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Items: 36


Alternate subunit assembly diversifies the function of a bacterial toxin.

Fowler CC, Stack G, Jiao X, Lara-Tejero M, Galán JE.

Nat Commun. 2019 Aug 15;10(1):3684. doi: 10.1038/s41467-019-11592-0.


Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model.

Gibani MM, Jones E, Barton A, Jin C, Meek J, Camara S, Galal U, Heinz E, Rosenberg-Hasson Y, Obermoser G, Jones C, Campbell D, Black C, Thomaides-Brears H, Darlow C, Dold C, Silva-Reyes L, Blackwell L, Lara-Tejero M, Jiao X, Stack G, Blohmke CJ, Hill J, Angus B, Dougan G, Galán J, Pollard AJ.

Nat Med. 2019 Jul;25(7):1082-1088. doi: 10.1038/s41591-019-0505-4. Epub 2019 Jul 3.


The Type III Secretion System Sorting Platform.

Lara-Tejero M.

Curr Top Microbiol Immunol. 2019 Jun 11. doi: 10.1007/82_2019_167. [Epub ahead of print]


The Injectisome, a Complex Nanomachine for Protein Injection into Mammalian Cells.

Lara-Tejero M, Galán JE.

EcoSal Plus. 2019 Mar;8(2). doi: 10.1128/ecosalplus.ESP-0039-2018. Review.


Role of SpaO in the assembly of the sorting platform of a Salmonella type III secretion system.

Lara-Tejero M, Qin Z, Hu B, Butan C, Liu J, Galán JE.

PLoS Pathog. 2019 Jan 22;15(1):e1007565. doi: 10.1371/journal.ppat.1007565. eCollection 2019 Jan.


Visualization of the type III secretion mediated Salmonella-host cell interface using cryo-electron tomography.

Park D, Lara-Tejero M, Waxham MN, Li W, Hu B, Galán JE, Liu J.

Elife. 2018 Oct 3;7. pii: e39514. doi: 10.7554/eLife.39514.


Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin.

Geiger T, Pazos M, Lara-Tejero M, Vollmer W, Galán JE.

Nat Microbiol. 2018 Nov;3(11):1243-1254. doi: 10.1038/s41564-018-0248-x. Epub 2018 Sep 24.


Salmonella stimulates pro-inflammatory signalling through p21-activated kinases bypassing innate immune receptors.

Sun H, Kamanova J, Lara-Tejero M, Galán JE.

Nat Microbiol. 2018 Oct;3(10):1122-1130. doi: 10.1038/s41564-018-0246-z. Epub 2018 Sep 17.


Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni.

Gao B, Vorwerk H, Huber C, Lara-Tejero M, Mohr J, Goodman AL, Eisenreich W, Galán JE, Hofreuter D.

PLoS Biol. 2017 May 19;15(5):e2001390. doi: 10.1371/journal.pbio.2001390. eCollection 2017 May.


Visualization and characterization of individual type III protein secretion machines in live bacteria.

Zhang Y, Lara-Tejero M, Bewersdorf J, Galán JE.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6098-6103. doi: 10.1073/pnas.1705823114. Epub 2017 May 22.


In Situ Molecular Architecture of the Salmonella Type III Secretion Machine.

Hu B, Lara-Tejero M, Kong Q, Galán JE, Liu J.

Cell. 2017 Mar 9;168(6):1065-1074.e10. doi: 10.1016/j.cell.2017.02.022.


The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members.

Kamanova J, Sun H, Lara-Tejero M, Galán JE.

PLoS Pathog. 2016 Apr 8;12(4):e1005552. doi: 10.1371/journal.ppat.1005552. eCollection 2016 Apr.


A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis.

Sun H, Kamanova J, Lara-Tejero M, Galán JE.

PLoS Pathog. 2016 Mar 2;12(3):e1005484. doi: 10.1371/journal.ppat.1005484. eCollection 2016 Mar.


A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP.

Spanò S, Gao X, Hannemann S, Lara-Tejero M, Galán JE.

Cell Host Microbe. 2016 Feb 10;19(2):216-26. doi: 10.1016/j.chom.2016.01.004.


Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates.

Tsou LK, Lara-Tejero M, RoseFigura J, Zhang ZJ, Wang YC, Yount JS, Lefebre M, Dossa PD, Kato J, Guan F, Lam W, Cheng YC, Galán JE, Hang HC.

