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Items: 1 to 50 of 160

1.

A novel dual glucagon-like peptide and glucagon receptor agonist SAR425899: Results of randomized, placebo-controlled first-in-human and first-in-patient trials.

Tillner J, Posch MG, Wagner F, Teichert L, Hijazi Y, Einig C, Keil S, Haack T, Wagner M, Bossart M, Larsen PJ.

Diabetes Obes Metab. 2018 Aug 8. doi: 10.1111/dom.13494. [Epub ahead of print]

PMID:
30091218
2.

Team Players or Opponents: Coadministration of Selective Glucagon and GLP-1 Receptor Agonists in Obese Diabetic Monkeys.

Elvert R, Bossart M, Herling AW, Weiss T, Zhang B, Kannt A, Wagner M, Haack T, Evers A, Dudda A, Keil S, Lorenz M, Lorenz K, Riz M, Hennerici W, Larsen PJ.

Endocrinology. 2018 Aug 1;159(8):3105-3119. doi: 10.1210/en.2018-00399.

PMID:
29992313
3.

Running on mixed fuel-dual agonistic approach of GLP-1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non-human primates.

Elvert R, Herling AW, Bossart M, Weiss T, Zhang B, Wenski P, Wandschneider J, Kleutsch S, Butty U, Kannt A, Wagner M, Haack T, Evers A, Dudda A, Lorenz M, Keil S, Larsen PJ.

Diabetes Obes Metab. 2018 Aug;20(8):1836-1851. doi: 10.1111/dom.13212. Epub 2018 Jun 25.

4.

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.

Fernandez-Cachon ML, Pedersen SL, Rigbolt KT, Zhang C, Fabricius K, Hansen HH, Elster L, Fink LN, Schäfer M, Rhee NA, Langholz E, Wandall E, Friis SU, Vilmann P, Kristiansen VB, Schmidt C, Schreiter K, Breitschopf K, Hübschle T, Jorsal T, Vilsbøll T, Schmidt T, Theis S, Knop FK, Larsen PJ, Jelsing J.

Peptides. 2018 Mar;101:32-43. doi: 10.1016/j.peptides.2017.12.024. Epub 2017 Dec 28.

PMID:
29289697
5.

On ceramides, other sphingolipids and impaired glucose homeostasis.

Larsen PJ, Tennagels N.

Mol Metab. 2014 Jan 28;3(3):252-60. doi: 10.1016/j.molmet.2014.01.011. eCollection 2014 Jun. Review.

6.

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion.

Paulsen SJ, Larsen LK, Hansen G, Chelur S, Larsen PJ, Vrang N.

PLoS One. 2014 Feb 10;9(2):e88227. doi: 10.1371/journal.pone.0088227. eCollection 2014.

7.

Foetal proglucagon processing in relation to adult appetite control: lessons from a transplantable rat glucagonoma with severe anorexia.

Jensen PB, Larsen PJ, Karlsen C, Jensen HI, Holst JJ, Madsen OD.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:60-8. doi: 10.1111/j.1463-1326.2011.01439.x. Review.

PMID:
21824258
8.

Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function.

Paulsen SJ, Vrang N, Larsen LK, Larsen PJ, Jelsing J.

J Anat. 2010 Nov;217(5):624-30. doi: 10.1111/j.1469-7580.2010.01285.x. Epub 2010 Aug 30.

9.

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides.

Vrang N, Larsen PJ.

Prog Neurobiol. 2010 Nov;92(3):442-62. doi: 10.1016/j.pneurobio.2010.07.003. Epub 2010 Jul 16. Review.

PMID:
20638440
10.

Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome.

Madsen AN, Hansen G, Paulsen SJ, Lykkegaard K, Tang-Christensen M, Hansen HS, Levin BE, Larsen PJ, Knudsen LB, Fosgerau K, Vrang N.

J Endocrinol. 2010 Sep;206(3):287-96. doi: 10.1677/JOE-10-0004. Epub 2010 May 27.

