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Items: 1 to 50 of 486

1.

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation.

Hipolito VEB, Diaz JA, Tandoc KV, Oertlin C, Ristau J, Chauhan N, Saric A, Mclaughlan S, Larsson O, Topisirovic I, Botelho RJ.

PLoS Biol. 2019 Dec 4;17(12):e3000535. doi: 10.1371/journal.pbio.3000535. [Epub ahead of print]

2.

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.

Chan K, Robert F, Oertlin C, Kapeller-Libermann D, Avizonis D, Gutierrez J, Handly-Santana A, Doubrovin M, Park J, Schoepfer C, Da Silva B, Yao M, Gorton F, Shi J, Thomas CJ, Brown LE, Porco JA Jr, Pollak M, Larsson O, Pelletier J, Chio IIC.

Nat Commun. 2019 Nov 13;10(1):5151. doi: 10.1038/s41467-019-13086-5.

3.

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity.

Ristau J, van Hoef V, Peuget S, Zhu J, Guan BJ, Liang S, Hatzoglou M, Topisirovic I, Selivanova G, Larsson O.

Cell Death Dis. 2019 Nov 7;10(11):845. doi: 10.1038/s41419-019-2074-3.

4.

eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.

Müller D, Shin S, Goullet de Rugy T, Samain R, Baer R, Strehaiano M, Masvidal-Sanz L, Guillermet-Guibert J, Jean C, Tsukumo Y, Sonenberg N, Marion F, Guilbaud N, Hoffmann JS, Larsson O, Bousquet C, Pyronnet S, Martineau Y.

JCI Insight. 2019 Nov 1;4(21). pii: 121951. doi: 10.1172/jci.insight.121951.

5.

Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response.

Johnson JL, Stoica L, Liu Y, Zhu PJ, Bhattacharya A, Buffington SA, Huq R, Eissa NT, Larsson O, Porse BT, Domingo D, Nawaz U, Carroll R, Jolly L, Scerri TS, Kim HG, Brignell A, Coleman MJ, Braden R, Kini U, Jackson V, Baxter A, Bahlo M, Scheffer IE, Amor DJ, Hildebrand MS, Bonnen PE, Beeton C, Gecz J, Morgan AT, Costa-Mattioli M.

Neuron. 2019 Nov 20;104(4):665-679.e8. doi: 10.1016/j.neuron.2019.08.027. Epub 2019 Oct 1.

PMID:
31585809
6.

Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression.

Lorent J, Kusnadi EP, van Hoef V, Rebello RJ, Leibovitch M, Ristau J, Chen S, Lawrence MG, Szkop KJ, Samreen B, Balanathan P, Rapino F, Close P, Bukczynska P, Scharmann K, Takizawa I, Risbridger GP, Selth LA, Leidel SA, Lin Q, Topisirovic I, Larsson O, Furic L.

EMBO J. 2019 Dec 2;38(23):e101323. doi: 10.15252/embj.2018101323. Epub 2019 Sep 26.

PMID:
31556460
7.

Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK+ T-cell lymphoma.

George B, George SK, Shi W, Haque A, Shi P, Eskandari G, Axelson M, Larsson O, Kaseb AO, Amin HM.

J Hematol Oncol. 2019 Jul 24;12(1):80. doi: 10.1186/s13045-019-0768-8.

8.

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis.

Smith HW, Hirukawa A, Sanguin-Gendreau V, Nandi I, Dufour CR, Zuo D, Tandoc K, Leibovitch M, Singh S, Rennhack JP, Swiatnicki M, Lavoie C, Papavasiliou V, Temps C, Carragher NO, Unciti-Broceta A, Savage P, Basik M, van Hoef V, Larsson O, Cooper CL, Vargas Calderon AC, Beith J, Millar E, Selinger C, Giguère V, Park M, Harris LN, Varadan V, Andrechek ER, O'Toole SA, Topisirovic I, Muller WJ.

Nat Commun. 2019 Jul 1;10(1):2901. doi: 10.1038/s41467-019-10681-4.

9.

