Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 47

1.

Why Is There No Cure for Tinnitus?

McFerran DJ, Stockdale D, Holme R, Large CH, Baguley DM.

Front Neurosci. 2019 Aug 6;13:802. doi: 10.3389/fnins.2019.00802. eCollection 2019.

2.

A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: The QUIET-1 trial.

Hall DA, Ray J, Watson J, Sharman A, Hutchison J, Harris P, Daniel M, Millar B, Large CH.

Hear Res. 2019 Jun;377:153-166. doi: 10.1016/j.heares.2019.03.018. Epub 2019 Mar 27.

3.

Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice.

El-Hassar L, Song L, Tan WJT, Large CH, Alvaro G, Santos-Sacchi J, Kaczmarek LK.

J Neurosci. 2019 Jun 12;39(24):4797-4813. doi: 10.1523/JNEUROSCI.0839-18.2019. Epub 2019 Apr 1.

4.

Evaluation of Possible Effects of a Potassium Channel Modulator on Temporal Processing by Cochlear Implant Listeners.

Carlyon RP, Deeks JM, Guérit F, Lamping W, Billig AJ, Large CH, Saeed SR, Harris P.

J Assoc Res Otolaryngol. 2018 Dec;19(6):669-680. doi: 10.1007/s10162-018-00694-z. Epub 2018 Sep 19.

5.

Increased spontaneous firing rates in auditory midbrain following noise exposure are specifically abolished by a Kv3 channel modulator.

Anderson LA, Hesse LL, Pilati N, Bakay WMH, Alvaro G, Large CH, McAlpine D, Schaette R, Linden JF.

Hear Res. 2018 Aug;365:77-89. doi: 10.1016/j.heares.2018.04.012. Epub 2018 Apr 30.

PMID:
29773471
6.

Kv3 K+ currents contribute to spike-timing in dorsal cochlear nucleus principal cells.

Olsen T, Capurro A, Pilati N, Large CH, Hamann M.

Neuropharmacology. 2018 May 1;133:319-333. doi: 10.1016/j.neuropharm.2018.02.004. Epub 2018 Feb 5.

7.

Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage.

Chambers AR, Pilati N, Balaram P, Large CH, Kaczmarek LK, Polley DB.

Sci Rep. 2017 Dec 13;7(1):17496. doi: 10.1038/s41598-017-17406-x.

8.

Antimanic Efficacy of a Novel Kv3 Potassium Channel Modulator.

Parekh PK, Sidor MM, Gillman A, Becker-Krail D, Bettelini L, Arban R, Alvaro GS, Zambello E, Mutinelli C, Huang Y, Large CH, McClung CA.

Neuropsychopharmacology. 2018 Jan;43(2):435-444. doi: 10.1038/npp.2017.155. Epub 2017 Aug 31.

9.

Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons.

Brown MR, El-Hassar L, Zhang Y, Alvaro G, Large CH, Kaczmarek LK.

J Neurophysiol. 2016 Jul 1;116(1):106-21. doi: 10.1152/jn.00174.2016. Epub 2016 Apr 6.

10.

Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.

Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK.

Cell. 2016 Apr 7;165(2):434-448. doi: 10.1016/j.cell.2016.02.009. Epub 2016 Mar 17.

11.

A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons.

Rosato-Siri MD, Zambello E, Mutinelli C, Garbati N, Benedetti R, Aldegheri L, Graziani F, Virginio C, Alvaro G, Large CH.

J Pharmacol Exp Ther. 2015 Sep;354(3):251-60. doi: 10.1124/jpet.115.225748. Epub 2015 Jun 17.

PMID:
26085652
12.

Mechanisms contributing to central excitability changes during hearing loss.

Pilati N, Ison MJ, Barker M, Mulheran M, Large CH, Forsythe ID, Matthias J, Hamann M.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8292-7. doi: 10.1073/pnas.1116981109. Epub 2012 May 7.

13.

The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use.

Large CH, Sokal DM, Nehlig A, Gunthorpe MJ, Sankar R, Crean CS, Vanlandingham KE, White HS.

Epilepsia. 2012 Mar;53(3):425-36. doi: 10.1111/j.1528-1167.2011.03364.x. Epub 2012 Jan 5.

14.

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy.

Gunthorpe MJ, Large CH, Sankar R.

Epilepsia. 2012 Mar;53(3):412-24. doi: 10.1111/j.1528-1167.2011.03365.x. Epub 2012 Jan 5. Review.

15.
16.

The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia.

