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Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.

Orlovsky K, Kalinkovich A, Rozovskaia T, Shezen E, Itkin T, Alder H, Ozer HG, Carramusa L, Avigdor A, Volinia S, Buchberg A, Mazo A, Kollet O, Largman C, Croce CM, Nakamura T, Lapidot T, Canaani E.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7956-61. doi: 10.1073/pnas.1103154108. Epub 2011 Apr 25.


HOXA9 regulates miR-155 in hematopoietic cells.

Hu YL, Fong S, Largman C, Shen WF.

Nucleic Acids Res. 2010 Sep;38(16):5472-8. doi: 10.1093/nar/gkq337. Epub 2010 May 5.


HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis.

Hu YL, Fong S, Ferrell C, Largman C, Shen WF.

Mol Cell Biol. 2009 Sep;29(18):5181-92. doi: 10.1128/MCB.00545-09. Epub 2009 Jul 20.


MicroRNA-126 regulates HOXA9 by binding to the homeobox.

Shen WF, Hu YL, Uttarwar L, Passegue E, Largman C.

Mol Cell Biol. 2008 Jul;28(14):4609-19. doi: 10.1128/MCB.01652-07. Epub 2008 May 12.


Evidence that the Pim1 kinase gene is a direct target of HOXA9.

Hu YL, Passegué E, Fong S, Largman C, Lawrence HJ.

Blood. 2007 Jun 1;109(11):4732-8. Epub 2007 Feb 27.


Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells.

Lawrence HJ, Christensen J, Fong S, Hu YL, Weissman I, Sauvageau G, Humphries RK, Largman C.

Blood. 2005 Dec 1;106(12):3988-94. Epub 2005 Aug 9.


HOX genes: not just myeloid oncogenes any more.

Lawrence HJ, Fischbach NA, Largman C.

Leukemia. 2005 Aug;19(8):1328-30. No abstract available.


Activation of stem-cell specific genes by HOXA9 and HOXA10 homeodomain proteins in CD34+ human cord blood cells.

Ferrell CM, Dorsam ST, Ohta H, Humphries RK, Derynck MK, Haqq C, Largman C, Lawrence HJ.

Stem Cells. 2005 May;23(5):644-55.


HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.

Fischbach NA, Rozenfeld S, Shen W, Fong S, Chrobak D, Ginzinger D, Kogan SC, Radhakrishnan A, Le Beau MM, Largman C, Lawrence HJ.

Blood. 2005 Feb 15;105(4):1456-66. Epub 2004 Nov 2.


Analysis of HOX homeodomain proteins and gene transcripts in the epidermis.

Kömüves LG, Largman C.

Methods Mol Biol. 2005;289:157-70.


Veterans Administration support for medical research: opinions of the endangered species of physician-scientists.

Zucker S, Crabbe JC, Cooper G 4th, Finkelman F, Largman C, McCarley RW, Rice L, Rubin J, Richardson B, Seil F, Snider GL, Vandenbark AA.

FASEB J. 2004 Oct;18(13):1481-6.


HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process.

Shen W, Chrobak D, Krishnan K, Lawrence HJ, Largman C.

J Biol Chem. 2004 Sep 17;279(38):39895-904. Epub 2004 Jul 21.


Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation.

Vijapurkar U, Fischbach N, Shen W, Brandts C, Stokoe D, Lawrence HJ, Largman C.

Mol Cell Biol. 2004 May;24(9):3827-37.


The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cells.

Dorsam ST, Ferrell CM, Dorsam GP, Derynck MK, Vijapurkar U, Khodabakhsh D, Pau B, Bernstein H, Haqq CM, Largman C, Lawrence HJ.

Blood. 2004 Mar 1;103(5):1676-84. Epub 2003 Nov 6.


HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development.

Kömüves LG, Ma XK, Stelnicki E, Rozenfeld S, Oda Y, Largman C.

Dev Dyn. 2003 Jun;227(2):192-202.


Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing.

Mack JA, Abramson SR, Ben Y, Coffin JC, Rothrock JK, Maytin EV, Hascall VC, Largman C, Stelnicki EJ.

FASEB J. 2003 Jul;17(10):1352-4. Epub 2003 May 20.


Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses.

White P, Thomas DW, Fong S, Stelnicki E, Meijlink F, Largman C, Stephens P.

J Invest Dermatol. 2003 Jan;120(1):135-44.


HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation.

Kömüves LG, Michael E, Arbeit JM, Ma XK, Kwong A, Stelnicki E, Rozenfeld S, Morimune M, Yu QC, Largman C.

Dev Dyn. 2002 May;224(1):58-68.


The HOX homeodomain proteins block CBP histone acetyltransferase activity.

Shen WF, Krishnan K, Lawrence HJ, Largman C.

Mol Cell Biol. 2001 Nov;21(21):7509-22.


Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation.

Kömüves LG, Shen WF, Kwong A, Stelnicki E, Rozenfeld S, Oda Y, Blink A, Krishnan K, Lau B, Mauro T, Largman C.

Dev Dyn. 2000 Aug;218(4):636-47.


Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA.

Abramovich C, Shen WF, Pineault N, Imren S, Montpetit B, Largman C, Humphries RK.

J Biol Chem. 2000 Aug 25;275(34):26172-7.


Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias.

Lawrence HJ, Rozenfeld S, Cruz C, Matsukuma K, Kwong A, Kömüves L, Buchberg AM, Largman C.

Leukemia. 1999 Dec;13(12):1993-9.


Epithelial sodium channels are upregulated during epidermal differentiation.

Oda Y, Imanzahrai A, Kwong A, Kömüves L, Elias PM, Largman C, Mauro T.

J Invest Dermatol. 1999 Nov;113(5):796-801.


HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.

Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C.

Mol Cell Biol. 1999 Apr;19(4):3051-61.


Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1.

Krosl J, Baban S, Krosl G, Rozenfeld S, Largman C, Sauvageau G.

Oncogene. 1998 Jul 2;16(26):3403-12.


Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds.

Stelnicki EJ, Arbeit J, Cass DL, Saner C, Harrison M, Largman C.

J Invest Dermatol. 1998 Jul;111(1):57-63.


Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes.

Izon DJ, Rozenfeld S, Fong ST, Kömüves L, Largman C, Lawrence HJ.

Blood. 1998 Jul 15;92(2):383-93.


HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development.

Stelnicki EJ, Kömüves LG, Kwong AO, Holmes D, Klein P, Rozenfeld S, Lawrence HJ, Adzick NS, Harrison M, Largman C.

J Invest Dermatol. 1998 Feb;110(2):110-5.


Bone morphogenetic protein-2 induces scar formation and skin maturation in the second trimester fetus.

Stelnicki EJ, Longaker MT, Holmes D, Vanderwall K, Harrison MR, Largman C, Hoffman WY.

Plast Reconstr Surg. 1998 Jan;101(1):12-9.


The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin.

Stelnicki EJ, Kömüves LG, Holmes D, Clavin W, Harrison MR, Adzick NS, Largman C.

Differentiation. 1997 Oct;62(1):33-41.


Effects of HOX homeobox genes in blood cell differentiation.

Magli MC, Largman C, Lawrence HJ.

J Cell Physiol. 1997 Nov;173(2):168-77. Review.


AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.

Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C.

Mol Cell Biol. 1997 Nov;17(11):6448-58.


Alternatively spliced forms of the cGMP-gated channel in human keratinocytes.

Oda Y, Timpe LC, McKenzie RC, Sauder DN, Largman C, Mauro T.

FEBS Lett. 1997 Sep 1;414(1):140-5.


The Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target.

Shen WF, Rozenfeld S, Lawrence HJ, Largman C.

J Biol Chem. 1997 Mar 28;272(13):8198-206.


Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.

Lawrence HJ, Helgason CD, Sauvageau G, Fong S, Izon DJ, Humphries RK, Largman C.

Blood. 1997 Mar 15;89(6):1922-30.


Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation.

Sauvageau G, Thorsteinsdottir U, Hough MR, Hugo P, Lawrence HJ, Largman C, Humphries RK.

Immunity. 1997 Jan;6(1):13-22.


Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.

Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK.

Mol Cell Biol. 1997 Jan;17(1):495-505.


The role of HOX homeobox genes in normal and leukemic hematopoiesis.

Lawrence HJ, Sauvageau G, Humphries RK, Largman C.

Stem Cells. 1996 May;14(3):281-91. Review.


Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus.

Chang CP, Brocchieri L, Shen WF, Largman C, Cleary ML.

Mol Cell Biol. 1996 Apr;16(4):1734-45.


Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro.

Helgason CD, Sauvageau G, Lawrence HJ, Largman C, Humphries RK.

Blood. 1996 Apr 1;87(7):2740-9.


Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.

Shen WF, Chang CP, Rozenfeld S, Sauvageau G, Humphries RK, Lu M, Lawrence HJ, Cleary ML, Largman C.

Nucleic Acids Res. 1996 Mar 1;24(5):898-906.


Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells.

Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, Humphries K, Largman C.

Exp Hematol. 1995 Oct;23(11):1160-6.


Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM, Humphries RK.

Genes Dev. 1995 Jul 15;9(14):1753-65.


Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.

Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML.

Genes Dev. 1995 Mar 15;9(6):663-74.


Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.

Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK.

Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12223-7.


The role of homeobox genes in erythropoiesis.

Lawrence HJ, Johnson RA, Perrine S, Largman C.

Ann N Y Acad Sci. 1994 Apr 15;718:165-76; discussion 177-80. No abstract available.


Expression of class I homeobox genes in fetal and adult murine skin.

Detmer K, Lawrence HJ, Largman C.

J Invest Dermatol. 1993 Oct;101(4):517-22.


Expression of HOX C homeobox genes in lymphoid cells.

Lawrence HJ, Stage KM, Mathews CH, Detmer K, Scibienski R, MacKenzie M, Migliaccio E, Boncinelli E, Largman C.

Cell Growth Differ. 1993 Aug;4(8):665-9.


Expression of the Hox 2.2 homeobox gene in murine embryonic epidermis.

Mathews CH, Detmer K, Lawrence HJ, Largman C.

Differentiation. 1993 Jan;52(2):177-84.


Homeobox genes in normal hematopoiesis and leukemia.

Lawrence HJ, Largman C.

Blood. 1992 Nov 15;80(10):2445-53. Review. No abstract available.


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