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.

Götte B, Panas MD, Hellström K, Liu L, Samreen B, Larsson O, Ahola T, McInerney GM.

PLoS Pathog. 2019 Jun 14;15(6):e1007842. doi: 10.1371/journal.ppat.1007842. eCollection 2019 Jun.

10.

Generally applicable transcriptome-wide analysis of translation using anota2seq.

Oertlin C, Lorent J, Murie C, Furic L, Topisirovic I, Larsson O.

Nucleic Acids Res. 2019 Jul 9;47(12):e70. doi: 10.1093/nar/gkz223.

11.

Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.

Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7973-7981. doi: 10.1073/pnas.1816023116. Epub 2019 Mar 29.

12.

SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma.

Isfort I, Cyra M, Elges S, Kailayangiri S, Altvater B, Rossig C, Steinestel K, Grünewald I, Huss S, Eßeling E, Mikesch JH, Hafner S, Simmet T, Wozniak A, Schöffski P, Larsson O, Wardelmann E, Trautmann M, Hartmann W.

Clin Cancer Res. 2019 Jun 15;25(12):3718-3731. doi: 10.1158/1078-0432.CCR-17-3553. Epub 2019 Feb 27.

PMID:
30814111
13.

Distinct Cancer-Promoting Stromal Gene Expression Depending on Lung Function.

Sandri BJ, Masvidal L, Murie C, Bartish M, Avdulov S, Higgins L, Markowski T, Peterson M, Bergh J, Yang P, Rolny C, Limper AH, Griffin TJ, Bitterman PB, Wendt CH, Larsson O.

Am J Respir Crit Care Med. 2019 Aug 1;200(3):348-358. doi: 10.1164/rccm.201801-0080OC.

PMID:
30742544
14.

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

Hulea L, Gravel SP, Morita M, Cargnello M, Uchenunu O, Im YK, Lehuédé C, Ma EH, Leibovitch M, McLaughlan S, Blouin MJ, Parisotto M, Papavasiliou V, Lavoie C, Larsson O, Ohh M, Ferreira T, Greenwood C, Bridon G, Avizonis D, Ferbeyre G, Siegel P, Jones RG, Muller W, Ursini-Siegel J, St-Pierre J, Pollak M, Topisirovic I.

Cell Metab. 2018 Dec 4;28(6):817-832.e8. doi: 10.1016/j.cmet.2018.09.001. Epub 2018 Sep 20.

PMID:
30244971
15.

Reply.

Larsson O, Uddman R, Kumlien Georén S, Cardell LO.

J Allergy Clin Immunol. 2018 Nov;142(5):1677-1678. doi: 10.1016/j.jaci.2018.07.001. Epub 2018 Aug 9. No abstract available.

PMID:
30100093
16.

hTERT promoter mutations in chondrosarcomas associate with progression and disease-related mortality.

Lin Y, Seger N, Chen Y, Hesla AC, Wejde J, Ghaderi M, Tsagkozis P, Larsson O, Haglund F.

Mod Pathol. 2018 Dec;31(12):1834-1841. doi: 10.1038/s41379-018-0098-3. Epub 2018 Jul 31.

17.

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease.

Timmons JA, Atherton PJ, Larsson O, Sood S, Blokhin IO, Brogan RJ, Volmar CH, Josse AR, Slentz C, Wahlestedt C, Phillips SM, Phillips BE, Gallagher IJ, Kraus WE.

Nucleic Acids Res. 2018 Sep 6;46(15):7772-7792. doi: 10.1093/nar/gky570.

18.

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome.

Leroux LP, Lorent J, Graber TE, Chaparro V, Masvidal L, Aguirre M, Fonseca BD, van Kempen LC, Alain T, Larsson O, Jaramillo M.

Infect Immun. 2018 Aug 22;86(9). pii: e00244-18. doi: 10.1128/IAI.00244-18. Print 2018 Sep.

19.

Characterization of an activating R1353H insulin-like growth factor 1 receptor variant in a male with extreme tall height.