Large CH, Bison S, Sartori I, Read KD, Gozzi A, Quarta D, Antolini M, Hollands E, Gill CH, Gunthorpe MJ, Idris N, Neill JC, Alvaro GS.

J Pharmacol Exp Ther. 2011 Jul;338(1):100-13. doi: 10.1124/jpet.110.178475. Epub 2011 Apr 12.

PMID:
21487071
17.

Effects of lamotrigine on PCP-evoked elevations in monoamine levels in the medial prefrontal cortex of freely moving rats.

Quarta D, Large CH.

J Psychopharmacol. 2011 Dec;25(12):1703-11. doi: 10.1177/0269881110385598. Epub 2010 Nov 1.

PMID:
21041417
18.

Interleaved transcranial magnetic stimulation and fMRI suggests that lamotrigine and valproic acid have different effects on corticolimbic activity.

Li X, Ricci R, Large CH, Anderson B, Nahas Z, Bohning DE, George MS.

Psychopharmacology (Berl). 2010 Apr;209(3):233-44. doi: 10.1007/s00213-010-1786-y. Epub 2010 Mar 2.

PMID:
20195575
19.

Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat.

Kalinichev M, Bradford A, Bison S, Lucas A, Sartori I, Garbati N, Andreetta F, Bate S, Austin NE, Jones DN, Read KD, Alvaro G, Large CH.

Epilepsia. 2010 Aug;51(8):1543-51. doi: 10.1111/j.1528-1167.2009.02482.x. Epub 2010 Jan 7.

20.

Neural network dysfunction in bipolar depression: clues from the efficacy of lamotrigine.

Large CH, Di Daniel E, Li X, George MS.

Biochem Soc Trans. 2009 Oct;37(Pt 5):1080-4. doi: 10.1042/BST0371080. Review.

PMID:
19754456
21.

Comparison of the efficacy of two anticonvulsants, phenytoin and valproate to improve PCP and d-amphetamine induced deficits in a reversal learning task in the rat.

Idris NF, Neill JC, Large CH.

Front Behav Neurosci. 2009 Jun 11;3:8. doi: 10.3389/neuro.08.008.2009. eCollection 2009.

22.

Automated patch clamping using the QPatch.

Jones KA, Garbati N, Zhang H, Large CH.

Methods Mol Biol. 2009;565:209-23. doi: 10.1007/978-1-60327-258-2_10.

PMID:
19551364
23.

The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat.

Large CH, Kalinichev M, Lucas A, Carignani C, Bradford A, Garbati N, Sartori I, Austin NE, Ruffo A, Jones DN, Alvaro G, Read KD.

Epilepsy Res. 2009 Jul;85(1):96-106. doi: 10.1016/j.eplepsyres.2009.02.018. Epub 2009 Mar 28.

PMID:
19329281
24.

Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability.

Li X, Ricci R, Large CH, Anderson B, Nahas Z, George MS.

J Neural Transm (Vienna). 2009 Apr;116(4):423-9. doi: 10.1007/s00702-009-0195-z. Epub 2009 Feb 24.

PMID:
19238517
25.

The relationship between lamotrigine concentration and change in resting motor threshold in a rodent model of motor cortex stimulation.

Sokal DM, Girlanda E, Sabattini G, Large CH.

Epilepsy Res. 2009 Feb;83(2-3):103-11. doi: 10.1016/j.eplepsyres.2008.10.002. Epub 2008 Nov 28.

PMID:
19041227
26.

Chronic stress-induced alterations in amygdala responsiveness and behavior--modulation by trait anxiety and corticotropin-releasing factor systems.

Sandi C, Cordero MI, Ugolini A, Varea E, Caberlotto L, Large CH.

Eur J Neurosci. 2008 Nov;28(9):1836-48. doi: 10.1111/j.1460-9568.2008.06451.x.

PMID:
18973598
27.

CRF1 receptor activation increases the response of neurons in the basolateral nucleus of the amygdala to afferent stimulation.

Ugolini A, Sokal DM, Arban R, Large CH.

Front Behav Neurosci. 2008 Jul 16;2:2. doi: 10.3389/neuro.08.002.2008. eCollection 2008.

28.

The CB1 receptor antagonist, SR141716A, prevents high-frequency stimulation-induced reduction of feedback inhibition in the rat dentate gyrus following perforant path stimulation in vivo.

Sokal DM, Benetti C, Girlanda E, Large CH.

Brain Res. 2008 Aug 5;1223:50-8. doi: 10.1016/j.brainres.2008.05.065. Epub 2008 Jun 5.

