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Items: 1 to 50 of 170

1.

Genome-wide siRNA screening reveals a role for Cullin3-RING ligase signaling in heterologous sensitization of adenylyl cyclase.

Ding Z, Ejendal KFK, Soto Velasquez M, Hayes MP, Santoro N, Larsen MJ, Watts VJ.

J Pharmacol Exp Ther. 2019 Dec 19. pii: jpet.119.261255. doi: 10.1124/jpet.119.261255. [Epub ahead of print]

2.

Choline transporter-like 1 deficiency causes a new type of childhood-onset neurodegeneration.

Fagerberg CR, Taylor A, Distelmaier F, Schrøder HD, Kibæk M, Wieczorek D, Tarnopolsky M, Brady L, Larsen MJ, Jamra RA, Seibt A, Hejbøl EK, Gade E, Markovic L, Klee D, Nagy P, Rouse N, Agarwal P, Dolinsky VW, Bakovic M.

Brain. 2020 Jan 1;143(1):94-111. doi: 10.1093/brain/awz376.

PMID:
31855247
3.

Global expression profiling of cognitive level and decline in middle-aged monozygotic twins.

Nygaard M, Larsen MJ, Thomassen M, McGue M, Christensen K, Tan Q, Christiansen L.

Neurobiol Aging. 2019 Dec;84:141-147. doi: 10.1016/j.neurobiolaging.2019.08.019. Epub 2019 Aug 26.

PMID:
31585296
4.

The Optimal Sequencing Depth of Tumor Biopsies for Identifying Clonal Cell Populations.

Tabatabaeifar S, Larsen MJ, Thomassen M, Larsen SR, Kruse TA, Sørensen JA.

J Mol Diagn. 2019 Sep;21(5):790-795. doi: 10.1016/j.jmoldx.2019.04.005. Epub 2019 May 31.

PMID:
31158525
5.

[Genomic medicine and artificial intelligence].

Kruse TA, Larsen MJ, Tan Q, Andersen L, Thomassen M.

Ugeskr Laeger. 2019 Apr 1;181(7A). pii: V02190085. Danish.

PMID:
30950381
6.

Evaluation of tumor-infiltrating lymphocytes and association with prognosis in BRCA-mutated breast cancer.

Sønderstrup IMH, Jensen MB, Ejlertsen B, Eriksen JO, Gerdes AM, Kruse TA, Larsen MJ, Thomassen M, Laenkholm AV.

Acta Oncol. 2019 Mar;58(3):363-370. doi: 10.1080/0284186X.2018.1539239. Epub 2019 Jan 7.

PMID:
30614364
7.

Mosaic MECP2 variants in males with classical Rett syndrome features, including stereotypical hand movements.

Schönewolf-Greulich B, Bisgaard AM, Dunø M, Jespersgaard C, Rokkjaer M, Hansen LK, Tsoutsou E, Sofokleous C, Topcu M, Kaur S, Van Bergen NJ, Brøndum-Nielsen K, Larsen MJ, Sørensen KP, Christodoulou J, Fagerberg CR, Tümer Z.

Clin Genet. 2019 Mar;95(3):403-408. doi: 10.1111/cge.13473. Epub 2018 Dec 7.

PMID:
30417326
8.

Subtypes in BRCA-mutated breast cancer.

Sønderstrup IMH, Jensen MR, Ejlertsen B, Eriksen JO, Gerdes AM, Kruse TA, Larsen MJ, Thomassen M, Lænkholm AV.

Hum Pathol. 2019 Feb;84:192-201. doi: 10.1016/j.humpath.2018.10.005. Epub 2018 Oct 17. No abstract available.

PMID:
30342055
9.

Is MED13L-related intellectual disability a recognizable syndrome?

Tørring PM, Larsen MJ, Brasch-Andersen C, Krogh LN, Kibæk M, Laulund L, Illum N, Dunkhase-Heinl U, Wiesener A, Popp B, Marangi G, Hjortshøj TD, Ek J, Vogel I, Becher N, Roos L, Zollino M, Fagerberg CR.

