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Prospective Assessment of Clinical Risk Factors and Biomarkers of Hypercoagulability for the Identification of Patients with Lung Adenocarcinoma at Risk for Cancer-Associated Thrombosis: The Observational ROADMAP-CAT Study.

Syrigos K, Grapsa D, Sangare R, Evmorfiadis I, Larsen AK, Van Dreden P, Boura P, Charpidou A, Kotteas E, Sergentanis TN, Elalamy I, Falanga A, Gerotziafas GT.

Oncologist. 2018 Aug 13. pii: theoncologist.2017-0530. doi: 10.1634/theoncologist.2017-0530. [Epub ahead of print]


Combinations of Bevacizumab and Erlotinib Show Activity in Colorectal Cancer Independent of RAS Status.

Mésange P, Bouygues A, Ferrand N, Sabbah M, Escargueil AE, Savina A, Chibaudel B, Tournigand C, André T, de Gramont A, Larsen AK.

Clin Cancer Res. 2018 Jun 1;24(11):2548-2558. doi: 10.1158/1078-0432.CCR-17-3187. Epub 2018 Feb 28.


Brucella Antibodies in Alaskan True Seals and Eared Seals-Two Different Stories.

Nymo IH, Rødven R, Beckmen K, Larsen AK, Tryland M, Quakenbush L, Godfroid J.

Front Vet Sci. 2018 Jan 31;5:8. doi: 10.3389/fvets.2018.00008. eCollection 2018.


Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group.

Perego P, Hempel G, Linder S, Bradshaw TD, Larsen AK, Peters GJ, Phillips RM; EORTC PAMM Group.

Cancer Chemother Pharmacol. 2018 Mar;81(3):427-441. doi: 10.1007/s00280-017-3502-7. Epub 2017 Dec 28. Review.


The role of managers in addressing employees with musculoskeletal pain: a mixed methods study.

Larsen AK, Falkenstrøm S, Jørgensen MB, Rod MH.

Int Arch Occup Environ Health. 2018 Apr;91(3):361-372. doi: 10.1007/s00420-017-1284-1. Epub 2017 Dec 21.


Procoagulant microparticles derived from cancer cells have determinant role in the hypercoagulable state associated with cancer.

Rousseau A, Van Dreden P, Khaterchi A, Larsen AK, Elalamy I, Gerotziafas GT.

Int J Oncol. 2017 Dec;51(6):1793-1800. doi: 10.3892/ijo.2017.4170. Epub 2017 Oct 20.


Differential contribution of tissue factor and Factor XII to thrombin generation triggered by breast and pancreatic cancer cells.

Rousseau A, Larsen AK, Van Dreden P, Sabbah M, Elalamy I, Gerotziafas GT.

Int J Oncol. 2017 Dec;51(6):1747-1756. doi: 10.3892/ijo.2017.4172. Epub 2017 Oct 20.


Application of real-time quantitative PCR assays for detecting marine Brucella spp. in fish.

Norman SA, Delaney MA, Haman KH, Thomas AC, Godfroid J, Larsen AK, Nymo IH, Robbe-Austerman S, Quance C, Rhyan JC, Lambourn DM, Jeffries SJ, Rabinowitz P.

J Vet Diagn Invest. 2018 Jan;30(1):150-154. doi: 10.1177/1040638717733024. Epub 2017 Oct 6.


Graft Product for Autologous Peripheral Blood Stem Cell Transplantation Enhances Thrombin Generation and Expresses Procoagulant Microparticles and Tissue Factor.

Sidibe F, Spanoudaki A, Vanneaux V, Mbemba E, Larghero J, Van Dreden P, Lotz JP, Elalamy I, Larsen AK, Gerotziafas GT.

Clin Appl Thromb Hemost. 2018 May;24(4):684-690. doi: 10.1177/1076029617715116. Epub 2017 Jul 6.


The Role of BEAMing and Digital PCR for Multiplexed Analysis in Molecular Oncology in the Era of Next-Generation Sequencing.

Denis JA, Guillerm E, Coulet F, Larsen AK, Lacorte JM.

Mol Diagn Ther. 2017 Dec;21(6):587-600. doi: 10.1007/s40291-017-0287-7. Review.


A Predictive Score for Thrombosis Associated with Breast, Colorectal, Lung, or Ovarian Cancer: The Prospective COMPASS-Cancer-Associated Thrombosis Study.

Gerotziafas GT, Taher A, Abdel-Razeq H, AboElnazar E, Spyropoulos AC, El Shemmari S, Larsen AK, Elalamy I; COMPASS–CAT Working Group.

