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Items: 1 to 50 of 143

1.

Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13.

Cariulo C, Verani M, Martufi P, Ingenito R, Finotto M, Deguire SM, Lavery DJ, Toledo-Sherman L, Lee R, Doherty EM, Vogt TF, Dominguez C, Lashuel HA, Petricca L, Caricasole A.

Biochem Biophys Res Commun. 2019 Oct 30. pii: S0006-291X(19)31827-3. doi: 10.1016/j.bbrc.2019.09.097. [Epub ahead of print]

PMID:
31677786
2.

The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus.

Yalinca H, Gehin CJC, Oleinikovas V, Lashuel HA, Gervasio FL, Pastore A.

Front Mol Biosci. 2019 Oct 1;6:95. doi: 10.3389/fmolb.2019.00095. eCollection 2019.

3.

Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology.

Burtscher J, Copin JC, Rodrigues J, Kumar ST, Chiki A, Guillot de Suduiraut I, Sandi C, Lashuel HA.

Neurobiol Aging. 2019 Nov;83:11-20. doi: 10.1016/j.neurobiolaging.2019.08.007. Epub 2019 Aug 14.

4.

Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay.

Cariulo C, Martufi P, Verani M, Azzollini L, Bruni G, Weiss A, Deguire SM, Lashuel HA, Scaricamazza E, Sancesario GM, Schirinzi T, Mercuri NB, Sancesario G, Caricasole A, Petricca L.

Front Neurosci. 2019 Aug 22;13:889. doi: 10.3389/fnins.2019.00889. eCollection 2019.

5.

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease.

Levine PM, Galesic A, Balana AT, Mahul-Mellier AL, Navarro MX, De Leon CA, Lashuel HA, Pratt MR.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1511-1519. doi: 10.1073/pnas.1808845116. Epub 2019 Jan 16.

6.

Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding.

Ellmer D, Brehs M, Haj-Yahya M, Lashuel HA, Becker CFW.

Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1616-1620. doi: 10.1002/anie.201805238. Epub 2019 Jan 17.

7.

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.

DeGuire SM, Ruggeri FS, Fares MB, Chiki A, Cendrowska U, Dietler G, Lashuel HA.

J Biol Chem. 2018 Nov 30;293(48):18540-18558. doi: 10.1074/jbc.RA118.004621. Epub 2018 Sep 5.

8.

Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection.

Etezadi D, Warner Iv JB, Ruggeri FS, Dietler G, Lashuel HA, Altug H.

Light Sci Appl. 2017 Aug 25;6(8):e17029. doi: 10.1038/lsa.2017.29. eCollection 2017 Aug.

9.

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.

Mollenhauer B, Bowman FD, Drake D, Duong J, Blennow K, El-Agnaf O, Shaw LM, Masucci J, Taylor P, Umek RM, Dunty JM, Smith CL, Stoops E, Vanderstichele H, Schmid AW, Moniatte M, Zhang J, Kruse N, Lashuel HA, Teunissen C, Schubert T, Dave KD, Hutten SJ, Zetterberg H.

J Neurochem. 2019 Apr;149(1):126-138. doi: 10.1111/jnc.14569. Epub 2018 Nov 13.

10.

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy.

Reif A, Chiki A, Ricci J, Lashuel HA.

J Vis Exp. 2018 Jun 27;(136). doi: 10.3791/57506.

11.

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.

Ruggeri FS, Benedetti F, Knowles TPJ, Lashuel HA, Sekatskii S, Dietler G.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7230-7235. doi: 10.1073/pnas.1721220115. Epub 2018 Jun 25.

12.

Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces.

Rodrigo D, Tittl A, Ait-Bouziad N, John-Herpin A, Limaj O, Kelly C, Yoo D, Wittenberg NJ, Oh SH, Lashuel HA, Altug H.

Nat Commun. 2018 Jun 4;9(1):2160. doi: 10.1038/s41467-018-04594-x.

13.

Real-Time In Situ Secondary Structure Analysis of Protein Monolayer with Mid-Infrared Plasmonic Nanoantennas.

Etezadi D, Warner JB 4th, Lashuel HA, Altug H.

ACS Sens. 2018 Jun 22;3(6):1109-1117. doi: 10.1021/acssensors.8b00115. Epub 2018 Jun 12.

14.
15.

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.

El Turk F, De Genst E, Guilliams T, Fauvet B, Hejjaoui M, Di Trani J, Chiki A, Mittermaier A, Vendruscolo M, Lashuel HA, Dobson CM.

Protein Sci. 2018 Jul;27(7):1262-1274. doi: 10.1002/pro.3412.

16.

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.

