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Items: 50

1.

Active site profiling reveals coupling between domains in SRC-family kinases.

Krishnamurty R, Brigham JL, Leonard SE, Ranjitkar P, Larson ET, Dale EJ, Merritt EA, Maly DJ.

Nat Chem Biol. 2013 Jan;9(1):43-50. doi: 10.1038/nchembio.1118. Epub 2012 Nov 11.

2.

Affinity-based probes based on type II kinase inhibitors.

Ranjitkar P, Perera BG, Swaney DL, Hari SB, Larson ET, Krishnamurty R, Merritt EA, Villén J, Maly DJ.

J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6. Erratum in: J Am Chem Soc. 2013 Jan 16;135(2):948. Swaney, Daniel L [corrected to Swaney, Danielle L].

3.

Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.

Larson ET, Kim JE, Napuli AJ, Verlinde CL, Fan E, Zucker FH, Van Voorhis WC, Buckner FS, Hol WG, Merritt EA.

Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1194-200. doi: 10.1107/S0907444912024699. Epub 2012 Aug 18.

4.

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.

Zhang Z, Ojo KK, Johnson SM, Larson ET, He P, Geiger JA, Castellanos-Gonzalez A, White AC Jr, Parsons M, Merritt EA, Maly DJ, Verlinde CL, Van Voorhis WC, Fan E.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5264-7. doi: 10.1016/j.bmcl.2012.06.050. Epub 2012 Jun 23.

5.

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.

Ojo KK, Pfander C, Mueller NR, Burstroem C, Larson ET, Bryan CM, Fox AM, Reid MC, Johnson SM, Murphy RC, Kennedy M, Mann H, Leibly DJ, Hewitt SN, Verlinde CL, Kappe S, Merritt EA, Maly DJ, Billker O, Van Voorhis WC.

J Clin Invest. 2012 Jun;122(6):2301-5. doi: 10.1172/JCI61822. Epub 2012 May 8.

6.

Structural basis for type VI secretion effector recognition by a cognate immunity protein.

Li M, Le Trong I, Carl MA, Larson ET, Chou S, De Leon JA, Dove SL, Stenkamp RE, Mougous JD.

PLoS Pathog. 2012;8(4):e1002613. doi: 10.1371/journal.ppat.1002613. Epub 2012 Apr 12.

7.

Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.

Larson ET, Ojo KK, Murphy RC, Johnson SM, Zhang Z, Kim JE, Leibly DJ, Fox AM, Reid MC, Dale EJ, Perera BG, Kim J, Hewitt SN, Hol WG, Verlinde CL, Fan E, Van Voorhis WC, Maly DJ, Merritt EA.

J Med Chem. 2012 Mar 22;55(6):2803-10. doi: 10.1021/jm201725v. Epub 2012 Mar 13.

8.

Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.

Johnson SM, Murphy RC, Geiger JA, DeRocher AE, Zhang Z, Ojo KK, Larson ET, Perera BG, Dale EJ, He P, Reid MC, Fox AM, Mueller NR, Merritt EA, Fan E, Parsons M, Van Voorhis WC, Maly DJ.

J Med Chem. 2012 Mar 8;55(5):2416-26. doi: 10.1021/jm201713h. Epub 2012 Feb 27.

9.

The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer.

Larson ET, Kim JE, Castaneda LJ, Napuli AJ, Zhang Z, Fan E, Zucker FH, Verlinde CL, Buckner FS, Van Voorhis WC, Hol WG, Merritt EA.

J Mol Biol. 2011 Jun 3;409(2):159-76. doi: 10.1016/j.jmb.2011.03.026. Epub 2011 Mar 21.

10.

Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate.

Larson ET, Kim JE, Zucker FH, Kelley A, Mueller N, Napuli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG.

Biochimie. 2011 Mar;93(3):570-82. doi: 10.1016/j.biochi.2010.11.015. Epub 2010 Dec 7.

11.

Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.

