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Breast-Associated Adipocytes Secretome Induce Fatty Acid Uptake and Invasiveness in Breast Cancer Cells via CD36 Independently of Body Mass Index, Menopausal Status and Mammary Density.

Zaoui M, Morel M, Ferrand N, Fellahi S, Bastard JP, Lamazière A, Larsen AK, Béréziat V, Atlan M, Sabbah M.

Cancers (Basel). 2019 Dec 13;11(12). pii: E2012. doi: 10.3390/cancers11122012.


Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms.

Olsvik PA, Larsen AK, Berntssen MHG, Goksøyr A, Karlsen OA, Yadetie F, Sanden M, Kristensen T.

Front Genet. 2019 Sep 26;10:794. doi: 10.3389/fgene.2019.00794. eCollection 2019.


Dipyridamole as a new drug to prevent Epstein-Barr virus reactivation.

Thomé MP, Borde C, Larsen AK, Henriques JAP, Lenz G, Escargueil AE, Maréchal V.

Antiviral Res. 2019 Dec;172:104615. doi: 10.1016/j.antiviral.2019.104615. Epub 2019 Sep 30.


The Use of microRNAs in the Management of Endometrial Cancer: A Meta-Analysis.

Delangle R, De Foucher T, Larsen AK, Sabbah M, Azaïs H, Bendifallah S, Daraï E, Ballester M, Mehats C, Uzan C, Canlorbe G.

Cancers (Basel). 2019 Jun 16;11(6). pii: E832. doi: 10.3390/cancers11060832. Review.


Systemic Dysfunction of Osteoblast Differentiation in Adipose-Derived Stem Cells from Patients with Multiple Myeloma.

Béréziat V, Mazurier C, Auclair M, Ferrand N, Jolly S, Marie T, Kobari L, Toillon I, Delhommeau F, Fève B, Larsen AK, Sabbah M, Garderet L.

Cells. 2019 May 10;8(5). pii: E441. doi: 10.3390/cells8050441.


Protein and energy intake improved by in-between meals: An intervention study in hospitalized patients.

Mortensen MN, Larsen AK, Skadhauge LB, Høgsted RH, Beermann T, Cook ME, Rasmussen HH, Mikkelsen BE, Holst M.

Clin Nutr ESPEN. 2019 Apr;30:113-118. doi: 10.1016/j.clnesp.2019.01.007. Epub 2019 Feb 6.


Combined Fluorimetric Caspase-3/7 Assay and Bradford Protein Determination for Assessment of Polycation-Mediated Cytotoxicity.

Larsen AK, Hall A, Lundsgart H, Moghimi SM.

Methods Mol Biol. 2019;1943:301-311. doi: 10.1007/978-1-4939-9092-4_19.


The role of cytokines in the regulation of NK cells in the tumor environment.

Konjević GM, Vuletić AM, Mirjačić Martinović KM, Larsen AK, Jurišić VB.

Cytokine. 2019 May;117:30-40. doi: 10.1016/j.cyto.2019.02.001. Epub 2019 Feb 18. Review.


Efficacy of aflibercept with FOLFOX and maintenance with fluoropyrimidine as first‑line therapy for metastatic colorectal cancer: GERCOR VELVET phase II study.

Chibaudel B, Bachet JB, André T, Auby D, Desramé J, Deplanque G, Lecaille C, Louvet C, Tournigand C, Lebrun-Ly V, Dauba J, Lledo G, Garcia ML, Dubreuil O, Hamed NB, Meurisse A, Larsen AK, Tijeras-Raballand A, Bonnetain F, De Gramont A.

Int J Oncol. 2019 Apr;54(4):1433-1445. doi: 10.3892/ijo.2019.4709. Epub 2019 Feb 1.


The effect of strengthening health literacy in nursing homes on employee pain and consequences of pain ‒ a stepped-wedge intervention trial.

Larsen AK, Thygesen LC, Mortensen OS, Punnett L, Jørgensen MB.

Scand J Work Environ Health. 2019 Jul 1;45(4):386-395. doi: 10.5271/sjweh.3801. Epub 2019 Jan 24.