Lin Y, van Duyvenvoorde HA, Liu H, Yang C, Warsito D, Yin C, Kant SG, Haglund F, Wit JM, Larsson O.

Eur J Endocrinol. 2018 Aug;179(2):85-95. doi: 10.1530/EJE-18-0176. Epub 2018 May 22.

PMID:
29789409
20.

Co-expression of β Subunits with the Voltage-Gated Sodium Channel NaV1.7: the Importance of Subunit Association and Phosphorylation and Their Effects on Channel Pharmacology and Biophysics.

Sokolov MV, Henrich-Noack P, Raynoschek C, Franzén B, Larsson O, Main M, Dabrowski M.

J Mol Neurosci. 2018 Jun;65(2):154-166. doi: 10.1007/s12031-018-1082-6. Epub 2018 May 10.

PMID:
29744740
21.

eIF4E-Binding Proteins 1 and 2 Limit Macrophage Anti-Inflammatory Responses through Translational Repression of IL-10 and Cyclooxygenase-2.

William M, Leroux LP, Chaparro V, Lorent J, Graber TE, M'Boutchou MN, Charpentier T, Fabié A, Dozois CM, Stäger S, van Kempen LC, Alain T, Larsson O, Jaramillo M.

J Immunol. 2018 Jun 15;200(12):4102-4116. doi: 10.4049/jimmunol.1701670. Epub 2018 Apr 30.

22.

Telomerase promoter mutations and copy number alterations in solitary fibrous tumours.

Lin Y, Seger N, Tsagkozis P, Hesla AC, Ghaderi M, Chen Y, Ehnman M, Warsito D, Wejde J, Larsson O, Haglund F.

J Clin Pathol. 2018 Sep;71(9):832-839. doi: 10.1136/jclinpath-2018-205132. Epub 2018 Apr 27.

PMID:
29703757
23.

Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps.

Tengroth L, Arebro J, Larsson O, Bachert C, Georén SK, Cardell LO.

Sci Rep. 2018 Jan 24;8(1):1561. doi: 10.1038/s41598-018-19955-1.

24.

A Unique ISR Program Determines Cellular Responses to Chronic Stress.

Guan BJ, van Hoef V, Jobava R, Elroy-Stein O, Valasek LS, Cargnello M, Gao XH, Krokowski D, Merrick WC, Kimball SR, Komar AA, Koromilas AE, Wynshaw-Boris A, Topisirovic I, Larsson O, Hatzoglou M.

Mol Cell. 2017 Dec 7;68(5):885-900.e6. doi: 10.1016/j.molcel.2017.11.007.

25.

Normalization of mass spectrometry data (NOMAD).

Murie C, Sandri B, Sandberg AS, Griffin TJ, Lehtiö J, Wendt C, Larsson O.

Adv Biol Regul. 2018 Jan;67:128-133. doi: 10.1016/j.jbior.2017.11.005. Epub 2017 Nov 20.

26.

Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation.

Yin C, Fufa T, Chandrasekar G, Aeluri M, Zaky V, Abdelhady S, Rodríguez AB, Jakobsson J, Varnoosfaderani FS, Mahalingam J, Liu J, Larsson O, Hovatta O, Gaunitz F, Göndör A, Andäng M, Kitambi SS.

Front Pharmacol. 2017 Oct 24;8:726. doi: 10.3389/fphar.2017.00726. eCollection 2017.

27.

Phase I clinical trial of AXL1717 for treatment of relapsed malignant astrocytomas: analysis of dose and response.

Aiken R, Axelson M, Harmenberg J, Klockare M, Larsson O, Wassberg C.

Oncotarget. 2017 Sep 6;8(46):81501-81510. doi: 10.18632/oncotarget.20662. eCollection 2017 Oct 6.

28.

Polysome-profiling in small tissue samples.

Liang S, Bellato HM, Lorent J, Lupinacci FCS, Oertlin C, van Hoef V, Andrade VP, Roffé M, Masvidal L, Hajj GNM, Larsson O.

