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A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.

Thommen DS, Koelzer VH, Herzig P, Roller A, Trefny M, Dimeloe S, Kiialainen A, Hanhart J, Schill C, Hess C, Savic Prince S, Wiese M, Lardinois D, Ho PC, Klein C, Karanikas V, Mertz KD, Schumacher TN, Zippelius A.

Nat Med. 2018 Jul;24(7):994-1004. doi: 10.1038/s41591-018-0057-z. Epub 2018 Jun 11.


Retraction to 'Functional results after chest wall stabilization with a new screwless fixation device' [Eur J Cardiothorac Surg 2015;47:868-75].

Wiese MN, Kawel-Boehm N, de la Santa PM, Al-Shahrabani F, Toffel M, Rosenthal R, Schäfer J, Tamm M, Bremerich J, Lardinois D.

Eur J Cardiothorac Surg. 2018 Mar 1;53(3):695. doi: 10.1093/ejcts/ezy048. No abstract available.


The Spatial Relationship between Apparent Diffusion Coefficient and Standardized Uptake Value of 18F-Fluorodeoxyglucose Has a Crucial Influence on the Numeric Correlation of Both Parameters in PET/MRI of Lung Tumors.

Sauter AW, Stieltjes B, Weikert T, Gatidis S, Wiese M, Klarhöfer M, Wild D, Lardinois D, Bremerich J, Sommer G.

Contrast Media Mol Imaging. 2017 Dec 17;2017:8650853. doi: 10.1155/2017/8650853. eCollection 2017.


eComment. Narrative therapy for decision making about pectus excavatum treatment: Concepts clarification and basic claims demonstration challenge.

Tampaki EC, Tampakis A, Lardinois D.

Interact Cardiovasc Thorac Surg. 2018 Feb 1;26(2):276. doi: 10.1093/icvts/ivx367. No abstract available.


The T cell repertoire in tumors overlaps with pulmonary inflammatory lesions in patients treated with checkpoint inhibitors.

Läubli H, Koelzer VH, Matter MS, Herzig P, Dolder Schlienger B, Wiese MN, Lardinois D, Mertz KD, Zippelius A.

Oncoimmunology. 2017 Oct 26;7(2):e1386362. doi: 10.1080/2162402X.2017.1386362. eCollection 2018.


Signal enhancement ratio imaging of the lung parenchyma with ultra-fast steady-state free precession MRI at 1.5T.

Pusterla O, Sommer G, Santini F, Wiese M, Lardinois D, Tamm M, Bremerich J, Bauman G, Bieri O.

J Magn Reson Imaging. 2018 Jul;48(1):48-57. doi: 10.1002/jmri.25928. Epub 2018 Jan 3.


Postoperative deep wound dehiscence of thoracotomy with isolation of Corynebacterium tuberculostearicum: surgical site infection or colonization?

Tampakis A, Tampaki EC, Kontzoglou K, Patsouris E, Kouraklis G, Lardinois D.

Eur Rev Med Pharmacol Sci. 2017 Nov;21(22):5264-5267. doi: 10.26355/eurrev_201711_13850.


Multipotent mesenchymal stem cells in lung fibrosis.

Hostettler KE, Gazdhar A, Khan P, Savic S, Tamo L, Lardinois D, Roth M, Tamm M, Geiser T.

PLoS One. 2017 Aug 21;12(8):e0181946. doi: 10.1371/journal.pone.0181946. eCollection 2017. Erratum in: PLoS One. 2018 Jan 9;13(1):e0191144.


CME-Rheumatologie 11/Auflösung: Sternoclaviculäre Schwellung – immer ein Tietze-Syndrom?

Tamborrini G, Gut C, Schaefer DJ, Lardinois D.

Praxis (Bern 1994). 2017;106(7):387-389. doi: 10.1024/1661-8157/a002637. German. No abstract available.


CME-Rheumatologie 11: Sternoclaviculäre Schwellung – immer ein Tietze-Syndrom?

Tamborrini G, Gut C, Schaefer DJ, Lardinois D.

Praxis (Bern 1994). 2017;106(6):295-296. doi: 10.1024/1661-8157/a002636. German. No abstract available.


Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling.

Sun Q, Liu L, Wang H, Mandal J, Khan P, Hostettler KE, Stolz D, Tamm M, Molino A, Lardinois D, Lu S, Roth M.

J Allergy Clin Immunol. 2017 Aug;140(2):510-524.e3. doi: 10.1016/j.jaci.2016.11.013. Epub 2017 Jan 9.


Intrathoracic tumor of the chest wall: A case of Castleman's disease mimicking myositis of the lower extremities.

