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Items: 35

1.

Author Correction: Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis.

Rauch A, Haakonsson AK, Madsen JGS, Larsen M, Forss I, Madsen MR, Van Hauwaert EL, Wiwie C, Jespersen NZ, Tencerova M, Nielsen R, Larsen BD, Röttger R, Baumbach J, Scheele C, Kassem M, Mandrup S.

Nat Genet. 2019 Apr;51(4):766. doi: 10.1038/s41588-019-0400-4.

PMID:
30911162
2.

Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis.

Rauch A, Haakonsson AK, Madsen JGS, Larsen M, Forss I, Madsen MR, Van Hauwaert EL, Wiwie C, Jespersen NZ, Tencerova M, Nielsen R, Larsen BD, Röttger R, Baumbach J, Scheele C, Kassem M, Mandrup S.

Nat Genet. 2019 Apr;51(4):716-727. doi: 10.1038/s41588-019-0359-1. Epub 2019 Mar 4. Erratum in: Nat Genet. 2019 Mar 25;:.

PMID:
30833796
3.

Transcriptional regulation of Hepatic Stellate Cell activation in NASH.

Marcher AB, Bendixen SM, Terkelsen MK, Hohmann SS, Hansen MH, Larsen BD, Mandrup S, Dimke H, Detlefsen S, Ravnskjaer K.

Sci Rep. 2019 Feb 20;9(1):2324. doi: 10.1038/s41598-019-39112-6.

4.

Chromatin Immunoprecipitation for Identification of Protein-DNA Interactions in Human Cells.

Larsen BD, Madsen MR, Nielsen R, Mandrup S.

Methods Mol Biol. 2018;1794:335-352. doi: 10.1007/978-1-4939-7871-7_24.

PMID:
29855970
5.

Inhibition of Cx43 gap junction uncoupling prevents high glucose-induced apoptosis and reduces excess cell monolayer permeability in retinal vascular endothelial cells.

Kim D, Mouritzen U, Larsen BD, Roy S.

Exp Eye Res. 2018 Aug;173:85-90. doi: 10.1016/j.exer.2018.05.003. Epub 2018 May 9.

PMID:
29750972
6.

The caspase-activated DNase: apoptosis and beyond.

Larsen BD, Sørensen CS.

FEBS J. 2017 Apr;284(8):1160-1170. doi: 10.1111/febs.13970. Epub 2016 Dec 15. Review.

7.

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells.

Schmidt SF, Madsen JG, Frafjord KØ, Poulsen Ll, Salö S, Boergesen M, Loft A, Larsen BD, Madsen MS, Holst JJ, Maechler P, Dalgaard LT, Mandrup S.

Cell Rep. 2016 Aug 30;16(9):2359-72. doi: 10.1016/j.celrep.2016.07.063. Epub 2016 Aug 18.

8.

Temporal activation of XRCC1-mediated DNA repair is essential for muscle differentiation.

Al-Khalaf MH, Blake LE, Larsen BD, Bell RA, Brunette S, Parks RJ, Rudnicki MA, McKinnon PJ, Jeffrey Dilworth F, Megeney LA.

Cell Discov. 2016 Jan 12;2:15041. doi: 10.1038/celldisc.2015.41. eCollection 2016.

9.

Cofactor squelching: Artifact or fact?

Schmidt SF, Larsen BD, Loft A, Mandrup S.

Bioessays. 2016 Jul;38(7):618-26. doi: 10.1002/bies.201600034. Epub 2016 Jun 7. Review.

PMID:
27273739
10.

ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function.

Ahlskog JK, Larsen BD, Achanta K, Sørensen CS.

EMBO Rep. 2016 May;17(5):671-81. doi: 10.15252/embr.201541455. Epub 2016 Apr 4.

11.

Effects of selected bioactive food compounds on human white adipocyte function.

Björk C, Wilhelm U, Mandrup S, Larsen BD, Bordoni A, Hedén P, Rydén M, Arner P, Laurencikiene J.

Nutr Metab (Lond). 2016 Jan 19;13:4. doi: 10.1186/s12986-016-0064-3. eCollection 2016.

12.

