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Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study.

Lazou Ahrén I, Berggren A, Teixeira C, Martinsson Niskanen T, Larsson N.

Eur J Nutr. 2019 Nov 16. doi: 10.1007/s00394-019-02137-8. [Epub ahead of print]


MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition.

Busch JD, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schöndorf T, Li X, Pearce SF, Milenkovic D, Rorbach J, Larsson NG.

Cell Rep. 2019 Nov 5;29(6):1728-1738.e9. doi: 10.1016/j.celrep.2019.09.080.


Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.

Nicholls TJ, Spåhr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM.

Mol Cell. 2019 Sep 27. pii: S1097-2765(19)30695-1. doi: 10.1016/j.molcel.2019.09.010. [Epub ahead of print]


Mitochondrial fusion is required for regulation of mitochondrial DNA replication.

Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A.

PLoS Genet. 2019 Jun 6;15(6):e1008085. doi: 10.1371/journal.pgen.1008085. eCollection 2019 Jun.


TEFM regulates both transcription elongation and RNA processing in mitochondria.

Jiang S, Koolmeister C, Misic J, Siira S, Kühl I, Silva Ramos E, Miranda M, Jiang M, Posse V, Lytovchenko O, Atanassov I, Schober FA, Wibom R, Hultenby K, Milenkovic D, Gustafsson CM, Filipovska A, Larsson NG.

EMBO Rep. 2019 Jun;20(6). pii: e48101. doi: 10.15252/embr.201948101. Epub 2019 Apr 29.


Engineering a Model Cell for Rational Tuning of GPCR Signaling.

Shaw WM, Yamauchi H, Mead J, Gowers GF, Bell DJ, Öling D, Larsson N, Wigglesworth M, Ladds G, Ellis T.

Cell. 2019 Apr 18;177(3):782-796.e27. doi: 10.1016/j.cell.2019.02.023. Epub 2019 Apr 4.


Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse.

Filograna R, Koolmeister C, Upadhyay M, Pajak A, Clemente P, Wibom R, Simard ML, Wredenberg A, Freyer C, Stewart JB, Larsson NG.

Sci Adv. 2019 Apr 3;5(4):eaav9824. doi: 10.1126/sciadv.aav9824. eCollection 2019 Apr.


Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.

Bacman SR, Kauppila JHK, Pereira CV, Nissanka N, Miranda M, Pinto M, Williams SL, Larsson NG, Stewart JB, Moraes CT.

Nat Med. 2018 Dec;24(12):1940. doi: 10.1038/s41591-018-0234-0.


MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.

Bacman SR, Kauppila JHK, Pereira CV, Nissanka N, Miranda M, Pinto M, Williams SL, Larsson NG, Stewart JB, Moraes CT.

Nat Med. 2018 Nov;24(11):1696-1700. doi: 10.1038/s41591-018-0166-8. Epub 2018 Sep 24. Erratum in: Nat Med. 2018 Oct 5;:.


Mutations of mitochondrial DNA are not major contributors to aging of fruit flies.

Kauppila TES, Bratic A, Jensen MB, Baggio F, Partridge L, Jasper H, Grönke S, Larsson NG.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9620-E9629. doi: 10.1073/pnas.1721683115. Epub 2018 Sep 24.


Heparin-binding protein in ventilator-induced lung injury.

Tydén J, Larsson N, Lehtipalo S, Herwald H, Hultin M, Walldén J, Behndig AF, Johansson J.

Intensive Care Med Exp. 2018 Sep 10;6(1):33. doi: 10.1186/s40635-018-0198-x.


Large Scale Synthetic Site Saturation GPCR Libraries Reveal Novel Mutations That Alter Glucose Signaling.

Öling D, Lawenius L, Shaw W, Clark S, Kettleborough R, Ellis T, Larsson N, Wigglesworth M.

ACS Synth Biol. 2018 Sep 21;7(9):2317-2321. doi: 10.1021/acssynbio.8b00118. Epub 2018 Sep 12.


