce JN, McLendon RE, Yan H, Aldape K, Finocchiaro G, Mikkelsen T, Privé GG, Bigner DD, Lasorella A, Rabadan R, Iavarone A.

Nat Genet. 2013 Oct;45(10):1141-9. doi: 10.1038/ng.2734. Epub 2013 Aug 5.

31.

RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation.

Danussi C, Akavia UD, Niola F, Jovic A, Lasorella A, Pe'er D, Iavarone A.

Cancer Res. 2013 Aug 15;73(16):5140-50. doi: 10.1158/0008-5472.CAN-13-1168-T. Epub 2013 Jun 17.

32.

Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.

Niola F, Zhao X, Singh D, Sullivan R, Castano A, Verrico A, Zoppoli P, Friedmann-Morvinski D, Sulman E, Barrett L, Zhuang Y, Verma I, Benezra R, Aldape K, Iavarone A, Lasorella A.

J Clin Invest. 2013 Jan;123(1):405-17. doi: 10.1172/JCI63811. Epub 2012 Dec 17. Erratum in: J Clin Invest. 2014 Sep 2;124(9):4134.

33.

Transforming fusions of FGFR and TACC genes in human glioblastoma.

Singh D, Chan JM, Zoppoli P, Niola F, Sullivan R, Castano A, Liu EM, Reichel J, Porrati P, Pellegatta S, Qiu K, Gao Z, Ceccarelli M, Riccardi R, Brat DJ, Guha A, Aldape K, Golfinos JG, Zagzag D, Mikkelsen T, Finocchiaro G, Lasorella A, Rabadan R, Iavarone A.

Science. 2012 Sep 7;337(6099):1231-5. doi: 10.1126/science.1220834. Epub 2012 Jul 26.

34.

Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis.

Lin YY, Jones-Mason ME, Inoue M, Lasorella A, Iavarone A, Li QJ, Shinohara ML, Zhuang Y.

J Immunol. 2012 Aug 1;189(3):1400-5. doi: 10.4049/jimmunol.1200491. Epub 2012 Jun 27.

35.

Id proteins synchronize stemness and anchorage to the niche of neural stem cells.

Niola F, Zhao X, Singh D, Castano A, Sullivan R, Lauria M, Nam HS, Zhuang Y, Benezra R, Di Bernardo D, Iavarone A, Lasorella A.

Nat Cell Biol. 2012 Apr 22;14(5):477-87. doi: 10.1038/ncb2490.

36.

E protein transcription factors are required for the development of CD4(+) lineage T cells.

Jones-Mason ME, Zhao X, Kappes D, Lasorella A, Iavarone A, Zhuang Y.

Immunity. 2012 Mar 23;36(3):348-61. doi: 10.1016/j.immuni.2012.02.010. Epub 2012 Mar 15.

37.

Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F.

Coma S, Amin DN, Shimizu A, Lasorella A, Iavarone A, Klagsbrun M.

Cancer Res. 2010 May 1;70(9):3823-32. doi: 10.1158/0008-5472.CAN-09-3048. Epub 2010 Apr 13.

38.

Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum.

D'Arca D, Zhao X, Xu W, Ramirez-Martinez NC, Iavarone A, Lasorella A.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5875-80. doi: 10.1073/pnas.0912874107. Epub 2010 Mar 15.

39.

The transcriptional network for mesenchymal transformation of brain tumours.

Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY, Sulman EP, Anne SL, Doetsch F, Colman H, Lasorella A, Aldape K, Califano A, Iavarone A.

Nature. 2010 Jan 21;463(7279):318-25. doi: 10.1038/nature08712. Epub 2009 Dec 23.

40.

The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.

Zhao X, D' Arca D, Lim WK, Brahmachary M, Carro MS, Ludwig T, Cardo CC, Guillemot F, Aldape K, Califano A, Iavarone A, Lasorella A.

Dev Cell. 2009 Aug;17(2):210-21. doi: 10.1016/j.devcel.2009.07.009.

41.

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.

Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F, Iavarone A, Lasorella A.

Nat Cell Biol. 2008 Jun;10(6):643-53. doi: 10.1038/ncb1727. Epub 2008 May 18.

42.

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

Guardavaccaro D, Frescas D, Dorrello NV, Peschiaroli A, Multani AS, Cardozo T, Lasorella A, Iavarone A, Chang S, Hernando E, Pagano M.

Nature. 2008 Mar 20;452(7185):365-9. doi: 10.1038/nature06641.

43.

ID proteins as targets in cancer and tools in neurobiology.

Iavarone A, Lasorella A.

Trends Mol Med. 2006 Dec;12(12):588-94. Epub 2006 Oct 30. Review.

PMID:
17071138
44.

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.

Lasorella A, Stegmüller J, Guardavaccaro D, Liu G, Carro MS, Rothschild G, de la Torre-Ubieta L, Pagano M, Bonni A, Iavarone A.

Nature. 2006 Jul 27;442(7101):471-4. Epub 2006 Jun 28.

PMID:
16810178
45.

E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells.

Rothschild G, Zhao X, Iavarone A, Lasorella A.

Mol Cell Biol. 2006 Jun;26(11):4351-61.

46.

The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system.

Lasorella A, Iavarone A.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4976-81. Epub 2006 Mar 20.

47.

Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice.

Lasorella A, Rothschild G, Yokota Y, Russell RG, Iavarone A.

Mol Cell Biol. 2005 May;25(9):3563-74.

48.

Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells.

Light W, Vernon AE, Lasorella A, Iavarone A, LaBonne C.

Development. 2005 Apr;132(8):1831-41. Epub 2005 Mar 16.

49.

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages.

Iavarone A, King ER, Dai XM, Leone G, Stanley ER, Lasorella A.

Nature. 2004 Dec 23;432(7020):1040-5.

PMID:
15616565
50.

Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium.

Russell RG, Lasorella A, Dettin LE, Iavarone A.

Cancer Res. 2004 Oct 15;64(20):7220-5.

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