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Mechanisms Underlying the Dual Effect of Polyunsaturated Fatty Acid Analogs on Kv7.1.

Liin SI, Yazdi S, Ramentol R, Barro-Soria R, Larsson HP.

Cell Rep. 2018 Sep 11;24(11):2908-2918. doi: 10.1016/j.celrep.2018.08.031.


ω-6 and ω-9 polyunsaturated fatty acids with double bonds near the carboxyl head have the highest affinity and largest effects on the cardiac IK s potassium channel.

Bohannon BM, Perez ME, Liin SI, Larsson HP.

Acta Physiol (Oxf). 2019 Feb;225(2):e13186. doi: 10.1111/apha.13186. Epub 2018 Oct 17.


Gating charge displacement in a monomeric voltage-gated proton (Hv1) channel.

Carmona EM, Larsson HP, Neely A, Alvarez O, Latorre R, Gonzalez C.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9240-9245. doi: 10.1073/pnas.1809705115. Epub 2018 Aug 20.


KCNE1 tunes the sensitivity of KV7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site.

Larsson JE, Larsson HP, Liin SI.

Elife. 2018 Jul 17;7. pii: e37257. doi: 10.7554/eLife.37257.


Mutations in ATP1A1 Cause Dominant Charcot-Marie-Tooth Type 2.

Lassuthova P, Rebelo AP, Ravenscroft G, Lamont PJ, Davis MR, Manganelli F, Feely SM, Bacon C, Brožková DŠ, Haberlova J, Mazanec R, Tao F, Saghira C, Abreu L, Courel S, Powell E, Buglo E, Bis DM, Baxter MF, Ong RW, Marns L, Lee YC, Bai Y, Isom DG, Barro-Soria R, Chung KW, Scherer SS, Larsson HP, Laing NG, Choi BO, Seeman P, Shy ME, Santoro L, Zuchner S.

Am J Hum Genet. 2018 Mar 1;102(3):505-514. doi: 10.1016/j.ajhg.2018.01.023.


KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions.

Barro-Soria R, Ramentol R, Liin SI, Perez ME, Kass RS, Larsson HP.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7367-E7376. doi: 10.1073/pnas.1710335114. Epub 2017 Aug 14.


Using fluorescence to understand β subunit-NaV channel interactions.

Barro-Soria R, Liin SI, Larsson HP.

J Gen Physiol. 2017 Jul 18. pii: jgp.201711843. doi: 10.1085/jgp.201711843. [Epub ahead of print] No abstract available.


Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations.

Peng G, Barro-Soria R, Sampson KJ, Larsson HP, Kass RS.

Sci Rep. 2017 Apr 6;7:45911. doi: 10.1038/srep45911.


Specificity of M-channel activators: binding or effect?

Barro-Soria R, Liin SI, Larsson HP.

J Physiol. 2017 Feb 1;595(3):605-606. doi: 10.1113/JP273250. No abstract available.


Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations.

Liin SI, Larsson JE, Barro-Soria R, Bentzen BH, Larsson HP.

Elife. 2016 Sep 30;5. pii: e20272. doi: 10.7554/eLife.20272.


Molecular mechanism of Zn2+ inhibition of a voltage-gated proton channel.

Qiu F, Chamberlin A, Watkins BM, Ionescu A, Perez ME, Barro-Soria R, González C, Noskov SY, Larsson HP.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5962-E5971. Epub 2016 Sep 19.


High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure.

Dahl GP, Conner GE, Qiu F, Wang J, Spindler E, Campagna JA, Larsson HP.

EBioMedicine. 2016 Aug;10:291-7. doi: 10.1016/j.ebiom.2016.06.027. Epub 2016 Jun 22.


KCNE3 acts by promoting voltage sensor activation in KCNQ1.

Barro-Soria R, Perez ME, Larsson HP.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7286-92. doi: 10.1073/pnas.1516238112. Epub 2015 Dec 14.


Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel.