Murphy RC, Ojo KK, Larson ET, Castellanos-Gonzalez A, Perera BG, Keyloun KR, Kim JE, Bhandari JG, Muller NR, Verlinde CL, White AC Jr, Merritt EA, Van Voorhis WC, Maly DJ.

ACS Med Chem Lett. 2010 Oct 14;1(7):331-335.

12.

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.

Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, Derocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, Napuli AJ, Maly DJ, Verlinde CL, Buckner FS, Parsons M, Hol WG, Merritt EA, Van Voorhis WC.

Nat Struct Mol Biol. 2010 May;17(5):602-7. doi: 10.1038/nsmb.1818. Epub 2010 May 2.

13.

Prediction of protein crystallization outcome using a hybrid method.

Zucker FH, Stewart C, dela Rosa J, Kim J, Zhang L, Xiao L, Ross J, Napuli AJ, Mueller N, Castaneda LJ, Nakazawa Hewitt SR, Arakaki TL, Larson ET, Subramanian E, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG.

J Struct Biol. 2010 Jul;171(1):64-73. doi: 10.1016/j.jsb.2010.03.016. Epub 2010 Mar 27.

14.

Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.

Merritt EA, Arakaki TL, Gillespie JR, Larson ET, Kelley A, Mueller N, Napuli AJ, Kim J, Zhang L, Verlinde CL, Fan E, Zucker F, Buckner FS, van Voorhis WC, Hol WG.

J Mol Biol. 2010 Mar 26;397(2):481-94. doi: 10.1016/j.jmb.2010.01.051. Epub 2010 Feb 2.

15.

The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.

Larson ET, Mudeppa DG, Gillespie JR, Mueller N, Napuli AJ, Arif JA, Ross J, Arakaki TL, Lauricella A, Detitta G, Luft J, Zucker F, Verlinde CL, Fan E, Van Voorhis WC, Buckner FS, Rathod PK, Hol WG, Merritt EA.

J Mol Biol. 2010 Mar 12;396(5):1244-59. doi: 10.1016/j.jmb.2010.01.013. Epub 2010 Jan 11.

16.

Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium.

Verlinde CL, Fan E, Shibata S, Zhang Z, Sun Z, Deng W, Ross J, Kim J, Xiao L, Arakaki TL, Bosch J, Caruthers JM, Larson ET, Letrong I, Napuli A, Kelly A, Mueller N, Zucker F, Van Voorhis WC, Buckner FS, Merritt EA, Hol WG.

Curr Top Med Chem. 2009;9(18):1678-87. Review.

17.

Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.

Merritt EA, Arakaki TL, Larson ET, Kelley A, Mueller N, Napuli AJ, Zhang L, Deditta G, Luft J, Verlinde CL, Fan E, Zucker F, Buckner FS, Van Voorhis WC, Hol WG.

Mol Biochem Parasitol. 2010 Feb;169(2):95-100. doi: 10.1016/j.molbiopara.2009.10.005. Epub 2009 Oct 27.

18.

Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.

Larson ET, Parussini F, Huynh MH, Giebel JD, Kelley AM, Zhang L, Bogyo M, Merritt EA, Carruthers VB.

J Biol Chem. 2009 Sep 25;284(39):26839-50. doi: 10.1074/jbc.M109.003780. Epub 2009 Jul 13.

19.

Melanocortin peptides affect the motivation to feed in rainbow trout (Oncorhynchus mykiss).

Schjolden J, Schiöth HB, Larhammar D, Winberg S, Larson ET.

Gen Comp Endocrinol. 2009 Jan 15;160(2):134-8. doi: 10.1016/j.ygcen.2008.11.003. Epub 2008 Nov 8.

PMID:
19027741
20.

Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.

Larson ET, Deng W, Krumm BE, Napuli A, Mueller N, Van Voorhis WC, Buckner FS, Fan E, Lauricella A, DeTitta G, Luft J, Zucker F, Hol WG, Verlinde CL, Merritt EA.

