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Exclusive imidazole ligation to CuO2 and CuIIICuO2 cores.

Keown W, Large TAG, Chiang L, Wasinger EC, Stack TDP.

Chem Commun (Camb). 2019 Jun 7. doi: 10.1039/c9cc02982f. [Epub ahead of print]


Posttraumatic Avascular Necrosis After Proximal Femur, Proximal Humerus, Talar Neck, and Scaphoid Fractures.

Large TM, Adams MR, Loeffler BJ, Gardner MJ.

J Am Acad Orthop Surg. 2019 May 29. doi: 10.5435/JAAOS-D-18-00225. [Epub ahead of print]


INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.

Beekhof R, van Alphen C, Henneman AA, Knol JC, Pham TV, Rolfs F, Labots M, Henneberry E, Le Large TY, de Haas RR, Piersma SR, Vurchio V, Bertotti A, Trusolino L, Verheul HM, Jimenez CR.

Mol Syst Biol. 2019 May 24;15(5):e8981. doi: 10.15252/msb.20198981. No abstract available.


INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases.

Beekhof R, van Alphen C, Henneman AA, Knol JC, Pham TV, Rolfs F, Labots M, Henneberry E, Le Large TY, de Haas RR, Piersma SR, Vurchio V, Bertotti A, Trusolino L, Verheul HM, Jimenez CR.

Mol Syst Biol. 2019 Apr 12;15(4):e8250. doi: 10.15252/msb.20188250. Erratum in: Mol Syst Biol. 2019 May 24;15(5):e8981.


Emerging Technologies in Lithotripsy.

Large T, Krambeck AE.

Urol Clin North Am. 2019 May;46(2):215-223. doi: 10.1016/j.ucl.2018.12.012. Epub 2019 Mar 4. Review.


Use of the Quick Sequential Organ Failure Assessment Score for Prediction of Intensive Care Unit Admission Due to Septic Shock after Percutaneous Nephrolithotomy: A Multicenter Study.

Yaghoubian A, Batter T, Mozafarpour S, Sacco D, Chew BH, Monga M, Krambeck A, Sur R, Knudsen B, Mikkilineni N, Shah O, Stern K, De S, Miller N, Broutian T, Sourial M, Rose J, Large T, Scotland K, Lundeen C, Lange D, DiPina T, Bechis SK, Eisner BH; Edge Research Consortium.

J Urol. 2019 Feb 25:101097JU0000000000000195. doi: 10.1097/JU.0000000000000195. [Epub ahead of print]


Development of Decreased-Gluten Wheat Enabled by Determination of the Genetic Basis of lys3a Barley.

Moehs CP, Austill WJ, Holm A, Large TAG, Loeffler D, Mullenberg J, Schnable PS, Skinner W, van Boxtel J, Wu L, McGuire C.

Plant Physiol. 2019 Apr;179(4):1692-1703. doi: 10.1104/pp.18.00771. Epub 2019 Jan 29.


Best practice in the management of benign prostatic hyperplasia in the patients requiring anticoagulation.

Heiman J, Large T, Krambeck A.

Ther Adv Urol. 2018 Oct 29;10(12):431-436. doi: 10.1177/1756287218807591. eCollection 2018 Dec. Review.


Plasma miR-181a-5p Downregulation Predicts Response and Improved Survival After FOLFIRINOX in Pancreatic Ductal Adenocarcinoma.

Meijer LL, Garajová I, Caparello C, Le Large TYS, Frampton AE, Vasile E, Funel N, Kazemier G, Giovannetti E.

Ann Surg. 2018 Dec 9. doi: 10.1097/SLA.0000000000003084. [Epub ahead of print]


Multidrug-resistant transporter expression does not always result in drug resistance.

Le Large TYS, El Hassouni B, Kazemier G, Piersma SR, van Laarhoven HWM, Bijlsma MF, Jimenez CR, Giovannetti E.

Cancer Sci. 2018 Oct;109(10):3360-3362. doi: 10.1111/cas.13756. Epub 2018 Sep 8. No abstract available.


Trends and Perioperative Outcomes Across Major Benign Prostatic Hyperplasia Procedures from the ACS-NSQIP 2011-2015.

Anderson BB, Heiman J, Large T, Lingeman J, Krambeck A.

J Endourol. 2019 Jan;33(1):62-68. doi: 10.1089/end.2018.0266.


Initial Experience with Narcotic-Free Ureteroscopy: A Feasibility Analysis.

Large T, Heiman J, Ross A, Anderson B, Krambeck A.

J Endourol. 2018 Oct;32(10):907-911. doi: 10.1089/end.2018.0459. Epub 2018 Sep 12.


Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis.

