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Increased OGA Expression and Activity in Leukocytes from Patients with Diabetes: Correlation with Inflammation Markers.

Pagesy P, Tachet C, Mostefa-Kara A, Larger E, Issad T.

Exp Clin Endocrinol Diabetes. 2018 Jun 11. doi: 10.1055/a-0596-7337. [Epub ahead of print]


Sex Difference In the Effect of Fetal Exposure to Maternal Diabetes on Insulin Secretion.

Gautier JF, Fetita LS, Riveline JP, Ibrahim F, Porcher R, Abi Khalil C, Velho G, Choukem SP, Hadjadj S, Larger E, Roussel R, Boudou P, Marre M, Ravussin E, Mauvais-Jarvis F.

J Endocr Soc. 2018 Mar 22;2(5):391-397. doi: 10.1210/js.2017-00482. eCollection 2018 May 1.


Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group, Carel JC, Tubiana-Rufi N, Martinerie L, Poidvin A, JacqzAigrain E, Corvez L, Berruer V, Gautier JF, Baz B, Haddadi N, Andreelli F, Amouyal C, Jaqueminet S, Bourron O, Dasque E, Hartemann A, Lemoine-Yazigi A, Dubois-Laforgue D, Travert F, Feron M, Rolland P, Vignali V, Marre M, Chanson P, Briet C, Guillausseau PJ, Ait-Bachir L, Collet C, Beziaud F, Desforges-Bullet V, Petit-Aubert G, Christin-Maitre S, Fève B, Vatier C, Bourcigaux N, Lautridou C, Lahlou N, Bakouboula P, Elie C, Morel H, Treluyer JM, Gagnerault MC, Maillard C, Jones A.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.


Decreased α-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: An analysis based on the nPOD repository.

Bonnet-Serrano F, Diedisheim M, Mallone R, Larger E.

PLoS One. 2018 Jan 19;13(1):e0191528. doi: 10.1371/journal.pone.0191528. eCollection 2018.


Early worsening of diabetic retinopathy after rapid improvement of blood glucose control in patients with diabetes.

Feldman-Billard S, Larger É, Massin P; Standards for screeningand surveillance of ocular complications in people with diabetes SFD study group.

Diabetes Metab. 2018 Feb;44(1):4-14. doi: 10.1016/j.diabet.2017.10.014. Epub 2017 Nov 11. Review.


Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation.

Larger E, Wewer Albrechtsen NJ, Hansen LH, Gelling RW, Capeau J, Deacon CF, Madsen OD, Yakushiji F, De Meyts P, Holst JJ, Nishimura E.

Endocrinol Diabetes Metab Case Rep. 2016;2016. pii: 16-0081. Epub 2016 Nov 21.


Intellectual disability in patients with MODY due to hepatocyte nuclear factor 1B (HNF1B) molecular defects.

Dubois-Laforgue D, Bellanné-Chantelot C, Charles P, Jacquette A, Larger E, Ciangura C, Saint-Martin C, Rastel C, Keren B, Timsit J; Monogenic Diabetes Study Group of the Société Francophone du Diabète (SFD).

Diabetes Metab. 2017 Feb;43(1):89-92. doi: 10.1016/j.diabet.2016.10.003. Epub 2016 Nov 10. No abstract available.


Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case-control study.

