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Items: 1 to 50 of 79

1.
2.

Alternative splicing in a presenilin 2 variant associated with Alzheimer disease.

Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto-Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross C, Grabowski T, Nik SHM, Newman M, Garden GA, Leverenz JB, Tsuang D, Latimer C, Gonzalez-Cuyar LF, Keene CD, Morrison RS, Rhoads K, Wijsman EM, Dorschner MO, Lardelli M, Young JE, Valdmanis PN, Bird TD, Jayadev S.

Ann Clin Transl Neurol. 2019 Mar 10;6(4):762-777. doi: 10.1002/acn3.755. eCollection 2019 Apr.

3.

A Review of the Familial Alzheimer's Disease Locus PRESENILIN 2 and Its Relationship to PRESENILIN 1.

Jiang H, Jayadev S, Lardelli M, Newman M.

J Alzheimers Dis. 2018;66(4):1323-1339. doi: 10.3233/JAD-180656. Review.

PMID:
30412492
4.

The zebrafish orthologue of familial Alzheimer's disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation.

Jiang H, Newman M, Lardelli M.

PLoS One. 2018 Oct 25;13(10):e0206155. doi: 10.1371/journal.pone.0206155. eCollection 2018.

5.

Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease.

Lumsden AL, Rogers JT, Majd S, Newman M, Sutherland GT, Verdile G, Lardelli M.

Front Neurosci. 2018 Aug 13;12:533. doi: 10.3389/fnins.2018.00533. eCollection 2018.

6.

Degenerate codon mixing for PCR-based manipulation of highly repetitive sequences.

Ratnayake D, Newman M, Lardelli M.

BMC Res Notes. 2018 Mar 27;11(1):202. doi: 10.1186/s13104-018-3298-5.

7.

Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer's disease.

Newman M, Halter L, Lim A, Lardelli M.

PLoS One. 2017 Jun 21;12(6):e0179859. doi: 10.1371/journal.pone.0179859. eCollection 2017.

8.

The Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease.

Richards RI, Robertson SA, O'Keefe LV, Fornarino D, Scott A, Lardelli M, Baune BT.

Front Neurosci. 2016 May 10;10:193. doi: 10.3389/fnins.2016.00193. eCollection 2016.

9.

Evidence For and Against a Pathogenic Role of Reduced γ-Secretase Activity in Familial Alzheimer's Disease.

Jayne T, Newman M, Verdile G, Sutherland G, Münch G, Musgrave I, Moussavi Nik SH, Lardelli M.

J Alzheimers Dis. 2016 Apr 4;52(3):781-99. doi: 10.3233/JAD-151186. Review.

PMID:
27060961
10.

The Zebrafish Equivalent of Alzheimer's Disease-Associated PRESENILIN Isoform PS2V Regulates Inflammatory and Other Responses to Hypoxic Stress.

Ebrahimie E, Moussavi Nik SH, Newman M, Van Der Hoek M, Lardelli M.

J Alzheimers Dis. 2016 Mar 31;52(2):581-608. doi: 10.3233/JAD-150678.

PMID:
27031468
11.

Analysis of nicastrin gene phylogeny and expression in zebrafish.

Lim A, Moussavi Nik SH, Ebrahimie E, Lardelli M.

Dev Genes Evol. 2015 Jun;225(3):171-8. doi: 10.1007/s00427-015-0500-9. Epub 2015 May 5.

PMID:
25940938
12.

Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity.

Moussavi Nik SH, Newman M, Wilson L, Ebrahimie E, Wells S, Musgrave I, Verdile G, Martins RN, Lardelli M.

Hum Mol Genet. 2015 Jul 1;24(13):3662-78. doi: 10.1093/hmg/ddv110. Epub 2015 Mar 26.

13.

Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain.

Klarić T, Lardelli M, Key B, Koblar S, Lewis M.

Front Neuroanat. 2014 Dec 4;8:148. doi: 10.3389/fnana.2014.00148. eCollection 2014.

14.

Hypoxia alters expression of zebrafish microtubule-associated protein tau (mapta, maptb) gene transcripts.

Moussavi Nik SH, Newman M, Ganesan S, Chen M, Martins R, Verdile G, Lardelli M.

BMC Res Notes. 2014 Oct 31;7:767. doi: 10.1186/1756-0500-7-767.

15.

Using the zebrafish model for Alzheimer's disease research.

Newman M, Ebrahimie E, Lardelli M.

Front Genet. 2014 Jun 30;5:189. doi: 10.3389/fgene.2014.00189. eCollection 2014. Review.

16.

Identification and expression analysis of the zebrafish orthologues of the mammalian MAP1LC3 gene family.

Ganesan S, Moussavi Nik SH, Newman M, Lardelli M.

Exp Cell Res. 2014 Oct 15;328(1):228-37. doi: 10.1016/j.yexcr.2014.07.014. Epub 2014 Jul 19.