PMID:
18599027
29.

State of the art: Pharmacologic effects on cortical excitability measures tested by transcranial magnetic stimulation.

Paulus W, Classen J, Cohen LG, Large CH, Di Lazzaro V, Nitsche M, Pascual-Leone A, Rosenow F, Rothwell JC, Ziemann U.

Brain Stimul. 2008 Jul;1(3):151-63. doi: 10.1016/j.brs.2008.06.002. Epub 2008 Jun 30. Review.

PMID:
20633382
30.

AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala.

Ugolini A, Large CH, Corsi M.

Neuropharmacology. 2008 Sep;55(4):532-6. doi: 10.1016/j.neuropharm.2008.04.020. Epub 2008 Apr 30.

PMID:
18533198
31.

Modulation of high-frequency oscillations associated with NMDA receptor hypofunction in the rodent nucleus accumbens by lamotrigine.

Hunt MJ, Garcia R, Large CH, Kasicki S.

Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1312-9. doi: 10.1016/j.pnpbp.2008.04.009. Epub 2008 Apr 20.

PMID:
18514376
32.

Differential effects of antipsychotic and glutamatergic agents on the phMRI response to phencyclidine.

Gozzi A, Large CH, Schwarz A, Bertani S, Crestan V, Bifone A.

Neuropsychopharmacology. 2008 Jun;33(7):1690-703. Epub 2007 Sep 5.

33.
34.

An investigation of the efficacy of mood stabilizers in rodent models of prepulse inhibition.

Ong JC, Brody SA, Large CH, Geyer MA.

J Pharmacol Exp Ther. 2005 Dec;315(3):1163-71. Epub 2005 Aug 25.

PMID:
16123308
35.

The potential role of lamotrigine in schizophrenia.

Large CH, Webster EL, Goff DC.

Psychopharmacology (Berl). 2005 Sep;181(3):415-36. Epub 2005 Oct 12. Review.

PMID:
16001126
36.

Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and D-amphetamine in the rat.

Idris NF, Repeto P, Neill JC, Large CH.

Psychopharmacology (Berl). 2005 May;179(2):336-48. Epub 2005 Jan 12.

PMID:
15645224
38.

Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat.

Nissinen J, Large CH, Stratton SC, Pitkänen A.

Epilepsy Res. 2004 Feb;58(2-3):119-32.

PMID:
15120743
39.

Lamotrigine prevents ketamine but not amphetamine-induced deficits in prepulse inhibition in mice.

Brody SA, Geyer MA, Large CH.

Psychopharmacology (Berl). 2003 Sep;169(3-4):240-6. Epub 2003 Apr 16.

PMID:
12698229
40.

Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model.

Stratton SC, Large CH, Cox B, Davies G, Hagan RM.

Epilepsy Res. 2003 Feb;53(1-2):95-106.

PMID:
12576171
41.
42.

Electrophysiological characterisation of the dentate gyrus in five inbred strains of mouse.

Bampton ET, Gray RA, Large CH.

Brain Res. 1999 Sep 11;841(1-2):123-34.

PMID:
10546995
43.

Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse.

Anderson R, Barnes JC, Bliss TV, Cain DP, Cambon K, Davies HA, Errington ML, Fellows LA, Gray RA, Hoh T, Stewart M, Large CH, Higgins GA.

Neuroscience. 1998 Jul;85(1):93-110.

PMID:
9607706
44.

Increased expression of dendritic mRNA following the induction of long-term potentiation.

Roberts LA, Large CH, Higgins MJ, Stone TW, O'Shaughnessy CT, Morris BJ.

Brain Res Mol Brain Res. 1998 May;56(1-2):38-44.

PMID:
9602046
45.

Long-term potentiation in perforant path/granule cell synapses is associated with a post-synaptic induction of proenkephalin gene expression.

Roberts LA, Large CH, O'Shaughnessy CT, Morris BJ.

Neurosci Lett. 1997 May 23;227(3):205-8.

PMID:
9185686
46.

Apolipoprotein E and Alzheimer's disease: a review of recent studies.

Higgins GA, Large CH, Rupniak HT, Barnes JC.

Pharmacol Biochem Behav. 1997 Apr;56(4):675-85. Review.

PMID:
9130294
47.

The dopamine D3 receptor: Chinese hamsters or Chinese whispers?

Large CH, Stubbs CM.

Trends Pharmacol Sci. 1994 Feb;15(2):46-7. No abstract available.

PMID:
8165723

Supplemental Content

Loading ...
Support Center