Balazard F, Le Fur S, Valtat S, Valleron AJ, Bougnères P; Isis-Diab collaborative group, Thevenieau D, Chatel CF, Desailloud R, Bony-Trifunovic H, Ducluzeau PH, Coutant R, Caudrelier S, Pambou A, Dubosclard E, Joubert F, Jan P, Marcoux E, Bertrand AM, Mignot B, Penformis A, Stuckens C, Piquemal R, Barat P, Rigalleau V, Stheneur C, Fournier S, Kerlan V, Metz C, Fargeot-Espaliat A, Reznic Y, Olivier F, Gueorguieva I, Monier A, Radet C, Gajdos V, Terral D, Vervel C, Bendifallah D, Signor CB, Dervaux D, Benmahammed A, Loeuille GA, Popelard F, Guillou A, Benhamou PY, Khoury J, Brossier JP, Bassil J, Clavel S, Le Luyer B, Bougnères P, Labay F, Guemas I, Weill J, Cappoen JP, Nadalon S, Lienhardt-Roussie A, Paoli A, Kerouedan C, Yollin E, Nicolino M, Simonin G, Cohen J, Atlan C, Tamboura A, Dubourg H, Pignol ML, Talon P, Jellimann S, Chaillous L, Baron S, Bortoluzzi MN, Baechler E, Salet R, Zelinsky-Gurung A, Dallavale F, Larger E, Laloi-Michelin M, Gautier JF, Guérin B, Oilleau L, Pantalone L, Lukas C, Guilhem I, De Kerdanet M, Wielickzo MC, Priou-Guesdon M, Richard O, Kurtz F, Laisney N, Ancelle D, Parlier G, Boniface C, Bockel DP, Dufillot D, Razafimahefa B, Gourdy P, Lecomte P, Pepin-Donat M, Combes-Moukhovsky ME, Zymmermann B, Raoulx M, Dumont AG.

BMC Public Health. 2016 Sep 29;16(1):1021.


β-cell Mass in Nondiabetic Autoantibody-Positive Subjects: An Analysis Based on the Network for Pancreatic Organ Donors Database.

Diedisheim M, Mallone R, Boitard C, Larger E.

J Clin Endocrinol Metab. 2016 Apr;101(4):1390-7. doi: 10.1210/jc.2015-3756. Epub 2016 Feb 1.


[GLP-1 receptor agonists: current state].

Larger É, Dehghani L, Saatdjian L, Wucher H.

Rev Prat. 2015 Oct;65(8):1037-8. French. No abstract available.


Kidney Dysfunction in Adult Offspring Exposed In Utero to Type 1 Diabetes Is Associated with Alterations in Genome-Wide DNA Methylation.

Gautier JF, Porcher R, Abi Khalil C, Bellili-Munoz N, Fetita LS, Travert F, Choukem SP, Riveline JP, Hadjadj S, Larger E, Boudou P, Blondeau B, Roussel R, Ferré P, Ravussin E, Rouzet F, Marre M.

PLoS One. 2015 Aug 10;10(8):e0134654. doi: 10.1371/journal.pone.0134654. eCollection 2015.


Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients.

Magalhaes I, Pingris K, Poitou C, Bessoles S, Venteclef N, Kiaf B, Beaudoin L, Da Silva J, Allatif O, Rossjohn J, Kjer-Nielsen L, McCluskey J, Ledoux S, Genser L, Torcivia A, Soudais C, Lantz O, Boitard C, Aron-Wisnewsky J, Larger E, Clément K, Lehuen A.

J Clin Invest. 2015 Apr;125(4):1752-62. doi: 10.1172/JCI78941. Epub 2015 Mar 9.


A rapid lateral flow immunoassay for the detection of tyrosine phosphatase-like protein IA-2 autoantibodies in human serum.

Kikkas I, Mallone R, Larger E, Volland H, Morel N.

PLoS One. 2014 Jul 21;9(7):e103088. doi: 10.1371/journal.pone.0103088. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e106611.


Anaemia, a common but often unrecognized risk in diabetic patients: a review.

Angelousi A, Larger E.

Diabetes Metab. 2015 Feb;41(1):18-27. doi: 10.1016/j.diabet.2014.06.001. Epub 2014 Jul 17. Review.


Long-term evolution of nutritional deficiencies after gastric bypass: an assessment according to compliance to medical care.

Ledoux S, Calabrese D, Bogard C, Dupré T, Castel B, Msika S, Larger E, Coupaye M.

Ann Surg. 2014 Jun;259(6):1104-10. doi: 10.1097/SLA.0000000000000249.


In vein: blinding bilateral ophthalmic thrombosis.

Angelousi A, Lemoine AY, Louvet M, Larger E.

Am J Med. 2014 Sep;127(9):826-8. doi: 10.1016/j.amjmed.2014.05.001. Epub 2014 May 9. No abstract available.


Potential role of IL-17-producing iNKT cells in type 1 diabetes.