Oncologist. 2017 Oct;22(10):1222-1231. doi: 10.1634/theoncologist.2016-0414. Epub 2017 May 26.


WISP1/CCN4 inhibits adipocyte differentiation through repression of PPARγ activity.

Ferrand N, Béreziat V, Moldes M, Zaoui M, Larsen AK, Sabbah M.

Sci Rep. 2017 May 11;7(1):1749. doi: 10.1038/s41598-017-01866-2.


A need to simplify informed consent documents in cancer clinical trials. A position paper of the ARCAD Group.

Bleiberg H, Decoster G, de Gramont A, Rougier P, Sobrero A, Benson A, Chibaudel B, Douillard JY, Eng C, Fuchs C, Fujii M, Labianca R, Larsen AK, Mitchell E, Schmoll HJ, Sprumont D, Zalcberg J.

Ann Oncol. 2017 May 1;28(5):922-930. doi: 10.1093/annonc/mdx050.


How health-related quality of life assessment should be used in advanced colorectal cancer clinical trials.

Bonnetain F, Borg C, Adams RR, Ajani JA, Benson A, Bleiberg H, Chibaudel B, Diaz-Rubio E, Douillard JY, Fuchs CS, Giantonio BJ, Goldberg R, Heinemann V, Koopman M, Labianca R, Larsen AK, Maughan T, Mitchell E, Peeters M, Punt CJA, Schmoll HJ, Tournigand C, de Gramont A.

Ann Oncol. 2017 Sep 1;28(9):2077-2085. doi: 10.1093/annonc/mdx191. Review.


Impact of blood hypercoagulability on in vitro fertilization outcomes: a prospective longitudinal observational study.

Gerotziafas GT, Van Dreden P, Mathieu d'Argent E, Lefkou E, Grusse M, Comtet M, Sangare R, Ketatni H, Larsen AK, Elalamy I.

Thromb J. 2017 Mar 28;15:9. doi: 10.1186/s12959-017-0131-7. eCollection 2017.


Cross Validation of HS-GC/MS to Quantify Total Carbon Dioxide in Horse Plasma.

Heffron B, Bash J, Larsen AK.

J Anal Toxicol. 2017 Apr 1;41(3):230-235. doi: 10.1093/jat/bkw133.


Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus.

Zang Y, Genta-Jouve G, Escargueil AE, Larsen AK, Guedon L, Nay B, Prado S.

J Nat Prod. 2016 Dec 23;79(12):2991-2996. doi: 10.1021/acs.jnatprod.6b00458. Epub 2016 Dec 14.


The Antithrombotic Potential of Tinzaparin and Enoxaparin Upon Thrombin Generation Triggered In Vitro by Human Ovarian Cancer Cells IGROV1.

Sassi M, Chakroun T, Mbemba E, Van Dreden P, Elalamy I, Larsen AK, Gerotziafas GT.

Clin Appl Thromb Hemost. 2017 Mar;23(2):155-163. doi: 10.1177/1076029616665922. Epub 2016 Sep 24.


Genotype- or Phenotype-Targeting Anticancer Therapies? Lessons from Tumor Evolutionary Biology.

Escargueil AE, Prado S, Dezaire A, Clairambault J, Larsen AK, Soares DG.

Curr Pharm Des. 2016;22(44):6625-6644. doi: 10.2174/1381612822666160831114002. Review.


Experimental Challenge of Atlantic Cod (Gadus morhua) with a Brucella pinnipedialis Strain from Hooded Seal (Cystophora cristata).

Nymo IH, Seppola M, Al Dahouk S, Bakkemo KR, Jiménez de Bagüés MP, Godfroid J, Larsen AK.

PLoS One. 2016 Jul 14;11(7):e0159272. doi: 10.1371/journal.pone.0159272. eCollection 2016.


Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery.

Denis JA, Patroni A, Guillerm E, Pépin D, Benali-Furet N, Wechsler J, Manceau G, Bernard M, Coulet F, Larsen AK, Karoui M, Lacorte JM.

Mol Oncol. 2016 Oct;10(8):1221-31. doi: 10.1016/j.molonc.2016.05.009. Epub 2016 Jun 7.


Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.

Lima M, Bouzid H, Soares DG, Selle F, Morel C, Galmarini CM, Henriques JA, Larsen AK, Escargueil AE.

Oncotarget. 2016 May 3;7(18):25885-901. doi: 10.18632/oncotarget.8292.


Brucella pinnipedialis in hooded seal (Cystophora cristata) primary epithelial cells.