Eur J Med Genet. 2019 Feb;62(2):129-136. doi: 10.1016/j.ejmg.2018.06.014. Epub 2018 Jun 27.

PMID:
29959045
10.

Compound heterozygous mutations in two different domains of ALDH18A1 do not affect the amino acid levels in a patient with hereditary spastic paraplegia.

Steenhof M, Kibæk M, Larsen MJ, Christensen M, Lund AM, Brusgaard K, Hertz JM.

Neurogenetics. 2018 Aug;19(3):145-149. doi: 10.1007/s10048-018-0547-7. Epub 2018 May 12.

PMID:
29754261
11.

Association of miR-548c-5p, miR-7-5p, miR-210-3p, miR-128-3p with recurrence in systemically untreated breast cancer.

Block I, Burton M, Sørensen KP, Andersen L, Larsen MJ, Bak M, Cold S, Thomassen M, Tan Q, Kruse TA.

Oncotarget. 2018 Jan 9;9(10):9030-9042. doi: 10.18632/oncotarget.24088. eCollection 2018 Feb 6.

12.

Identification of metastasis driver genes by massive parallel sequencing of successive steps of breast cancer progression.

Krøigård AB, Larsen MJ, Lænkholm AV, Knoop AS, Jensen JD, Bak M, Mollenhauer J, Thomassen M, Kruse TA.

PLoS One. 2018 Jan 2;13(1):e0189887. doi: 10.1371/journal.pone.0189887. eCollection 2018.

13.

De Novo Variants in GRIA4 Lead to Intellectual Disability with or without Seizures and Gait Abnormalities.

Martin S, Chamberlin A, Shinde DN, Hempel M, Strom TM, Schreiber A, Johannsen J, Ousager LB, Larsen MJ, Hansen LK, Fatemi A, Cohen JS, Lemke J, Sørensen KP, Helbig KL, Lessel D, Abou Jamra R.

Am J Hum Genet. 2017 Dec 7;101(6):1013-1020. doi: 10.1016/j.ajhg.2017.11.004.

14.

A genotype-first approach identifies an intellectual disability-overweight syndrome caused by PHIP haploinsufficiency.

Jansen S, Hoischen A, Coe BP, Carvill GL, Van Esch H, Bosch DGM, Andersen UA, Baker C, Bauters M, Bernier RA, van Bon BW, Claahsen-van der Grinten HL, Gecz J, Gilissen C, Grillo L, Hackett A, Kleefstra T, Koolen D, Kvarnung M, Larsen MJ, Marcelis C, McKenzie F, Monin ML, Nava C, Schuurs-Hoeijmakers JH, Pfundt R, Steehouwer M, Stevens SJC, Stumpel CT, Vansenne F, Vinci M, van de Vorst M, Vries P, Witherspoon K, Veltman JA, Brunner HG, Mefford HC, Romano C, Vissers LELM, Eichler EE, de Vries BBA.

Eur J Hum Genet. 2018 Jan;26(1):54-63. doi: 10.1038/s41431-017-0039-5. Epub 2017 Dec 5.

15.

Clinical and molecular characterization of BRCA-associated breast cancer: results from the DBCG.

Soenderstrup IMH, Laenkholm AV, Jensen MB, Eriksen JO, Gerdes AM, Hansen TVO, Kruse TA, Larsen MJ, Pedersen IS, Rossing M, Thomassen M, Ejlertsen B.

Acta Oncol. 2018 Jan;57(1):95-101. doi: 10.1080/0284186X.2017.1398415. Epub 2017 Nov 22.

PMID:
29164974
16.

Development and Implementation of an HTS-Compatible Assay for the Discovery of Selective Small-Molecule Ligands for Pre-microRNAs.

Lorenz DA, Vander Roest S, Larsen MJ, Garner AL.

