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Items: 1 to 50 of 57

1.

Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs.

Madsen KK, Clausen RP, Larsson OM, Krogsgaard-Larsen P, Schousboe A, White HS.

J Neurochem. 2009 May;109 Suppl 1:139-44. doi: 10.1111/j.1471-4159.2009.05982.x.

2.

Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).

Smith MD, Saunders GW, Clausen RP, Frølund B, Krogsgaard-Larsen P, Larsson OM, Schousboe A, Wilcox KS, White HS.

Epilepsy Res. 2008 Mar;79(1):6-13. doi: 10.1016/j.eplepsyres.2007.12.009. Epub 2008 Feb 8.

3.

Regulation of excitation by GABA neurotransmission: focus on metabolism and transport.

Madsen KK, Larsson OM, Schousboe A.

Results Probl Cell Differ. 2008;44:201-21. Review.

PMID:
17579816
4.

Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors.

Clausen RP, Madsen K, Larsson OM, Frølund B, Krogsgaard-Larsen P, Schousboe A.

Adv Pharmacol. 2006;54:265-84. Review. No abstract available.

PMID:
17175818
5.

Structure-activity relationships of selective GABA uptake inhibitors.

Høg S, Greenwood JR, Madsen KB, Larsson OM, Frølund B, Schousboe A, Krogsgaard-Larsen P, Clausen RP.

Curr Top Med Chem. 2006;6(17):1861-82. Review.

PMID:
17017962
6.

Neurotransmitter transporters: molecular function of important drug targets.

Gether U, Andersen PH, Larsson OM, Schousboe A.

Trends Pharmacol Sci. 2006 Jul;27(7):375-83. Epub 2006 Jun 9. Review.

PMID:
16762425
7.

A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.

Clausen RP, Frølund B, Larsson OM, Schousboe A, Krogsgaard-Larsen P, White HS.

Neurochem Int. 2006 May-Jun;48(6-7):637-42. Epub 2006 Mar 3. Review.

PMID:
16517017
8.

Effect of hyperosmotic conditions on the expression of the betaine-GABA-transporter (BGT-1) in cultured mouse astrocytes.

Olsen M, Sarup A, Larsson OM, Schousboe A.

Neurochem Res. 2005 Jun-Jul;30(6-7):855-65.

PMID:
16187220
9.

Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.

Clausen RP, Moltzen EK, Perregaard J, Lenz SM, Sanchez C, Falch E, Frølund B, Bolvig T, Sarup A, Larsson OM, Schousboe A, Krogsgaard-Larsen P.

Bioorg Med Chem. 2005 Feb 1;13(3):895-908.

PMID:
15653355
10.

First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.

White HS, Watson WP, Hansen SL, Slough S, Perregaard J, Sarup A, Bolvig T, Petersen G, Larsson OM, Clausen RP, Frølund B, Falch E, Krogsgaard-Larsen P, Schousboe A.

J Pharmacol Exp Ther. 2005 Feb;312(2):866-74. Epub 2004 Nov 18.

PMID:
15550575
11.

Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy.

Schousboe A, Larsson OM, Sarup A, White HS.

Eur J Pharmacol. 2004 Oct 1;500(1-3):281-7. Review.

PMID:
15464040
12.

GABA transporters as drug targets for modulation of GABAergic activity.

Schousboe A, Sarup A, Larsson OM, White HS.

Biochem Pharmacol. 2004 Oct 15;68(8):1557-63.

PMID:
15451399
13.

Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission.

Schousboe A, Sarup A, Bak LK, Waagepetersen HS, Larsson OM.

Neurochem Int. 2004 Sep;45(4):521-7. Review.

PMID:
15186918
14.

GABA transporters and GABA-transaminase as drug targets.

Sarup A, Larsson OM, Schousboe A.

Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):269-77. Review.

PMID:
12871037
15.
16.

Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs.

White HS, Sarup A, Bolvig T, Kristensen AS, Petersen G, Nelson N, Pickering DS, Larsson OM, Frølund B, Krogsgaard-Larsen P, Schousboe A.

J Pharmacol Exp Ther. 2002 Aug;302(2):636-44.

PMID:
12130726
17.
18.

Metabolic distinction between vesicular and cytosolic GABA in cultured GABAergic neurons using 13C magnetic resonance spectroscopy.

Waagepetersen HS, Sonnewald U, Gegelashvili G, Larsson OM, Schousboe A.

J Neurosci Res. 2001 Feb 15;63(4):347-55.

PMID:
11170185
19.

A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons.

Waagepetersen HS, Sonnewald U, Larsson OM, Schousboe A.

J Neurochem. 2000 Aug;75(2):471-9.

20.

Compartmentation of TCA cycle metabolism in cultured neocortical neurons revealed by 13C MR spectroscopy.

Waagepetersen HS, Sonnewald U, Larsson OM, Schousboe A.

Neurochem Int. 2000 Apr;36(4-5):349-58.

PMID:
10733002
21.

Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues.

Falch E, Perregaard J, FrŁlund B, SŁkilde B, Buur A, Hansen LM, Frydenvang K, Brehm L, Bolvig T, Larsson OM, Sanchez C, White HS, Schousboe A, Krogsgaard-Larsen P.

J Med Chem. 1999 Dec 30;42(26):5402-14.

PMID:
10639282
22.

Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity.

Bolvig T, Larsson OM, Pickering DS, Nelson N, Falch E, Krogsgaard-Larsen P, Schousboe A.

