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Items: 42


Myelin breakdown favours Mycobacterium leprae survival in Schwann cells.

Mietto BS, de Souza BJ, Rosa PS, Pessolani MCV, Lara FA, Sarno EN.

Cell Microbiol. 2019 Oct 25:e13128. doi: 10.1111/cmi.13128. [Epub ahead of print]


Miniemulsion RAFT Copolymerization of MMA with Acrylic Acid and Methacrylic Acid and Bioconjugation with BSA.

Way DV, Braido RS, Dos Reis SA, Lara FA, Pinto JC.

Nanomaterials (Basel). 2019 May 31;9(6). pii: E828. doi: 10.3390/nano9060828.


Ticks as potential vectors of Mycobacterium leprae: Use of tick cell lines to culture the bacilli and generate transgenic strains.

Ferreira JDS, Souza Oliveira DA, Santos JP, Ribeiro CCDU, Baêta BA, Teixeira RC, Neumann ADS, Rosa PS, Pessolani MCV, Moraes MO, Bechara GH, de Oliveira PL, Sorgine MHF, Suffys PN, Fontes ANB, Bell-Sakyi L, Fonseca AH, Lara FA.

PLoS Negl Trop Dis. 2018 Dec 19;12(12):e0007001. doi: 10.1371/journal.pntd.0007001. eCollection 2018 Dec.


PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves.

Díaz Acosta CC, Dias AA, Rosa TLSA, Batista-Silva LR, Rosa PS, Toledo-Pinto TG, Costa FDMR, Lara FA, Rodrigues LS, Mattos KA, Sarno EN, Bozza PT, Guilhot C, de Berrêdo-Pinho M, Pessolani MCV.

PLoS Pathog. 2018 Jul 6;14(7):e1007151. doi: 10.1371/journal.ppat.1007151. eCollection 2018 Jul.


Type I Interferons, Autophagy and Host Metabolism in Leprosy.

Toledo Pinto TG, Batista-Silva LR, Medeiros RCA, Lara FA, Moraes MO.

Front Immunol. 2018 Apr 23;9:806. doi: 10.3389/fimmu.2018.00806. eCollection 2018. Review.


Blood coagulation abnormalities in multibacillary leprosy patients.

Silva DSD, Teixeira LAC, Beghini DG, Ferreira ATDS, Pinho MBM, Rosa PS, Ribeiro MR, Freire MDC, Hacker MA, Nery JADC, Pessolani MCV, Tovar AMF, Sarno EN, Perales J, Bozza FA, Esquenazi D, Monteiro RQ, Lara FA.

PLoS Negl Trop Dis. 2018 Mar 22;12(3):e0006214. doi: 10.1371/journal.pntd.0006214. eCollection 2018 Mar.


The toxic nature of murine amylin and the immune responsivity of pancreatic islet to conformational antibody in mice.

Erthal LCS, Jotha-Mattos L, Lara FA, Dos Reis SA, de Oliveira Pascarelli BM, Costa CM, Souza KLA, Lima LMTR.

Mol Cell Biochem. 2018 Oct;447(1-2):1-7. doi: 10.1007/s11010-018-3288-x. Epub 2018 Jan 25.


A Promising Antiprion Trimethoxychalcone Binds to the Globular Domain of the Cellular Prion Protein and Changes Its Cellular Location.

Ferreira NC, Ascari LM, Hughson AG, Cavalheiro GR, Góes CF, Fernandes PN, Hollister JR, da Conceição RA, Silva DS, Souza AMT, Barbosa MLC, Lara FA, Martins RAP, Caughey B, Cordeiro Y.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01441-17. doi: 10.1128/AAC.01441-17. Print 2018 Feb.


Production and Characterization of F(Ab')2 Fragments Obtained by Enzymatic Digestion from Murine Anti-MRSA PBP2a Monoclonal Antibodies.

de Araujo AEV, de Souza NP, de Sousa APB, Lara FA, Senna JPM.

Appl Biochem Biotechnol. 2018 May;185(1):72-80. doi: 10.1007/s12010-017-2624-z. Epub 2017 Oct 30.


Indoleamine 2,3-dioxygenase and iron are required for Mycobacterium leprae survival.

de Mattos Barbosa MG, da Silva Prata RB, Andrade PR, Ferreira H, de Andrade Silva BJ, da Paixão de Oliveira JA, Assis TQ, de Toledo-Pinto TG, de Lima Bezerra OC, da Costa Nery JA, Rosa PS, Bozza MT, Lara FA, Moraes MO, Schmitz V, Sarno EN, Pinheiro RO.