SLAS Discov. 2018 Jan;23(1):47-54. doi: 10.1177/2472555217717944. Epub 2017 Jul 7.

17.

Investigating a case of possible field cancerization in oral squamous cell carcinoma by the use of next-generation sequencing.

Tabatabaeifar S, Larsen MJ, Larsen SR, Kruse TA, Thomassen M, Sørensen JA.

Oral Oncol. 2017 May;68:74-80. doi: 10.1016/j.oraloncology.2017.03.018. Epub 2017 Apr 2.

PMID:
28438297
18.

Genomic Analyses of Breast Cancer Progression Reveal Distinct Routes of Metastasis Emergence.

Krøigård AB, Larsen MJ, Brasch-Andersen C, Lænkholm AV, Knoop AS, Jensen JD, Bak M, Mollenhauer J, Thomassen M, Kruse TA.

Sci Rep. 2017 Mar 9;7:43813. doi: 10.1038/srep43813.

19.

The subclonal structure and genomic evolution of oral squamous cell carcinoma revealed by ultra-deep sequencing.

Tabatabaeifar S, Thomassen M, Larsen MJ, Larsen SR, Kruse TA, Sørensen JA.

Oncotarget. 2017 Mar 7;8(10):16571-16580. doi: 10.18632/oncotarget.15014.

20.

Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3.

Costa MDC, Ashraf NS, Fischer S, Yang Y, Schapka E, Joshi G, McQuade TJ, Dharia RM, Dulchavsky M, Ouyang M, Cook D, Sun D, Larsen MJ, Gestwicki JE, Todi SV, Ivanova MI, Paulson HL.

Brain. 2016 Nov 1;139(11):2891-2908. doi: 10.1093/brain/aww228.

21.

Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis.

Pang AH, Garzan A, Larsen MJ, McQuade TJ, Garneau-Tsodikova S, Tsodikov OV.

ACS Chem Biol. 2016 Nov 18;11(11):3084-3092. Epub 2016 Sep 26.

PMID:
27622287
22.

Bone structure in two adult subjects with impaired minor spliceosome function resulting from RNU4ATAC mutations causing microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1).

Krøigård AB, Frost M, Larsen MJ, Ousager LB, Frederiksen AL.

Bone. 2016 Nov;92:145-149. doi: 10.1016/j.bone.2016.08.023. Epub 2016 Aug 31.

23.

DamX Controls Reversible Cell Morphology Switching in Uropathogenic Escherichia coli.

Khandige S, Asferg CA, Rasmussen KJ, Larsen MJ, Overgaard M, Andersen TE, Møller-Jensen J.

mBio. 2016 Aug 2;7(4). pii: e00642-16. doi: 10.1128/mBio.00642-16.

24.

Molecular Concordance Between Primary Breast Cancer and Matched Metastases.

Krøigård AB, Larsen MJ, Thomassen M, Kruse TA.

Breast J. 2016 Jul;22(4):420-30. doi: 10.1111/tbj.12596. Epub 2016 Apr 18. Review.

PMID:
27089067
25.

Evaluation of Nine Somatic Variant Callers for Detection of Somatic Mutations in Exome and Targeted Deep Sequencing Data.

Krøigård AB, Thomassen M, Lænkholm AV, Kruse TA, Larsen MJ.

PLoS One. 2016 Mar 22;11(3):e0151664. doi: 10.1371/journal.pone.0151664. eCollection 2016.

26.

Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts.

Cruz PG, Fribley AM, Miller JR, Larsen MJ, Schultz PJ, Jacob RT, Tamayo-Castillo G, Kaufman RJ, Sherman DH.

ACS Med Chem Lett. 2015 Jul 6;6(8):877-81. doi: 10.1021/acsmedchemlett.5b00127. eCollection 2015 Aug 13.

27.

Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65).

Frederiksen AL, Larsen MJ, Brusgaard K, Novack DV, Knudsen PJ, Schrøder HD, Qiu W, Eckhardt C, McAlister WH, Kassem M, Mumm S, Frost M, Whyte MP.

