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Items: 16


Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and postabsorptive responses of mice in an age-dependent manner.

Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH.

Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1118-E1135. doi: 10.1152/ajpendo.00496.2018. Epub 2019 Mar 5.


Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.

Salisbury-Ruf CT, Bertram CC, Vergeade A, Lark DS, Shi Q, Heberling ML, Fortune NL, Okoye GD, Jerome WG, Wells QS, Fessel J, Moslehi J, Chen H, Roberts LJ 2nd, Boutaud O, Gamazon ER, Zinkel SS.

Elife. 2018 Oct 3;7. pii: e40907. doi: 10.7554/eLife.40907.


Reduced Nonexercise Activity Attenuates Negative Energy Balance in Mice Engaged in Voluntary Exercise.

Lark DS, Kwan JR, McClatchey PM, James MN, James FD, Lighton JRB, Lantier L, Wasserman DH.

Diabetes. 2018 May;67(5):831-840. doi: 10.2337/db17-1293. Epub 2018 Mar 6.


Meta-fibrosis links positive energy balance and mitochondrial metabolism to insulin resistance.

Lark DS, Wasserman DH.

F1000Res. 2017 Sep 27;6:1758. doi: 10.12688/f1000research.11653.1. eCollection 2017. Review.


Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers.

Lark DS, Torres MJ, Lin CT, Ryan TE, Anderson EJ, Neufer PD.

Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C239-45. doi: 10.1152/ajpcell.00124.2016. Epub 2016 Jun 22.


Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction.

Gilliam LA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin CT, Cathey BL, Neufer PD.

Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E293-301. doi: 10.1152/ajpendo.00540.2015. Epub 2016 Jun 21.


Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice.

Kang L, Mokshagundam S, Reuter B, Lark DS, Sneddon CC, Hennayake C, Williams AS, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH.

Diabetes. 2016 Jun;65(6):1590-600. doi: 10.2337/db15-1434. Epub 2016 Apr 5.


Protein Kinase A Governs Oxidative Phosphorylation Kinetics and Oxidant Emitting Potential at Complex I.

Lark DS, Reese LR, Ryan TE, Torres MJ, Smith CD, Lin CT, Neufer PD.

Front Physiol. 2015 Nov 17;6:332. doi: 10.3389/fphys.2015.00332. eCollection 2015.


Enhanced mitochondrial superoxide scavenging does not improve muscle insulin action in the high fat-fed mouse.

Lark DS, Kang L, Lustig ME, Bonner JS, James FD, Neufer PD, Wasserman DH.

PLoS One. 2015 May 19;10(5):e0126732. doi: 10.1371/journal.pone.0126732. eCollection 2015.


Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.

Fisher-Wellman KH, Lin CT, Ryan TE, Reese LR, Gilliam LA, Cathey BL, Lark DS, Smith CD, Muoio DM, Neufer PD.

Biochem J. 2015 Apr 15;467(2):271-80. doi: 10.1042/BJ20141447.


Do fish oil omega-3 fatty acids enhance antioxidant capacity and mitochondrial fatty acid oxidation in human atrial myocardium via PPARĪ³ activation?

Anderson EJ, Thayne KA, Harris M, Shaikh SR, Darden TM, Lark DS, Williams JM, Chitwood WR, Kypson AP, Rodriguez E.

Antioxid Redox Signal. 2014 Sep 10;21(8):1156-63. doi: 10.1089/ars.2014.5888. Epub 2014 Apr 10.


Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle.

DeBalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS, Hui ST, Szweda L, Neufer PD, Muoio DM.

J Biol Chem. 2014 Mar 21;289(12):8106-20. doi: 10.1074/jbc.M113.511535. Epub 2014 Jan 30.


Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload.

Fisher-Wellman KH, Gilliam LAA, Lin CT, Cathey BL, Lark DS, Darrell Neufer P.

Free Radic Biol Med. 2013 Dec;65:1201-1208. doi: 10.1016/j.freeradbiomed.2013.09.008. Epub 2013 Sep 19.


High-fat load: mechanism(s) of insulin resistance in skeletal muscle.

Lark DS, Fisher-Wellman KH, Neufer PD.

Int J Obes Suppl. 2012 Dec;2(Suppl 2):S31-S36.


Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle.

Perry CG, Kane DA, Herbst EA, Mukai K, Lark DS, Wright DC, Heigenhauser GJ, Neufer PD, Spriet LL, Holloway GP.

J Physiol. 2012 Nov 1;590(21):5475-86. doi: 10.1113/jphysiol.2012.234682. Epub 2012 Aug 20.


Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle.

Perry CG, Kane DA, Lin CT, Kozy R, Cathey BL, Lark DS, Kane CL, Brophy PM, Gavin TP, Anderson EJ, Neufer PD.

Biochem J. 2011 Jul 15;437(2):215-22. doi: 10.1042/BJ20110366.

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