Microbes Infect. 2017 Nov;19(11):505-514. doi: 10.1016/j.micinf.2017.06.006. Epub 2017 Jul 3.


Subversion of Schwann cell glucose metabolism by Mycobacterium leprae.

Medeiros RC, Girardi KD, Cardoso FK, Mietto BS, Pinto TG, Gomez LS, Rodrigues LS, Gandini M, Amaral JJ, Antunes SL, Corte-Real S, Rosa PS, Pessolani MC, Nery JA, Sarno EN, Batista-Silva LR, Sola-Penna M, de Oliveira MF, Moraes MO, Lara FA.

J Biol Chem. 2016 Nov 18;291(47):24803. No abstract available.


Role of TEFFECTOR/MEMORY Cells, TBX21 Gene Expression and T-Cell Homing Receptor on Type 1 Reaction in Borderline Lepromatous Leprosy Patients.

Dos Santos LN, da Silva PH, Alvim IM, Nery JA, Lara FA, Sarno EN, Esquenazi D.

PLoS One. 2016 Oct 20;11(10):e0164543. doi: 10.1371/journal.pone.0164543. eCollection 2016.


Effect of physical exercise training in patients with Chagas heart disease: study protocol for a randomized controlled trial (PEACH study).

Mendes Fde S, Sousa AS, Souza FC, Pinto VL, Silva PS, Saraiva RM, Xavier SS, Veloso HH, Holanda MT, Costa AR, Carneiro FM, Silva GM, Borges JP, Tibirica E, Pinheiro RO, Lara FA, Hasslocher-Moreno AM, Brasil PE, Mediano MF.

Trials. 2016 Sep 2;17(1):433. doi: 10.1186/s13063-016-1553-4.


Subversion of Schwann Cell Glucose Metabolism by Mycobacterium leprae.

Medeiros RC, Girardi KD, Cardoso FK, Mietto BS, Pinto TG, Gomez LS, Rodrigues LS, Gandini M, Amaral JJ, Antunes SL, Corte-Real S, Rosa PS, Pessolani MC, Nery JA, Sarno EN, Batista-Silva LR, Sola-Penna M, Oliveira MF, Moraes MO, Lara FA.

J Biol Chem. 2016 Oct 7;291(41):21375-21387. Epub 2016 Aug 23. Erratum in: J Biol Chem. 2016 Nov 18;291(47):24803.


DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum.

Dias AA, Silva CO, Santos JP, Batista-Silva LR, Acosta CC, Fontes AN, Pinheiro RO, Lara FA, Machado AM, Nery JA, Sarno EN, Pereira GM, Pessolani MC.

J Immunol. 2016 Sep 1;197(5):1905-13. doi: 10.4049/jimmunol.1600042. Epub 2016 Jul 29.


Fluorescent membrane markers elucidate the association of Borrelia burgdorferi with tick cell lines.

Teixeira RC, Baêta BA, Ferreira JS, Medeiros RC, Maya-Monteiro CM, Lara FA, Bell-Sakyi L, Fonseca AH.

Braz J Med Biol Res. 2016 Jun 20;49(7). pii: S0100-879X2016000700601. doi: 10.1590/1414-431X20165211.


Experimental Infection of Rhodnius prolixus (Hemiptera, Triatominae) with Mycobacterium leprae Indicates Potential for Leprosy Transmission.

Neumann Ada S, Dias Fde A, Ferreira Jda S, Fontes AN, Rosa PS, Macedo RE, Oliveira JH, Teixeira RL, Pessolani MC, Moraes MO, Suffys PN, Oliveira PL, Sorgine MH, Lara FA.

PLoS One. 2016 May 20;11(5):e0156037. doi: 10.1371/journal.pone.0156037. eCollection 2016.


STING-Dependent 2'-5' Oligoadenylate Synthetase-Like Production Is Required for Intracellular Mycobacterium leprae Survival.

de Toledo-Pinto TG, Ferreira AB, Ribeiro-Alves M, Rodrigues LS, Batista-Silva LR, Silva BJ, Lemes RM, Martinez AN, Sandoval FG, Alvarado-Arnez LE, Rosa PS, Shannon EJ, Pessolani MC, Pinheiro RO, Antunes SL, Sarno EN, Lara FA, Williams DL, Ozório Moraes M.

J Infect Dis. 2016 Jul 15;214(2):311-20. doi: 10.1093/infdis/jiw144. Epub 2016 May 14.


Monitoring of the Parasite Load in the Digestive Tract of Rhodnius prolixus by Combined qPCR Analysis and Imaging Techniques Provides New Insights into the Trypanosome Life Cycle.

