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Items: 1 to 50 of 254


Long-term Respiratory Effects of Mustard Vesicants.

Malaviya R, Laskin JD, Laskin DL.

Toxicol Lett. 2019 Nov 4;319:168-174. doi: 10.1016/j.toxlet.2019.10.026. [Epub ahead of print]


Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard.

Sunil VR, Vayas KN, Abramova EV, Rancourt R, Cervelli JA, Malaviya R, Goedken M, Venosa A, Gow AJ, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2019 Oct 30:114798. doi: 10.1016/j.taap.2019.114798. [Epub ahead of print]


Regulation of Macrophage Foam Cell Formation During Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis by Lung Lipids.

Venosa A, Smith LC, Murray A, Banota T, Gow AJ, Laskin JD, Laskin DL.

Toxicol Sci. 2019 Dec 1;172(2):344-358. doi: 10.1093/toxsci/kfz187.


Phototoxicity of 7-oxycoumarins with keratinocytes in culture.

Guillon C, Jan YH, Heck DE, Mariano TM, Rapp RD, Jetter M, Kardos K, Whittemore M, Akyea E, Jabin I, Laskin JD, Heindel ND.

Bioorg Chem. 2019 Aug;89:103014. doi: 10.1016/j.bioorg.2019.103014. Epub 2019 May 25.


Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns.

Son Y, Mishin V, Laskin JD, Mainelis G, Wackowski OA, Delnevo C, Schwander S, Khlystov A, Samburova V, Meng Q.

Chem Res Toxicol. 2019 Jun 17;32(6):1087-1095. doi: 10.1021/acs.chemrestox.8b00400. Epub 2019 Apr 23.


Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells.

Jan YH, Heck DE, Laskin DL, Laskin JD.

Chem Res Toxicol. 2019 Jun 17;32(6):1123-1133. doi: 10.1021/acs.chemrestox.8b00417. Epub 2019 Apr 22.


Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers.

Sunil VR, Radbel J, Hussain S, Vayas KN, Cervelli J, Deen M, Kipen H, Udasin I, Laumbach R, Sunderram J, Laskin JD, Laskin DL.

Int J Environ Res Public Health. 2019 Mar 6;16(5). pii: E815. doi: 10.3390/ijerph16050815.


Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions.

Guillon CD, Jan YH, Foster N, Ressner J, Heck DE, Laskin JD, Heindel ND.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):619-622. doi: 10.1016/j.bmcl.2018.12.048. Epub 2018 Dec 22.


Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis.

Szilagyi JT, Composto-Wahler GM, Joseph LB, Wang B, Rosen T, Laskin JD, Aleksunes LM.

Pharmacol Res. 2019 Mar;141:331-342. doi: 10.1016/j.phrs.2019.01.002. Epub 2019 Jan 2.


Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants.

Laskin DL, Malaviya R, Laskin JD.

Toxicol Sci. 2019 Apr 1;168(2):287-301. doi: 10.1093/toxsci/kfy309.


Placental BCRP/ABCG2 Transporter Prevents Fetal Exposure to the Estrogenic Mycotoxin Zearalenone.

Szilagyi JT, Gorczyca L, Brinker A, Buckley B, Laskin JD, Aleksunes LM.

Toxicol Sci. 2019 Apr 1;168(2):394-404. doi: 10.1093/toxsci/kfy303.


Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase.

Szilagyi JT, Fussell KC, Wang Y, Jan YH, Mishin V, Richardson JR, Heck DE, Yang S, Aleksunes LM, Laskin DL, Laskin JD.

Toxicol Appl Pharmacol. 2018 Nov 15;359:102-107. doi: 10.1016/j.taap.2018.09.011. Epub 2018 Sep 15.


Protective Role of Surfactant Protein-D Against Lung Injury and Oxidative Stress Induced by Nitrogen Mustard.

Sunil VR, Vayas KN, Cervelli JA, Ebramova EV, Gow AJ, Goedken M, Malaviya R, Laskin JD, Laskin DL.