Gap junction modifier rotigaptide decreases the susceptibility to ventricular arrhythmia by enhancing conduction velocity and suppressing discordant alternans during therapeutic hypothermia in isolated rabbit hearts.

Hsieh YC, Lin JC, Hung CY, Li CH, Lin SF, Yeh HI, Huang JL, Lo CP, Haugan K, Larsen BD, Wu TJ.

Heart Rhythm. 2016 Jan;13(1):251-61. doi: 10.1016/j.hrthm.2015.07.023. Epub 2015 Jul 15.

PMID:
26188250
13.

Acute TNF-induced repression of cell identity genes is mediated by NFκB-directed redistribution of cofactors from super-enhancers.

Schmidt SF, Larsen BD, Loft A, Nielsen R, Madsen JG, Mandrup S.

Genome Res. 2015 Sep;25(9):1281-94. doi: 10.1101/gr.188300.114. Epub 2015 Jun 25.

14.

iRNA-seq: computational method for genome-wide assessment of acute transcriptional regulation from total RNA-seq data.

Madsen JG, Schmidt SF, Larsen BD, Loft A, Nielsen R, Mandrup S.

Nucleic Acids Res. 2015 Mar 31;43(6):e40. doi: 10.1093/nar/gku1365. Epub 2015 Jan 6.

15.

Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control.

Klein DK, Hoffmann S, Ahlskog JK, O'Hanlon K, Quaas M, Larsen BD, Rolland B, Rösner HI, Walter D, Kousholt AN, Menzel T, Lees M, Johansen JV, Rappsilber J, Engeland K, Sørensen CS.

Nat Commun. 2015 Jan 5;6:5800. doi: 10.1038/ncomms6800.

PMID:
25557911
16.

The design and discovery of lixisenatide for the treatment of type 2 diabetes mellitus.

Christensen M, Miossec P, Larsen BD, Werner U, Knop FK.

Expert Opin Drug Discov. 2014 Oct;9(10):1223-51. doi: 10.1517/17460441.2014.942638. Epub 2014 Aug 14. Review.

PMID:
25119443
17.

Osteoclastogenesis is influenced by modulation of gap junctional communication with antiarrhythmic peptides.

Kylmäoja E, Kokkonen H, Kauppinen K, Hussar P, Sato T, Haugan K, Larsen BD, Tuukkanen J.

Calcif Tissue Int. 2013 Mar;92(3):270-81. doi: 10.1007/s00223-012-9680-8. Epub 2012 Dec 16.

PMID:
23241925
18.

CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.

Kousholt AN, Fugger K, Hoffmann S, Larsen BD, Menzel T, Sartori AA, Sørensen CS.

J Cell Biol. 2012 Jun 25;197(7):869-76. doi: 10.1083/jcb.201111065.

19.

Characterization of a novel peripheral pro-lipolytic mechanism in mice: role of VGF-derived peptide TLQP-21.

Possenti R, Muccioli G, Petrocchi P, Cero C, Cabassi A, Vulchanova L, Riedl MS, Manieri M, Frontini A, Giordano A, Cinti S, Govoni P, Graiani G, Quaini F, Ghè C, Bresciani E, Bulgarelli I, Torsello A, Locatelli V, Sanghez V, Larsen BD, Petersen JS, Palanza P, Parmigiani S, Moles A, Levi A, Bartolomucci A.

Biochem J. 2012 Jan 1;441(1):511-22. doi: 10.1042/BJ20111165.

PMID:
21880012
20.

Parole terms for a killer: directing caspase3/CAD induced DNA strand breaks to coordinate changes in gene expression.

Larsen BD, Megeney LA.

Cell Cycle. 2010 Aug 1;9(15):2940-5. doi: 10.4161/cc.9.15.12335.

21.

Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctions.

Verma V, Larsen BD, Coombs W, Lin X, Sarrou E, Taffet SM, Delmar M.

Heart Rhythm. 2010 Oct;7(10):1491-8. doi: 10.1016/j.hrthm.2010.06.028. Epub 2010 Jun 26.

22.

Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks.

Larsen BD, Rampalli S, Burns LE, Brunette S, Dilworth FJ, Megeney LA.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4230-5. doi: 10.1073/pnas.0913089107. Epub 2010 Feb 16.