Concomitant Temperature Stress and Immune Activation may Increase Mortality Despite Efficient Clearance of an Intracellular Bacterial Infection in Atlantic Cod.

Larsen AK, Nymo IH, Sørensen KK, Seppola M, Rødven R, Jiménez de Bagüés MP, Al Dahouk S, Godfroid J.

Front Microbiol. 2018 Dec 4;9:2963. doi: 10.3389/fmicb.2018.02963. eCollection 2018.


Mesenchymal Stem Cell Administration Attenuates Colon Cancer Progression by Modulating the Immune Component within the Colorectal Tumor Microenvironment.

François S, Usunier B, Forgue-Lafitte ME, L'Homme B, Benderitter M, Douay L, Gorin NC, Larsen AK, Chapel A.

Stem Cells Transl Med. 2019 Mar;8(3):285-300. doi: 10.1002/sctm.18-0117. Epub 2018 Nov 19.


Longer procoagulant phospholipid-dependent clotting time, lower endogenous thrombin potential and higher tissue factor pathway inhibitor concentrations are associated with increased VTE occurrence in patients with newly diagnosed multiple myeloma: results of the prospective ROADMAP-MM-CAT study.

Fotiou D, Sergentanis TN, Papageorgiou L, Stamatelopoulos K, Gavriatopoulou M, Kastritis E, Psaltopoulou T, Salta S, Van Dreden P, Sangare R, Larsen AK, Terpos E, Elalamy I, Dimopoulos MA, Gerotziafas GT.

Blood Cancer J. 2018 Nov 7;8(11):102. doi: 10.1038/s41408-018-0135-y.


Comparison of antithrombin-dependent and direct inhibitors of factor Xa or thrombin on the kinetics and qualitative characteristics of blood clots.

Salta S, Papageorgiou L, Larsen AK, Van Dreden P, Soulier C, Cokkinos DV, Elalamy I, Gerotziafas GT.

Res Pract Thromb Haemost. 2018 Jul 17;2(4):696-707. doi: 10.1002/rth2.12120. eCollection 2018 Oct.


Transient increase of CA 19-9 serum concentrations in a liver transplant recipient with cystic fibrosis and hepatic abscess: a case report and brief literature review.

Denis JA, Mazzola A, Nguyen G, Lacorte JM, Brochet C, Larsen AK, Conti F.

Clin Biochem. 2019 Feb;64:53-56. doi: 10.1016/j.clinbiochem.2018.10.009. Epub 2018 Oct 17. Review.


FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer.

Carola C, Ghiringhelli F, Kim S, André T, Barlet J, Bengrine-Lefevre L, Marijon H, Garcia-Larnicol ML, Borg C, Dainese L, Steuer N, Richa H, Benetkiewicz M, Larsen AK, de Gramont A, Chibaudel B.

World J Clin Oncol. 2018 Sep 14;9(5):110-118. doi: 10.5306/wjco.v9.i5.110.


[Classification of vascular anomalies].

Larsen AK, Damsgaard TE, Hedelund L.

Ugeskr Laeger. 2018 Sep 3;180(36). pii: V11170857. Review. Danish.


Prospective Assessment of Clinical Risk Factors and Biomarkers of Hypercoagulability for the Identification of Patients with Lung Adenocarcinoma at Risk for Cancer-Associated Thrombosis: The Observational ROADMAP-CAT Study.

Syrigos K, Grapsa D, Sangare R, Evmorfiadis I, Larsen AK, Van Dreden P, Boura P, Charpidou A, Kotteas E, Sergentanis TN, Elalamy I, Falanga A, Gerotziafas GT.

Oncologist. 2018 Nov;23(11):1372-1381. doi: 10.1634/theoncologist.2017-0530. Epub 2018 Aug 13.


Combinations of Bevacizumab and Erlotinib Show Activity in Colorectal Cancer Independent of RAS Status.

Mésange P, Bouygues A, Ferrand N, Sabbah M, Escargueil AE, Savina A, Chibaudel B, Tournigand C, André T, de Gramont A, Larsen AK.

Clin Cancer Res. 2018 Jun 1;24(11):2548-2558. doi: 10.1158/1078-0432.CCR-17-3187. Epub 2018 Feb 28.