Eur J Pharmacol. 1999 Jun 30;375(1-3):367-74.

PMID:
10443590
23.

Synthesis of vesicular GABA from glutamine involves TCA cycle metabolism in neocortical neurons.

Waagepetersen HS, Sonnewald U, Larsson OM, Schousboe A.

J Neurosci Res. 1999 Aug 1;57(3):342-9.

PMID:
10412025
24.

Comparison of lactate and glucose metabolism in cultured neocortical neurons and astrocytes using 13C-NMR spectroscopy.

Waagepetersen HS, Bakken IJ, Larsson OM, Sonnewald U, Schousboe A.

Dev Neurosci. 1998;20(4-5):310-20.

PMID:
9778567
25.

Metabolism of lactate in cultured GABAergic neurons studied by 13C nuclear magnetic resonance spectroscopy.

Waagepetersen HS, Bakken IJ, Larsson OM, Sonnewald U, Schousboe A.

J Cereb Blood Flow Metab. 1998 Jan;18(1):109-17.

PMID:
9428311
26.

Trafficking between glia and neurons of TCA cycle intermediates and related metabolites.

Schousboe A, Westergaard N, Waagepetersen HS, Larsson OM, Bakken IJ, Sonnewald U.

Glia. 1997 Sep;21(1):99-105.

PMID:
9298852
27.

Synthesis and release of GABA in cerebral cortical neurons co-cultured with astrocytes from cerebral cortex or cerebellum.

Westergaard N, Larsson OM, Jensen B, Schousboe A.

Neurochem Int. 1992 Jun;20(4):567-75.

PMID:
1339021
28.
29.

Neuromodulatory actions of glutamate, GABA and taurine: regulatory role of astrocytes.

Schousboe A, Larsson OM, Frandsen A, Belhage B, Pasantes-Morales H, Krogsgaard-Larsen P.

Adv Exp Med Biol. 1991;296:165-80. Review. No abstract available.

PMID:
1685849
30.

Kinetic characterization of GABA-transaminase from cultured neurons and astrocytes.

Larsson OM, Schousboe A.

Neurochem Res. 1990 Nov;15(11):1073-7.

PMID:
2089267
31.

In vitro screening for anticonvulsant-induced teratogenesis in neural primary cultures and cell lines.

Regan CM, Gorman AM, Larsson OM, Maguire C, Martin ML, Schousboe A, Williams DC.

Int J Dev Neurosci. 1990;8(2):143-50.

PMID:
2109499
32.

Experimental studies of the influence of vigabatrin on the GABA system.

Gram L, Larsson OM, Johnsen A, Schousboe A.

Br J Clin Pharmacol. 1989;27 Suppl 1:13S-17S.

33.
35.

Effects of valproate, vigabatrin and aminooxyacetic acid on release of endogenous and exogenous GABA from cultured neurons.

Gram L, Larsson OM, Johnsen AH, Schousboe A.

Epilepsy Res. 1988 Mar-Apr;2(2):87-95.

PMID:
3143560
36.

GABA uptake inhibitors: relevance to antiepileptic drug research.

Krogsgaard-Larsen P, Falch E, Larsson OM, Schousboe A.

Epilepsy Res. 1987 Mar;1(2):77-93. Review. No abstract available.

PMID:
2973980
37.
39.

Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes.

Larsson OM, Gram L, Schousboe I, Schousboe A.

Neuropharmacology. 1986 Jun;25(6):617-25.

PMID:
3092125
40.
41.
42.

Ontogenetic development of glutamate and GABA metabolizing enzymes in cultured cerebral cortex interneurons and in cerebral cortex in vivo.

Larsson OM, Drejer J, Kvamme E, Svenneby G, Hertz L, Schousboe A.

Int J Dev Neurosci. 1985;3(2):177-85. doi: 10.1016/0736-5748(85)90008-5.

PMID:
24874599
43.

Characterization of the uptake of GABA, nipecotic acid and cis-4-OH-nipecotic acid in cultured neurons and astrocytes.

Larsson OM, Krogsgaard-Larsen P, Schousboe A.

Neurochem Int. 1985;7(5):853-60.

PMID:
20492996
44.
45.

Ontogenetic development of glutamate metabolizing enzymes in cultured cerebellar granule cells and in cerebellum in vivo.

Drejer J, Larsson OM, Kvamme E, Svenneby G, Hertz L, Schousboe A.

Neurochem Res. 1985 Jan;10(1):49-62.

PMID:
2858827
46.

Transport and metabolism of gamma-aminobutyric acid in neurons and glia: implications for epilepsy.

Schousboe A, Larsson OM, Wood JD, Krogsgaard-Larsen P.

Epilepsia. 1983 Oct;24(5):531-8.

PMID:
6311524
47.
48.
49.

Ion dependency of uptake and release of GABA and (RS)-nipecotic acid studied in cultured mouse brain cortex neurons.

Larsson OM, Drejer J, Hertz L, Schousboe A.

J Neurosci Res. 1983;9(3):291-302.

PMID:
6854668
50.

Variations in the kinetic pattern of astrocytic gamma-aminobutyric acid uptake when inhibited by different barbiturates.

Larsson OM, Schousboe A, Krogsgaard-Larsen P, Hertz L.

Biochem Pharmacol. 1982 Aug 15;31(16):2694-6. No abstract available.

PMID:
7138565

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