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Items: 23


Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet.

Wallenius V, Elias E, Elebring E, Haisma B, Casselbrant A, Larraufie P, Spak E, Reimann F, le Roux CW, Docherty NG, Gribble FM, Fändriks L.

Gut. 2019 Nov 21. pii: gutjnl-2019-319372. doi: 10.1136/gutjnl-2019-319372. [Epub ahead of print]


Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells.

Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F.

Mol Metab. 2019 Nov;29:158-169. doi: 10.1016/j.molmet.2019.09.001. Epub 2019 Sep 7.


Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion.

Dye FS, Larraufie P, Kay R, Darwish T, Rievaj J, Goldspink DA, Meek CL, Middleton SJ, Hardwick RH, Roberts GP, Percival-Alwyn JL, Vaughan T, Ferraro F, Challis BG, O'Rahilly S, Groves M, Gribble FM, Reimann F.

Sci Rep. 2019 Oct 30;9(1):15574. doi: 10.1038/s41598-019-52049-0.


Ghrelin does not directly stimulate secretion of glucagon-like peptide-1.

Jepsen SL, Vestergaard ET, Larraufie P, Gribble FM, Reimann F, Jørgensen JOL, Holst JJ, Kuhre RE.

J Clin Endocrinol Metab. 2019 Oct 14. pii: dgz046. doi: 10.1210/clinem/dgz046. [Epub ahead of print]


Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.

Cyranka M, Veprik A, McKay EJ, van Loon N, Thijsse A, Cotter L, Hare N, Saibudeen A, Lingam S, Pires E, Larraufie P, Reimann F, Gribble F, Stewart M, Bentley E, Lear P, McCullagh J, Cantley J, Cox RD, de Wet H.

Obesity (Silver Spring). 2019 Aug;27(8):1292-1304. doi: 10.1002/oby.22521.


Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism.

Zhang X, Grosfeld A, Williams E, Vasiliauskas D, Barretto S, Smith L, Mariadassou M, Philippe C, Devime F, Melchior C, Gourcerol G, Dourmap N, Lapaque N, Larraufie P, Blottière HM, Herberden C, Gerard P, Rehfeld JF, Ferraris RP, Fritton JC, Ellero-Simatos S, Douard V.

FASEB J. 2019 Jun;33(6):7126-7142. doi: 10.1096/fj.201801526RR. Epub 2019 Apr 2.


Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM.

Diabetes. 2019 May;68(5):1062-1072. doi: 10.2337/db18-0883. Epub 2019 Feb 7.


Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients.

Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2581-2592. doi: 10.1210/jc.2018-02503.


Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery.

Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM.

Cell Rep. 2019 Feb 5;26(6):1399-1408.e6. doi: 10.1016/j.celrep.2019.01.047.


PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.

Guida C, Stephen SD, Watson M, Dempster N, Larraufie P, Marjot T, Cargill T, Rickers L, Pavlides M, Tomlinson J, Cobbold JFL, Zhao CM, Chen D, Gribble F, Reimann F, Gillies R, Sgromo B, Rorsman P, Ryan JD, Ramracheya RD.

EBioMedicine. 2019 Feb;40:67-76. doi: 10.1016/j.ebiom.2018.12.040. Epub 2019 Jan 11.


Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.

Martin-Gallausiaux C, Larraufie P, Jarry A, Béguet-Crespel F, Marinelli L, Ledue F, Reimann F, Blottière HM, Lapaque N.

Front Immunol. 2018 Dec 11;9:2838. doi: 10.3389/fimmu.2018.02838. eCollection 2018.


Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.

Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O'Rahilly S, Merkle FT.

Mol Metab. 2018 Nov;17:82-97. doi: 10.1016/j.molmet.2018.08.006. Epub 2018 Aug 21.


Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells.

Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F.

Mol Metab. 2018 Oct;16:65-75. doi: 10.1016/j.molmet.2018.07.011. Epub 2018 Jul 30.


SCFAs strongly stimulate PYY production in human enteroendocrine cells.

Larraufie P, Martin-Gallausiaux C, Lapaque N, Dore J, Gribble FM, Reimann F, Blottiere HM.

Sci Rep. 2018 Jan 8;8(1):74. doi: 10.1038/s41598-017-18259-0.


Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells.

Goldspink DA, Lu VB, Billing LJ, Larraufie P, Tolhurst G, Gribble FM, Reimann F.

Mol Metab. 2018 Jan;7:90-101. doi: 10.1016/j.molmet.2017.11.005. Epub 2017 Nov 11.


Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine.

Glass LL, Calero-Nieto FJ, Jawaid W, Larraufie P, Kay RG, Göttgens B, Reimann F, Gribble FM.

Mol Metab. 2017 Oct;6(10):1296-1303. doi: 10.1016/j.molmet.2017.07.014. Epub 2017 Aug 1.


Chylomicrons stimulate incretin secretion in mouse and human cells.

Psichas A, Larraufie PF, Goldspink DA, Gribble FM, Reimann F.

Diabetologia. 2017 Dec;60(12):2475-2485. doi: 10.1007/s00125-017-4420-2. Epub 2017 Sep 2.


Liquid chromatography/mass spectrometry based detection and semi-quantitative analysis of INSL5 in human and murine tissues.

Kay RG, Galvin S, Larraufie P, Reimann F, Gribble FM.

Rapid Commun Mass Spectrom. 2017 Dec 15;31(23):1963-1973. doi: 10.1002/rcm.7978.


The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1.

Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL.

Diabetes. 2017 Sep;66(9):2327-2338. doi: 10.2337/db16-1403. Epub 2017 Jun 8.


Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans.

Pais R, Rievaj J, Larraufie P, Gribble F, Reimann F.

Endocrinology. 2016 Oct;157(10):3821-3831. Epub 2016 Jul 22.


TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways.

Larraufie P, Doré J, Lapaque N, Blottière HM.

Cell Microbiol. 2017 Feb;19(2). doi: 10.1111/cmi.12648. Epub 2016 Aug 9.


Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.

Cauvin C, Rosendale M, Gupta-Rossi N, Rocancourt M, Larraufie P, Salomon R, Perrais D, Echard A.

Curr Biol. 2016 Jan 11;26(1):120-8. doi: 10.1016/j.cub.2015.11.040. Epub 2015 Dec 24.


Functional metagenomics to decipher food-microbe-host crosstalk.

Larraufie P, de Wouters T, Potocki-Veronese G, Blottière HM, Doré J.

Proc Nutr Soc. 2015 Feb;74(1):1-4. doi: 10.1017/S0029665114001566. Epub 2014 Nov 24.


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