PMID:
25051050
17.

The comparison of methods for measuring oxidative stress in zebrafish brains.

Moussavi Nik SH, Croft K, Mori TA, Lardelli M.

Zebrafish. 2014 Jun;11(3):248-54. doi: 10.1089/zeb.2013.0958. Epub 2014 May 5.

PMID:
24798242
18.

Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease.

Newman M, Wilson L, Verdile G, Lim A, Khan I, Moussavi Nik SH, Pursglove S, Chapman G, Martins RN, Lardelli M.

Hum Mol Genet. 2014 Feb 1;23(3):602-17. doi: 10.1093/hmg/ddt448. Epub 2013 Sep 18.

19.

The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes.

Sharman MJ, Moussavi Nik SH, Chen MM, Ong D, Wijaya L, Laws SM, Taddei K, Newman M, Lardelli M, Martins RN, Verdile G.

PLoS One. 2013 Jun 21;8(6):e66235. doi: 10.1371/journal.pone.0066235. Print 2013.

20.

The development of an in vivo γ-secretase assay using zebrafish embryos.

Wilson L, Lardelli M.

J Alzheimers Dis. 2013;36(3):521-34. doi: 10.3233/JAD-130332.

PMID:
23666177
21.

Regular care and maintenance of a zebrafish (Danio rerio) laboratory: an introduction.

Avdesh A, Chen M, Martin-Iverson MT, Mondal A, Ong D, Rainey-Smith S, Taddei K, Lardelli M, Groth DM, Verdile G, Martins RN.

J Vis Exp. 2012 Nov 18;(69):e4196. doi: 10.3791/4196.

22.

Robust homeostasis of Presenilin1 protein levels by transcript regulation.

Newman M, Nornes S, Martins RN, Lardelli MT.

Neurosci Lett. 2012 Jun 21;519(1):14-9. doi: 10.1016/j.neulet.2012.04.064. Epub 2012 May 3.

PMID:
22580062
23.

The BACE1-PSEN-AβPP regulatory axis has an ancient role in response to low oxygen/oxidative stress.

Moussavi Nik SH, Wilson L, Newman M, Croft K, Mori TA, Musgrave I, Lardelli M.

J Alzheimers Dis. 2012;28(3):515-30. doi: 10.3233/JAD-2011-110533.

PMID:
22045484
24.

Evaluation of color preference in zebrafish for learning and memory.

Avdesh A, Martin-Iverson MT, Mondal A, Chen M, Askraba S, Morgan N, Lardelli M, Groth DM, Verdile G, Martins RN.

J Alzheimers Dis. 2012;28(2):459-69. doi: 10.3233/JAD-2011-110704.

PMID:
22008261
25.

Identification and expression analysis of the zebrafish orthologue of Klotho.

Sugano Y, Lardelli M.

Dev Genes Evol. 2011 Aug;221(3):179-86. doi: 10.1007/s00427-011-0367-3. Epub 2011 Jul 3.

PMID:
21725870
26.

Transgenic zebrafish recapitulating tbx16 gene early developmental expression.

Wells S, Nornes S, Lardelli M.

PLoS One. 2011;6(6):e21559. doi: 10.1371/journal.pone.0021559. Epub 2011 Jun 24.

27.

The response of HMGA1 to changes in oxygen availability is evolutionarily conserved.

Moussavi Nik SH, Newman M, Lardelli M.

Exp Cell Res. 2011 Jul 1;317(11):1503-12. doi: 10.1016/j.yexcr.2011.04.004. Epub 2011 Apr 20.

PMID:
21530505
28.

A hyperactive sleeping beauty transposase enhances transgenesis in zebrafish embryos.

Newman M, Lardelli M.

BMC Res Notes. 2010 Nov 4;3:282. doi: 10.1186/1756-0500-3-282.

29.

Zebrafish as a tool in Alzheimer's disease research.

Newman M, Verdile G, Martins RN, Lardelli M.

Biochim Biophys Acta. 2011 Mar;1812(3):346-52. doi: 10.1016/j.bbadis.2010.09.012. Epub 2010 Oct 12. Review.

30.

Cryptic organisation within an apparently irregular rostrocaudal distribution of interneurons in the embryonic zebrafish spinal cord.

Wells S, Conran JG, Tamme R, Gaudin A, Webb J, Lardelli M.

Exp Cell Res. 2010 Nov 15;316(19):3292-303. doi: 10.1016/j.yexcr.2010.06.020. Epub 2010 Jul 1.

PMID:
20599944
31.

A zebrafish melanophore model of amyloid beta toxicity.

Newman M, Wilson L, Camp E, Verdile G, Martins R, Lardelli M.

Zebrafish. 2010 Jun;7(2):155-9. doi: 10.1089/zeb.2009.0628.