Li S, Joseph C, Becourt C, Klibi J, Luce S, Dubois-Laforgue D, Larger E, Boitard C, Benlagha K.

PLoS One. 2014 Apr 30;9(4):e96151. doi: 10.1371/journal.pone.0096151. eCollection 2014.


[Management of diabetes, a public health challenge].

Tourneur ML, Guillaume C, Defer F, Larger E.

Rev Infirm. 2014 Jan;(197):45-6. French. No abstract available.


Hypoglycaemia in adults: when should it be raised? How can hypoglycaemia be confirmed in non-diabetic adults?

Guerci B, Kuhn JM, Larger É, Reznik Y; French Endocrine Society.

Ann Endocrinol (Paris). 2013 Jul;74(3):168-73. doi: 10.1016/j.ando.2013.05.002. Epub 2013 Jun 18. No abstract available.


Case report: insulin edema and acute renal failure.

Laroche S, Wucher H, Nguyen YL, Timsit J, Larger E.

Diabetes Care. 2013 May;36(5):e65. doi: 10.2337/dc12-2137. No abstract available.


Adipose tissue angiogenesis in obesity.

Lemoine AY, Ledoux S, Larger E.

Thromb Haemost. 2013 Oct;110(4):661-8. doi: 10.1160/TH13-01-0073. Epub 2013 Apr 18. Review.


Effect of dietary protein on post-prandial glucose in patients with type 1 diabetes.

Borie-Swinburne C, Sola-Gazagnes A, Gonfroy-Leymarie C, Boillot J, Boitard C, Larger E.

J Hum Nutr Diet. 2013 Dec;26(6):606-11. doi: 10.1111/jhn.12082. Epub 2013 Mar 22.


Diagnosing diabetic foot osteomyelitis in patients without signs of soft tissue infection by coupling hybrid 67Ga SPECT/CT with bedside percutaneous bone puncture.

Aslangul E, M'bemba J, Caillat-Vigneron N, Coignard S, Larger E, Boitard C, Lipsky BA.

Diabetes Care. 2013 Aug;36(8):2203-10. doi: 10.2337/dc12-2108. Epub 2013 Mar 20.


[Low residue diet].

Chérino-Marchand S, Rigoir-Louvel A, Nadreau L, Fiquet P, Larger E.

Rev Prat. 2012 Oct;62(8):1142. French. No abstract available.


[High protein diet].

Chérino-Marchand S, Rigoir-Louvel A, Nadreau L, Fiquet P, Larger E.

Rev Prat. 2012 Oct;62(8):1141. French. No abstract available.


[Gluten-free diet].

Chérino-Marchand S, Rigoir-Louvel A, Nadreau L, Fiquet P, Larger E.

Rev Prat. 2012 Oct;62(8):1140. French. No abstract available.


[Controlled supply of carbohydrates and lipids].

Chérino-Marchand S, Rigoir-Louvel A, Nadreau L, Fiquet P, Larger E.

Rev Prat. 2012 Oct;62(8):1139. French. No abstract available.


[Controlled supply of sodium].

Chérino-Marchand S, Rigoir-Louvel A, Nadreau L, Fiquet P, Larger E.

Rev Prat. 2012 Oct;62(8):1137-8. French. No abstract available.


[Controlled supply of potassium].

Chérino-Marchand S, Rigoir-Louvel A, Nadreau L, Fiquet P, Larger E.

Rev Prat. 2012 Oct;62(8):1136. French. No abstract available.


HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes.

Scotto M, Afonso G, Østerbye T, Larger E, Luce S, Raverdy C, Novelli G, Bruno G, Gonfroy-Leymarie C, Launay O, Lemonnier FA, Buus S, Carel JC, Boitard C, Mallone R.

Diabetes. 2012 Oct;61(10):2546-55.


Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients.

Scotto M, Afonso G, Larger E, Raverdy C, Lemonnier FA, Carel JC, Dubois-Laforgue D, Baz B, Levy D, Gautier JF, Launay O, Bruno G, Boitard C, Sechi LA, Hutton JC, Davidson HW, Mallone R.