J Mol Biol. 2008 Sep 12;381(4):975-88. doi: 10.1016/j.jmb.2008.06.048. Epub 2008 Jun 24.

21.

Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization.

Salaneck E, Larsson TA, Larson ET, Larhammar D.

Gene. 2008 Feb 15;409(1-2):61-71. doi: 10.1016/j.gene.2007.11.011. Epub 2007 Dec 4.

PMID:
18191918
22.

A winged-helix protein from Sulfolobus turreted icosahedral virus points toward stabilizing disulfide bonds in the intracellular proteins of a hyperthermophilic virus.

Larson ET, Eilers B, Menon S, Reiter D, Ortmann A, Young MJ, Lawrence CM.

Virology. 2007 Nov 25;368(2):249-61. Epub 2007 Jul 31.

23.

Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes.

Haitina T, Klovins J, Takahashi A, Löwgren M, Ringholm A, Enberg J, Kawauchi H, Larson ET, Fredriksson R, Schiöth HB.

BMC Evol Biol. 2007 Jun 29;7:101.

24.

A new DNA binding protein highly conserved in diverse crenarchaeal viruses.

Larson ET, Eilers BJ, Reiter D, Ortmann AC, Young MJ, Lawrence CM.

Virology. 2007 Jul 5;363(2):387-96. Epub 2007 Mar 2.

25.

Cloning and sequence analysis of the neuropeptide Y receptors Y5 and Y6 in the coelacanth Latimeria chalumnae.

Larsson TA, Larson ET, Larhammar D.

Gen Comp Endocrinol. 2007 Jan 15;150(2):337-42. Epub 2006 Oct 27.

PMID:
17070811
26.
27.

Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss.

Larsson TA, Larson ET, Fredriksson R, Conlon JM, Larhammar D.

Peptides. 2006 Jun;27(6):1320-7. Epub 2005 Dec 15.

PMID:
16359756
28.

Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses.

Khayat R, Tang L, Larson ET, Lawrence CM, Young M, Johnson JE.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18944-9. Epub 2005 Dec 15.

29.

Cloning and characterization of a zebrafish Y2 receptor.

Fredriksson R, Sjödin P, Larson ET, Conlon JM, Larhammar D.

Regul Pept. 2006 Jan 15;133(1-3):32-40. Epub 2005 Oct 28.

PMID:
16257457
30.

Aggression and vasotocin are associated with dominant-subordinate relationships in zebrafish.

Larson ET, O'Malley DM, Melloni RH Jr.

Behav Brain Res. 2006 Feb 15;167(1):94-102. Epub 2005 Oct 4.

PMID:
16213035
31.

Does serotonin influence aggression? comparing regional activity before and during social interaction.

Summers CH, Korzan WJ, Lukkes JL, Watt MJ, Forster GL, Øverli Ø, Höglund E, Larson ET, Ronan PJ, Matter JM, Summers TR, Renner KJ, Greenberg N.

Physiol Biochem Zool. 2005 Sep-Oct;78(5):679-94. Epub 2005 Jul 29.

PMID:
16059845
32.
33.

Effects of a teleost tetraploidization on neuropeptide Y receptor gene repertoire in ray-finned fishes.

Salaneck E, Larson ET, Larsson TA, Larhammar D.

Ann N Y Acad Sci. 2005 Apr;1040:457-9. Review.

PMID:
15891088
34.

Expression of engrailed in the developing brain and appendages of the onychophoran euperipatoides kanangrensis (Reid).

Eriksson BJ, Larson ET, Thörnqvist PO, Tait NN, Budd GE.

J Exp Zool B Mol Dev Evol. 2005 May 15;304(3):220-8.

PMID:
15834939
35.
36.

Dynamics and mechanics of social rank reversal.

Summers CH, Forster GL, Korzan WJ, Watt MJ, Larson ET, Overli O, Höglund E, Ronan PJ, Summers TR, Renner KJ, Greenberg N.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005 Mar;191(3):241-52. Epub 2004 Sep 11.

