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Type-1 interferons prolong the lifespan of neutrophils by interfering with members of the apoptotic cascade.

Aga E, Mukherjee A, Rane D, More V, Patil T, van Zandbergen G, Solbach W, Dandapat J, Tackenberg H, Ohms M, Sarkar A, Laskay T.

Cytokine. 2018 Dec;112:21-26. doi: 10.1016/j.cyto.2018.06.027. Epub 2018 Jul 7.


Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides.

Lamprecht P, Kerstein A, Klapa S, Schinke S, Karsten CM, Yu X, Ehlers M, Epplen JT, Holl-Ulrich K, Wiech T, Kalies K, Lange T, Laudien M, Laskay T, Gemoll T, Schumacher U, Ullrich S, Busch H, Ibrahim S, Fischer N, Hasselbacher K, Pries R, Petersen F, Weppner G, Manz R, Humrich JY, Nieberding R, Riemekasten G, Müller A.

Front Immunol. 2018 Apr 9;9:680. doi: 10.3389/fimmu.2018.00680. eCollection 2018. Review.


Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita.

Samavedam UK, Mitschker N, Kasprick A, Bieber K, Schmidt E, Laskay T, Recke A, Goletz S, Vidarsson G, Schulze FS, Armbrust M, Schulze Dieckhoff K, Pas HH, Jonkman MF, Kalies K, Zillikens D, Gupta Y, Ibrahim SM, Ludwig RJ.

Front Immunol. 2018 Feb 15;9:249. doi: 10.3389/fimmu.2018.00249. eCollection 2018.


Changes in Neutrophil Metabolism upon Activation and Aging.

Richer BC, Salei N, Laskay T, Seeger K.

Inflammation. 2018 Mar;41(2):710-721. doi: 10.1007/s10753-017-0725-z.


Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases.

Bieber K, Sun S, Witte M, Kasprick A, Beltsiou F, Behnen M, Laskay T, Schulze FS, Pipi E, Reichhelm N, Pagel R, Zillikens D, Schmidt E, Sparwasser T, Kalies K, Ludwig RJ.

Front Immunol. 2017 Nov 24;8:1628. doi: 10.3389/fimmu.2017.01628. eCollection 2017.


Early Production of the Neutrophil-Derived Lipid Mediators LTB4 and LXA4 Is Modulated by Intracellular Infection with Leishmania major.

Plagge M, Laskay T.

Biomed Res Int. 2017;2017:2014583. doi: 10.1155/2017/2014583. Epub 2017 Oct 18.


Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps.

Behnen M, Möller S, Brozek A, Klinger M, Laskay T.

Front Immunol. 2017 Feb 28;8:184. doi: 10.3389/fimmu.2017.00184. eCollection 2017.


Enhanced survival of Leishmania major in neutrophil granulocytes in the presence of apoptotic cells.

Salei N, Hellberg L, Köhl J, Laskay T.

PLoS One. 2017 Feb 10;12(2):e0171850. doi: 10.1371/journal.pone.0171850. eCollection 2017.


Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis.

Gadisa E, Tasew G, Abera A, Gelaye W, Chanyalew M, Abebe M, Laskay T, Aseffa A.

Cytokine. 2017 Mar;91:6-9. doi: 10.1016/j.cyto.2016.11.016. Epub 2016 Dec 8.


In vitro permissiveness of bovine neutrophils and monocyte derived macrophages to Leishmania donovani of Ethiopian isolate.

Tasew G, Gadisa E, Abera A, Zewude A, Chanyalew M, Aseffa A, Abebe M, Ritter U, van Zandbergen G, Laskay T, Tafess K.

Parasit Vectors. 2016 Apr 18;9:218. doi: 10.1186/s13071-016-1441-5.


IL-16 and MIF: messengers beyond neutrophil cell death.

Roth S, Solbach W, Laskay T.

Cell Death Dis. 2016 Jan 14;7:e2049. doi: 10.1038/cddis.2015.388. No abstract available.


Dimethylfumarate Impairs Neutrophil Functions.

Müller S, Behnen M, Bieber K, Möller S, Hellberg L, Witte M, Hänsel M, Zillikens D, Solbach W, Laskay T, Ludwig RJ.

