Sort by
Items per page

Send to

Choose Destination

Search results

Items: 50


Design and Synthesis of Basic Selective Estrogen Receptor Degraders (B-SERDs) for Endocrine Therapy Resistant Breast Cancer.

Lu Y, Gutgesell L, Xiong R, Zhao J, Li Y, Rosales C, Hollas M, Shen Z, Gordon-Blake J, Dye K, Wang YT, Lee S, Chen H, He D, Dubrovyskyii O, Zhao H, Huang F, Lasek AW, Tonetti DA, Thatcher GR.

J Med Chem. 2019 Nov 20. doi: 10.1021/acs.jmedchem.9b01580. [Epub ahead of print]


Anaplastic lymphoma kinase regulates internalization of the dopamine D2 receptor.

He D, Lasek AW.

Mol Pharmacol. 2019 Nov 16. pii: mol.119.117473. doi: 10.1124/mol.119.117473. [Epub ahead of print]


Receptor Tyrosine Kinases as Therapeutic Targets for Alcohol Use Disorder.

Hamada K, Lasek AW.

Neurotherapeutics. 2019 Oct 15. doi: 10.1007/s13311-019-00795-4. [Epub ahead of print] Review.


Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol.

Park HM, Satta R, Davis RG, Goo YA, LeDuc RD, Fellers RT, Greer JB, Romanova EV, Rubakhin SS, Tai R, Thomas PM, Sweedler JV, Kelleher NL, Patrie SM, Lasek AW.

J Proteome Res. 2019 Nov 1;18(11):3999-4012. doi: 10.1021/acs.jproteome.9b00481. Epub 2019 Oct 2.


Perineuronal nets in the insula regulate aversion-resistant alcohol drinking.

Chen H, Lasek AW.

Addict Biol. 2019 Aug 21:e12821. doi: 10.1111/adb.12821. [Epub ahead of print]


The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alleviates depression-like behavior and normalizes epigenetic changes in the hippocampus during ethanol withdrawal.

Chen WY, Zhang H, Gatta E, Glover EJ, Pandey SC, Lasek AW.

Alcohol. 2019 Aug;78:79-87. doi: 10.1016/j.alcohol.2019.02.005. Epub 2019 Mar 6.


Scn4b regulates the hypnotic effects of ethanol and other sedative drugs.

Blednov YA, Bajo M, Roberts AJ, Da Costa AJ, Black M, Edmunds S, Mayfield J, Roberto M, Homanics GE, Lasek AW, Hitzemann RJ, Harris RA.

Genes Brain Behav. 2019 Jul;18(6):e12562. doi: 10.1111/gbb.12562. Epub 2019 May 2.


Correction to: Transcriptional Regulators as Targets for Alcohol Pharmacotherapies.

Savarese AM, Lasek AW.

Handb Exp Pharmacol. 2018;248:623-624. doi: 10.1007/164_2018_194.


Ethanol acts on KCNK13 potassium channels in the ventral tegmental area to increase firing rate and modulate binge-like drinking.

You C, Savarese A, Vandegrift BJ, He D, Pandey SC, Lasek AW, Brodie MS.

Neuropharmacology. 2019 Jan;144:29-36. doi: 10.1016/j.neuropharm.2018.10.008. Epub 2018 Oct 14.


Histone Deacetylase Inhibitor Suberanilohydroxamic Acid Treatment Reverses Hyposensitivity to γ-Aminobutyric Acid in the Ventral Tegmental Area During Ethanol Withdrawal.

You C, Vandegrift BJ, Zhang H, Lasek AW, Pandey SC, Brodie MS.

Alcohol Clin Exp Res. 2018 Nov;42(11):2160-2171. doi: 10.1111/acer.13870. Epub 2018 Sep 7.


Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol.

Fernández-Calle R, Vicente-Rodríguez M, Pastor M, Gramage E, Di Geronimo B, Zapico JM, Coderch C, Pérez-García C, Lasek AW, de Pascual-Teresa B, Ramos A, Herradón G.

Neuropharmacology. 2018 Jul 15;137:86-95. doi: 10.1016/j.neuropharm.2018.04.027. Epub 2018 May 9.


Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3.

Savarese A, Lasek AW.

Psychoneuroendocrinology. 2018 Jun;92:13-20. doi: 10.1016/j.psyneuen.2018.03.016. Epub 2018 Mar 27.


Transcriptional Regulators as Targets for Alcohol Pharmacotherapies.

Savarese AM, Lasek AW.

Handb Exp Pharmacol. 2018;248:505-533. doi: 10.1007/164_2018_101. Erratum in: Handb Exp Pharmacol. 2018;248:623-624.


Estradiol enhances ethanol reward in female mice through activation of ERα and ERβ.

Hilderbrand ER, Lasek AW.

Horm Behav. 2018 Feb;98:159-164. doi: 10.1016/j.yhbeh.2018.01.001. Epub 2018 Feb 9.


Estrogen Receptor β in the Nucleus Accumbens Regulates the Rewarding Properties of Cocaine in Female Mice.