Brucella Antibodies in Alaskan True Seals and Eared Seals-Two Different Stories.

Nymo IH, Rødven R, Beckmen K, Larsen AK, Tryland M, Quakenbush L, Godfroid J.

Front Vet Sci. 2018 Jan 31;5:8. doi: 10.3389/fvets.2018.00008. eCollection 2018.


Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group.

Perego P, Hempel G, Linder S, Bradshaw TD, Larsen AK, Peters GJ, Phillips RM; EORTC PAMM Group.

Cancer Chemother Pharmacol. 2018 Mar;81(3):427-441. doi: 10.1007/s00280-017-3502-7. Epub 2017 Dec 28. Review.


The role of managers in addressing employees with musculoskeletal pain: a mixed methods study.

Larsen AK, Falkenstrøm S, Jørgensen MB, Rod MH.

Int Arch Occup Environ Health. 2018 Apr;91(3):361-372. doi: 10.1007/s00420-017-1284-1. Epub 2017 Dec 21.


Procoagulant microparticles derived from cancer cells have determinant role in the hypercoagulable state associated with cancer.

Rousseau A, Van Dreden P, Khaterchi A, Larsen AK, Elalamy I, Gerotziafas GT.

Int J Oncol. 2017 Dec;51(6):1793-1800. doi: 10.3892/ijo.2017.4170. Epub 2017 Oct 20.


Differential contribution of tissue factor and Factor XII to thrombin generation triggered by breast and pancreatic cancer cells.

Rousseau A, Larsen AK, Van Dreden P, Sabbah M, Elalamy I, Gerotziafas GT.

Int J Oncol. 2017 Dec;51(6):1747-1756. doi: 10.3892/ijo.2017.4172. Epub 2017 Oct 20.


Application of real-time quantitative PCR assays for detecting marine Brucella spp. in fish.

Norman SA, Delaney MA, Haman KH, Thomas AC, Godfroid J, Larsen AK, Nymo IH, Robbe-Austerman S, Quance C, Rhyan JC, Lambourn DM, Jeffries SJ, Rabinowitz P.

J Vet Diagn Invest. 2018 Jan;30(1):150-154. doi: 10.1177/1040638717733024. Epub 2017 Oct 6.


Graft Product for Autologous Peripheral Blood Stem Cell Transplantation Enhances Thrombin Generation and Expresses Procoagulant Microparticles and Tissue Factor.

Sidibe F, Spanoudaki A, Vanneaux V, Mbemba E, Larghero J, Van Dreden P, Lotz JP, Elalamy I, Larsen AK, Gerotziafas GT.

Clin Appl Thromb Hemost. 2018 May;24(4):684-690. doi: 10.1177/1076029617715116. Epub 2017 Jul 6.


The Role of BEAMing and Digital PCR for Multiplexed Analysis in Molecular Oncology in the Era of Next-Generation Sequencing.

Denis JA, Guillerm E, Coulet F, Larsen AK, Lacorte JM.

Mol Diagn Ther. 2017 Dec;21(6):587-600. doi: 10.1007/s40291-017-0287-7. Review.


A Predictive Score for Thrombosis Associated with Breast, Colorectal, Lung, or Ovarian Cancer: The Prospective COMPASS-Cancer-Associated Thrombosis Study.

Gerotziafas GT, Taher A, Abdel-Razeq H, AboElnazar E, Spyropoulos AC, El Shemmari S, Larsen AK, Elalamy I; COMPASS–CAT Working Group.

Oncologist. 2017 Oct;22(10):1222-1231. doi: 10.1634/theoncologist.2016-0414. Epub 2017 May 26.


WISP1/CCN4 inhibits adipocyte differentiation through repression of PPARγ activity.

Ferrand N, Béreziat V, Moldes M, Zaoui M, Larsen AK, Sabbah M.

Sci Rep. 2017 May 11;7(1):1749. doi: 10.1038/s41598-017-01866-2.


A need to simplify informed consent documents in cancer clinical trials. A position paper of the ARCAD Group.