J Invest Dermatol. 2016 Jan;136(1):117-26. doi: 10.1038/JID.2015.361.


Dimethylfumarate Impairs Neutrophil Functions.

Müller S, Behnen M, Bieber K, Möller S, Hellberg L, Witte M, Hänsel M, Zillikens D, Solbach W, Laskay T, Ludwig RJ.

J Invest Dermatol. 2015 Oct 5. doi: 10.1038/jid.2015.361. [Epub ahead of print]


Mechanisms of apoptosis inhibition in Chlamydia pneumoniae-infected neutrophils.

Sarkar A, Möller S, Bhattacharyya A, Behnen M, Rupp J, van Zandbergen G, Solbach W, Laskay T.

Int J Med Microbiol. 2015 Sep;305(6):493-500. doi: 10.1016/j.ijmm.2015.04.006. Epub 2015 May 8.


The retinoid-related orphan receptor alpha is essential for the end-stage effector phase of experimental epidermolysis bullosa acquisita.

Sadeghi H, Gupta Y, Möller S, Samavedam UK, Behnen M, Kasprick A, Bieber K, Müller S, Kalies K, de Castro Marques A, Recke A, Schmidt E, Zillikens D, Laskay T, Mariani J, Ibrahim SM, Ludwig RJ.

J Pathol. 2015 Sep;237(1):111-22. doi: 10.1002/path.4556. Epub 2015 Jun 15.


Heat shock protein 90 is required for ex vivo neutrophil-driven autoantibody-induced tissue damage in experimental epidermolysis bullosa acquisita.

Tukaj S, Hellberg L, Ueck C, Hänsel M, Samavedam U, Zillikens D, Ludwig RJ, Laskay T, Kasperkiewicz M.

Exp Dermatol. 2015 Jun;24(6):471-3. doi: 10.1111/exd.12680. Epub 2015 Mar 25.


Secondary necrotic neutrophils release interleukin-16C and macrophage migration inhibitory factor from stores in the cytosol.

Roth S, Agthe M, Eickhoff S, Möller S, Karsten CM, Borregaard N, Solbach W, Laskay T.

Cell Death Discov. 2015 Nov 30;1:15056. doi: 10.1038/cddiscovery.2015.56. eCollection 2015.


Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcγRIIIB and Mac-1.

Behnen M, Leschczyk C, Möller S, Batel T, Klinger M, Solbach W, Laskay T.

J Immunol. 2014 Aug 15;193(4):1954-65. doi: 10.4049/jimmunol.1400478. Epub 2014 Jul 14.


Flavonoids and 5-aminosalicylic acid inhibit the formation of neutrophil extracellular traps.

Kirchner T, Hermann E, Möller S, Klinger M, Solbach W, Laskay T, Behnen M.

Mediators Inflamm. 2013;2013:710239. doi: 10.1155/2013/710239. Epub 2013 Dec 7.


Methylprednisolone blocks autoantibody-induced tissue damage in experimental models of bullous pemphigoid and epidermolysis bullosa acquisita through inhibition of neutrophil activation.

Hellberg L, Samavedam UKSRL, Holdorf K, Hänsel M, Recke A, Beckmann T, Steinhorst K, Boehncke WH, Kirchner T, Möckel N, Solbach W, Zillikens D, Schmidt E, Ludwig RJ, Laskay T.

J Invest Dermatol. 2013 Oct;133(10):2390-2399. doi: 10.1038/jid.2013.91. Epub 2013 Feb 28.


Infection of neutrophil granulocytes with Leishmania major activates ERK 1/2 and modulates multiple apoptotic pathways to inhibit apoptosis.

Sarkar A, Aga E, Bussmeyer U, Bhattacharyya A, Möller S, Hellberg L, Behnen M, Solbach W, Laskay T.

Med Microbiol Immunol. 2013 Feb;202(1):25-35. doi: 10.1007/s00430-012-0246-1. Epub 2012 Jun 3.


The impact of various reactive oxygen species on the formation of neutrophil extracellular traps.

Kirchner T, Möller S, Klinger M, Solbach W, Laskay T, Behnen M.