Satta R, Certa B, He D, Lasek AW.

Int J Neuropsychopharmacol. 2018 Apr 1;21(4):382-392. doi: 10.1093/ijnp/pyx118.


Releasing Addiction Memories Trapped in Perineuronal Nets.

Lasek AW, Chen H, Chen WY.

Trends Genet. 2018 Mar;34(3):197-208. doi: 10.1016/j.tig.2017.12.004. Epub 2017 Dec 27. Review.


Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders.

Pastor M, Fernández-Calle R, Di Geronimo B, Vicente-Rodríguez M, Zapico JM, Gramage E, Coderch C, Pérez-García C, Lasek AW, Puchades-Carrasco L, Pineda-Lucena A, de Pascual-Teresa B, Herradón G, Ramos A.

Eur J Med Chem. 2018 Jan 20;144:318-329. doi: 10.1016/j.ejmech.2017.11.080. Epub 2017 Nov 28.


Studying Sex Differences in Animal Models of Addiction: An Emphasis on Alcohol-Related Behaviors.

Hilderbrand ER, Lasek AW.

ACS Chem Neurosci. 2018 Aug 15;9(8):1907-1916. doi: 10.1021/acschemneuro.7b00449. Epub 2017 Dec 26. Review.


Ovarian Hormones Contribute to High Levels of Binge-Like Drinking by Female Mice.

Satta R, Hilderbrand ER, Lasek AW.

Alcohol Clin Exp Res. 2018 Feb;42(2):286-294. doi: 10.1111/acer.13571. Epub 2018 Jan 8.


Estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol.

Vandegrift BJ, You C, Satta R, Brodie MS, Lasek AW.

PLoS One. 2017 Nov 6;12(11):e0187698. doi: 10.1371/journal.pone.0187698. eCollection 2017.


Anaplastic Lymphoma Kinase Is a Regulator of Alcohol Consumption and Excitatory Synaptic Plasticity in the Nucleus Accumbens Shell.

Mangieri RA, Maier EY, Buske TR, Lasek AW, Morrisett RA.

Front Pharmacol. 2017 Aug 15;8:533. doi: 10.3389/fphar.2017.00533. eCollection 2017.


Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking.

Ding ZM, Ingraham CM, Hauser SR, Lasek AW, Bell RL, McBride WJ.

Alcohol Clin Exp Res. 2017 Nov;41(11):1896-1906. doi: 10.1111/acer.13488. Epub 2017 Oct 3.


Midkine in the mouse ventral tegmental area limits ethanol intake and Ccl2 gene expression.

Chen H, He D, Lasek AW.

Genes Brain Behav. 2017 Sep;16(7):699-708. doi: 10.1111/gbb.12384. Epub 2017 May 2.


The Sodium Channel β4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons.

Ji X, Saha S, Gao G, Lasek AW, Homanics GE, Guildford M, Tapper AR, Martin GE.

Front Cell Neurosci. 2017 Feb 13;11:17. doi: 10.3389/fncel.2017.00017. eCollection 2017.


Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE.

J Neurosci. 2017 Feb 1;37(5):1139-1155. doi: 10.1523/JNEUROSCI.2002-16.2016. Epub 2016 Dec 16.


Defining the role of corticotropin releasing factor binding protein in alcohol consumption.

Haass-Koffler CL, Henry AT, Melkus G, Simms JA, Naemmuddin M, Nielsen CK, Lasek AW, Magill M, Schwandt ML, Momenan R, Hodgkinson CA, Bartlett SE, Swift RM, Bonci A, Leggio L.

Transl Psychiatry. 2016 Nov 15;6(11):e953. doi: 10.1038/tp.2016.208.


Inhibition of IKKβ Reduces Ethanol Consumption in C57BL/6J Mice.

Truitt JM, Blednov YA, Benavidez JM, Black M, Ponomareva O, Law J, Merriman M, Horani S, Jameson K, Lasek AW, Harris RA, Mayfield RD.

eNeuro. 2016 Oct 31;3(5). pii: ENEURO.0256-16.2016. eCollection 2016 Sep-Oct.


Effects of Ethanol on Brain Extracellular Matrix: Implications for Alcohol Use Disorder.

Lasek AW.

Alcohol Clin Exp Res. 2016 Oct;40(10):2030-2042. doi: 10.1111/acer.13200. Epub 2016 Sep 1. Review.


Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice.

Schweitzer P, Cates-Gatto C, Varodayan FP, Nadav T, Roberto M, Lasek AW, Roberts AJ.

Neuropharmacology. 2016 Aug;107:1-8. doi: 10.1016/j.neuropharm.2016.03.003. Epub 2016 Mar 2.


Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area.

Dutton JW 3rd, Chen H, You C, Brodie MS, Lasek AW.

Addict Biol. 2017 May;22(3):665-678. doi: 10.1111/adb.12358. Epub 2016 Jan 11.


Involvement of Purinergic P2X4 Receptors in Alcohol Intake of High-Alcohol-Drinking (HAD) Rats.

