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Items: 40

1.

RTD-1 therapeutically normalizes synovial gene signatures in rat autoimmune arthritis and suppresses proinflammatory mediators in RA synovial fibroblasts.

Tongaonkar P, Punj V, Subramanian A, Tran DQ, Trinh KK, Schaal JB, Laragione T, Ouellette AJ, Gulko PS, Selsted ME.

Physiol Genomics. 2019 Dec 1;51(12):657-667. doi: 10.1152/physiolgenomics.00066.2019. Epub 2019 Nov 25.

PMID:
31762409
2.

TRPV2 suppresses Rac1 and RhoA activation and invasion in rheumatoid arthritis fibroblast-like synoviocytes.

Laragione T, Harris C, Gulko PS.

Int Immunopharmacol. 2019 May;70:268-273. doi: 10.1016/j.intimp.2019.02.051. Epub 2019 Mar 6.

PMID:
30851707
3.

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis.

Tanner MR, Pennington MW, Chauhan SS, Laragione T, Gulko PS, Beeton C.

Arthritis Res Ther. 2019 Jan 7;21(1):6. doi: 10.1186/s13075-018-1783-9.

4.

Huntingtin-interacting protein 1 (HIP1) regulates arthritis severity and synovial fibroblast invasiveness by altering PDGFR and Rac1 signalling.

Laragione T, Brenner M, Lahiri A, Gao E, Harris C, Gulko PS.

Ann Rheum Dis. 2018 Nov;77(11):1627-1635. doi: 10.1136/annrheumdis-2018-213498. Epub 2018 Jul 26.

PMID:
30049830
5.

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes.

Ai R, Laragione T, Hammaker D, Boyle DL, Wildberg A, Maeshima K, Palescandolo E, Krishna V, Pocalyko D, Whitaker JW, Bai Y, Nagpal S, Bachman KE, Ainsworth RI, Wang M, Ding B, Gulko PS, Wang W, Firestein GS.

Nat Commun. 2018 May 15;9(1):1921. doi: 10.1038/s41467-018-04310-9.

6.

Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis.

Tanner MR, Pennington MW, Chamberlain BH, Huq R, Gehrmann EJ, Laragione T, Gulko PS, Beeton C.

J Pharmacol Exp Ther. 2018 May;365(2):227-236. doi: 10.1124/jpet.117.245118. Epub 2018 Feb 16.

7.

Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide.

Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME.

PLoS One. 2017 Nov 16;12(11):e0187868. doi: 10.1371/journal.pone.0187868. eCollection 2017.

8.

KCa1.1 channels regulate β1-integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes.

Tanner MR, Pennington MW, Laragione T, Gulko PS, Beeton C.

FASEB J. 2017 Aug;31(8):3309-3320. doi: 10.1096/fj.201601097R. Epub 2017 Apr 20.

9.

Short-term low-magnesium diet reduces autoimmune arthritis severity and synovial tissue gene expression.

Brenner M, Laragione T, Gulko PS.

Physiol Genomics. 2017 Apr 1;49(4):238-242. doi: 10.1152/physiolgenomics.00003.2017. Epub 2017 Mar 3.

PMID:
28258078
10.

Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.

Sula Karreci E, Fan H, Uehara M, Mihali AB, Singh PK, Kurdi AT, Solhjou Z, Riella LV, Ghobrial I, Laragione T, Routray S, Assaker JP, Wang R, Sukenick G, Shi L, Barrat FJ, Nathan CF, Lin G, Azzi J.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8425-E8432. doi: 10.1073/pnas.1618548114. Epub 2016 Dec 12.

11.

Erratum to: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes.

Pethő Z, Tanner MR, Tajhya RB, Huq R, Laragione T, Panyi G, Gulko PS, Beeton C.

Arthritis Res Ther. 2016 Jun 1;18(1):122. No abstract available.

12.

Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes.

Pethő Z, Tanner MR, Tajhya RB, Huq R, Laragione T, Panyi G, Gulko PS, Beeton C.

Arthritis Res Ther. 2016 May 10;18(1):103. doi: 10.1186/s13075-016-1003-4. Erratum in: Arthritis Res Ther. 2016;18(1):122.

13.

The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion.