J Bone Miner Res. 2016 Jan;31(1):163-72. doi: 10.1002/jbmr.2590. Epub 2015 Aug 6.

28.

Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries.

Lowell AN, Santoro N, Swaney SM, McQuade TJ, Schultz PJ, Larsen MJ, Sherman DH.

Chem Biol Drug Des. 2015 Dec;86(6):1331-8. doi: 10.1111/cbdd.12614. Epub 2015 Jul 25.

29.

Global gene expression profiling of telangiectasial tissue from patients with hereditary hemorrhagic telangiectasia.

Tørring PM, Larsen MJ, Kjeldsen AD, Ousager LB, Tan Q, Brusgaard K.

Microvasc Res. 2015 May;99:118-26. doi: 10.1016/j.mvr.2015.04.002. Epub 2015 Apr 16.

PMID:
25892364
30.

Long non-coding RNA expression profiles predict metastasis in lymph node-negative breast cancer independently of traditional prognostic markers.

Sørensen KP, Thomassen M, Tan Q, Bak M, Cold S, Burton M, Larsen MJ, Kruse TA.

Breast Cancer Res. 2015 Apr 11;17:55. doi: 10.1186/s13058-015-0557-4.

31.

Narrow-spectrum inhibitors of Campylobacter jejuni flagellar expression and growth.

Johnson JG, Yuhas C, McQuade TJ, Larsen MJ, DiRita VJ.

Antimicrob Agents Chemother. 2015 Jul;59(7):3880-6. doi: 10.1128/AAC.04926-14. Epub 2015 Apr 13.

32.

Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis.

Krøigård AB, Larsen MJ, Lænkholm AV, Knoop AS, Jensen JD, Bak M, Mollenhauer J, Kruse TA, Thomassen M.

Oncotarget. 2015 Mar 20;6(8):5634-49.

33.

Acute hypoxia induces upregulation of microRNA-210 expression in glioblastoma spheroids.

Rosenberg T, Thomassen M, Jensen SS, Larsen MJ, Sørensen KP, Hermansen SK, Kruse TA, Kristensen BW.

CNS Oncol. 2015;4(1):25-35. doi: 10.2217/cns.14.48.

34.

The combined use of alphavirus replicons and pseudoinfectious particles for the discovery of antivirals derived from natural products.

Delekta PC, Raveh A, Larsen MJ, Schultz PJ, Tamayo-Castillo G, Sherman DH, Miller DJ.

J Biomol Screen. 2015 Jun;20(5):673-80. doi: 10.1177/1087057114564868. Epub 2014 Dec 30.

35.

Hereditary breast cancer: clinical, pathological and molecular characteristics.

Larsen MJ, Thomassen M, Gerdes AM, Kruse TA.

Breast Cancer (Auckl). 2014 Oct 15;8:145-55. doi: 10.4137/BCBCR.S18715. eCollection 2014. Review.

36.

Use of next generation sequencing in head and neck squamous cell carcinomas: a review.

Tabatabaeifar S, Kruse TA, Thomassen M, Larsen MJ, Sørensen JA.

Oral Oncol. 2014 Nov;50(11):1035-40. doi: 10.1016/j.oraloncology.2014.08.013. Epub 2014 Sep 13. Review.

PMID:
25223596
37.

Immunodeficiency associated with a nonsense mutation of IKBKB.

Nielsen C, Jakobsen MA, Larsen MJ, Müller AC, Hansen S, Lillevang ST, Fisker N, Barington T.

J Clin Immunol. 2014 Nov;34(8):916-21. doi: 10.1007/s10875-014-0097-1. Epub 2014 Sep 14.

PMID:
25216719
38.

Microarray-based RNA profiling of breast cancer: batch effect removal improves cross-platform consistency.

Larsen MJ, Thomassen M, Tan Q, Sørensen KP, Kruse TA.

Biomed Res Int. 2014;2014:651751. doi: 10.1155/2014/651751. Epub 2014 Jul 3.