Nucleic Acids Res. 2018 Jan 9;46(1):e3. doi: 10.1093/nar/gkx940.

29.

Cancer as an ecomolecular disease and a neoplastic consortium.

Ramón Y Cajal S, Capdevila C, Hernandez-Losa J, De Mattos-Arruda L, Ghosh A, Lorent J, Larsson O, Aasen T, Postovit LM, Topisirovic I.

Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):484-499. doi: 10.1016/j.bbcan.2017.09.004. Epub 2017 Sep 23. Review.

PMID:
28947238
30.

Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage.

Waraky A, Lin Y, Warsito D, Haglund F, Aleem E, Larsson O.

J Biol Chem. 2017 Nov 3;292(44):18227-18239. doi: 10.1074/jbc.M117.781492. Epub 2017 Sep 18.

31.

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

Morita M, Prudent J, Basu K, Goyon V, Katsumura S, Hulea L, Pearl D, Siddiqui N, Strack S, McGuirk S, St-Pierre J, Larsson O, Topisirovic I, Vali H, McBride HM, Bergeron JJ, Sonenberg N.

Mol Cell. 2017 Sep 21;67(6):922-935.e5. doi: 10.1016/j.molcel.2017.08.013. Epub 2017 Sep 14.

32.

FNA cytology of solitary fibrous tumors and the diagnostic value of STAT6 immunocytochemistry.

Tani E, Wejde J, Åström K, Wingmo IL, Larsson O, Haglund F.

Cancer Cytopathol. 2018 Jan;126(1):36-43. doi: 10.1002/cncy.21923. Epub 2017 Sep 15.

33.

mTOR-sensitive translation: Cleared fog reveals more trees.

Masvidal L, Hulea L, Furic L, Topisirovic I, Larsson O.

RNA Biol. 2017 Oct 3;14(10):1299-1305. doi: 10.1080/15476286.2017.1290041. Epub 2017 Feb 10. Review.

34.

Substance P represents a novel first-line defense mechanism in the nose.

Larsson O, Tengroth L, Xu Y, Uddman R, Kumlien Georén S, Cardell LO.

J Allergy Clin Immunol. 2018 Jan;141(1):128-136.e3. doi: 10.1016/j.jaci.2017.01.021. Epub 2017 Feb 20.

PMID:
28219705
35.

SUMO-modified insulin-like growth factor 1 receptor (IGF-1R) increases cell cycle progression and cell proliferation.

Lin Y, Liu H, Waraky A, Haglund F, Agarwal P, Jernberg-Wiklund H, Warsito D, Larsson O.

J Cell Physiol. 2017 Oct;232(10):2722-2730. doi: 10.1002/jcp.25818. Epub 2017 Apr 25.

36.

Pericyte-fibroblast transition promotes tumor growth and metastasis.

Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, Hartman J, Religa P, Morikawa H, Ishii Y, Sasahara M, Larsson O, Cossu G, Cao R, Lim S, Cao Y.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5618-27. doi: 10.1073/pnas.1608384113. Epub 2016 Sep 7.

37.

Downregulation of IGF-1 receptor occurs after hepatic linage commitment during hepatocyte differentiation from human embryonic stem cells.

Waraky A, Aleem E, Larsson O.

Biochem Biophys Res Commun. 2016 Sep 30;478(4):1575-81. doi: 10.1016/j.bbrc.2016.08.157. Epub 2016 Aug 31.

38.

HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat.

Angelika Ihle M, Merkelbach-Bruse S, Hartmann W, Bauer S, Ratner N, Sonobe H, Nishio J, Larsson O, Åman P, Pedeutour F, Taguchi T, Wardelmann E, Buettner R, Schildhaus HU.

J Pathol Clin Res. 2016 Feb 5;2(2):59-71. doi: 10.1002/cjp2.35. eCollection 2016 Apr.

39.

IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells.

Mao Y, van Hoef V, Zhang X, Wennerberg E, Lorent J, Witt K, Masvidal L, Liang S, Murray S, Larsson O, Kiessling R, Lundqvist A.