Laragione T, Cheng KF, Tanner MR, He M, Beeton C, Al-Abed Y, Gulko PS.

Clin Immunol. 2015 Jun;158(2):183-92. doi: 10.1016/j.clim.2015.04.001. Epub 2015 Apr 11.

14.

KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis.

Tanner MR, Hu X, Huq R, Tajhya RB, Sun L, Khan FS, Laragione T, Horrigan FT, Gulko PS, Beeton C.

Arthritis Rheumatol. 2015 Jan;67(1):96-106. doi: 10.1002/art.38883.

15.

Analyses of synovial tissues from arthritic and protected congenic rat strains reveal a new core set of genes associated with disease severity.

Brenner M, Laragione T, Gulko PS.

Physiol Genomics. 2013 Nov 15;45(22):1109-22. doi: 10.1152/physiolgenomics.00108.2013. Epub 2013 Sep 17.

16.

The multiple chemokine-binding bovine herpesvirus 1 glycoprotein G (BHV1gG) inhibits polymorphonuclear cell but not monocyte migration into inflammatory sites.

Liu Z, Bethunaickan R, Sahu R, Brenner M, Laragione T, Gulko PS, Davidson A.

Mol Med. 2013;19:276-85. doi: 10.2119/molmed.2013.00339.

17.

Arthritis severity locus Cia4 is an early regulator of IL-6, IL-1β, and NF-κB activators' expression in pristane-induced arthritis.

Brenner M, Laragione T, Gulko PS.

Physiol Genomics. 2013 Jul 2;45(13):552-64. doi: 10.1152/physiolgenomics.00029.2013. Epub 2013 May 21.

18.

Whole-genome sequences of DA and F344 rats with different susceptibilities to arthritis, autoimmunity, inflammation and cancer.

Guo X, Brenner M, Zhang X, Laragione T, Tai S, Li Y, Bu J, Yin Y, Shah AA, Kwan K, Li Y, Jun W, Gulko PS.

Genetics. 2013 Aug;194(4):1017-28. doi: 10.1534/genetics.113.153049. Epub 2013 May 20.

19.
20.

Identification of two new arthritis severity loci that regulate levels of autoantibodies, interleukin-1β, and joint damage in pristane- and collagen-induced arthritis.

Brenner M, Laragione T, Shah A, Mello A, Remmers EF, Wilder RL, Gulko PS.

Arthritis Rheum. 2012 May;64(5):1369-78. doi: 10.1002/art.33468.

21.

KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis.

Hu X, Laragione T, Sun L, Koshy S, Jones KR, Ismailov II, Yotnda P, Horrigan FT, Gulko PS, Beeton C.

J Biol Chem. 2012 Feb 3;287(6):4014-22. doi: 10.1074/jbc.M111.312264. Epub 2011 Nov 10.

22.

The vitamin D receptor regulates rheumatoid arthritis synovial fibroblast invasion and morphology.

Laragione T, Shah A, Gulko PS.

Mol Med. 2012 Mar 27;18:194-200. doi: 10.2119/molmed.2011.00410.

23.

Synovial expression of Th17-related and cancer-associated genes is regulated by the arthritis severity locus Cia10.

Jenkins E, Brenner M, Laragione T, Gulko PS.

Genes Immun. 2012 Apr;13(3):221-31. doi: 10.1038/gene.2011.73. Epub 2011 Nov 3.

24.

CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis.

Laragione T, Brenner M, Sherry B, Gulko PS.

Arthritis Rheum. 2011 Nov;63(11):3274-83. doi: 10.1002/art.30573.

25.

Strain differences in alveolar neutrophil infiltration and macrophage phenotypes in an acute lung inflammation model.

Zhang Y, Lin X, Koga K, Takahashi K, Linge HM, Mello A, Laragione T, Gulko PS, Miller EJ.

Mol Med. 2011;17(7-8):780-9. doi: 10.2119/molmed.2010.00064. Epub 2011 Apr 28.

26.

mTOR regulates the invasive properties of synovial fibroblasts in rheumatoid arthritis.

Laragione T, Gulko PS.

Mol Med. 2010 Sep-Oct;16(9-10):352-8. doi: 10.2119/molmed.2010.00049. Epub 2010 May 27.

27.