Tampakis A, Tampaki EC, Daikeler T, Lardinois D.

Gen Thorac Cardiovasc Surg. 2017 Nov;65(11):664-666. doi: 10.1007/s11748-016-0743-z. Epub 2017 Jan 10.


The MNK-1/eIF4E pathway as a new therapeutic pathway to target inflammation and remodelling in asthma.

Seidel P, Sun Q, Costa L, Lardinois D, Tamm M, Roth M.

Cell Signal. 2016 Oct;28(10):1555-62. doi: 10.1016/j.cellsig.2016.07.004. Epub 2016 Jul 11.


66P Highly exhausted PD-1hi T cell subsets in human NSCLC are co-defined by the predominant expression of distinct inhibitory receptors and correlate with clinical outcome.

Thommen D, Uhlenbrock F, Herzig P, Prince SS, Moersig W, Lardinois D, Zippelius A.

J Thorac Oncol. 2016 Apr;11(4 Suppl):S83. doi: 10.1016/S1556-0864(16)30179-4. Epub 2016 Apr 15. No abstract available.


Expression of inhibitory receptors on intratumoral T cells modulates the activity of a T cell-bispecific antibody targeting folate receptor.

Schreiner J, Thommen DS, Herzig P, Bacac M, Klein C, Roller A, Belousov A, Levitsky V, Savic S, Moersig W, Uhlenbrock F, Heinzelmann-Schwarz VA, Umana P, Pisa P, von Bergwelt-Baildon M, Lardinois D, Müller P, Karanikas V, Zippelius A.

Oncoimmunology. 2015 Jun 24;5(2):e1062969. eCollection 2016 Feb.


Diffuse lymphatic leakage after continuous vacuum-assisted closure therapy for thoracic wound infection after rib stabilization.

Dackam S, Furrer K, Haug M, Lardinois D.

J Surg Case Rep. 2015 Dec 16;2015(12). pii: rjv155. doi: 10.1093/jscr/rjv155.


Aclidinium bromide combined with formoterol inhibits remodeling parameters in lung epithelial cells through cAMP.

Lambers C, Costa L, Ying Q, Zhong J, Lardinois D, Dekan G, Schuller E, Roth M.

Pharmacol Res. 2015 Dec;102:310-8. doi: 10.1016/j.phrs.2015.09.010. Epub 2015 Nov 4.


Serum IgE Induced Airway Smooth Muscle Cell Remodeling Is Independent of Allergens and Is Prevented by Omalizumab.

Roth M, Zhao F, Zhong J, Lardinois D, Tamm M.

PLoS One. 2015 Sep 2;10(9):e0136549. doi: 10.1371/journal.pone.0136549. eCollection 2015.


Progression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors.

Thommen DS, Schreiner J, Müller P, Herzig P, Roller A, Belousov A, Umana P, Pisa P, Klein C, Bacac M, Fischer OS, Moersig W, Savic Prince S, Levitsky V, Karanikas V, Lardinois D, Zippelius A.

Cancer Immunol Res. 2015 Dec;3(12):1344-55. doi: 10.1158/2326-6066.CIR-15-0097. Epub 2015 Aug 7.


Preoperative mediastinal lymph node staging for non-small cell lung cancer: 2014 update of the 2007 ESTS guidelines.

De Leyn P, Dooms C, Kuzdzal J, Lardinois D, Passlick B, Rami-Porta R, Turna A, Van Schil P, Venuta F, Waller D, Weder W, Zielinski M.

Transl Lung Cancer Res. 2014 Aug;3(4):225-33. doi: 10.3978/j.issn.2218-6751.2014.08.05. Review.


Long-term survival after extended resection of primary atrial myxosarcoma.

Kakaty D, Grapow M, Huber B, Lardinois D.

J Surg Case Rep. 2015 Jan 12;2015(1). pii: rju146. doi: 10.1093/jscr/rju146.


Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis.

Hostettler KE, Zhong J, Papakonstantinou E, Karakiulakis G, Tamm M, Seidel P, Sun Q, Mandal J, Lardinois D, Lambers C, Roth M.

Respir Res. 2014 Dec 12;15:157. doi: 10.1186/s12931-014-0157-3.


Functional results after chest wall stabilization with a new screwless fixation device.

Wiese MN, Kawel-Boehm N, Moreno de la Santa P, Al-Shahrabani F, Toffel M, Rosenthal R, Schäfer J, Tamm M, Bremerich J, Lardinois D.

Eur J Cardiothorac Surg. 2015 May;47(5):868-75. doi: 10.1093/ejcts/ezu318. Epub 2014 Sep 4.