11.

The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant.

Hansen HH, Hansen G, Tang-Christensen M, Larsen PJ, Axel AM, Raben A, Mikkelsen JD.

Eur J Pharmacol. 2010 Jun 25;636(1-3):88-95. doi: 10.1016/j.ejphar.2010.03.026. Epub 2010 Apr 10.

PMID:
20385125
12.

ADD1/SREBP1c activates the PGC1-alpha promoter in brown adipocytes.

Hao Q, Hansen JB, Petersen RK, Hallenborg P, Jørgensen C, Cinti S, Larsen PJ, Steffensen KR, Wang H, Collins S, Wang J, Gustafsson JA, Madsen L, Kristiansen K.

Biochim Biophys Acta. 2010 Apr;1801(4):421-9. doi: 10.1016/j.bbalip.2009.11.008. Epub 2009 Dec 2.

PMID:
19962449
13.

The imprinted gene neuronatin is regulated by metabolic status and associated with obesity.

Vrang N, Meyre D, Froguel P, Jelsing J, Tang-Christensen M, Vatin V, Mikkelsen JD, Thirstrup K, Larsen LK, Cullberg KB, Fahrenkrug J, Jacobson P, Sjöström L, Carlsson LM, Liu Y, Liu X, Deng HW, Larsen PJ.

Obesity (Silver Spring). 2010 Jul;18(7):1289-96. doi: 10.1038/oby.2009.361. Epub 2009 Oct 22.

14.

Characterization of beta-cell mass and insulin resistance in diet-induced obese and diet-resistant rats.

Paulsen SJ, Jelsing J, Madsen AN, Hansen G, Lykkegaard K, Larsen LK, Larsen PJ, Levin BE, Vrang N.

Obesity (Silver Spring). 2010 Feb;18(2):266-73. doi: 10.1038/oby.2009.245. Epub 2009 Aug 6.

15.

The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion.

Jelsing J, Larsen PJ, Vrang N.

Neurosci Lett. 2009 Oct 2;463(2):125-9. doi: 10.1016/j.neulet.2009.07.011. Epub 2009 Jul 9.

PMID:
19596404
16.

Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2.

Jelsing J, Galzin AM, Guillot E, Pruniaux MP, Larsen PJ, Vrang N.

Brain Res Bull. 2009 Mar 16;78(4-5):202-10. doi: 10.1016/j.brainresbull.2008.10.014. Epub 2008 Nov 25.

PMID:
19038314
17.

Rimonabant induced anorexia in rodents is not mediated by vagal or sympathetic gut afferents.

Madsen AN, Jelsing J, van de Wall EH, Vrang N, Larsen PJ, Schwartz GJ.

Neurosci Lett. 2009 Jan 2;449(1):20-3. doi: 10.1016/j.neulet.2008.10.001. Epub 2008 Oct 7.

PMID:
18926875
18.

Dissociation of antihyperglycaemic and adverse effects of partial perioxisome proliferator-activated receptor (PPAR-gamma) agonist balaglitazone.

Larsen PJ, Lykkegaard K, Larsen LK, Fleckner J, Sauerberg P, Wassermann K, Wulff EM.

Eur J Pharmacol. 2008 Oct 31;596(1-3):173-9. doi: 10.1016/j.ejphar.2008.08.004. Epub 2008 Aug 16.

PMID:
18761337
19.

Higher physical activity is associated with increased androgens, low interleukin 6 and less aortic calcification in peripheral obese elderly women.

Straub RH, Tankó LB, Christiansen C, Larsen PJ, Jessop DS.

J Endocrinol. 2008 Oct;199(1):61-8. doi: 10.1677/JOE-08-0319. Epub 2008 Jul 10.

20.

The once-daily human GLP-1 analog, liraglutide, reduces olanzapine-induced weight gain and glucose intolerance.

Lykkegaard K, Larsen PJ, Vrang N, Bock C, Bock T, Knudsen LB.