J Am Chem Soc. 2016 Feb 24;138(7):2209-18. doi: 10.1021/jacs.5b11575. Epub 2016 Feb 16.


Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells.

Galán JE, Lara-Tejero M, Marlovits TC, Wagner S.

Annu Rev Microbiol. 2014;68:415-38. doi: 10.1146/annurev-micro-092412-155725. Epub 2014 Jun 18. Review.


Novel components of the flagellar system in epsilonproteobacteria.

Gao B, Lara-Tejero M, Lefebre M, Goodman AL, Galán JE.

MBio. 2014 Jun 24;5(3):e01349-14. doi: 10.1128/mBio.01349-14.


NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system.

Rathinavelan T, Lara-Tejero M, Lefebre M, Chatterjee S, McShan AC, Guo DC, Tang C, Galan JE, De Guzman RN.

J Mol Biol. 2014 Aug 12;426(16):2958-69. doi: 10.1016/j.jmb.2014.06.009. Epub 2014 Jun 18.


Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery.

Carleton HA, Lara-Tejero M, Liu X, Galán JE.

Nat Commun. 2013;4:1590. doi: 10.1038/ncomms2594.


A sorting platform determines the order of protein secretion in bacterial type III systems.

Lara-Tejero M, Kato J, Wagner S, Liu X, Galán JE.

Science. 2011 Mar 4;331(6021):1188-91. doi: 10.1126/science.1201476. Epub 2011 Feb 3.


Organization and coordinated assembly of the type III secretion export apparatus.

Wagner S, Königsmaier L, Lara-Tejero M, Lefebre M, Marlovits TC, Galán JE.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17745-50. doi: 10.1073/pnas.1008053107. Epub 2010 Sep 27.


Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells.

Bruno VM, Hannemann S, Lara-Tejero M, Flavell RA, Kleinstein SH, Galán JE.

PLoS Pathog. 2009 Aug;5(8):e1000538. doi: 10.1371/journal.ppat.1000538. Epub 2009 Aug 7.


A MyD88-deficient mouse model reveals a role for Nramp1 in Campylobacter jejuni infection.

Watson RO, Novik V, Hofreuter D, Lara-Tejero M, Galán JE.

Infect Immun. 2007 Apr;75(4):1994-2003. Epub 2006 Dec 28.


Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse.

Kamanaka M, Kim ST, Wan YY, Sutterwala FS, Lara-Tejero M, Galán JE, Harhaj E, Flavell RA.

Immunity. 2006 Dec;25(6):941-52. Epub 2006 Nov 30.


Assembly of the inner rod determines needle length in the type III secretion injectisome.

Marlovits TC, Kubori T, Lara-Tejero M, Thomas D, Unger VM, Galán JE.

Nature. 2006 Jun 1;441(7093):637-40.


Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.

Lara-Tejero M, Sutterwala FS, Ogura Y, Grant EP, Bertin J, Coyle AJ, Flavell RA, Galán JE.

J Exp Med. 2006 Jun 12;203(6):1407-12. Epub 2006 May 22.


Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.

Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP, Bertin J, Coyle AJ, Galán JE, Askenase PW, Flavell RA.

Immunity. 2006 Mar;24(3):317-27.


A new twist in the hijacking of the actin-nucleating machinery.

Lara-Tejero M, Galán JE.

Mol Cell. 2004 Aug 27;15(4):495-7.


Rapid development of T cell memory.

Wong P, Lara-Tejero M, Ploss A, Leiner I, Pamer EG.

J Immunol. 2004 Jun 15;172(12):7239-45.


T cell responses to Listeria monocytogenes.

Lara-Tejero M, Pamer EG.

Curr Opin Microbiol. 2004 Feb;7(1):45-50. Review.


A bacterial toxin that causes DNA damage to modulate cellular responses.

Lara-Tejero M.

ScientificWorldJournal. 2001 May 1;1:190-1. Review.


Cytolethal distending toxin: limited damage as a strategy to modulate cellular functions.

Lara-Tejero M, Galán JE.

Trends Microbiol. 2002 Mar;10(3):147-52. Review.


Supramolecular structure of the Salmonella typhimurium type III protein secretion system.

Kubori T, Matsushima Y, Nakamura D, Uralil J, Lara-Tejero M, Sukhan A, Galán JE, Aizawa SI.

Science. 1998 Apr 24;280(5363):602-5.

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