23.

Discovery of a class of potent gap-junction modifiers as novel antiarrhythmic agents.

Piatnitski Chekler EL, Butera JA, Di L, Swillo RE, Morgan GA, Rossman EI, Huselton C, Larsen BD, Hennan JK.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4551-4. doi: 10.1016/j.bmcl.2009.07.014. Epub 2009 Jul 9.

PMID:
19616941
24.

Novel pharmacophores of connexin43 based on the "RXP" series of Cx43-binding peptides.

Verma V, Larsen BD, Coombs W, Lin X, Spagnol G, Sorgen PL, Taffet SM, Delmar M.

Circ Res. 2009 Jul 17;105(2):176-84. doi: 10.1161/CIRCRESAHA.109.200576. Epub 2009 Jun 25.

25.

Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation.

Butera JA, Larsen BD, Hennan JK, Kerns E, Di L, Alimardanov A, Swillo RE, Morgan GA, Liu K, Wang Q, Rossman EI, Unwalla R, McDonald L, Huselton C, Petersen JS.

J Med Chem. 2009 Feb 26;52(4):908-11. doi: 10.1021/jm801558d.

PMID:
19175320
26.

Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).

Axelsen LN, Stahlhut M, Mohammed S, Larsen BD, Nielsen MS, Holstein-Rathlou NH, Andersen S, Jensen ON, Hennan JK, Kjølbye AL.

J Mol Cell Cardiol. 2006 Jun;40(6):790-8. Epub 2006 May 5.

PMID:
16678851
27.

Rotigaptide (ZP123) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs.

Hennan JK, Swillo RE, Morgan GA, Keith JC Jr, Schaub RG, Smith RP, Feldman HS, Haugan K, Kantrowitz J, Wang PJ, Abu-Qare A, Butera J, Larsen BD, Crandall DL.

J Pharmacol Exp Ther. 2006 Apr;317(1):236-43. Epub 2005 Dec 12.

PMID:
16344331
28.

Effects of the new antiarrhythmic peptide ZP123 on epicardial activation and repolarization pattern.

Dhein S, Larsen BD, Petersen JS, Mohr FW.

Cell Commun Adhes. 2003 Jul-Dec;10(4-6):371-8.

PMID:
14681044
29.

Glucagon-like peptide 1 receptor agonist ZP10A increases insulin mRNA expression and prevents diabetic progression in db/db mice.

Thorkildsen C, Neve S, Larsen BD, Meier E, Petersen JS.

J Pharmacol Exp Ther. 2003 Nov;307(2):490-6. Epub 2003 Sep 15.

PMID:
12975499
30.

Pharmacological characterization of the new stable antiarrhythmic peptide analog Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2 (ZP123): in vivo and in vitro studies.

Kjølbye AL, Knudsen CB, Jepsen T, Larsen BD, Petersen JS.

J Pharmacol Exp Ther. 2003 Sep;306(3):1191-9. Epub 2003 Jun 26.

PMID:
12829724
31.

Pharmacological characterization of the novel nociceptin/orphanin FQ receptor ligand, ZP120: in vitro and in vivo studies in mice.

Rizzi A, Rizzi D, Marzola G, Regoli D, Larsen BD, Petersen JS, Calo' G.

Br J Pharmacol. 2002 Oct;137(3):369-74.

32.

Stability, metabolism and transport of D-Asp(OBzl)-Ala--a model prodrug with affinity for the oligopeptide transporter.

Steffansen B, Lepist EI, Taub ME, Larsen BD, Frokjaer S, Lennernäs H.

Eur J Pharm Sci. 1999 Apr;8(1):67-73.

PMID:
10072480
33.

N-terminal 4-imidazolidinone prodrugs of Leu-enkephalin: synthesis, chemical and enzymatic stability studies.

Bak A, Fich M, Larsen BD, Frokjaer S, Friis GJ.

Eur J Pharm Sci. 1999 Mar;7(4):317-23.

PMID:
9971915
34.
35.

Incomplete Fmoc deprotection in solid-phase synthesis of peptides.

Larsen BD, Holm A.

Int J Pept Protein Res. 1994 Jan;43(1):1-9.

PMID:
8138344

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