Dias Fde A, Guerra B, Vieira LR, Perdomo HD, Gandara AC, Amaral RJ, Vollú RE, Gomes SA, Lara FA, Sorgine MH, Medei E, de Oliveira PL, Salmon D.

PLoS Negl Trop Dis. 2015 Oct 23;9(10):e0004186. doi: 10.1371/journal.pntd.0004186. eCollection 2015.


ATP Binding Cassette Transporter Mediates Both Heme and Pesticide Detoxification in Tick Midgut Cells.

Lara FA, Pohl PC, Gandara AC, Ferreira Jda S, Nascimento-Silva MC, Bechara GH, Sorgine MH, Almeida IC, Vaz Ida S Jr, Oliveira PL.

PLoS One. 2015 Aug 10;10(8):e0134779. doi: 10.1371/journal.pone.0134779. eCollection 2015.


Chitin is a component of the Rhodnius prolixus midgut.

Alvarenga ES, Mansur JF, Justi SA, Figueira-Mansur J, Dos Santos VM, Lopez SG, Masuda H, Lara FA, Melo AC, Moreira MF.

Insect Biochem Mol Biol. 2016 Feb;69:61-70. doi: 10.1016/j.ibmb.2015.04.003. Epub 2015 Apr 22.


Statins increase rifampin mycobactericidal effect.

Lobato LS, Rosa PS, Ferreira Jda S, Neumann Ada S, da Silva MG, do Nascimento DC, Soares CT, Pedrini SC, Oliveira DS, Monteiro CP, Pereira GM, Ribeiro-Alves M, Hacker MA, Moraes MO, Pessolani MC, Duarte RS, Lara FA.

Antimicrob Agents Chemother. 2014 Oct;58(10):5766-74. doi: 10.1128/AAC.01826-13. Epub 2014 Jul 21.


Genotyping of Mycobacterium leprae present on Ziehl-Neelsen-stained microscopic slides and in skin biopsy samples from leprosy patients in different geographic regions of Brazil.

Fontes AN, Gomes HM, Araujo MI, Albuquerque EC, Baptista IM, Moura MM, Rezende DS, Pessolani MC, Lara FA, Pontes MA, Gonçalves Hde S, Lucena-Silva N, Sarno EN, Vissa VD, Brennan PJ, Suffys PN.

Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:143-9.


Leprosy patients: neurotrophic factors and axonal markers in skin lesions.

Michellin LB, Barreto JA, Marciano LH, Lara FA, Nogueira ME, Souza VN, Costa MR.

Arq Neuropsiquiatr. 2012 Apr;70(4):281-6.


The role of indoleamine 2, 3-dioxygenase in lepromatous leprosy immunosuppression.

de Souza Sales J, Lara FA, Amadeu TP, de Oliveira Fulco T, da Costa Nery JA, Sampaio EP, Pinheiro RO, Sarno EN.

Clin Exp Immunol. 2011 Aug;165(2):251-63. doi: 10.1111/j.1365-2249.2011.04412.x. Epub 2011 May 18.


Blood meal-derived heme decreases ROS levels in the midgut of Aedes aegypti and allows proliferation of intestinal microbiota.

Oliveira JH, Gonçalves RL, Lara FA, Dias FA, Gandara AC, Menna-Barreto RF, Edwards MC, Laurindo FR, Silva-Neto MA, Sorgine MH, Oliveira PL.

PLoS Pathog. 2011 Mar;7(3):e1001320. doi: 10.1371/journal.ppat.1001320. Epub 2011 Mar 17. Erratum in: PLoS Pathog. 2013 Feb;9(2). doi:10.1371/annotation/34fed6f4-4096-4980-bf2f-b918e14f5ff5.


Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes.

Mattos KA, Lara FA, Oliveira VG, Rodrigues LS, D'Avila H, Melo RC, Manso PP, Sarno EN, Bozza PT, Pessolani MC.

Cell Microbiol. 2011 Feb;13(2):259-73. doi: 10.1111/j.1462-5822.2010.01533.x. Epub 2010 Nov 2.


Sn-protoporphyrin inhibits both heme degradation and hemozoin formation in Rhodnius prolixus midgut.

Caiaffa CD, Stiebler R, Oliveira MF, Lara FA, Paiva-Silva GO, Oliveira PL.

Insect Biochem Mol Biol. 2010 Dec;40(12):855-60. doi: 10.1016/j.ibmb.2010.08.005. Epub 2010 Sep 22.


Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts.

Silva SR, Tempone AJ, Silva TP, Costa MR, Pereira GM, Lara FA, Pessolani MC, Esquenazi D.

Mem Inst Oswaldo Cruz. 2010 Aug;105(5):627-32.