Ex vivo anti-inflammatory effects of probiotics for periodontal health.

Schmitter T, Fiebich BL, Fischer JT, Gajfulin M, Larsson N, Rose T, Goetz MR.

J Oral Microbiol. 2018 Jul 25;10(1):1502027. doi: 10.1080/20002297.2018.1502027. eCollection 2018.


Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice.

Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG.

Nucleic Acids Res. 2018 Jul 27;46(13):6642-6669. doi: 10.1093/nar/gky456.


PTCD1 Is Required for 16S rRNA Maturation Complex Stability and Mitochondrial Ribosome Assembly.

Perks KL, Rossetti G, Kuznetsova I, Hughes LA, Ermer JA, Ferreira N, Busch JD, Rudler DL, Spahr H, Schöndorf T, Shearwood AJ, Viola HM, Siira SJ, Hool LC, Milenkovic D, Larsson NG, Rackham O, Filipovska A.

Cell Rep. 2018 Apr 3;23(1):127-142. doi: 10.1016/j.celrep.2018.03.033.


Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, Bauer U, Kessler H, Cai M, Hruby VJ, Plowright AT, Craik DJ.

J Med Chem. 2018 Apr 26;61(8):3674-3684. doi: 10.1021/acs.jmedchem.8b00170. Epub 2018 Apr 11.


Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.

Matic S, Jiang M, Nicholls TJ, Uhler JP, Dirksen-Schwanenland C, Polosa PL, Simard ML, Li X, Atanassov I, Rackham O, Filipovska A, Stewart JB, Falkenberg M, Larsson NG, Milenkovic D.

Nat Commun. 2018 Mar 23;9(1):1202. doi: 10.1038/s41467-018-03552-x.


SnapShot: Mitochondrial Nucleoid.

Bonekamp NA, Larsson NG.

Cell. 2018 Jan 11;172(1-2):388-388.e1. doi: 10.1016/j.cell.2017.12.039. Review.


Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.

Nicholls TJ, Nadalutti CA, Motori E, Sommerville EW, Gorman GS, Basu S, Hoberg E, Turnbull DM, Chinnery PF, Larsson NG, Larsson E, Falkenberg M, Taylor RW, Griffith JD, Gustafsson CM.

Mol Cell. 2018 Jan 4;69(1):9-23.e6. doi: 10.1016/j.molcel.2017.11.033. Epub 2017 Dec 28.


LRPPRC-mediated folding of the mitochondrial transcriptome.

Siira SJ, Spåhr H, Shearwood AJ, Ruzzenente B, Larsson NG, Rackham O, Filipovska A.

Nat Commun. 2017 Nov 16;8(1):1532. doi: 10.1038/s41467-017-01221-z.


Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals.

Kühl I, Miranda M, Atanassov I, Kuznetsova I, Hinze Y, Mourier A, Filipovska A, Larsson NG.

Elife. 2017 Nov 14;6. pii: e30952. doi: 10.7554/eLife.30952.


Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load.

Jiang M, Kauppila TES, Motori E, Li X, Atanassov I, Folz-Donahue K, Bonekamp NA, Albarran-Gutierrez S, Stewart JB, Larsson NG.

Cell Metab. 2017 Aug 1;26(2):429-436.e4. doi: 10.1016/j.cmet.2017.07.003.


Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila.

Brandt T, Mourier A, Tain LS, Partridge L, Larsson NG, Kühlbrandt W.

Elife. 2017 Jul 12;6. pii: e24662. doi: 10.7554/eLife.24662.


Efficacy and Safety of Lactobacillus plantarum DSM 9843 (LP299V) in the Prevention of Antibiotic-Associated Gastrointestinal Symptoms in Children-Randomized, Double-Blind, Placebo-Controlled Study.

Olek A, Woynarowski M, Ahrén IL, Kierkuś J, Socha P, Larsson N, Önning G.

J Pediatr. 2017 Jul;186:82-86. doi: 10.1016/j.jpeds.2017.03.047. Epub 2017 Apr 21.