Meijer LL, Alberga AJ, de Bakker JK, van der Vliet HJ, Le Large TYS, van Grieken NCT, de Vries R, Daams F, Zonderhuis BM, Kazemier G.

Ann Surg Oncol. 2018 Sep;25(9):2681-2692. doi: 10.1245/s10434-018-6567-6. Epub 2018 Jun 26.


Evidence-based outcomes of holmium laser enucleation of the prostate.

Large T, Krambeck AE.

Curr Opin Urol. 2018 May;28(3):301-308. doi: 10.1097/MOU.0000000000000498.


Data Standardization for Results Management.

Campbell RM, Dymshitz J, Eastwood BJ, Emkey R, Greenen DP, Heerding JM, Johnson D, Large TH, Littlejohn T, Montrose C, Nutter SE, Sawyer BD, Sigmund SK, Smith M, Weidner JR, Zink RW.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2012 May 1 [updated 2017 Oct 20].


Prognosis of sporadic resected small (≤2 cm) nonfunctional pancreatic neuroendocrine tumors - a multi-institutional study.

Sallinen VJ, Le Large TYS, Tieftrunk E, Galeev S, Kovalenko Z, Haugvik SP, Antila A, Franklin O, Martinez-Moneo E, Robinson SM, Panzuto F, Regenet N, Muffatti F, Partelli S, Wiese D, Ruszniewski P, Dousset B, Edwin B, Bartsch DK, Sauvanet A, Falconi M, Ceyhan GO, Gaujoux S; Pancreas 2000 research group.

HPB (Oxford). 2018 Mar;20(3):251-259. doi: 10.1016/j.hpb.2017.08.034. Epub 2017 Oct 5.


miRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma.

Puik JR, Meijer LL, Le Large TY, Prado MM, Frampton AE, Kazemier G, Giovannetti E.

Pharmacogenomics. 2017 Sep;18(14):1343-1358. doi: 10.2217/pgs-2017-0010. Epub 2017 Aug 23. Review.


Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets.

Best MG, Sol N, In 't Veld SGJG, Vancura A, Muller M, Niemeijer AN, Fejes AV, Tjon Kon Fat LA, Huis In 't Veld AE, Leurs C, Le Large TY, Meijer LL, Kooi IE, Rustenburg F, Schellen P, Verschueren H, Post E, Wedekind LE, Bracht J, Esenkbrink M, Wils L, Favaro F, Schoonhoven JD, Tannous J, Meijers-Heijboer H, Kazemier G, Giovannetti E, Reijneveld JC, Idema S, Killestein J, Heger M, de Jager SC, Urbanus RT, Hoefer IE, Pasterkamp G, Mannhalter C, Gomez-Arroyo J, Bogaard HJ, Noske DP, Vandertop WP, van den Broek D, Ylstra B, Nilsson RJA, Wesseling P, Karachaliou N, Rosell R, Lee-Lewandrowski E, Lewandrowski KB, Tannous BA, de Langen AJ, Smit EF, van den Heuvel MM, Wurdinger T.

Cancer Cell. 2017 Aug 14;32(2):238-252.e9. doi: 10.1016/j.ccell.2017.07.004.


Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies.

Le Large TYS, Bijlsma MF, Kazemier G, van Laarhoven HWM, Giovannetti E, Jimenez CR.

Semin Cancer Biol. 2017 Jun;44:153-169. doi: 10.1016/j.semcancer.2017.03.008. Epub 2017 Mar 30. Review.


Surveillance strategy for small asymptomatic non-functional pancreatic neuroendocrine tumors - a systematic review and meta-analysis.

Sallinen V, Le Large TY, Galeev S, Kovalenko Z, Tieftrunk E, Araujo R, Ceyhan GO, Gaujoux S.

HPB (Oxford). 2017 Apr;19(4):310-320. doi: 10.1016/j.hpb.2016.12.010. Epub 2017 Feb 21. Review.


Long-term follow-up of composite bladder augmentation incorporating stomach in a multi-institutional cohort of patients with cloacal exstrophy.

Casey JT, Chan KH, Hasegawa Y, Large T, Judge B, Kaefer M, Misseri R, Rink RC, Ueoka K, Cain MP.

J Pediatr Urol. 2017 Feb;13(1):43.e1-43.e6. doi: 10.1016/j.jpurol.2016.09.013. Epub 2016 Oct 28.


Ambulatory patients with spina bifida are 50% more likely to be fecally continent than non-ambulatory patients, particularly after a MACE procedure.

Large T, Szymanski KM, Whittam B, Misseri R, Chan KH, Kaefer M, Rink RC, Cain MP.

J Pediatr Urol. 2017 Feb;13(1):60.e1-60.e6. doi: 10.1016/j.jpurol.2016.06.019. Epub 2016 Aug 24.


FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer.

Caparello C, Meijer LL, Garajova I, Falcone A, Le Large TY, Funel N, Kazemier G, Peters GJ, Vasile E, Giovannetti E.

World J Gastroenterol. 2016 Aug 21;22(31):6987-7005. doi: 10.3748/wjg.v22.i31.6987. Review.


A realistic in silico model for structure/function studies of molybdenum-copper CO dehydrogenase.

Rokhsana D, Large TA, Dienst MC, Retegan M, Neese F.

J Biol Inorg Chem. 2016 Jul;21(4):491-9. doi: 10.1007/s00775-016-1359-6. Epub 2016 May 26.


Bioinformatic analysis reveals pancreatic cancer molecular subtypes specific to the tumor and the microenvironment.

Le Large TY, Mato Prado M, Krell J, Bijlsma MF, Meijer LL, Kazemier G, Frampton AE, Giovannetti E.

Expert Rev Mol Diagn. 2016 Jul;16(7):733-6. doi: 10.1080/14737159.2016.1175940. Epub 2016 Apr 27. Review.


The Role of MicroRNAs in Resistance to Current Pancreatic Cancer Treatment: Translational Studies and Basic Protocols for Extraction and PCR Analysis.

Garajová I, Le Large TY, Giovannetti E, Kazemier G, Biasco G, Peters GJ.

Methods Mol Biol. 2016;1395:163-87. doi: 10.1007/978-1-4939-3347-1_10.


Circulating microRNAs as diagnostic biomarkers for pancreatic cancer.

Le Large TY, Meijer LL, Prado MM, Kazemier G, Frampton AE, Giovannetti E.

Expert Rev Mol Diagn. 2015;15(12):1525-9. doi: 10.1586/14737159.2015.1112273. Epub 2015 Nov 15.


Fabrication of Novel Transparent Touch Sensing Device via Drop-on-Demand Inkjet Printing Technique.

Ma S, Ribeiro F, Powell K, Lutian J, Møller C, Large T, Holbery J.

ACS Appl Mater Interfaces. 2015 Oct 7;7(39):21628-33. doi: 10.1021/acsami.5b04717. Epub 2015 Sep 24.


Current opinions regarding care of the mature pediatric urology patient.

Szymanski KM, Misseri R, Whittam B, Large T, Cain MP.

J Pediatr Urol. 2015 Oct;11(5):251.e1-4. doi: 10.1016/j.jpurol.2015.05.020. Epub 2015 Jun 21.


Test-retest reliability of evoked heat stimulation BOLD fMRI.

Upadhyay J, Lemme J, Anderson J, Bleakman D, Large T, Evelhoch JL, Hargreaves R, Borsook D, Becerra L.

J Neurosci Methods. 2015 Sep 30;253:38-46. doi: 10.1016/j.jneumeth.2015.06.001. Epub 2015 Jun 10.


Usefulness of Measuring microRNAs in Bile and Plasma for Pancreatic Ductal Adenocarcinoma Diagnosis.

Le Large TY, Frampton AE, Meijer LL, Stebbing J, Kazemier G, Giovannetti E.

Am J Gastroenterol. 2015 May;110(5):768-9. doi: 10.1038/ajg.2015.77. No abstract available.


Interobserver Variability in the Measurement of Lower Leg Compartment Pressures.

Large TM, Agel J, Holtzman DJ, Benirschke SK, Krieg JC.

J Orthop Trauma. 2015 Jul;29(7):316-21. doi: 10.1097/BOT.0000000000000317.


Long-term renal functional outcomes after primary gastrocystoplasty.

Hubert KC, Large T, Leiser J, Judge B, Szymanski K, Whittam B, Kaefer M, Misseri R, Rink R, Cain MP.

J Urol. 2015 Jun;193(6):2079-84. doi: 10.1016/j.juro.2014.12.088. Epub 2015 Jan 3.


Molecular mechanisms underlying the role of microRNAs in the chemoresistance of pancreatic cancer.

Garajová I, Le Large TY, Frampton AE, Rolfo C, Voortman J, Giovannetti E.

Biomed Res Int. 2014;2014:678401. doi: 10.1155/2014/678401. Epub 2014 Aug 28. Review.


AKT1 and SELP polymorphisms predict the risk of developing cachexia in pancreatic cancer patients.

Avan A, Avan A, Le Large TY, Mambrini A, Funel N, Maftouh M, Ghayour-Mobarhan M, Cantore M, Boggi U, Peters GJ, Pacetti P, Giovannetti E.

PLoS One. 2014 Sep 19;9(9):e108057. doi: 10.1371/journal.pone.0108057. eCollection 2014.


Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation.