Larsen AK, Godfroid J, Nymo IH.

Acta Vet Scand. 2016 Jan 25;58:9. doi: 10.1186/s13028-016-0188-5.


PEPCOL: a GERCOR randomized phase II study of nanoliposomal irinotecan PEP02 (MM-398) or irinotecan with leucovorin/5-fluorouracil as second-line therapy in metastatic colorectal cancer.

Chibaudel B, Maindrault-Gœbel F, Bachet JB, Louvet C, Khalil A, Dupuis O, Hammel P, Garcia ML, Bennamoun M, Brusquant D, Tournigand C, André T, Arbaud C, Larsen AK, Wang YW, Yeh CG, Bonnetain F, de Gramont A.

Cancer Med. 2016 Apr;5(4):676-83. doi: 10.1002/cam4.635. Epub 2016 Jan 24.


Afatinib, an Irreversible EGFR Family Inhibitor, Shows Activity Toward Pancreatic Cancer Cells, Alone and in Combination with Radiotherapy, Independent of KRAS Status.

Huguet F, Fernet M, Giocanti N, Favaudon V, Larsen AK.

Target Oncol. 2016 Jun;11(3):371-81. doi: 10.1007/s11523-015-0403-8.


Unique features of trabectedin mechanism of action.

Larsen AK, Galmarini CM, D'Incalci M.

Cancer Chemother Pharmacol. 2016 Apr;77(4):663-71. doi: 10.1007/s00280-015-2918-1. Epub 2015 Dec 14. Review.


Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer (GERCOR DREAM; OPTIMOX3): a randomised, open-label, phase 3 trial.

Tournigand C, Chibaudel B, Samson B, Scheithauer W, Vernerey D, Mésange P, Lledo G, Viret F, Ramée JF, Tubiana-Mathieu N, Dauba J, Dupuis O, Rinaldi Y, Mabro M, Aucoin N, Latreille J, Bonnetain F, Louvet C, Larsen AK, André T, de Gramont A.

Lancet Oncol. 2015 Nov;16(15):1493-1505. doi: 10.1016/S1470-2045(15)00216-8. Epub 2015 Oct 22. Erratum in: Lancet Oncol. 2015 Dec;16(16):e589.


Organizing workplace health literacy to reduce musculoskeletal pain and consequences.

Larsen AK, Holtermann A, Mortensen OS, Punnett L, Rod MH, Jørgensen MB.

BMC Nurs. 2015 Sep 17;14:46. doi: 10.1186/s12912-015-0096-4. eCollection 2015.


Unexpected talaroenamine derivatives and an undescribed polyester from the fungus Talaromyces stipitatus ATCC10500.

Zang Y, Genta-Jouve G, Sun TA, Li X, Didier B, Mann S, Mouray E, Larsen AK, Escargueil AE, Nay B, Prado S.

Phytochemistry. 2015 Nov;119:70-5. doi: 10.1016/j.phytochem.2015.09.002. Epub 2015 Sep 18.


Mixed exposure to bacterial lipopolysaccharide and seafood proteases augments inflammatory signalling in an airway epithelial cell model (A549).

Bhagwat SS, Larsen AK, Seternes OM, Bang BE.

Toxicol Ind Health. 2015 Jul 6. pii: 0748233715590914. [Epub ahead of print]


Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors.

Ayadi M, Bouygues A, Ouaret D, Ferrand N, Chouaib S, Thiery JP, Muchardt C, Sabbah M, Larsen AK.

Oncotarget. 2015 Jul 30;6(21):18518-33.


BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.

Rocca CJ, Soares DG, Bouzid H, Henriques JA, Larsen AK, Escargueil AE.

Cell Cycle. 2015;14(13):2080-90. doi: 10.1080/15384101.2015.1042632.


Emergence of drug tolerance in cancer cell populations: an evolutionary outcome of selection, nongenetic instability, and stress-induced adaptation.

Chisholm RH, Lorenzi T, Lorz A, Larsen AK, de Almeida LN, Escargueil A, Clairambault J.

Cancer Res. 2015 Mar 15;75(6):930-9. doi: 10.1158/0008-5472.CAN-14-2103. Epub 2015 Jan 27.


[Marjolin's ulcer in a 54-year-old skin graft].

Larsen AK, Nielsen AM.

Ugeskr Laeger. 2014 Dec 15;176(25A). pii: V12120744. Danish.


Polyethylenimine architecture-dependent metabolic imprints and perturbation of cellular redox homeostasis.