Toxicol Sci. 2018 Nov 1;166(1):108-122. doi: 10.1093/toxsci/kfy188.


Expression of cytokines and chemokines in mouse skin treated with sulfur mustard.

Chang YC, Soriano M, Hahn RA, Casillas RP, Gordon MK, Laskin JD, Gerecke DR.

Toxicol Appl Pharmacol. 2018 Sep 15;355:52-59. doi: 10.1016/j.taap.2018.06.008. Epub 2018 Jun 20.


Identification of a Pyranocoumarin Photosensitizer that is a Potent Inhibitor of Keratinocyte Growth.

Laskin JD, Jan YH, Jetter MM, Guillon CD, Mariano TM, Heck DE, Heindel ND.

Photochem Photobiol. 2018 May;94(3):577-582. doi: 10.1111/php.12882. Epub 2018 Mar 2.


Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug.

Joseph LB, Composto GM, Perez RM, Kim HD, Casillas RP, Heindel ND, Young SC, Lacey CJ, Saxena J, Guillon CD, Croutch CR, Laskin JD, Heck DE.

Toxicol Lett. 2018 Sep 1;293:77-81. doi: 10.1016/j.toxlet.2017.11.005. Epub 2017 Nov 7.


Anti-TNFα therapy in inflammatory lung diseases.

Malaviya R, Laskin JD, Laskin DL.

Pharmacol Ther. 2017 Dec;180:90-98. doi: 10.1016/j.pharmthera.2017.06.008. Epub 2017 Jun 19. Review.


Localization of the placental BCRP/ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity.

Szilagyi JT, Vetrano AM, Laskin JD, Aleksunes LM.

Placenta. 2017 Jul;55:29-36. doi: 10.1016/j.placenta.2017.04.006. Epub 2017 Apr 12.


Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells.

Yang S, Jan YH, Mishin V, Heck DE, Laskin DL, Laskin JD.

Chem Res Toxicol. 2017 Jul 17;30(7):1406-1418. doi: 10.1021/acs.chemrestox.7b00052. Epub 2017 Jun 26.


Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor.

Venosa A, Gow JG, Hall L, Malaviya R, Gow AJ, Laskin JD, Laskin DL.

Toxicol Sci. 2017 May 1;157(1):222-234. doi: 10.1093/toxsci/kfx032.


World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung.

Sunil VR, Vayas KN, Fang M, Zarbl H, Massa C, Gow AJ, Cervelli JA, Kipen H, Laumbach RJ, Lioy PJ, Laskin JD, Laskin DL.

Exp Mol Pathol. 2017 Feb;102(1):50-58. doi: 10.1016/j.yexmp.2016.12.005. Epub 2016 Dec 13.


Editor's Highlight: CCR2 Regulates Inflammatory Cell Accumulation in the Lung and Tissue Injury following Ozone Exposure.

Francis M, Groves AM, Sun R, Cervelli JA, Choi H, Laskin JD, Laskin DL.

Toxicol Sci. 2017 Feb;155(2):474-484. doi: 10.1093/toxsci/kfw226. Epub 2016 Nov 11.


Editor's Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury.

Francis M, Sun R, Cervelli JA, Choi H, Mandal M, Abramova EV, Gow AJ, Laskin JD, Laskin DL.

Toxicol Sci. 2017 Jan;155(1):182-195. doi: 10.1093/toxsci/kfw192. Epub 2016 Oct 5.


Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury.

Lacey CJ, Wohlman I, Guillon C, Saxena J, Fianu-Velgus C, Aponte E, Young SC, Heck DE, Joseph LB, Laskin JD, Heindel ND.

Ann N Y Acad Sci. 2016 Aug;1378(1):174-179. doi: 10.1111/nyas.13177. Epub 2016 Aug 9. Review.


Preparedness and response to chemical and biological threats: the role of exposure science.

Lioy PJ, Laskin JD, Georgopoulos PG.

Ann N Y Acad Sci. 2016 Aug;1378(1):108-117. doi: 10.1111/nyas.13173. Epub 2016 Aug 1. Review.


Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione.

Jan YH, Richardson JR, Baker AA, Mishin V, Heck DE, Laskin DL, Laskin JD.

Ann N Y Acad Sci. 2016 Aug;1378(1):80-86. doi: 10.1111/nyas.13156. Epub 2016 Jul 21. Review.


Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants.

Malaviya R, Sunil VR, Venosa A, Vayas KN, Businaro R, Heck DE, Laskin JD, Laskin DL.

Ann N Y Acad Sci. 2016 Jun;1374(1):168-75. doi: 10.1111/nyas.13123. Epub 2016 Jun 28. Review.


Mustard vesicant-induced lung injury: Advances in therapy.

Weinberger B, Malaviya R, Sunil VR, Venosa A, Heck DE, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2016 Aug 15;305:1-11. doi: 10.1016/j.taap.2016.05.014. Epub 2016 May 19. Review.


Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug.

Composto GM, Laskin JD, Laskin DL, Gerecke DR, Casillas RP, Heindel ND, Joseph LB, Heck DE.

Exp Mol Pathol. 2016 Jun;100(3):522-31. doi: 10.1016/j.yexmp.2016.05.008. Epub 2016 May 14.


The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury.

Mandal M, Gardner CR, Sun R, Choi H, Lad S, Mishin V, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2016 Aug 1;304:110-20. doi: 10.1016/j.taap.2016.04.019. Epub 2016 May 7.


Mustard vesicants alter expression of the endocannabinoid system in mouse skin.

Wohlman IM, Composto GM, Heck DE, Heindel ND, Lacey CJ, Guillon CD, Casillas RP, Croutch CR, Gerecke DR, Laskin DL, Joseph LB, Laskin JD.

Toxicol Appl Pharmacol. 2016 Jul 15;303:30-44. doi: 10.1016/j.taap.2016.04.014. Epub 2016 Apr 26.


ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure.

DeSantis-Rodrigues A, Chang YC, Hahn RA, Po IP, Zhou P, Lacey CJ, Pillai A, C Young S, Flowers RA 2nd, Gallo MA, Laskin JD, Gerecke DR, Svoboda KK, Heindel ND, Gordon MK.

Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1687-98. doi: 10.1167/iovs.15-17269.


Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium.

Szilagyi JT, Mishin V, Heck DE, Jan YH, Aleksunes LM, Richardson JR, Heindel ND, Laskin DL, Laskin JD.

Toxicol Sci. 2016 May;151(1):150-9. doi: 10.1093/toxsci/kfw031. Epub 2016 Feb 14.


A Novel High-Throughput Approach to Measure Hydroxyl Radicals Induced by Airborne Particulate Matter.

Son Y, Mishin V, Welsh W, Lu SE, Laskin JD, Kipen H, Meng Q.

Int J Environ Res Public Health. 2015 Oct 28;12(11):13678-95. doi: 10.3390/ijerph121113678.


Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents.

Saxena J, Meloni D, Huang MT, Heck DE, Laskin JD, Heindel ND, Young SC.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5609-12. doi: 10.1016/j.bmcl.2015.10.039. Epub 2015 Oct 23.


Inflammatory mechanisms of pulmonary injury induced by mustards.

Malaviya R, Sunil VR, Venosa A, Vayas KN, Heck DE, Laskin JD, Laskin DL.

Toxicol Lett. 2016 Feb 26;244:2-7. doi: 10.1016/j.toxlet.2015.10.011. Epub 2015 Oct 23. Review.


Protective role of spleen-derived macrophages in lung inflammation, injury, and fibrosis induced by nitrogen mustard.

Venosa A, Malaviya R, Gow AJ, Hall L, Laskin JD, Laskin DL.

Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1487-98. doi: 10.1152/ajplung.00276.2015. Epub 2015 Oct 16.


Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1).

Udasin RG, Wen X, Bircsak KM, Aleksunes LM, Shakarjian MP, Kong AN, Heck DE, Laskin DL, Laskin JD.