Diabetologia. 2012 Jul;55(7):2026-31. doi: 10.1007/s00125-012-2543-z. Epub 2012 Apr 20.


Link between adipose tissue angiogenesis and fat accumulation in severely obese subjects.

Lemoine AY, Ledoux S, Quéguiner I, Caldérari S, Mechler C, Msika S, Corvol P, Larger E.

J Clin Endocrinol Metab. 2012 May;97(5):E775-80. doi: 10.1210/jc.2011-2649. Epub 2012 Mar 14.


Population pharmacokinetics of metformin in obese and non-obese patients with type 2 diabetes mellitus.

Bardin C, Nobecourt E, Larger E, Chast F, Treluyer JM, Urien S.

Eur J Clin Pharmacol. 2012 Jun;68(6):961-8. doi: 10.1007/s00228-011-1207-0. Epub 2012 Jan 25.


Pancreatic exocrine function in patients with diabetes.

Larger E, Philippe MF, Barbot-Trystram L, Radu A, Rotariu M, Nobécourt E, Boitard C.

Diabet Med. 2012 Aug;29(8):1047-54. doi: 10.1111/j.1464-5491.2012.03597.x.


Angiopoietin 2 alters pancreatic vascularization in diabetic conditions.

Calderari S, Chougnet C, Clemessy M, Kempf H, Corvol P, Larger E.

PLoS One. 2012;7(1):e29438. doi: 10.1371/journal.pone.0029438. Epub 2012 Jan 17.


Elevated soluble Flt1 inhibits endothelial repair in PR3-ANCA-associated vasculitis.

Le Roux S, Pepper RJ, Dufay A, Néel M, Meffray E, Lamandé N, Rimbert M, Josien R, Hamidou M, Hourmant M, Cook HT, Charreau B, Larger E, Salama AD, Fakhouri F.

J Am Soc Nephrol. 2012 Jan;23(1):155-64. doi: 10.1681/ASN.2010080858. Epub 2011 Oct 27.


Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes.

Luce S, Lemonnier F, Briand JP, Coste J, Lahlou N, Muller S, Larger E, Rocha B, Mallone R, Boitard C.

Diabetes. 2011 Dec;60(12):3289-99. doi: 10.2337/db11-0270. Epub 2011 Oct 13.


Ambulatory 24-hour fast using flexible insulin therapy in patients with type 1 diabetes.

Vigeral C, Sola-Gazagnes A, Nejjar S, M'Bemba J, Boitard C, Slama G, Elgrably F, Larger E.

Diabetes Metab. 2011 Dec;37(6):553-9. doi: 10.1016/j.diabet.2011.06.002. Epub 2011 Jul 28.


Clinical characteristics and diagnostic criteria of maturity-onset diabetes of the young (MODY) due to molecular anomalies of the HNF1A gene.

Bellanné-Chantelot C, Lévy DJ, Carette C, Saint-Martin C, Riveline JP, Larger E, Valéro R, Gautier JF, Reznik Y, Sola A, Hartemann A, Laboureau-Soares S, Laloi-Michelin M, Lecomte P, Chaillous L, Dubois-Laforgue D, Timsit J; French Monogenic Diabetes Study Group.

J Clin Endocrinol Metab. 2011 Aug;96(8):E1346-51. doi: 10.1210/jc.2011-0268. Epub 2011 Jun 15.


Pancreatic volume and endocrine and exocrine functions in patients with diabetes.

Philippe MF, Benabadji S, Barbot-Trystram L, Vadrot D, Boitard C, Larger E.

Pancreas. 2011 Apr;40(3):359-63. doi: 10.1097/MPA.0b013e3182072032.


Poor prognosis of pregnancy in women with autoimmune type 1 diabetes mellitus masquerading as gestational diabetes.

Wucher H, Lepercq J, Carette C, Colas C, Dubois-Laforgue D, Gautier JF, Lalej D, Larger E, Ledoux S, Mbemba J, Mosnier-Pudar H, Piétri L, Saltiel A, Sola A, Timsit J.

Diabetes Metab. 2011 Feb;37(1):47-51. doi: 10.1016/j.diabet.2010.07.005. Epub 2010 Dec 3.