Hall A, Parhamifar L, Lange MK, Meyle KD, Sanderhoff M, Andersen H, Roursgaard M, Larsen AK, Jensen PB, Christensen C, Bartek J, Moghimi SM.

Biochim Biophys Acta. 2015 Mar;1847(3):328-342. doi: 10.1016/j.bbabio.2014.12.002. Epub 2014 Dec 5.


Long-term Survival after Metastatic Childhood Melanoma.

Larsen AK, Jensen MB, Krag C.

Plast Reconstr Surg Glob Open. 2014 Jul 9;2(6):e163. doi: 10.1097/GOX.0000000000000122. eCollection 2014 Jun.


Neglected giant scalp Basal cell carcinoma.

Larsen AK, El-Charnoubi WA, Gehl J, Krag C.

Plast Reconstr Surg Glob Open. 2014 Apr 7;2(3):e120. doi: 10.1097/GOX.0000000000000066. eCollection 2014 Mar.


Isolated malignant melanoma metastasis to the pancreas.

Larsen AK, Krag C, Geertsen P, Jakobsen LP.

Plast Reconstr Surg Glob Open. 2013 Dec 6;1(8):e74. doi: 10.1097/GOX.0000000000000018. eCollection 2013 Nov.


Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression.

Akalay I, Tan TZ, Kumar P, Janji B, Mami-Chouaib F, Charpy C, Vielh P, Larsen AK, Thiery JP, Sabbah M, Chouaib S.

Oncogene. 2015 Apr 23;34(17):2261-71. doi: 10.1038/onc.2014.151. Epub 2014 Jun 16.


Adoption of workplaces and reach of employees for a multi-faceted intervention targeting low back pain among nurses' aides.

Rasmussen CD, Larsen AK, Holtermann A, Søgaard K, Jørgensen MB.

BMC Med Res Methodol. 2014 May 1;14:60. doi: 10.1186/1471-2288-14-60.


Manifestations of Gorlin-Goltz syndrome.

Larsen AK, Mikkelsen DB, Hertz JM, Bygum A.

Dan Med J. 2014 May;61(5):A4829.


Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line.

Bhagwat SS, Larsen AK, Winberg JO, Seternes OM, Bang BE.

Food Chem Toxicol. 2014 Jul;69:303-11. doi: 10.1016/j.fct.2014.04.030. Epub 2014 Apr 30.


A small molecule screen identifies an inhibitor of DNA repair inducing the degradation of TFIIH and the chemosensitization of tumor cells to platinum.

Alekseev S, Ayadi M, Brino L, Egly JM, Larsen AK, Coin F.

Chem Biol. 2014 Mar 20;21(3):398-407. doi: 10.1016/j.chembiol.2013.12.014. Epub 2014 Feb 6.


Loss of WISP2/CCN5 in estrogen-dependent MCF7 human breast cancer cells promotes a stem-like cell phenotype.

Ferrand N, Gnanapragasam A, Dorothee G, Redeuilh G, Larsen AK, Sabbah M.

PLoS One. 2014 Feb 3;9(2):e87878. doi: 10.1371/journal.pone.0087878. eCollection 2014.


Entrance and survival of Brucella pinnipedialis hooded seal strain in human macrophages and epithelial cells.

Larsen AK, Nymo IH, Briquemont B, Sørensen KK, Godfroid J.

PLoS One. 2013 Dec 20;8(12):e84861. doi: 10.1371/journal.pone.0084861. eCollection 2013.


Platinum-sensitivity in metastatic colorectal cancer: towards a definition.

Chibaudel B, Tournigand C, Bonnetain F, Maindrault-Goebel F, Lledo G, André T, Larsen AK, Bengrine-Lefevre L, Louvet C, de Gramont A.

Eur J Cancer. 2013 Dec;49(18):3813-20. doi: 10.1016/j.ejca.2013.07.150. Epub 2013 Sep 3.


Entry and elimination of marine mammal Brucella spp. by hooded seal (Cystophora cristata) alveolar macrophages in vitro.

Larsen AK, Nymo IH, Boysen P, Tryland M, Godfroid J.

PLoS One. 2013 Jul 25;8(7):e70186. doi: 10.1371/journal.pone.0070186. Print 2013.


DNA alkylation damage and autophagy induction.

Bordin DL, Lima M, Lenz G, Saffi J, Meira LB, Mésange P, Soares DG, Larsen AK, Escargueil AE, Henriques JA.

Mutat Res. 2013 Oct-Dec;753(2):91-9. doi: 10.1016/j.mrrev.2013.07.001. Epub 2013 Jul 18. Review.


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