Toxicol Sci. 2016 Jan;149(1):202-12. doi: 10.1093/toxsci/kfv226. Epub 2015 Oct 9.


Thioredoxin Cross-Linking by Nitrogen Mustard in Lung Epithelial Cells: Formation of Multimeric Thioredoxin/Thioredoxin Reductase Complexes and Inhibition of Disulfide Reduction.

Jan YH, Heck DE, Casillas RP, Laskin DL, Laskin JD.

Chem Res Toxicol. 2015 Nov 16;28(11):2091-103. doi: 10.1021/acs.chemrestox.5b00194. Epub 2015 Oct 19.


Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis.

Venosa A, Malaviya R, Choi H, Gow AJ, Laskin JD, Laskin DL.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):436-46. doi: 10.1165/rcmb.2015-0120OC.


Attenuation of Nitrogen Mustard-Induced Pulmonary Injury and Fibrosis by Anti-Tumor Necrosis Factor-α Antibody.

Malaviya R, Sunil VR, Venosa A, Verissimo VL, Cervelli JA, Vayas KN, Hall L, Laskin JD, Laskin DL.

Toxicol Sci. 2015 Nov;148(1):71-88. doi: 10.1093/toxsci/kfv161. Epub 2015 Aug 4.


Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication.

Jan YH, Richardson JR, Baker AA, Mishin V, Heck DE, Laskin DL, Laskin JD.

Toxicol Appl Pharmacol. 2015 Oct 1;288(1):114-20. doi: 10.1016/j.taap.2015.07.023. Epub 2015 Jul 23.


Parametrial fat tissue from high fat diet-treated SKH-1 mice stimulates transformation of mouse epidermal JB6 cells.

Bernard JJ, Lou YR, Peng QY, Li T, Vakil PR, Ding N, Laskin JD, Dong Z, Conney AH, Lu YP.

J Carcinog Mutagen. 2014 Jul 31;5(183):2157-2518.


Regulation of ozone-induced lung inflammation and injury by the β-galactoside-binding lectin galectin-3.

Sunil VR, Francis M, Vayas KN, Cervelli JA, Choi H, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2015 Apr 15;284(2):236-45. doi: 10.1016/j.taap.2015.02.002. Epub 2015 Feb 25.


Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and surfactant protein D.

Malaviya R, Gow AJ, Francis M, Abramova EV, Laskin JD, Laskin DL.

Toxicol Sci. 2015 Mar;144(1):27-38. doi: 10.1093/toxsci/kfu255. Epub 2014 Dec 30.


Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase.

Yang S, Jan YH, Mishin V, Richardson JR, Hossain MM, Heindel ND, Heck DE, Laskin DL, Laskin JD.

J Pharmacol Exp Ther. 2015 Mar;352(3):529-40. doi: 10.1124/jpet.114.221572. Epub 2014 Dec 30.



Guillon CD, Wisnoski DD, Saxena J, Heindel ND, Heck DE, Wolff DJ, Laskin JD.

Mod Res Inflamm. 2014 May;3(2):48-58.


Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard.

Chang YC, Wang JD, Hahn RA, Gordon MK, Joseph LB, Heck DE, Heindel ND, Young SC, Sinko PJ, Casillas RP, Laskin JD, Laskin DL, Gerecke DR.

Toxicol Appl Pharmacol. 2014 Oct 15;280(2):236-44. doi: 10.1016/j.taap.2014.07.016. Epub 2014 Aug 13.


Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions.

Mishin V, Heck DE, Laskin DL, Laskin JD.

Toxicol Sci. 2014 Oct;141(2):344-52. doi: 10.1093/toxsci/kfu133. Epub 2014 Jul 24.


Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation.

Sunil VR, Vayas KN, Cervelli JA, Malaviya R, Hall L, Massa CB, Gow AJ, Laskin JD, Laskin DL.

Exp Mol Pathol. 2014 Aug;97(1):89-98. doi: 10.1016/j.yexmp.2014.05.009. Epub 2014 Jun 2.

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