Familial young-onset forms of diabetes related to HNF4A and rare HNF1A molecular aetiologies.

Carette C, Dubois-Laforgue D, Saint-Martin C, Clauin S, Beaufils S, Larger E, Sola A, Mosnier-Pudar H, Timsit J, Bellanné-Chantelot C.

Diabet Med. 2010 Dec;27(12):1454-8.


Fetal exposure to maternal type 1 diabetes is associated with renal dysfunction at adult age.

Abi Khalil C, Travert F, Fetita S, Rouzet F, Porcher R, Riveline JP, Hadjadj S, Larger E, Roussel R, Vexiau P, Le Guludec D, Gautier JF, Marre M.

Diabetes. 2010 Oct;59(10):2631-6. doi: 10.2337/db10-0419. Epub 2010 Jul 9.


Peak-time determination of post-meal glucose excursions in insulin-treated diabetic patients.

Daenen S, Sola-Gazagnes A, M'Bemba J, Dorange-Breillard C, Defer F, Elgrably F, Larger E, Slama G.

Diabetes Metab. 2010 Apr;36(2):165-9. doi: 10.1016/j.diabet.2009.12.002. Epub 2010 Mar 11.


Traditional anthropometric parameters still predict metabolic disorders in women with severe obesity.

Ledoux S, Coupaye M, Essig M, Msika S, Roy C, Queguiner I, Clerici C, Larger E.

Obesity (Silver Spring). 2010 May;18(5):1026-32. doi: 10.1038/oby.2009.349. Epub 2009 Oct 22.


The soluble VEGF receptor sFlt1 contributes to endothelial dysfunction in CKD.

Di Marco GS, Reuter S, Hillebrand U, Amler S, König M, Larger E, Oberleithner H, Brand E, Pavenstädt H, Brand M.

J Am Soc Nephrol. 2009 Oct;20(10):2235-45. doi: 10.1681/ASN.2009010061. Epub 2009 Jul 16.


The clinical variability of maternally inherited diabetes and deafness is associated with the degree of heteroplasmy in blood leukocytes.

Laloi-Michelin M, Meas T, Ambonville C, Bellanné-Chantelot C, Beaufils S, Massin P, Vialettes B, Gin H, Timsit J, Bauduceau B, Bernard L, Bertin E, Blickle JF, Cahen-Varsaux J, Cailleba A, Casanova S, Cathebras P, Charpentier G, Chedin P, Crea T, Delemer B, Dubois-Laforgue D, Duchemin F, Ducluzeau PH, Bouhanick B, Dusselier L, Gabreau T, Grimaldi A, Guerci B, Jacquin V, Kaloustian E, Larger E, Lecleire-Collet A, Lorenzini F, Louis J, Mausset J, Murat A, Nadler-Fluteau S, Olivier F, Paquis-Flucklinger V, Paris-Bockel D, Raynaud I, Reznik Y, Riveline JP, Schneebeli S, Sonnet E, Sola-Gazagnes A, Thomas JL, Trabulsi B, Virally M, Guillausseau PJ; Mitochondrial Diabetes French Study Group.

J Clin Endocrinol Metab. 2009 Aug;94(8):3025-30. doi: 10.1210/jc.2008-2680. Epub 2009 May 26.


[Orange facial skin discolouration].

Brahimi N, Maubec E, Palazzo E, Larger E, Mohammedi K, Landry J, Descamps V, Crickx B.

Ann Dermatol Venereol. 2009 Apr;136(4):377-8. doi: 10.1016/j.annder.2008.06.010. Epub 2008 Dec 23. French. No abstract available.


Hyperparathyroidism in a patient with autoimmune polyglandular syndrome.

Pelletier-Morel L, Fabien N, Mouhoub Y, Boitard C, Larger E.

Intern Med. 2008;47(21):1911-5. Epub 2008 Nov 4.


Nutritional deficiencies after Roux-en-Y gastric bypass can be prevented by standard multivitamin supplementation.

Ledoux S, Larger E.

Am J Clin Nutr. 2008 Oct;88(4):1176; author reply 1176-7. doi: 10.1093/ajcn/88.4.1176. No abstract available.


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