Liin SI, Silverå Ejneby M, Barro-Soria R, Skarsfeldt MA, Larsson JE, Starck Härlin F, Parkkari T, Bentzen BH, Schmitt N, Larsson HP, Elinder F.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5714-9. doi: 10.1073/pnas.1503488112. Epub 2015 Apr 21.


The KCNQ1 channel - remarkable flexibility in gating allows for functional versatility.

Liin SI, Barro-Soria R, Larsson HP.

J Physiol. 2015 Jun 15;593(12):2605-15. doi: 10.1113/jphysiol.2014.287607. Epub 2015 Mar 18. Review.


Mapping the gating and permeation pathways in the voltage-gated proton channel Hv1.

Chamberlin A, Qiu F, Wang Y, Noskov SY, Larsson HP.

J Mol Biol. 2015 Jan 16;427(1):131-45. doi: 10.1016/j.jmb.2014.11.018. Epub 2014 Dec 4.


EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake.

Zhou Y, Wang X, Tzingounis AV, Danbolt NC, Larsson HP.

J Neurosci. 2014 Oct 1;34(40):13472-85. doi: 10.1523/JNEUROSCI.2282-14.2014.


KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps.

Barro-Soria R, Rebolledo S, Liin SI, Perez ME, Sampson KJ, Kass RS, Larsson HP.

Nat Commun. 2014 Apr 28;5:3750. doi: 10.1038/ncomms4750.


Hydrophobic plug functions as a gate in voltage-gated proton channels.

Chamberlin A, Qiu F, Rebolledo S, Wang Y, Noskov SY, Larsson HP.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):E273-82. doi: 10.1073/pnas.1318018111. Epub 2013 Dec 30.


Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening.

Zaydman MA, Silva JR, Delaloye K, Li Y, Liang H, Larsson HP, Shi J, Cui J.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13180-5. doi: 10.1073/pnas.1305167110. Epub 2013 Jul 16.


Neurotransmitter transporters: structure meets function.

Focke PJ, Wang X, Larsson HP.

Structure. 2013 May 7;21(5):694-705. doi: 10.1016/j.str.2013.03.002. Review.


What determines the kinetics of the slow afterhyperpolarization (sAHP) in neurons?

Larsson HP.

Biophys J. 2013 Jan 22;104(2):281-3. doi: 10.1016/j.bpj.2012.11.3832. No abstract available.


Molecular mechanism of voltage sensing in voltage-gated proton channels.

Gonzalez C, Rebolledo S, Perez ME, Larsson HP.

J Gen Physiol. 2013 Mar;141(3):275-85. doi: 10.1085/jgp.201210857. Epub 2013 Feb 11.


Subunit interactions during cooperative opening of voltage-gated proton channels.

Qiu F, Rebolledo S, Gonzalez C, Larsson HP.

Neuron. 2013 Jan 23;77(2):288-98. doi: 10.1016/j.neuron.2012.12.021.


Gating of the designed trimeric/tetrameric voltage-gated H+ channel.

Fujiwara Y, Kurokawa T, Takeshita K, Nakagawa A, Larsson HP, Okamura Y.

J Physiol. 2013 Feb 1;591(3):627-40. doi: 10.1113/jphysiol.2012.243006. Epub 2012 Nov 19.


Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.

Osteen JD, Barro-Soria R, Robey S, Sampson KJ, Kass RS, Larsson HP.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7103-8. doi: 10.1073/pnas.1201582109. Epub 2012 Apr 16.


Opposite movement of the external gate of a glutamate transporter homolog upon binding cotransported sodium compared with substrate.

Focke PJ, Moenne-Loccoz P, Larsson HP.

J Neurosci. 2011 Apr 20;31(16):6255-62. doi: 10.1523/JNEUROSCI.6096-10.2011.


Functional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume.

Manzanares D, Gonzalez C, Ivonnet P, Chen RS, Valencia-Gattas M, Conner GE, Larsson HP, Salathe M.