Mediators Inflamm. 2012;2012:849136. doi: 10.1155/2012/849136. Epub 2012 Jan 26.


Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury.

Kasperkiewicz M, Nimmerjahn F, Wende S, Hirose M, Iwata H, Jonkman MF, Samavedam U, Gupta Y, Möller S, Rentz E, Hellberg L, Kalies K, Yu X, Schmidt E, Häsler R, Laskay T, Westermann J, Köhl J, Zillikens D, Ludwig RJ.

J Pathol. 2012 Sep;228(1):8-19. doi: 10.1002/path.4023. Epub 2012 May 8.


Infection with Anaplasma phagocytophilum activates the phosphatidylinositol 3-Kinase/Akt and NF-κB survival pathways in neutrophil granulocytes.

Sarkar A, Hellberg L, Bhattacharyya A, Behnen M, Wang K, Lord JM, Möller S, Kohler M, Solbach W, Laskay T.

Infect Immun. 2012 Apr;80(4):1615-23. doi: 10.1128/IAI.05219-11. Epub 2012 Jan 17.


Proinflammatory stimuli enhance phagocytosis of apoptotic cells by neutrophil granulocytes.

Hellberg L, Fuchs S, Gericke C, Sarkar A, Behnen M, Solbach W, Laskay T.

ScientificWorldJournal. 2011;11:2230-6. doi: 10.1100/2011/413271. Epub 2011 Nov 15.


The protective Th1 response in mice is induced in the T-cell zone only three weeks after infection with Leishmania major and not during early T-cell activation.

Barthelmann J, Nietsch J, Blessenohl M, Laskay T, van Zandbergen G, Westermann J, Kalies K.

Med Microbiol Immunol. 2012 Feb;201(1):25-35. doi: 10.1007/s00430-011-0201-6. Epub 2011 May 6.


Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells.

Esmann L, Idel C, Sarkar A, Hellberg L, Behnen M, Möller S, van Zandbergen G, Klinger M, Köhl J, Bussmeyer U, Solbach W, Laskay T.

J Immunol. 2010 Jan 1;184(1):391-400. doi: 10.4049/jimmunol.0900564. Epub 2009 Nov 30.


Impairment of gamma interferon signaling in human neutrophils infected with Anaplasma phagocytophilum.

Bussmeyer U, Sarkar A, Broszat K, Lüdemann T, Möller S, van Zandbergen G, Bogdan C, Behnen M, Dumler JS, von Loewenich FD, Solbach W, Laskay T.

Infect Immun. 2010 Jan;78(1):358-63. doi: 10.1128/IAI.01005-09. Epub 2009 Oct 26.


Chlamydia pneumoniae hides inside apoptotic neutrophils to silently infect and propagate in macrophages.

Rupp J, Pfleiderer L, Jugert C, Moeller S, Klinger M, Dalhoff K, Solbach W, Stenger S, Laskay T, van Zandbergen G.

PLoS One. 2009 Jun 23;4(6):e6020. doi: 10.1371/journal.pone.0006020.


Immunity against HIV/AIDS, malaria, and tuberculosis during co-infections with neglected infectious diseases: recommendations for the European Union research priorities.

Boraschi D, Abebe Alemayehu M, Aseffa A, Chiodi F, Chisi J, Del Prete G, Doherty TM, Elhassan I, Engers H, Gyan B, Harandi AM, Kariuki T, Kironde F, Kouriba B, Langhorne J, Laskay T, Medaglini D, Olesen O, Onyebujoh P, Palma C, Sauerwein R, Sibanda E, Steinhoff U, Tagliabue A, Thiel A, Vahedi M, Troye-Blomberg M.

PLoS Negl Trop Dis. 2008 Jun 25;2(6):e255. doi: 10.1371/journal.pntd.0000255.


Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: apoptosis as infection-promoting factor.

Laskay T, van Zandbergen G, Solbach W.

Immunobiology. 2008;213(3-4):183-91. doi: 10.1016/j.imbio.2007.11.010. Epub 2008 Feb 8. Review.


Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils.

Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones SA, Rose-John S, Scheller J.

Blood. 2007 Sep 15;110(6):1748-55. Epub 2007 Jun 13.