PMID:
15372303
37.

Behavioral and neuroendocrine correlates of displaced aggression in trout.

Øverli Ø, Korzan WJ, Larson ET, Winberg S, Lepage O, Pottinger TG, Renner KJ, Summers CH.

Horm Behav. 2004 May;45(5):324-9.

PMID:
15109906
38.

Social stress affects circulating melatonin levels in rainbow trout.

Larson ET, Winberg S, Mayer I, Lepage O, Summers CH, Øverli Ø.

Gen Comp Endocrinol. 2004 May 1;136(3):322-7.

PMID:
15081831
39.

Cloning, tissue distribution, pharmacology and three-dimensional modelling of melanocortin receptors 4 and 5 in rainbow trout suggest close evolutionary relationship of these subtypes.

Haitina T, Klovins J, Andersson J, Fredriksson R, Lagerström MC, Larhammar D, Larson ET, Schiöth HB.

Biochem J. 2004 Jun 1;380(Pt 2):475-86.

40.

Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications.

Fredriksson R, Larson ET, Yan YL, Postlethwait JH, Larhammar D.

J Mol Evol. 2004 Jan;58(1):106-14.

PMID:
14743318
41.

Three neuropeptide Y receptor genes in the spiny dogfish, Squalus acanthias, support en bloc duplications in early vertebrate evolution.

Salaneck E, Ardell DH, Larson ET, Larhammar D.

Mol Biol Evol. 2003 Aug;20(8):1271-80. Epub 2003 May 30.

PMID:
12777532
42.

Monoaminergic changes associated with socially induced sex reversal in the saddleback wrasse.

Larson ET, Norris DO, Summers CH.

Neuroscience. 2003;119(1):251-63.

PMID:
12763086
43.

Cloning, pharmacology, and distribution of the neuropeptide Y-receptor Yb in rainbow trout.

Larson ET, Fredriksson R, Johansson SR, Larhammar D.

Peptides. 2003 Mar;24(3):385-95.

PMID:
12732336
44.

Rapid glucocorticoid stimulation and GABAergic inhibition of hippocampal serotonergic response: in vivo dialysis in the lizard anolis carolinensis.

Summers TR, Matter JM, McKay JM, Ronan PJ, Larson ET, Renner KJ, Summers CH.

Horm Behav. 2003 Jan;43(1):245-53.

PMID:
12614656
45.

Monoamines stimulate sex reversal in the saddleback wrasse.

Larson ET, Norris DO, Gordon Grau E, Summers CH.

Gen Comp Endocrinol. 2003 Feb 15;130(3):289-98.

PMID:
12606271
46.

Presence of melanocortin (MC4) receptor in spiny dogfish suggests an ancient vertebrate origin of central melanocortin system.

Ringholm A, Klovins J, Fredriksson R, Poliakova N, Larson ET, Kukkonen JP, Larhammar D, Schiöth HB.

Eur J Biochem. 2003 Jan;270(2):213-21.

47.

A neuropeptide Y receptor Y1-subfamily gene from an agnathan, the European river lamprey. A potential ancestral gene.

Salaneck E, Fredriksson R, Larson ET, Conlon JM, Larhammar D.

Eur J Biochem. 2001 Dec;268(23):6146-54.

48.

Serotonin reverses dominant social status.

Larson ET, Summers CH.

Behav Brain Res. 2001 Jun;121(1-2):95-102.

PMID:
11275287
49.

Serotonergic responses to corticosterone and testosterone in the limbic system.

Summers CH, Larson ET, Ronan PJ, Hofmann PM, Emerson AJ, Renner KJ.

Gen Comp Endocrinol. 2000 Jan;117(1):151-9.

PMID:
10620431
50.

Regional and temporal separation of serotonergic activity mediating social stress.

Summers CH, Larson ET, Summers TR, Renner KJ, Greenberg N.

Neuroscience. 1998 Nov;87(2):489-96.

PMID:
9740407

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