Cia5d regulates a new fibroblast-like synoviocyte invasion-associated gene expression signature.

Laragione T, Brenner M, Li W, Gulko PS.

Arthritis Res Ther. 2008;10(4):R92. doi: 10.1186/ar2476. Epub 2008 Aug 15.

28.

The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts.

Laragione T, Brenner M, Mello A, Symons M, Gulko PS.

Arthritis Rheum. 2008 Aug;58(8):2296-306. doi: 10.1002/art.23610.

29.
30.

Cia25 on rat chromosome 12 regulates severity of autoimmune arthritis induced with pristane and with collagen.

Brenner M, Laragione T, Mello A, Gulko PS.

Ann Rheum Dis. 2007 Jul;66(7):952-7. Epub 2007 Feb 28.

31.

The arthritis severity quantitative trait loci Cia4 and Cia6 regulate neutrophil migration into inflammatory sites and levels of TNF-alpha and nitric oxide.

Laragione T, Yarlett NC, Brenner M, Mello A, Sherry B, Miller EJ, Metz CN, Gulko PS.

J Immunol. 2007 Feb 15;178(4):2344-51.

32.

The arthritis severity quantitative trait locus Cia7 regulates neutrophil migration into inflammatory sites.

Laragione T, Brenner M, Yarlett NC, Mello A, Miller EJ, Metz CN, Sherry B, Gulko PS.

Genes Immun. 2007 Mar;8(2):147-53. Epub 2007 Feb 1.

PMID:
17268510
33.

Regulation of redox-sensitive exofacial protein thiols in CHO cells.

Laragione T, Gianazza E, Tonelli R, Bigini P, Mennini T, Casoni F, Massignan T, Bonetto V, Ghezzi P.

Biol Chem. 2006 Oct-Nov;387(10-11):1371-6. Review.

PMID:
17081109
34.

Cia27 is a novel non-MHC arthritis severity locus on rat chromosome 10 syntenic to the rheumatoid arthritis 17q22-q25 locus.

Brenner M, Laragione T, Yarlett NC, Li W, Mello A, Gulko PS.

Genes Immun. 2006 Jul;7(5):335-41. Epub 2006 May 4.

PMID:
16691185
35.

Microarray analyses of peripheral blood cells identifies unique gene expression signature in psoriatic arthritis.

Batliwalla FM, Li W, Ritchlin CT, Xiao X, Brenner M, Laragione T, Shao T, Durham R, Kemshetti S, Schwarz E, Coe R, Kern M, Baechler EC, Behrens TW, Gregersen PK, Gulko PS.

Mol Med. 2005 Jan-Dec;11(1-12):21-9.

36.

Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats.

Fiordaliso F, Bianchi R, Staszewsky L, Cuccovillo I, Doni M, Laragione T, Salio M, Savino C, Melucci S, Santangelo F, Scanziani E, Masson S, Ghezzi P, Latini R.

J Mol Cell Cardiol. 2004 Nov;37(5):959-68.

PMID:
15522273
37.

Redox regulation of surface protein thiols: identification of integrin alpha-4 as a molecular target by using redox proteomics.

Laragione T, Bonetto V, Casoni F, Massignan T, Bianchi G, Gianazza E, Ghezzi P.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14737-41. Epub 2003 Dec 1. Erratum in: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4718.

38.

Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis.

Villa P, Bigini P, Mennini T, Agnello D, Laragione T, Cagnotto A, Viviani B, Marinovich M, Cerami A, Coleman TR, Brines M, Ghezzi P.

J Exp Med. 2003 Sep 15;198(6):971-5.

39.

Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection.

Ghezzi P, Romines B, Fratelli M, Eberini I, Gianazza E, Casagrande S, Laragione T, Mengozzi M, Herzenberg LA, Herzenberg LA.

Mol Immunol. 2002 Feb;38(10):773-80.

PMID:
11841837
40.

7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.

Macchia M, Salvetti F, Bertini S, Di Bussolo V, Gattuso L, Gesi M, Hamdan M, Klotz KN, Laragione T, Lucacchini A, Minutolo F, Nencetti S, Papi C, Tuscano D, Martini C.

Bioorg Med Chem Lett. 2001 Dec 3;11(23):3023-6.

PMID:
11714602

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