Terry-Lorenzo RT, Chun LE, Brown SP, Heffernan ML, Fang QK, Orsini MA, Pollegioni L, Hardy LW, Spear KL, Large TH.

Biosci Rep. 2014 Aug 11;34(4). pii: e00133. doi: 10.1042/BSR20140071.


Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo.

Hopkins SC, Campbell UC, Heffernan ML, Spear KL, Jeggo RD, Spanswick DC, Varney MA, Large TH.

Pharmacol Res Perspect. 2013 Oct;1(1):e00007. doi: 10.1002/prp2.7. Epub 2013 Oct 1.


Does perioperative systemic infection or fever increase surgical infection risks after internal fixation of femur and tibia fractures in an intensive care polytrauma unit?

Large TM, Alton TB, Patton DJ, Beingessner D.

J Trauma Acute Care Surg. 2013 Oct;75(4):664-8. doi: 10.1097/TA.0b013e31829a0a94.


BamHI-A rightward frame 1, an Epstein-Barr virus-encoded oncogene and immune modulator.

Hoebe EK, Le Large TY, Greijer AE, Middeldorp JM.

Rev Med Virol. 2013 Nov;23(6):367-83. doi: 10.1002/rmv.1758. Epub 2013 Aug 31. Review.


Internal fixation in a combat theater hospital.

Large TM, Bonds C, Howard M.

Orthopedics. 2013 Aug;36(8):610-8. doi: 10.3928/01477447-20130724-06.


Predictors of Gleason score upgrading in a large African-American population.

Vora A, Large T, Aronica J, Haynes S, Harbin A, Marchalik D, Nissim H, Lynch J, Bandi G, McGeagh K, Kowalczyk K, Ghasemian R, Venkatesan K, Verghese M, Hwang J.

Int Urol Nephrol. 2013 Oct;45(5):1257-62. doi: 10.1007/s11255-013-0495-y. Epub 2013 Jul 18.


Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.

Hopkins SC, Heffernan ML, Saraswat LD, Bowen CA, Melnick L, Hardy LW, Orsini MA, Allen MS, Koch P, Spear KL, Foglesong RJ, Soukri M, Chytil M, Fang QK, Jones SW, Varney MA, Panatier A, Oliet SH, Pollegioni L, Piubelli L, Molla G, Nardini M, Large TH.

J Med Chem. 2013 May 9;56(9):3710-24. doi: 10.1021/jm4002583. Epub 2013 Apr 30.


Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.

Hopkins SC, Zhao FY, Bowen CA, Fang X, Wei H, Heffernan ML, Spear KL, Spanswick DC, Varney MA, Large TH.

J Pharmacol Exp Ther. 2013 Jun;345(3):502-11. doi: 10.1124/jpet.113.204016. Epub 2013 Mar 21.


Epstein-Barr virus-encoded BARF1 protein is a decoy receptor for macrophage colony stimulating factor and interferes with macrophage differentiation and activation.

Hoebe EK, Le Large TY, Tarbouriech N, Oosterhoff D, De Gruijl TD, Middeldorp JM, Greijer AE.

Viral Immunol. 2012 Dec;25(6):461-70. doi: 10.1089/vim.2012.0034. Epub 2012 Oct 12.


Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain.

Borsook D, Upadhyay J, Klimas M, Schwarz AJ, Coimbra A, Baumgartner R, George E, Potter WZ, Large T, Bleakman D, Evelhoch J, Iyengar S, Becerra L, Hargreaves RJ.

Drug Discov Today. 2012 Sep;17(17-18):964-73. doi: 10.1016/j.drudis.2012.05.004. Epub 2012 May 10. Review.


Effect of negative pressure wound therapy on the elution of antibiotics from polymethylmethacrylate beads in a porcine simulated open femur fracture model.

Large TM, Douglas G, Erickson G, Grayson JK.

J Orthop Trauma. 2012 Sep;26(9):506-11. doi: 10.1097/BOT.0b013e31825354ce.


Image capture via a wedge light-guide with no margins.

Travis AR, Large T, Emerton N, Zhu Z, Bathiche S.

Opt Express. 2010 Apr 12;18(8):8453-8. doi: 10.1364/OE.18.008453.


Collimated light from a waveguide for a display backlight.

Travis A, Large T, Emerton N, Bathiche S.

Opt Express. 2009 Oct 26;17(22):19714-9. doi: 10.1364/OE.17.019714.


Locked plating of supracondylar periprosthetic femur fractures.

Large TM, Kellam JF, Bosse MJ, Sims SH, Althausen P, Masonis JL.

J Arthroplasty. 2008 Sep;23(6 Suppl 1):115-20. doi: 10.1016/j.arth.2008.04.021. Epub 2008 Jul 9.


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