Apoptosis driven infection.

van Zandbergen G, Solbach W, Laskay T.

Autoimmunity. 2007 Jun;40(4):349-52. Review.


Direct stimulatory effects of the TLR2/6 ligand bacterial lipopeptide MALP-2 on neutrophil granulocytes.

Wilde I, Lotz S, Engelmann D, Starke A, van Zandbergen G, Solbach W, Laskay T.

Med Microbiol Immunol. 2007 Jun;196(2):61-71. Epub 2006 Sep 28.


Evidence of direct interactions between the CC-chemokines CCL3, CCL4 and CCL5 and Leishmania promastigotes.

Roychoudhury K, Dasgupta B, Sen P, Laskay T, Solbach W, De T, Roy S.

Mol Biochem Parasitol. 2006 Dec;150(2):374-7. Epub 2006 Sep 14. No abstract available.


Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum.

van Zandbergen G, Bollinger A, Wenzel A, Kamhawi S, Voll R, Klinger M, Müller A, Hölscher C, Herrmann M, Sacks D, Solbach W, Laskay T.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13837-42. Epub 2006 Aug 31. Erratum in: Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16615.


Beta-lactam antibiotic-induced release of lipoteichoic acid from Staphylococcus aureus leads to activation of neutrophil granulocytes.

Lotz S, Starke A, Ziemann C, Morath S, Hartung T, Solbach W, Laskay T.

Ann Clin Microbiol Antimicrob. 2006 Jun 27;5:15.


Cutting edge: neutrophil granulocyte serves as a vector for Leishmania entry into macrophages.

van Zandbergen G, Klinger M, Mueller A, Dannenberg S, Gebert A, Solbach W, Laskay T.

J Immunol. 2004 Dec 1;173(11):6521-5.


Different patterns of the L-histidine decarboxylase (HDC) gene expression in mice resistant and susceptible to experimental cutaneous leishmaniasis.

Pós Z, Müller K, Novalphak I, Buzás E, Solbach W, Falus A, Laskay T.

Inflamm Res. 2004 Jan;53(1):38-43. Epub 2004 Jan 1.


Chlamydia pneumoniae multiply in neutrophil granulocytes and delay their spontaneous apoptosis.

van Zandbergen G, Gieffers J, Kothe H, Rupp J, Bollinger A, Aga E, Klinger M, Brade H, Dalhoff K, Maass M, Solbach W, Laskay T.

J Immunol. 2004 Feb 1;172(3):1768-76.


Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2.

Lotz S, Aga E, Wilde I, van Zandbergen G, Hartung T, Solbach W, Laskay T.

J Leukoc Biol. 2004 Mar;75(3):467-77. Epub 2003 Dec 12.


Neutrophil granulocytes--Trojan horses for Leishmania major and other intracellular microbes?

Laskay T, van Zandbergen G, Solbach W.

Trends Microbiol. 2003 May;11(5):210-4.


Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major.

Aga E, Katschinski DM, van Zandbergen G, Laufs H, Hansen B, Müller K, Solbach W, Laskay T.

J Immunol. 2002 Jul 15;169(2):898-905.


Polarized expression of Tamm-Horsfall protein by renal tubular epithelial cells activates human granulocytes.

Kreft B, Jabs WJ, Laskay T, Klinger M, Solbach W, Kumar S, van Zandbergen G.

Infect Immun. 2002 May;70(5):2650-6.


Intracellular survival of Leishmania major in neutrophil granulocytes after uptake in the absence of heat-labile serum factors.

Laufs H, Müller K, Fleischer J, Reiling N, Jahnke N, Jensenius JC, Solbach W, Laskay T.

Infect Immun. 2002 Feb;70(2):826-35.


Chemokines, natural killer cells and granulocytes in the early course of Leishmania major infection in mice.

Müller K, van Zandbergen G, Hansen B, Laufs H, Jahnke N, Solbach W, Laskay T.

Med Microbiol Immunol. 2001 Nov;190(1-2):73-6.


Novel multi-probe RNase protection assay (RPA) sets for the detection of murine chemokine gene expression.

Müller K, Ehlers S, Solbach W, Laskay T.

J Immunol Methods. 2001 Mar 1;249(1-2):155-65.


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