Mathur V, Burai R, Vest RT, Bonanno LN, Lehallier B, Zardeneta ME, Mistry KN, Do D, Marsh SE, Abud EM, Blurton-Jones M, Li L, Lashuel HA, Wyss-Coray T.

Neuron. 2017 Dec 20;96(6):1290-1302.e6. doi: 10.1016/j.neuron.2017.11.032.

17.

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.

Ait-Bouziad N, Lv G, Mahul-Mellier AL, Xiao S, Zorludemir G, Eliezer D, Walz T, Lashuel HA.

Nat Commun. 2017 Nov 22;8(1):1678. doi: 10.1038/s41467-017-01575-4.

18.

Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.

Cariulo C, Azzollini L, Verani M, Martufi P, Boggio R, Chiki A, Deguire SM, Cherubini M, Gines S, Marsh JL, Conforti P, Cattaneo E, Santimone I, Squitieri F, Lashuel HA, Petricca L, Caricasole A.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10809-E10818. doi: 10.1073/pnas.1705372114. Epub 2017 Nov 21.

19.

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths.

Warner JB 4th, Ruff KM, Tan PS, Lemke EA, Pappu RV, Lashuel HA.

J Am Chem Soc. 2017 Oct 18;139(41):14456-14469. doi: 10.1021/jacs.7b06659. Epub 2017 Oct 9.

20.

Amyloid single-cell cytotoxicity assays by nanomotion detection.

Ruggeri FS, Mahul-Mellier AL, Kasas S, Lashuel HA, Longo G, Dietler G.

Cell Death Discov. 2017 Aug 21;3:17053. doi: 10.1038/cddiscovery.2017.53. eCollection 2017.

21.

A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations.

Mollenhauer B, Batrla R, El-Agnaf O, Galasko DR, Lashuel HA, Merchant KM, Shaw LM, Selkoe DJ, Umek R, Vanderstichele H, Zetterberg H, Zhang J, Caspell-Garcia C, Coffey C, Hutten SJ, Frasier M, Taylor P; Investigating Synuclein Consortium of the Michael J. Fox Foundation for Parkinson's Research.

Mov Disord. 2017 Aug;32(8):1117-1130. doi: 10.1002/mds.27090. Epub 2017 Jul 22. Review.

22.

Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.

Daldin M, Fodale V, Cariulo C, Azzollini L, Verani M, Martufi P, Spiezia MC, Deguire SM, Cherubini M, Macdonald D, Weiss A, Bresciani A, Vonsattel JG, Petricca L, Marsh JL, Gines S, Santimone I, Marano M, Lashuel HA, Squitieri F, Caricasole A.

Sci Rep. 2017 Jul 11;7(1):5070. doi: 10.1038/s41598-017-05336-7.

23.

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.

Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.

Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056.

PMID:
28398476
24.

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Apr 5;15(4):e1002601. doi: 10.1371/journal.pbio.1002601. eCollection 2017 Apr.

25.

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

Chiki A, DeGuire SM, Ruggeri FS, Sanfelice D, Ansaloni A, Wang ZM, Cendrowska U, Burai R, Vieweg S, Pastore A, Dietler G, Lashuel HA.

Angew Chem Int Ed Engl. 2017 May 2;56(19):5202-5207. doi: 10.1002/anie.201611750. Epub 2017 Mar 23.

PMID:
28334491
26.

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. Erratum in: PLoS Biol. 2017 Apr 5;15(4):e1002601.

27.

The America I believe in.

Lashuel HA.

Science. 2017 Feb 17;355(6326):766. doi: 10.1126/science.355.6326.766. No abstract available.

PMID:
28209903
28.

A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides.

Awad L, Jejelava N, Burai R, Lashuel HA.

Chembiochem. 2016 Dec 14;17(24):2353-2360. doi: 10.1002/cbic.201600474. Epub 2016 Nov 25.

PMID:
27788286
29.

Nanoscale studies link amyloid maturity with polyglutamine diseases onset.

Ruggeri FS, Vieweg S, Cendrowska U, Longo G, Chiki A, Lashuel HA, Dietler G.

Sci Rep. 2016 Aug 8;6:31155. doi: 10.1038/srep31155.

30.

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D.

ACS Chem Biol. 2016 Sep 16;11(9):2428-37. doi: 10.1021/acschembio.6b00539. Epub 2016 Jul 11.

31.

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation.

Vieweg S, Ansaloni A, Wang ZM, Warner JB, Lashuel HA.

J Biol Chem. 2016 Jun 3;291(23):12074-86. doi: 10.1074/jbc.M116.713982. Epub 2016 Mar 21.

32.

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease.

Fares MB, Maco B, Oueslati A, Rockenstein E, Ninkina N, Buchman VL, Masliah E, Lashuel HA.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E912-21. doi: 10.1073/pnas.1512876113. Epub 2016 Feb 2.