J Biol Chem. 2011 Jun 3;286(22):19830-9. doi: 10.1074/jbc.M110.185074. Epub 2011 Mar 31.


KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.

Osteen JD, Gonzalez C, Sampson KJ, Iyer V, Rebolledo S, Larsson HP, Kass RS.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22710-5. doi: 10.1073/pnas.1016300108. Epub 2010 Dec 13.


How is the heart rate regulated in the sinoatrial node? Another piece to the puzzle.

Larsson HP.

J Gen Physiol. 2010 Sep;136(3):237-41. doi: 10.1085/jgp.201010506. Epub 2010 Aug 16. No abstract available.


Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model.

Larsson HP, Wang X, Lev B, Baconguis I, Caplan DA, Vyleta NP, Koch HP, Diez-Sampedro A, Noskov SY.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13912-7. doi: 10.1073/pnas.1006289107. Epub 2010 Jul 15.


Permeation mechanism in voltage-activated proton channels: a new glimpse.

Gonzalez C, Larsson HP.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1817-8. doi: 10.1073/pnas.0913919107. Epub 2010 Feb 1. No abstract available.


Strong cooperativity between subunits in voltage-gated proton channels.

Gonzalez C, Koch HP, Drum BM, Larsson HP.

Nat Struct Mol Biol. 2010 Jan;17(1):51-6. doi: 10.1038/nsmb.1739. Epub 2009 Dec 20.


An acid-activated nucleobase transporter from Leishmania major.

Ortiz D, Sanchez MA, Koch HP, Larsson HP, Landfear SM.

J Biol Chem. 2009 Jun 12;284(24):16164-9. doi: 10.1074/jbc.M109.006718. Epub 2009 Apr 14.


Multimeric nature of voltage-gated proton channels.

Koch HP, Kurokawa T, Okochi Y, Sasaki M, Okamura Y, Larsson HP.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9111-6. doi: 10.1073/pnas.0801553105. Epub 2008 Jun 26.


Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.

Vemana S, Pandey S, Larsson HP.

Am J Physiol Cell Physiol. 2008 Aug;295(2):C557-65. doi: 10.1152/ajpcell.00154.2008. Epub 2008 Jun 25.


Kinetic relationship between the voltage sensor and the activation gate in spHCN channels.

Bruening-Wright A, Elinder F, Larsson HP.

J Gen Physiol. 2007 Jul;130(1):71-81.


Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.

Elinder F, Männikkö R, Pandey S, Larsson HP.

J Physiol. 2006 Sep 1;575(Pt 2):417-31. Epub 2006 Jun 15.


Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties.

Männikkö R, Pandey S, Larsson HP, Elinder F.

J Gen Physiol. 2005 Mar;125(3):305-26. Epub 2005 Feb 14.


Fluorometric measurements of conformational changes in glutamate transporters.

Larsson HP, Tzingounis AV, Koch HP, Kavanaugh MP.

Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3951-6. Epub 2004 Mar 4. Erratum in: Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12777.


S4 movement in a mammalian HCN channel.

Vemana S, Pandey S, Larsson HP.

J Gen Physiol. 2004 Jan;123(1):21-32. Epub 2003 Dec 15.


Molecular movement of the voltage sensor in a K channel.

Broomand A, Männikkö R, Larsson HP, Elinder F.

J Gen Physiol. 2003 Dec;122(6):741-8. Epub 2003 Nov 10.


Electrostatic model of S4 motion in voltage-gated ion channels.

Lecar H, Larsson HP, Grabe M.

Biophys J. 2003 Nov;85(5):2854-64.


Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages.

Männikkö R, Elinder F, Larsson HP.

Nature. 2002 Oct 24;419(6909):837-41.


The search is on for the voltage sensor-to-gate coupling.

Larsson HP.

J Gen Physiol. 2002 Oct;120(4):475-81. Review. No abstract available.


S4 charges move close to residues in the pore domain during activation in a K channel.

Elinder F, Männikkö R, Larsson HP.

J Gen Physiol. 2001 Jul;118(1):1-10.

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