The Enigma of the Respiratory Chain Supercomplex.

Milenkovic D, Blaza JN, Larsson NG, Hirst J.

Cell Metab. 2017 Apr 4;25(4):765-776. doi: 10.1016/j.cmet.2017.03.009. Review.


An Adaptable High-Throughput Technology Enabling the Identification of Specific Transcription Modulators.

Bergbrede T, Hoberg E, Larsson NG, Falkenberg M, Gustafsson CM.

SLAS Discov. 2017 Apr;22(4):378-386. doi: 10.1177/2472555217690326. Epub 2017 Jan 31.


Mammalian Mitochondria and Aging: An Update.

Kauppila TES, Kauppila JHK, Larsson NG.

Cell Metab. 2017 Jan 10;25(1):57-71. doi: 10.1016/j.cmet.2016.09.017. Epub 2016 Oct 27. Review.


A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, Filograna R, Larsson NG, Greaves LC, Stewart JB.

Cell Rep. 2016 Sep 13;16(11):2980-2990. doi: 10.1016/j.celrep.2016.08.037.


COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation.

Pérez-Pérez R, Lobo-Jarne T, Milenkovic D, Mourier A, Bratic A, García-Bartolomé A, Fernández-Vizarra E, Cadenas S, Delmiro A, García-Consuegra I, Arenas J, Martín MA, Larsson NG, Ugalde C.

Cell Rep. 2016 Aug 30;16(9):2387-98. doi: 10.1016/j.celrep.2016.07.081. Epub 2016 Aug 18.


POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.

Kühl I, Miranda M, Posse V, Milenkovic D, Mourier A, Siira SJ, Bonekamp NA, Neumann U, Filipovska A, Polosa PL, Gustafsson CM, Larsson NG.

Sci Adv. 2016 Aug 5;2(8):e1600963. doi: 10.1126/sciadv.1600963. eCollection 2016 Aug.


Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.

Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A.

Cell Rep. 2016 Aug 16;16(7):1874-90. doi: 10.1016/j.celrep.2016.07.031. Epub 2016 Aug 4.


SLIRP stabilizes LRPPRC via an RRM-PPR protein interface.

Spåhr H, Rozanska A, Li X, Atanassov I, Lightowlers RN, Chrzanowska-Lightowlers ZM, Rackham O, Larsson NG.

Nucleic Acids Res. 2016 Aug 19;44(14):6868-82. doi: 10.1093/nar/gkw575. Epub 2016 Jun 28.


Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice.

Richman TR, Spåhr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A.

Nat Commun. 2016 Jun 20;7:11884. doi: 10.1038/ncomms11884.


Change of Community Readiness Over Time: Measurements of Reduction of Parental Support and Availability of Alcohol in Seven Communities.

Åhström M, Larsson N, Lindberg L.

Health Promot Pract. 2016 Jul;17(4):586-95. doi: 10.1177/1524839916632741. Epub 2016 Apr 19.


Bioenergetic roles of mitochondrial fusion.

Silva Ramos E, Larsson NG, Mourier A.

Biochim Biophys Acta. 2016 Aug;1857(8):1277-1283. doi: 10.1016/j.bbabio.2016.04.002. Epub 2016 Apr 7. Review.


Maintenance and Expression of Mammalian Mitochondrial DNA.

Gustafsson CM, Falkenberg M, Larsson NG.

Annu Rev Biochem. 2016 Jun 2;85:133-60. doi: 10.1146/annurev-biochem-060815-014402. Epub 2016 Mar 24. Review.


Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents.

Fjellström O, Larsson N, Yasuda S, Tsuchida T, Oguma T, Marley A, Wennberg-Huldt C, Hovdal D, Fukuda H, Yoneyama Y, Sasaki K, Johansson A, Lundqvist S, Brengdahl J, Isaacs RJ, Brown D, Geschwindner S, Benthem L, Priest C, Turnbull A.

PLoS One. 2015 Dec 31;10(12):e0145849. doi: 10.1371/journal.pone.0145849. eCollection 2015.


Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.

Bratic A, Kauppila TE, Macao B, Grönke S, Siibak T, Stewart JB, Baggio F, Dols J, Partridge L, Falkenberg M, Wredenberg A, Larsson NG.

Nat Commun. 2015 Nov 10;6:8808. doi: 10.1038/ncomms9808.


Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing.

Lee S, Rose S, Metodiev MD, Becker L, Vernaleken A, Klopstock T, Gailus-Durner V, Fuchs H, Hrabě De Angelis M, Douthwaite S, Larsson NG.

Hum Mol Genet. 2015 Dec 20;24(25):7286-94. doi: 10.1093/hmg/ddv427. Epub 2015 Oct 12.


Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid.

Kukat C, Davies KM, Wurm CA, Spåhr H, Bonekamp NA, Kühl I, Joos F, Polosa PL, Park CB, Posse V, Falkenberg M, Jakobs S, Kühlbrandt W, Larsson NG.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11288-93. doi: 10.1073/pnas.1512131112. Epub 2015 Aug 24.


SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation.

Lagouge M, Mourier A, Lee HJ, Spåhr H, Wai T, Kukat C, Silva Ramos E, Motori E, Busch JD, Siira S; German Mouse Clinic Consortium, Kremmer E, Filipovska A, Larsson NG.

PLoS Genet. 2015 Aug 6;11(8):e1005423. doi: 10.1371/journal.pgen.1005423. eCollection 2015 Aug.


Mic10 Oligomerization Pinches off Mitochondrial Cristae.

Milenkovic D, Larsson NG.

Cell Metab. 2015 May 5;21(5):660-1. doi: 10.1016/j.cmet.2015.04.020.


Identification of vitamin C transporters in the human airways: a cross-sectional in vivo study.

Larsson N, Rankin GD, Bicer EM, Roos-Engstrand E, Pourazar J, Blomberg A, Mudway IS, Behndig AF.

BMJ Open. 2015 Apr 8;5(4):e006979. doi: 10.1136/bmjopen-2014-006979.


Percutaneously inserted long-term central venous catheters in pigs of different sizes.

Larsson N, Claesson Lingehall H, Al Zaidi N, Claesson J, Jensen-Waern M, Lehtipalo S.

Lab Anim. 2015 Jul;49(3):215-9. doi: 10.1177/0023677215575222. Epub 2015 Mar 2.


Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels.

Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG.

J Cell Biol. 2015 Feb 16;208(4):429-42. doi: 10.1083/jcb.201411100.


Using the BioAssay Ontology for analyzing high-throughput screening data.

Zander Balderud L, Murray D, Larsson N, Vempati U, Schürer SC, Bjäreland M, Engkvist O.

J Biomol Screen. 2015 Mar;20(3):402-15. doi: 10.1177/1087057114563493. Epub 2014 Dec 15.


Partial agonist activity of R3(BΔ23-27)R/I5 at RXFP3--investigation of in vivo and in vitro pharmacology.

Kristensson L, Mayer G, Ploj K, Wetterlund M, Arlbrandt S, Björquist A, Wissing BM, Castaldo M, Larsson N.

Eur J Pharmacol. 2015 Jan 15;747:123-31. doi: 10.1016/j.ejphar.2014.11.041. Epub 2014 Dec 11.


The respiratory chain supercomplex organization is independent of COX7a2l isoforms.

Mourier A, Matic S, Ruzzenente B, Larsson NG, Milenkovic D.

Cell Metab. 2014 Dec 2;20(6):1069-75. doi: 10.1016/j.cmet.2014.11.005.


Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation.

Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG.

Nucleic Acids Res. 2014 Dec 16;42(22):13920-38. doi: 10.1093/nar/gku1132. Epub 2014 Nov 26.


Keeping mtDNA in shape between generations.

Stewart JB, Larsson NG.

PLoS Genet. 2014 Oct 9;10(10):e1004670. doi: 10.1371/journal.pgen.1004670. eCollection 2014 Oct. Review.

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