33.

Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons.

Adamcik J, Sánchez-Ferrer A, Ait-Bouziad N, Reynolds NP, Lashuel HA, Mezzenga R.

Angew Chem Int Ed Engl. 2016 Jan 11;55(2):618-22. doi: 10.1002/anie.201508968. Epub 2015 Dec 4.

PMID:
26636567
34.

Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies.

Benmessaoud IR, Mahul-Mellier AL, Horváth E, Maco B, Spina M, Lashuel HA, Forró L.

Toxicol Res (Camb). 2015 Nov 25;5(2):407-419. doi: 10.1039/c5tx00303b. eCollection 2016 Mar 1.

35.

Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease.

Oueslati A, Lovisa B, Perrin J, Wagnières G, van den Bergh H, Tardy Y, Lashuel HA.

PLoS One. 2015 Oct 20;10(10):e0140880. doi: 10.1371/journal.pone.0140880. eCollection 2015.

36.

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein.

Fauvet B, Lashuel HA.

Methods Mol Biol. 2016;1345:3-20. doi: 10.1007/978-1-4939-2978-8_1.

PMID:
26453202
37.

Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death.

Mahul-Mellier AL, Vercruysse F, Maco B, Ait-Bouziad N, De Roo M, Muller D, Lashuel HA.

Cell Death Differ. 2015 Dec;22(12):2107-22. doi: 10.1038/cdd.2015.79. Epub 2015 Jul 3.

38.

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.

Burai R, Ait-Bouziad N, Chiki A, Lashuel HA.

J Am Chem Soc. 2015 Apr 22;137(15):5041-52. doi: 10.1021/ja5131726. Epub 2015 Apr 8.

PMID:
25768729
39.

Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.

Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA.

J Biol Chem. 2015 Apr 10;290(15):9412-27. doi: 10.1074/jbc.M114.610774. Epub 2015 Feb 5.

40.

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization.

Ruggeri FS, Adamcik J, Jeong JS, Lashuel HA, Mezzenga R, Dietler G.

Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2462-6. doi: 10.1002/anie.201409050. Epub 2015 Jan 14.

PMID:
25588987
41.

Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.

Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, Wrasidlo W, Wu F, Fraering PC, Masliah E, Lashuel HA.

Neurobiol Dis. 2015 Feb;74:144-57. doi: 10.1016/j.nbd.2014.08.017. Epub 2014 Aug 28.

42.

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.

Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA.

J Biol Chem. 2014 Aug 8;289(32):21856-76. doi: 10.1074/jbc.M114.553297. Epub 2014 Jun 16.

43.

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.

Fares MB, Ait-Bouziad N, Dikiy I, Mbefo MK, Jovičić A, Kiely A, Holton JL, Lee SJ, Gitler AD, Eliezer D, Lashuel HA.

Hum Mol Genet. 2014 Sep 1;23(17):4491-509. doi: 10.1093/hmg/ddu165. Epub 2014 Apr 11.

44.

One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease.

Ansaloni A, Wang ZM, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA.

Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1928-33. doi: 10.1002/anie.201307510. Epub 2014 Jan 20. Erratum in: Angew Chem Int Ed Engl. 2014 Jul 14;53(29):7389.

PMID:
24446188
45.

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.

Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA.

Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9.

46.

Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.

Fournier M, Roux A, Garrigue J, Muriel MP, Blanche P, Lashuel HA, Anderson JP, Barbour R, Huang J, du Montcel ST, Brice A, Corti O.

BMC Neurosci. 2013 Nov 5;14:135. doi: 10.1186/1471-2202-14-135.

47.

Real-time amyloid aggregation monitoring with a photonic crystal-based approach.

Santi S, Musi V, Descrovi E, Paeder V, Di Francesco J, Hvozdara L, van der Wal P, Lashuel HA, Pastore A, Neier R, Herzig HP.

Chemphyschem. 2013 Oct 21;14(15):3476-82. doi: 10.1002/cphc.201300633. Epub 2013 Sep 17.

PMID:
24105966
48.

Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.

Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, Hejjaoui M, Bavikar SN, Karthikeyan SV, Ciechanover A, Lashuel HA, Brik A.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17726-31. doi: 10.1073/pnas.1315654110. Epub 2013 Sep 16.

49.

One-pot total chemical synthesis of human α-synuclein.

Fauvet B, Butterfield SM, Fuks J, Brik A, Lashuel HA.

Chem Commun (Camb). 2013 Oct 18;49(81):9254-6. doi: 10.1039/c3cc45353g.

PMID:
23995579
50.

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo.

Oueslati A, Schneider BL, Aebischer P, Lashuel HA.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):E3945-54. doi: 10.1073/pnas.1309991110. Epub 2013 Aug 27.

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