Franklin KM, Hauser SR, Lasek AW, Bell RL, McBride WJ.

Alcohol Clin Exp Res. 2015 Oct;39(10):2022-31. doi: 10.1111/acer.12836. Epub 2015 Sep 3.


Repeated Binge Drinking Increases Perineuronal Nets in the Insular Cortex.

Chen H, He D, Lasek AW.

Alcohol Clin Exp Res. 2015 Oct;39(10):1930-8. doi: 10.1111/acer.12847. Epub 2015 Sep 1.


Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain.

He D, Chen H, Muramatsu H, Lasek AW.

J Neurochem. 2015 Nov;135(3):508-21. doi: 10.1111/jnc.13252. Epub 2015 Aug 11.


Reduction of alcohol drinking of alcohol-preferring (P) and high-alcohol drinking (HAD1) rats by targeting phosphodiesterase-4 (PDE4).

Franklin KM, Hauser SR, Lasek AW, McClintick J, Ding ZM, McBride WJ, Bell RL.

Psychopharmacology (Berl). 2015 Jul;232(13):2251-62. doi: 10.1007/s00213-014-3852-3. Epub 2015 Jan 15.


Increased behavioral responses to ethanol in Lmo3 knockout mice.

Savarese A, Zou ME, Kharazia V, Maiya R, Lasek AW.

Genes Brain Behav. 2014 Nov;13(8):777-83. doi: 10.1111/gbb.12176. Epub 2014 Sep 24.


Sex differences in cocaine conditioned place preference in C57BL/6J mice.

Hilderbrand ER, Lasek AW.

Neuroreport. 2014 Jan 22;25(2):105-9. doi: 10.1097/WNR.0000000000000053.


The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors.

Ben Hamida S, Neasta J, Lasek AW, Kharazia V, Zou M, Carnicella S, Janak PH, Ron D.

J Neurosci. 2012 Nov 7;32(45):15849-58. doi: 10.1523/JNEUROSCI.2846-12.2012.


Lmo4 in the basolateral complex of the amygdala modulates fear learning.

Maiya R, Kharazia V, Lasek AW, Heberlein U.

PLoS One. 2012;7(4):e34559. doi: 10.1371/journal.pone.0034559. Epub 2012 Apr 3.


Alk is a transcriptional target of LMO4 and ERα that promotes cocaine sensitization and reward.

Lasek AW, Gesch J, Giorgetti F, Kharazia V, Heberlein U.

J Neurosci. 2011 Oct 5;31(40):14134-41. doi: 10.1523/JNEUROSCI.3415-11.2011.


An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol.

Lasek AW, Lim J, Kliethermes CL, Berger KH, Joslyn G, Brush G, Xue L, Robertson M, Moore MS, Vranizan K, Morris SW, Schuckit MA, White RL, Heberlein U.

PLoS One. 2011;6(7):e22636. doi: 10.1371/journal.pone.0022636. Epub 2011 Jul 22.


Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse.

Lasek AW, Giorgetti F, Berger KH, Tayor S, Heberlein U.

Alcohol Clin Exp Res. 2011 Sep;35(9):1600-6. doi: 10.1111/j.1530-0277.2011.01506.x. Epub 2011 May 20.


Lmo4 in the nucleus accumbens regulates cocaine sensitivity.

Lasek AW, Kapfhamer D, Kharazia V, Gesch J, Giorgetti F, Heberlein U.

Genes Brain Behav. 2010 Oct;9(7):817-24. doi: 10.1111/j.1601-183X.2010.00620.x. Epub 2010 Aug 12.


Virus-delivered RNA interference in mouse brain to study addiction-related behaviors.

Lasek AW, Azouaou N.

Methods Mol Biol. 2010;602:283-98. doi: 10.1007/978-1-60761-058-8_17.


Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins.

Heberlein U, Tsai LT, Kapfhamer D, Lasek AW.

Neuropharmacology. 2009;56 Suppl 1:97-106. doi: 10.1016/j.neuropharm.2008.07.023. Epub 2008 Jul 24. Review.


Viral delivery of small-hairpin RNAs for reducing gene expression in the rodent brain.

Lasek AW, Heberlein U.

Alcohol Res Health. 2008;31(3):259-60. Review.


Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior.

Lesscher HM, McMahon T, Lasek AW, Chou WH, Connolly J, Kharazia V, Messing RO.

Genes Brain Behav. 2008 Apr;7(3):323-33. Epub 2007 Oct 1.


Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice.

Lasek AW, Janak PH, He L, Whistler JL, Heberlein U.

Genes Brain Behav. 2007 Nov;6(8):728-35. Epub 2007 Mar 26.


Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms.

Rothenfluh A, Threlkeld RJ, Bainton RJ, Tsai LT, Lasek AW, Heberlein U.

Cell. 2006 Oct 6;127(1):199-211.


Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine.

Karpf AR, Lasek AW, Ririe TO, Hanks AN, Grossman D, Jones DA.

Mol Pharmacol. 2004 Jan;65(1):18-27.


Supplemental Content

Loading ...
Support Center