39.

Long non-coding RNA expression profiles in hereditary haemorrhagic telangiectasia.

Tørring PM, Larsen MJ, Kjeldsen AD, Ousager LB, Tan Q, Brusgaard K.

PLoS One. 2014 Mar 6;9(3):e90272. doi: 10.1371/journal.pone.0090272. eCollection 2014.

40.

Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast.

Larsen MJ, Lancheros ER, Williams T, Lowery DE, Geary TG, Kubiak TM.

Int J Parasitol Drugs Drug Resist. 2012 Nov 15;3:1-7. doi: 10.1016/j.ijpddr.2012.10.002. eCollection 2013 Dec.

41.

RNA profiling reveals familial aggregation of molecular subtypes in non-BRCA1/2 breast cancer families.

Larsen MJ, Thomassen M, Tan Q, Lænkholm AV, Bak M, Sørensen KP, Andersen MK, Kruse TA, Gerdes AM.

BMC Med Genomics. 2014 Jan 31;7:9. doi: 10.1186/1755-8794-7-9.

42.

The role of HTS in drug discovery at the University of Michigan.

Larsen MJ, Larsen SD, Fribley A, Grembecka J, Homan K, Mapp A, Haak A, Nikolovska-Coleska Z, Stuckey JA, Sun D, Sherman DH.

Comb Chem High Throughput Screen. 2014 Mar;17(3):210-30. Review.

43.

Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer.

Sørensen KP, Thomassen M, Tan Q, Bak M, Cold S, Burton M, Larsen MJ, Kruse TA.

Breast Cancer Res Treat. 2013 Dec;142(3):529-36. doi: 10.1007/s10549-013-2776-7. Epub 2013 Nov 21.

PMID:
24258260
44.

Classifications within molecular subtypes enables identification of BRCA1/BRCA2 mutation carriers by RNA tumor profiling.

Larsen MJ, Kruse TA, Tan Q, Lænkholm AV, Bak M, Lykkesfeldt AE, Sørensen KP, Hansen TV, Ejlertsen B, Gerdes AM, Thomassen M.

PLoS One. 2013 May 21;8(5):e64268. doi: 10.1371/journal.pone.0064268. Print 2013.

45.

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.

Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR.

Nat Med. 2013 Mar;19(3):313-21. doi: 10.1038/nm.3082. Epub 2013 Feb 10.

46.

Highly ion-conducting poly(ionic liquid) layers.

Wood TJ, Schofield WC, Lund P, Larsen MJ, Badyal JP.

Chem Commun (Camb). 2012 Oct 21;48(82):10201-3.

PMID:
22962661
47.

Small molecule screening identifies regulators of the transcription factor ΔFosB.

Wang Y, Cesena TI, Ohnishi Y, Burger-Caplan R, Lam V, Kirchhoff PD, Larsen SD, Larsen MJ, Nestler EJ, Rudenko G.

ACS Chem Neurosci. 2012 Jul 18;3(7):546-56. doi: 10.1021/cn3000235. Epub 2012 Mar 29.

48.

MScreen: an integrated compound management and high-throughput screening data storage and analysis system.

Jacob RT, Larsen MJ, Larsen SD, Kirchhoff PD, Sherman DH, Neubig RR.

J Biomol Screen. 2012 Sep;17(8):1080-7. doi: 10.1177/1087057112450186. Epub 2012 Jun 15.

49.

Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice.

Sun H, Xu Y, Sitkiewicz I, Ma Y, Wang X, Yestrepsky BD, Huang Y, Lapadatescu MC, Larsen MJ, Larsen SD, Musser JM, Ginsburg D.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3469-74. doi: 10.1073/pnas.1201031109. Epub 2012 Feb 13.

50.

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.

Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, Ron D, Sherman DH, Kaufman RJ.

J Biomol Screen. 2011 Sep;16(8):825-35. doi: 10.1177/1087057111414893. Epub 2011 Aug 15.

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