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Items: 15

1.

CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I.

Zabaleta N, Barberia M, Martin-Higueras C, Zapata-Linares N, Betancor I, Rodriguez S, Martinez-Turrillas R, Torella L, Vales A, Olagüe C, Vilas-Zornoza A, Castro-Labrador L, Lara-Astiaso D, Prosper F, Salido E, Gonzalez-Aseguinolaza G, Rodriguez-Madoz JR.

Nat Commun. 2018 Dec 21;9(1):5454. doi: 10.1038/s41467-018-07827-1.

2.

Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network.

Román M, López I, Guruceaga E, Baraibar I, Ecay M, Collantes M, Nadal E, Vallejo A, Cadenas S, Miguel ME, Jang JH, Martin-Uriz PS, Castro-Labrador L, Vilas-Zornoza A, Lara-Astiaso D, Ponz-Sarvise M, Rolfo C, Santos ES, Raez LE, Taverna S, Behrens C, Weder W, Wistuba II, Vicent S, Gil-Bazo I.

Cancer Res. 2019 Feb 1;79(3):625-638. doi: 10.1158/0008-5472.CAN-18-1479. Epub 2018 Dec 18.

PMID:
30563891
3.

Early metazoan cell type diversity and the evolution of multicellular gene regulation.

Sebé-Pedrós A, Chomsky E, Pang K, Lara-Astiaso D, Gaiti F, Mukamel Z, Amit I, Hejnol A, Degnan BM, Tanay A.

Nat Ecol Evol. 2018 Jul;2(7):1176-1188. doi: 10.1038/s41559-018-0575-6. Epub 2018 Jun 25.

4.

Diverse continuum of CD4+ T-cell states is determined by hierarchical additive integration of cytokine signals.

Eizenberg-Magar I, Rimer J, Zaretsky I, Lara-Astiaso D, Reich-Zeliger S, Friedman N.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6447-E6456. doi: 10.1073/pnas.1615590114. Epub 2017 Jul 17.

5.

Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.

Mildner A, Schönheit J, Giladi A, David E, Lara-Astiaso D, Lorenzo-Vivas E, Paul F, Chappell-Maor L, Priller J, Leutz A, Amit I, Jung S.

Immunity. 2017 May 16;46(5):849-862.e7. doi: 10.1016/j.immuni.2017.04.018.

6.

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq.

Jaitin DA, Weiner A, Yofe I, Lara-Astiaso D, Keren-Shaul H, David E, Salame TM, Tanay A, van Oudenaarden A, Amit I.

Cell. 2016 Dec 15;167(7):1883-1896.e15. doi: 10.1016/j.cell.2016.11.039.

7.

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome.

Gury-BenAri M, Thaiss CA, Serafini N, Winter DR, Giladi A, Lara-Astiaso D, Levy M, Salame TM, Weiner A, David E, Shapiro H, Dori-Bachash M, Pevsner-Fischer M, Lorenzo-Vivas E, Keren-Shaul H, Paul F, Harmelin A, Eberl G, Itzkovitz S, Tanay A, Di Santo JP, Elinav E, Amit I.

Cell. 2016 Aug 25;166(5):1231-1246.e13. doi: 10.1016/j.cell.2016.07.043. Epub 2016 Aug 18.

8.

Co-ChIP enables genome-wide mapping of histone mark co-occurrence at single-molecule resolution.

Weiner A, Lara-Astiaso D, Krupalnik V, Gafni O, David E, Winter DR, Hanna JH, Amit I.

Nat Biotechnol. 2016 Sep;34(9):953-61. doi: 10.1038/nbt.3652. Epub 2016 Jul 25.

PMID:
27454738
9.

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors.

Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FKB, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I.

Cell. 2016 Jan 14;164(1-2):325. doi: 10.1016/j.cell.2015.12.046. Epub 2016 Jan 14. No abstract available.

10.

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors.

Paul F, Arkin Y, Giladi A, Jaitin DA, Kenigsberg E, Keren-Shaul H, Winter D, Lara-Astiaso D, Gury M, Weiner A, David E, Cohen N, Lauridsen FK, Haas S, Schlitzer A, Mildner A, Ginhoux F, Jung S, Trumpp A, Porse BT, Tanay A, Amit I.

Cell. 2015 Dec 17;163(7):1663-77. doi: 10.1016/j.cell.2015.11.013. Epub 2015 Nov 25. Erratum in: Cell. 2016 Jan 14;164(1-2):325.

11.

Corrigendum: Deterministic direct reprogramming of somatic cells to pluripotency.

Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, Mansour AA, Caspi I, Krupalnik V, Zerbib M, Maza I, Mor N, Baran D, Weinberger L, Jaitin DA, Lara-Astiaso D, Blecher-Gonen R, Shipony Z, Mukamel Z, Hagai T, Gilad S, Amann-Zalcenstein D, Tanay A, Amit I, Novershtern N, Hanna JH.

Nature. 2015 Apr 30;520(7549):710. doi: 10.1038/nature14369. Epub 2015 Apr 1. No abstract available.

PMID:
25830885
12.

Immunogenetics. Chromatin state dynamics during blood formation.

Lara-Astiaso D, Weiner A, Lorenzo-Vivas E, Zaretsky I, Jaitin DA, David E, Keren-Shaul H, Mildner A, Winter D, Jung S, Friedman N, Amit I.

Science. 2014 Aug 22;345(6199):943-9. doi: 10.1126/science.1256271. Epub 2014 Aug 7.

13.

Deterministic direct reprogramming of somatic cells to pluripotency.

Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, Mansour AA, Caspi I, Krupalnik V, Zerbib M, Maza I, Mor N, Baran D, Weinberger L, Jaitin DA, Lara-Astiaso D, Blecher-Gonen R, Shipony Z, Mukamel Z, Hagai T, Gilad S, Amann-Zalcenstein D, Tanay A, Amit I, Novershtern N, Hanna JH.

Nature. 2013 Oct 3;502(7469):65-70. doi: 10.1038/nature12587. Epub 2013 Sep 18. Erratum in: Nature. 2015 Apr 30;520(7549):710.

PMID:
24048479
14.

Complement anaphylatoxins C3a and C5a induce a failing regenerative program in cardiac resident cells. Evidence of a role for cardiac resident stem cells other than cardiomyocyte renewal.

Lara-Astiaso D, Izarra A, Estrada JC, Albo C, Moscoso I, Samper E, Moncayo J, Solano A, Bernad A, Díez-Juan A.

Springerplus. 2012 Dec;1(1):63. doi: 10.1186/2193-1801-1-63. Epub 2012 Dec 12.

15.

High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states.

Blecher-Gonen R, Barnett-Itzhaki Z, Jaitin D, Amann-Zalcenstein D, Lara-Astiaso D, Amit I.

Nat Protoc. 2013 Mar;8(3):539-54. doi: 10.1038/nprot.2013.023. Epub 2013 Feb 21.

PMID:
23429716

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