Microtubule-depolymerizing agents used in antibody-drug conjugates induce antitumor immunity by stimulation of dendritic cells.

Müller P, Martin K, Theurich S, Schreiner J, Savic S, Terszowski G, Lardinois D, Heinzelmann-Schwarz VA, Schlaak M, Kvasnicka HM, Spagnoli G, Dirnhofer S, Speiser DE, von Bergwelt-Baildon M, Zippelius A.

Cancer Immunol Res. 2014 Aug;2(8):741-55. doi: 10.1158/2326-6066.CIR-13-0198. Epub 2014 Apr 21.


The microtubule-depolymerizing agent ansamitocin P3 programs dendritic cells toward enhanced anti-tumor immunity.

Martin K, Müller P, Schreiner J, Prince SS, Lardinois D, Heinzelmann-Schwarz VA, Thommen DS, Zippelius A.

Cancer Immunol Immunother. 2014 Sep;63(9):925-38. doi: 10.1007/s00262-014-1565-4. Epub 2014 Jun 7.


Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer.

Cihoric N, Savic S, Schneider S, Ackermann I, Bichsel-Naef M, Schmid RA, Lardinois D, Gugger M, Bubendorf L, Zlobec I, Tapia C.

Br J Cancer. 2014 Jun 10;110(12):2914-22. doi: 10.1038/bjc.2014.229. Epub 2014 May 22.


Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small-cell lung cancer.

De Leyn P, Dooms C, Kuzdzal J, Lardinois D, Passlick B, Rami-Porta R, Turna A, Van Schil P, Venuta F, Waller D, Weder W, Zielinski M.

Eur J Cardiothorac Surg. 2014 May;45(5):787-98. doi: 10.1093/ejcts/ezu028. Epub 2014 Feb 26.


Bronchial smooth muscle cells of asthmatics promote angiogenesis through elevated secretion of CXC-chemokines (ENA-78, GRO-α, and IL-8).

Keglowich L, Roth M, Philippova M, Resink T, Tjin G, Oliver B, Lardinois D, Dessus-Babus S, Gosens R, Hostettler Haack K, Tamm M, Borger P.

PLoS One. 2013 Dec 5;8(12):e81494. doi: 10.1371/journal.pone.0081494. eCollection 2013.


Tiotropium sustains the anti-inflammatory action of olodaterol via the cyclic AMP pathway.

Costa L, Roth M, Miglino N, Keglowich L, Zhong J, Lardinois D, Tamm M, Borger P.

Pulm Pharmacol Ther. 2014 Feb;27(1):29-37. doi: 10.1016/j.pupt.2013.11.001. Epub 2013 Nov 19.


Calcineurin inhibitors in bronchiolitis obliterans syndrome following stem cell transplantation.

Hostettler KE, Halter JP, Gerull S, Lardinois D, Savic S, Roth M, Tamm M.

Eur Respir J. 2014 Jan;43(1):221-32. doi: 10.1183/09031936.00199312. Epub 2013 May 3.


[A rare complication after a violent coughing attack].

Meier L, Malè Sonderegger F, Tanneberger O, Rasch H, Lardinois D.

Praxis (Bern 1994). 2013 May 8;102(10):607-9. doi: 10.1024/1661-8157/a001289. German.


Prospective study of a panfungal PCR assay followed by sequencing, for the detection of fungal DNA in normally sterile specimens in a clinical setting: a complementary tool in the diagnosis of invasive fungal disease?

Babouee B, Goldenberger D, Elzi L, Lardinois D, Sadowski-Cron C, Bubendorf L, Savic Prince S, Battegay M, Frei R, Weisser M.

Clin Microbiol Infect. 2013 Aug;19(8):E354-7. doi: 10.1111/1469-0691.12231. Epub 2013 Apr 26.


Lung histology predicts outcome of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.

Holbro A, Lehmann T, Girsberger S, Stern M, Gambazzi F, Lardinois D, Heim D, Passweg JR, Tichelli A, Bubendorf L, Savic S, Hostettler K, Grendelmeier P, Halter JP, Tamm M.

Biol Blood Marrow Transplant. 2013 Jun;19(6):973-80. doi: 10.1016/j.bbmt.2013.03.017. Epub 2013 Apr 2.


Perioperative diclofenac application during video-assisted thoracic surgery pleurodesis modulates early inflammatory and fibrinolytic processes in an experimental model.

Opitz I, Arni S, Oberreiter B, Asmis LM, Vogt P, Rousson V, Weder W, Lardinois D.

Eur Surg Res. 2013;50(1):14-23. doi: 10.1159/000341670. Epub 2013 Feb 15.


Preoperative staging of non-small-cell lung cancer: comparison of whole-body diffusion-weighted magnetic resonance imaging and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography.