Bleiberg H, Decoster G, de Gramont A, Rougier P, Sobrero A, Benson A, Chibaudel B, Douillard JY, Eng C, Fuchs C, Fujii M, Labianca R, Larsen AK, Mitchell E, Schmoll HJ, Sprumont D, Zalcberg J.

Ann Oncol. 2017 May 1;28(5):922-930. doi: 10.1093/annonc/mdx050.


How health-related quality of life assessment should be used in advanced colorectal cancer clinical trials.

Bonnetain F, Borg C, Adams RR, Ajani JA, Benson A, Bleiberg H, Chibaudel B, Diaz-Rubio E, Douillard JY, Fuchs CS, Giantonio BJ, Goldberg R, Heinemann V, Koopman M, Labianca R, Larsen AK, Maughan T, Mitchell E, Peeters M, Punt CJA, Schmoll HJ, Tournigand C, de Gramont A.

Ann Oncol. 2017 Sep 1;28(9):2077-2085. doi: 10.1093/annonc/mdx191. Review.


Impact of blood hypercoagulability on in vitro fertilization outcomes: a prospective longitudinal observational study.

Gerotziafas GT, Van Dreden P, Mathieu d'Argent E, Lefkou E, Grusse M, Comtet M, Sangare R, Ketatni H, Larsen AK, Elalamy I.

Thromb J. 2017 Mar 28;15:9. doi: 10.1186/s12959-017-0131-7. eCollection 2017.


Cross Validation of HS-GC/MS to Quantify Total Carbon Dioxide in Horse Plasma.

Heffron B, Bash J, Larsen AK.

J Anal Toxicol. 2017 Apr 1;41(3):230-235. doi: 10.1093/jat/bkw133.


Antimicrobial Oligophenalenone Dimers from the Soil Fungus Talaromyces stipitatus.

Zang Y, Genta-Jouve G, Escargueil AE, Larsen AK, Guedon L, Nay B, Prado S.

J Nat Prod. 2016 Dec 23;79(12):2991-2996. doi: 10.1021/acs.jnatprod.6b00458. Epub 2016 Dec 14.


The Antithrombotic Potential of Tinzaparin and Enoxaparin Upon Thrombin Generation Triggered In Vitro by Human Ovarian Cancer Cells IGROV1.

Sassi M, Chakroun T, Mbemba E, Van Dreden P, Elalamy I, Larsen AK, Gerotziafas GT.

Clin Appl Thromb Hemost. 2017 Mar;23(2):155-163. doi: 10.1177/1076029616665922. Epub 2016 Sep 24.


Genotype- or Phenotype-Targeting Anticancer Therapies? Lessons from Tumor Evolutionary Biology.

Escargueil AE, Prado S, Dezaire A, Clairambault J, Larsen AK, Soares DG.

Curr Pharm Des. 2016;22(44):6625-6644. doi: 10.2174/1381612822666160831114002. Review.


Experimental Challenge of Atlantic Cod (Gadus morhua) with a Brucella pinnipedialis Strain from Hooded Seal (Cystophora cristata).

Nymo IH, Seppola M, Al Dahouk S, Bakkemo KR, Jiménez de Bagüés MP, Godfroid J, Larsen AK.

PLoS One. 2016 Jul 14;11(7):e0159272. doi: 10.1371/journal.pone.0159272. eCollection 2016.


Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery.

Denis JA, Patroni A, Guillerm E, Pépin D, Benali-Furet N, Wechsler J, Manceau G, Bernard M, Coulet F, Larsen AK, Karoui M, Lacorte JM.

Mol Oncol. 2016 Oct;10(8):1221-31. doi: 10.1016/j.molonc.2016.05.009. Epub 2016 Jun 7.


Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.

Lima M, Bouzid H, Soares DG, Selle F, Morel C, Galmarini CM, Henriques JA, Larsen AK, Escargueil AE.

Oncotarget. 2016 May 3;7(18):25885-901. doi: 10.18632/oncotarget.8292.


Brucella pinnipedialis in hooded seal (Cystophora cristata) primary epithelial cells.

Larsen AK, Godfroid J, Nymo IH.