Involvement of 9-O-Acetyl GD3 ganglioside in Mycobacterium leprae infection of Schwann cells.

Ribeiro-Resende VT, Ribeiro-Guimarães ML, Lemes RM, Nascimento IC, Alves L, Mendez-Otero R, Pessolani MC, Lara FA.

J Biol Chem. 2010 Oct 29;285(44):34086-96. doi: 10.1074/jbc.M110.147272. Epub 2010 Aug 25.


On the fate of extracellular hemoglobin and heme in brain.

Lara FA, Kahn SA, da Fonseca AC, Bahia CP, Pinho JP, Graca-Souza AV, Houzel JC, de Oliveira PL, Moura-Neto V, Oliveira MF.

J Cereb Blood Flow Metab. 2009 Jun;29(6):1109-20. doi: 10.1038/jcbfm.2009.34. Epub 2009 Apr 1.


Cellular and molecular characterization of an embryonic cell line (BME26) from the tick Rhipicephalus (Boophilus) microplus.

Esteves E, Lara FA, Lorenzini DM, Costa GH, Fukuzawa AH, Pressinotti LN, Silva JR, Ferro JA, Kurtti TJ, Munderloh UG, Daffre S.

Insect Biochem Mol Biol. 2008 May;38(5):568-80. doi: 10.1016/j.ibmb.2008.01.006. Epub 2008 Feb 9.


An aggregation-prone intermediate species is present in the unfolding pathway of the monomeric portal protein of bacteriophage P22: implications for portal assembly.

Braga CA, Carvalho D, Lara FA, Cortines JR, Moore SD, Prevelige PE Jr, Foguel D.

Biochemistry. 2007 Jun 26;46(25):7353-64. Epub 2007 Jun 2.


Extracellular lipid droplets promote hemozoin crystallization in the gut of the blood fluke Schistosoma mansoni.

Corrêa Soares JB, Maya-Monteiro CM, Bittencourt-Cunha PR, Atella GC, Lara FA, d'Avila JC, Menezes D, Vannier-Santos MA, Oliveira PL, Egan TJ, Oliveira MF.

FEBS Lett. 2007 May 1;581(9):1742-50. Epub 2007 Mar 30.


Heme requirement and intracellular trafficking in Trypanosoma cruzi epimastigotes.

Lara FA, Sant'anna C, Lemos D, Laranja GA, Coelho MG, Reis Salles I, Michel A, Oliveira PL, Cunha-E-Silva N, Salmon D, Paes MC.

Biochem Biophys Res Commun. 2007 Mar 30;355(1):16-22. Epub 2007 Jan 23.


Dopamine affects the stability, hydration, and packing of protofibrils and fibrils of the wild type and variants of alpha-synuclein.

Follmer C, Romão L, Einsiedler CM, Porto TC, Lara FA, Moncores M, Weissmüller G, Lashuel HA, Lansbury P, Neto VM, Silva JL, Foguel D.

Biochemistry. 2007 Jan 16;46(2):472-82.


Oxidative stress impairs heme detoxification in the midgut of the cattle tick, Rhipicephalus (Boophilus) microplus.

Citelli M, Lara FA, da Silva Vaz I Jr, Oliveira PL.

Mol Biochem Parasitol. 2007 Jan;151(1):81-8. Epub 2006 Nov 13.


Heparan sulfate glycosaminoglycan expression in the intestinal tract and ovary of fully engorged adult females of the cattle tick Boophilus microplus and in their laid eggs.

Onofre GR, Lara FA, Oliveira PL, Silva LC.

Mol Biochem Parasitol. 2003 Aug 31;130(2):163-6. No abstract available.


A new intracellular pathway of haem detoxification in the midgut of the cattle tick Boophilus microplus: aggregation inside a specialized organelle, the hemosome.

Lara FA, Lins U, Paiva-Silva G, Almeida IC, Braga CM, Miguens FC, Oliveira PL, Dansa-Petretski M.

J Exp Biol. 2003 May;206(Pt 10):1707-15.


Expression and immunolocalization of a Boophilus microplus cathepsin L-like enzyme.

Renard G, Lara FA, de Cardoso FC, Miguens FC, Dansa-Petretski M, Termignoni C, Masuda A.

Insect Mol Biol. 2002 Aug;11(4):325-8.


HeLp, a heme lipoprotein from the hemolymph of the cattle tick, Boophilus microplus.

Maya-Monteiro CM, Daffre S, Logullo C, Lara FA, Alves EW, Capurro ML, Zingali R, Almeida IC, Oliveira PL.

J Biol Chem. 2000 Nov 24;275(47):36584-9.

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