Sommer G, Wiese M, Winter L, Lenz C, Klarhöfer M, Forrer F, Lardinois D, Bremerich J.

Eur Radiol. 2012 Dec;22(12):2859-67. doi: 10.1007/s00330-012-2542-y. Epub 2012 Jul 9.


[Surgical operability of patients with locally advanced non-small cell lung cancer (NSCLC)].

Lardinois D.

Ther Umsch. 2012 Jul;69(7):411-9. doi: 10.1024/0040-5930/a000308. Review. German.


Calreticulin is a negative regulator of bronchial smooth muscle cell proliferation.

Miglino N, Roth M, Lardinois D, Tamm M, Borger P.

J Allergy (Cairo). 2012;2012:783290. doi: 10.1155/2012/783290. Epub 2012 Feb 21.


Lung resection in hematologic patients with pulmonary invasive fungal disease.

Nebiker CA, Lardinois D, Junker L, Gambazzi F, Matt P, Habicht JM, Halter J, Heim D, Stern M, Buser AS, Passweg J, Stolz D, Flückiger UM, Weisser M, Battegay M, Bubendorf L, Gratwohl A, Tamm M.

Chest. 2012 Oct;142(4):988-995. doi: 10.1378/chest.11-1964.


High prevalence of infections and autoimmunity in patients with thymoma.

Holbro A, Jauch A, Lardinois D, Tzankov A, Dirnhofer S, Hess C.

Hum Immunol. 2012 Mar;73(3):287-90. doi: 10.1016/j.humimm.2011.12.022. Epub 2011 Dec 31.


Significance of a new fluorodeoxyglucose-positive lesion on restaging positron emission tomography/computed tomography after induction therapy for non-small-cell lung cancer.

Collaud S, Lardinois D, Tischler V, Steinert HC, Stahel R, Weder W.

Eur J Cardiothorac Surg. 2012 Mar;41(3):612-6. doi: 10.1093/ejcts/ezr109. Epub 2011 Dec 14.


Cytokine & chemokine response in the lungs, pleural fluid and serum in thoracic surgery using one-lung ventilation.

Breunig A, Gambazzi F, Beck-Schimmer B, Tamm M, Lardinois D, Oertli D, Zingg U.

J Inflamm (Lond). 2011 Nov 11;8:32. doi: 10.1186/1476-9255-8-32.


Cigarette smoke inhibits lung fibroblast proliferation by translational mechanisms.

Miglino N, Roth M, Lardinois D, Sadowski C, Tamm M, Borger P.

Eur Respir J. 2012 Mar;39(3):705-11. doi: 10.1183/09031936.00174310. Epub 2011 Aug 18.


Pre- and intra-operative mediastinal staging in non-small-cell lung cancer.

Lardinois D.

Swiss Med Wkly. 2011 Mar 8;141:w13168. doi: 10.4414/smw.2011.13168. eCollection 2011. Review.


Rat mesothelioma cell proliferation requires p38δ mitogen activated protein kinase and C/EBP-α.

Zhong J, Lardinois D, Szilard J, Tamm M, Roth M.

Lung Cancer. 2011 Aug;73(2):166-70. doi: 10.1016/j.lungcan.2010.12.003. Epub 2011 Jan 11.


Contralateral recurrence of a malignant solitary fibrous tumor of the pleura.

Hoffmann H, Giger OT, Bubendorf L, Lardinois D.

Interact Cardiovasc Thorac Surg. 2011 Feb;12(2):306-7. doi: 10.1510/icvts.2010.252874. Epub 2010 Nov 12.


Accuracy of CT parameters for assessment of tumour size and aggressiveness in lung adenocarcinoma with bronchoalveolar elements.

Bhure UN, Lardinois D, Kalff V, Hany TF, Soltermann A, Seifert B, Steinert HC.

Br J Radiol. 2010 Oct;83(994):841-9. doi: 10.1259/bjr/13711326.


Black hole in the lung.

Cantoni N, Weisser M, Frei R, Lardinois D, Arber C.

Bone Marrow Transplant. 2011 Jan;46(1):154-5. doi: 10.1038/bmt.2010.72. Epub 2010 Mar 29. No abstract available.


Immuno-chemotherapy reduces recurrence of malignant pleural mesothelioma: an experimental setting.

Ampollini L, Soltermann A, Felley-Bosco E, Lardinois D, Arni S, Speck RF, Weder W, Opitz I.

Eur J Cardiothorac Surg. 2009 Mar;35(3):457-62. doi: 10.1016/j.ejcts.2008.11.030. Epub 2009 Jan 21.


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