Acta Vet Scand. 2016 Jan 25;58:9. doi: 10.1186/s13028-016-0188-5.


PEPCOL: a GERCOR randomized phase II study of nanoliposomal irinotecan PEP02 (MM-398) or irinotecan with leucovorin/5-fluorouracil as second-line therapy in metastatic colorectal cancer.

Chibaudel B, Maindrault-Gœbel F, Bachet JB, Louvet C, Khalil A, Dupuis O, Hammel P, Garcia ML, Bennamoun M, Brusquant D, Tournigand C, André T, Arbaud C, Larsen AK, Wang YW, Yeh CG, Bonnetain F, de Gramont A.

Cancer Med. 2016 Apr;5(4):676-83. doi: 10.1002/cam4.635. Epub 2016 Jan 24.


Afatinib, an Irreversible EGFR Family Inhibitor, Shows Activity Toward Pancreatic Cancer Cells, Alone and in Combination with Radiotherapy, Independent of KRAS Status.

Huguet F, Fernet M, Giocanti N, Favaudon V, Larsen AK.

Target Oncol. 2016 Jun;11(3):371-81. doi: 10.1007/s11523-015-0403-8.


Unique features of trabectedin mechanism of action.

Larsen AK, Galmarini CM, D'Incalci M.

Cancer Chemother Pharmacol. 2016 Apr;77(4):663-71. doi: 10.1007/s00280-015-2918-1. Epub 2015 Dec 14. Review.


Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer (GERCOR DREAM; OPTIMOX3): a randomised, open-label, phase 3 trial.

Tournigand C, Chibaudel B, Samson B, Scheithauer W, Vernerey D, Mésange P, Lledo G, Viret F, Ramée JF, Tubiana-Mathieu N, Dauba J, Dupuis O, Rinaldi Y, Mabro M, Aucoin N, Latreille J, Bonnetain F, Louvet C, Larsen AK, André T, de Gramont A.

Lancet Oncol. 2015 Nov;16(15):1493-1505. doi: 10.1016/S1470-2045(15)00216-8. Epub 2015 Oct 22. Erratum in: Lancet Oncol. 2015 Dec;16(16):e589.


Organizing workplace health literacy to reduce musculoskeletal pain and consequences.

Larsen AK, Holtermann A, Mortensen OS, Punnett L, Rod MH, Jørgensen MB.

BMC Nurs. 2015 Sep 17;14:46. doi: 10.1186/s12912-015-0096-4. eCollection 2015.


Unexpected talaroenamine derivatives and an undescribed polyester from the fungus Talaromyces stipitatus ATCC10500.

Zang Y, Genta-Jouve G, Sun TA, Li X, Didier B, Mann S, Mouray E, Larsen AK, Escargueil AE, Nay B, Prado S.

Phytochemistry. 2015 Nov;119:70-5. doi: 10.1016/j.phytochem.2015.09.002. Epub 2015 Sep 18.


Mixed exposure to bacterial lipopolysaccharide and seafood proteases augments inflammatory signalling in an airway epithelial cell model (A549).

Bhagwat SS, Larsen AK, Seternes OM, Bang BE.

Toxicol Ind Health. 2016 Nov;32(11):1866-1874. doi: 10.1177/0748233715590914. Epub 2016 Jul 9.


Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors.

Ayadi M, Bouygues A, Ouaret D, Ferrand N, Chouaib S, Thiery JP, Muchardt C, Sabbah M, Larsen AK.

Oncotarget. 2015 Jul 30;6(21):18518-33.


BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.

Rocca CJ, Soares DG, Bouzid H, Henriques JA, Larsen AK, Escargueil AE.

Cell Cycle. 2015;14(13):2080-90. doi: 10.1080/15384101.2015.1042632.


Emergence of drug tolerance in cancer cell populations: an evolutionary outcome of selection, nongenetic instability, and stress-induced adaptation.

Chisholm RH, Lorenzi T, Lorz A, Larsen AK, de Almeida LN, Escargueil A, Clairambault J.

Cancer Res. 2015 Mar 15;75(6):930-9. doi: 10.1158/0008-5472.CAN-14-2103. Epub 2015 Jan 27.

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