Blood. 2016 Sep 15;128(11):1475-89. doi: 10.1182/blood-2016-02-698027. Epub 2016 Jul 27.

40.

The bronchodilatory capacity of imiquimod: the existence of two mechanisms.

Larsson OJ, Manson ML, Starkhammar M, Fuchs B, Adner M, Kumlien Georén S, Cardell LO.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L178-9. doi: 10.1152/ajplung.00223.2016. No abstract available.

41.

Nuclearly translocated insulin-like growth factor 1 receptor phosphorylates histone H3 at tyrosine 41 and induces SNAI2 expression via Brg1 chromatin remodeling protein.

Warsito D, Lin Y, Gnirck AC, Sehat B, Larsson O.

Oncotarget. 2016 Jul 5;7(27):42288-42302. doi: 10.18632/oncotarget.9785.

42.

Novel strategies for the treatment of grass pollen-induced allergic rhinitis.

Larsson O, Hellkvist L, Peterson-Westin U, Cardell LO.

Expert Opin Biol Ther. 2016 Sep;16(9):1143-50. doi: 10.1080/14712598.2016.1190829. Epub 2016 Jun 9. Review.

PMID:
27269991
43.

iGEMS: an integrated model for identification of alternative exon usage events.

Sood S, Szkop KJ, Nakhuda A, Gallagher IJ, Murie C, Brogan RJ, Kaprio J, Kainulainen H, Atherton PJ, Kujala UM, Gustafsson T, Larsson O, Timmons JA.

Nucleic Acids Res. 2016 Jun 20;44(11):e109. doi: 10.1093/nar/gkw263. Epub 2016 Apr 19.

44.

The TLR7 agonist imiquimod induces bronchodilation via a nonneuronal TLR7-independent mechanism: a possible role for quinoline in airway dilation.

Larsson OJ, Manson ML, Starkhammar M, Fuchs B, Adner M, Kumlien Georén S, Cardell LO.

Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1121-9. doi: 10.1152/ajplung.00288.2015. Epub 2016 Apr 15.

45.

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.

Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, Tenkerian C, Morita M, Balanathan P, Jean-Jean O, Stambolic V, Trost M, Furic L, Larose L, Koromilas AE, Asano K, Litchfield D, Larsson O, Topisirovic I.

Nat Commun. 2016 Apr 4;7:11127. doi: 10.1038/ncomms11127.

46.

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.

Gandin V, Masvidal L, Hulea L, Gravel SP, Cargnello M, McLaughlan S, Cai Y, Balanathan P, Morita M, Rajakumar A, Furic L, Pollak M, Porco JA Jr, St-Pierre J, Pelletier J, Larsson O, Topisirovic I.

Genome Res. 2016 May;26(5):636-48. doi: 10.1101/gr.197566.115. Epub 2016 Mar 16.

47.

Tumor cell survival dependence on the DHX9 DExH-box helicase.

Lee T, Paquet M, Larsson O, Pelletier J.

Oncogene. 2016 Sep 29;35(39):5093-105. doi: 10.1038/onc.2016.52. Epub 2016 Mar 14.

48.

Stimulation of cannabinoid CB1 receptors prevents nerve-mediated airway hyperreactivity in NGF-induced inflammation in mouse airways.

Bozkurt TE, Larsson O, Adner M.

Eur J Pharmacol. 2016 Apr 5;776:132-8. doi: 10.1016/j.ejphar.2016.02.045. Epub 2016 Feb 16.

PMID:
26896777
49.

Intralymphatic immunotherapy of pollen-induced rhinoconjunctivitis: a double-blind placebo-controlled trial.

Hylander T, Larsson O, Petersson-Westin U, Eriksson M, Kumlien Georén S, Winqvist O, Cardell LO.

Respir Res. 2016 Jan 27;17:10. doi: 10.1186/s12931-016-0324-9.

50.

Microenvironmental Targets in Sarcoma.

Ehnman M, Larsson O.

Front Oncol. 2015 Nov 4;5:248. doi: 10.3389/fonc.2015.00248. eCollection 2015. Review.

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