PMID:
20515319
32.

Zebrafish aplnra functions in epiboly.

Nornes S, Tucker B, Lardelli M.

BMC Res Notes. 2009 Nov 19;2:231. doi: 10.1186/1756-0500-2-231.

33.

Selective neuronal requirement for huntingtin in the developing zebrafish.

Henshall TL, Tucker B, Lumsden AL, Nornes S, Lardelli MT, Richards RI.

Hum Mol Genet. 2009 Dec 15;18(24):4830-42. doi: 10.1093/hmg/ddp455. Epub 2009 Sep 29.

34.

Complex splicing and neural expression of duplicated tau genes in zebrafish embryos.

Chen M, Martins RN, Lardelli M.

J Alzheimers Dis. 2009;18(2):305-17. doi: 10.3233/JAD-2009-1145.

PMID:
19584432
35.

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.

Nornes S, Newman M, Wells S, Verdile G, Martins RN, Lardelli M.

Exp Cell Res. 2009 Oct 1;315(16):2791-801. doi: 10.1016/j.yexcr.2009.06.023. Epub 2009 Jun 27.

PMID:
19563801
36.

Mining the data on coal.

Lardelli M.

Science. 2009 May 15;324(5929):880-1. doi: 10.1126/science.324_880c. No abstract available.

PMID:
19443764
37.

Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesis.

Newman M, Tucker B, Nornes S, Ward A, Lardelli M.

J Alzheimers Dis. 2009;16(1):133-47. doi: 10.3233/JAD-2009-0945. Erratum in: J Alzheimers Dis. 2009 Dec;18(4):993.

PMID:
19158429
38.
39.

Evolutionary and expression analysis of the zebrafish deubiquitylating enzyme, usp9.

Khut PY, Tucker B, Lardelli M, Wood SA.

Zebrafish. 2007 Summer;4(2):95-101.

PMID:
18041927
40.

Interference with splicing of Presenilin transcripts has potent dominant negative effects on Presenilin activity.

Nornes S, Newman M, Verdile G, Wells S, Stoick-Cooper CL, Tucker B, Frederich-Sleptsova I, Martins R, Lardelli M.

Hum Mol Genet. 2008 Feb 1;17(3):402-12. Epub 2007 Nov 2.

PMID:
17981814
41.

The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development.

Wyatt L, Wadham C, Crocker LA, Lardelli M, Khew-Goodall Y.

J Cell Biol. 2007 Sep 24;178(7):1223-35.

42.

Huntingtin-deficient zebrafish exhibit defects in iron utilization and development.

Lumsden AL, Henshall TL, Dayan S, Lardelli MT, Richards RI.

Hum Mol Genet. 2007 Aug 15;16(16):1905-20. Epub 2007 Jun 13.

PMID:
17567778
43.

Scientists need to confront economists about peak oil.

Lardelli M.

Nature. 2007 Mar 15;446(7133):257. No abstract available.

PMID:
17361158
44.

Alzheimer disease: amyloidogenesis, the presenilins and animal models.

Newman M, Musgrave IF, Lardelli M.

Biochim Biophys Acta. 2007 Mar;1772(3):285-97. Epub 2006 Dec 8. Review. Erratum in: Biochim Biophys Acta. 2007 Sep;1772(9):1118. Musgrave, F I [corrected to Musgrave, I F].

45.

Zebrafish Angiotensin II Receptor-like 1a (agtrl1a) is expressed in migrating hypoblast, vasculature, and in multiple embryonic epithelia.

Tucker B, Hepperle C, Kortschak D, Rainbird B, Wells S, Oates AC, Lardelli M.

Gene Expr Patterns. 2007 Jan;7(3):258-65. Epub 2006 Sep 23.

PMID:
17085078
46.

Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome.

Tucker B, Richards RI, Lardelli M.

Hum Mol Genet. 2006 Dec 1;15(23):3446-58. Epub 2006 Oct 25.

PMID:
17065172
47.

Expression of three zebrafish orthologs of human FMR1-related genes and their phylogenetic relationships.

Tucker B, Richards R, Lardelli M.

Dev Genes Evol. 2004 Nov;214(11):567-74. Epub 2004 Sep 17.

PMID:
15378363
48.

Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary.

Scholpp S, Groth C, Lohs C, Lardelli M, Brand M.

Dev Genes Evol. 2004 Jun;214(6):285-95. Epub 2004 May 25.

PMID:
15221377
49.

Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos.

Nornes S, Groth C, Camp E, Ey P, Lardelli M.

Exp Cell Res. 2003 Sep 10;289(1):124-32.

PMID:
12941610
50.

The evolutionary relationships of zebrafish genes tbx6, tbx16/spadetail and mga.

Lardelli M.

Dev Genes Evol. 2003 Oct;213(10):519-22. Epub 2003 Aug 8.

PMID:
12908107

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