Schizophr Res. 2008 Aug;103(1-3):94-103. doi: 10.1016/j.schres.2008.05.011. Epub 2008 Jun 25.

PMID:
18579346
21.

Identification of cannabinoid type 1 receptor expressing cocaine amphetamine-regulated transcript neurons in the rat hypothalamus and brainstem using in situ hybridization and immunohistochemistry.

Jelsing J, Larsen PJ, Vrang N.

Neuroscience. 2008 Jun 23;154(2):641-52. doi: 10.1016/j.neuroscience.2008.03.051. Epub 2008 Mar 29.

PMID:
18472225
22.

Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats.

Larsen PJ, Wulff EM, Gotfredsen CF, Brand CL, Sturis J, Vrang N, Knudsen LB, Lykkegaard K.

Diabetes Obes Metab. 2008 Apr;10(4):301-11. doi: 10.1111/j.1463-1326.2008.00865.x.

PMID:
18333889
23.

Upregulation of the brainstem preproglucagon system in the obese Zucker rat.

Vrang N, Larsen PJ, Jensen PB, Lykkegaard K, Artmann A, Larsen LK, Tang-Christensen M.

Brain Res. 2008 Jan 2;1187:116-24. Epub 2007 Oct 22.

PMID:
18022140
24.

Characterization of brainstem preproglucagon projections to the paraventricular and dorsomedial hypothalamic nuclei.

Vrang N, Hansen M, Larsen PJ, Tang-Christensen M.

Brain Res. 2007 May 29;1149:118-26. Epub 2007 Feb 27.

PMID:
17433266
25.

PYY(3-36) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity.

Vrang N, Madsen AN, Tang-Christensen M, Hansen G, Larsen PJ.

Am J Physiol Regul Integr Comp Physiol. 2006 Aug;291(2):R367-75. Epub 2006 Apr 13.

26.

The role of CART in body weight homeostasis.

Larsen PJ, Hunter RG.

Peptides. 2006 Aug;27(8):1981-6. Epub 2006 Jun 9. Review.

PMID:
16762453
27.

Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors.

Petersen G, Sørensen C, Schmid PC, Artmann A, Tang-Christensen M, Hansen SH, Larsen PJ, Schmid HH, Hansen HS.

Biochim Biophys Acta. 2006 Feb;1761(2):143-50; discussion 141-2. Epub 2006 Jan 26.

PMID:
16478679
28.

ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity.

Tankó LB, Siddiq A, Lecoeur C, Larsen PJ, Christiansen C, Walley A, Froguel P.

Obes Res. 2005 Dec;13(12):2113-21.

29.

[Molecular pathogenesis in monogenic and polygenic obesity].

Larsen PJ, Echwald SM, Sørensen TI, Pedersen OB.

Ugeskr Laeger. 2006 Jan 9;168(2):152-5. Danish.

PMID:
16403339
30.

[The genetics of obesity].

Echwald SM, Larsen PJ, Pedersen OB, Sørensen TI.

Ugeskr Laeger. 2006 Jan 9;168(2):150-2. Danish.

PMID:
16403338
32.

Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women.

Tankó LB, Bagger YZ, Qin G, Alexandersen P, Larsen PJ, Christiansen C.

Circulation. 2005 Apr 19;111(15):1883-90.

PMID:
15837940
33.

Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter.

Larsen PJ, Holst JJ.

Regul Pept. 2005 Jun 15;128(2):97-107. Review.

PMID:
15780429
34.

Melanopsin is expressed in PACAP-containing retinal ganglion cells of the human retinohypothalamic tract.

Hannibal J, Hindersson P, Ostergaard J, Georg B, Heegaard S, Larsen PJ, Fahrenkrug J.

Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4202-9.

PMID:
15505076
35.

Novel associations between bioavailable estradiol and adipokines in elderly women with different phenotypes of obesity: implications for atherogenesis.

Tankó LB, Bruun JM, Alexandersen P, Bagger YZ, Richelsen B, Christiansen C, Larsen PJ.

Circulation. 2004 Oct 12;110(15):2246-52. Epub 2004 Sep 27.

PMID:
15451790
36.

Gut-derived signaling molecules and vagal afferents in the control of glucose and energy homeostasis.

Thorens B, Larsen PJ.

Curr Opin Clin Nutr Metab Care. 2004 Jul;7(4):471-8. Review.

PMID:
15192452
37.

Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis.

Larsen PJ, Jensen PB, Sørensen RV, Larsen LK, Vrang N, Wulff EM, Wassermann K.

Diabetes. 2003 Sep;52(9):2249-59.

38.

Central and peripheral fat mass have contrasting effect on the progression of aortic calcification in postmenopausal women.

Tankó LB, Bagger YZ, Alexandersen P, Larsen PJ, Christiansen C.

Eur Heart J. 2003 Aug;24(16):1531-7.

PMID:
12919778
39.

Projections from the raphe nuclei to the suprachiasmatic nucleus of the rat.

Hay-Schmidt A, Vrang N, Larsen PJ, Mikkelsen JD.

J Chem Neuroanat. 2003 Jul;25(4):293-310.

PMID:
12842274
40.

Central pre-proglucagon derived peptides: opportunities for treatment of obesity.

Larsen PJ, Vrang N, Tang-Christensen M.

Curr Pharm Des. 2003;9(17):1373-82. Review.

PMID:
12769729
41.

Variations in percentage of body fat within different BMI groups in young, middle-aged and old women.

Movsesyan L, Tankó LB, Larsen PJ, Christiansen C, Svendsen OL.

Clin Physiol Funct Imaging. 2003 May;23(3):130-3.

PMID:
12752553
42.

Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women.

Tankó LB, Bagger YZ, Alexandersen P, Larsen PJ, Christiansen C.

Circulation. 2003 Apr 1;107(12):1626-31. Epub 2003 Mar 17.

PMID:
12668497
43.

Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids.

Vrang N, Larsen PJ, Tang-Christensen M, Larsen LK, Kristensen P.

Brain Res. 2003 Mar 7;965(1-2):45-50.

PMID:
12591118
44.

Cocaine- and amphetamine-regulated transcript is present in hypothalamic neuroendocrine neurones and is released to the hypothalamic-pituitary portal circuit.

Larsen PJ, Seier V, Fink-Jensen A, Holst JJ, Warberg J, Vrang N.

J Neuroendocrinol. 2003 Mar;15(3):219-26.

PMID:
12588509
45.

PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly.

Ye JM, Iglesias MA, Watson DG, Ellis B, Wood L, Jensen PB, Sørensen RV, Larsen PJ, Cooney GJ, Wassermann K, Kraegen EW.

Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E531-40.

46.
47.

Cocaine-amphetamine regulated transcript (CART) expression is not regulated by amphetamine.

Vrang N, Larsen PJ, Kristensen P.

Neuroreport. 2002 Jul 2;13(9):1215-8.

PMID:
12151772
48.

Ups and downs for neuropeptides in body weight homeostasis: pharmacological potential of cocaine amphetamine regulated transcript and pre-proglucagon-derived peptides.

Larsen PJ, Vrang N, Tang-Christensen M, Jensen PB, Hay-Schmidt A, Rømer J, Bjerre-Knudsen L, Kristensen P.

Eur J Pharmacol. 2002 Apr 12;440(2-3):159-72. Review.

PMID:
12007533
49.

New therapeutic developments in the regulation of food intake by neuropeptides.

Larsen PJ, Tang-Christensen M, Vrang N.

Ann Endocrinol (Paris). 2002 Apr;63(2 Pt 1):171-5. Review. No abstract available.

PMID:
11994683
50.

Glucagon-like peptide containing pathways in the regulation of feeding behaviour.

Tang-Christensen M, Vrang N, Larsen PJ.

Int J Obes Relat Metab Disord. 2001 Dec;25 Suppl 5:S42-7.

PMID:
11840214

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