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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 2
2001 1
2002 4
2003 4
2004 2
2005 1
2006 2
2007 1
2008 3
2009 3
2010 1
2011 3
2012 4
2014 4
2015 3
2016 3
2017 4
2018 3
2019 4
2020 9
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2023 15
2024 2

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116 results

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Page 1
Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma.
Pan J, Zhang M, Dong L, Ji S, Zhang J, Zhang S, Lin Y, Wang X, Ding Z, Qiu S, Gao D, Zhou J, Fan J, Gao Q. Pan J, et al. Autophagy. 2023 Apr;19(4):1184-1198. doi: 10.1080/15548627.2022.2117893. Epub 2022 Sep 7. Autophagy. 2023. PMID: 36037300 Free PMC article.
cld-CASP3: cleaved caspase 3; cld-PARP: cleaved PARP; DTP: drug tolerant persister; GO: Gene Ontology; GTEx: The Genotype-Tissue Expression; HCC: hepatocellular carcinoma; HCQ: hydroxychloroquine; IC50: half maximal inhibitory concentration value; KEGG: Kyoto Encyclopedia of Gene …
cld-CASP3: cleaved caspase 3; cld-PARP: cleaved PARP; DTP: drug tolerant persister; GO: Gene Ontology; GTEx: The Genotype-Tissue Expression; …
LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival.
Yang X, Wen Y, Liu S, Duan L, Liu T, Tong Z, Wang Z, Gu Y, Xi Y, Wang X, Luo D, Zhang R, Liu Y, Wang Y, Cheng T, Jiang S, Zhu X, Yang X, Pan Y, Cheng S, Ye Q, Chen J, Xu X, Gao S. Yang X, et al. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2110428119. doi: 10.1073/pnas.2110428119. Proc Natl Acad Sci U S A. 2022. PMID: 35091468 Free PMC article.
Knockdown of LCDR, hnRNP K, or LAPTM5 promotes lysosomal membrane permeabilization and lysosomal cell death, thus consequently resulting in apoptosis. LAPTM5 overexpression or cathepsin B inhibitor partially restores the effects of this axis on lysosomal cell death …
Knockdown of LCDR, hnRNP K, or LAPTM5 promotes lysosomal membrane permeabilization and lysosomal cell death, thus consequently result …
LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway.
Wang Y, Liu J, Akatsu C, Zhang R, Zhang H, Zhu H, Liu K, Zhu HY, Min Q, Meng X, Cui C, Tang Y, Yu M, Li Y, Feng X, Wei H, Wen Z, Ji S, Weigert MG, Tsubata T, Wang JY. Wang Y, et al. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2205629119. doi: 10.1073/pnas.2205629119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037365 Free PMC article.
LAPTM5 causes BCR internalization, resulting in decreased phosphorylation of SYK and ERK. In addition, LAPTM5 targets the E3 ubiquitin ligase WWP2 for lysosomal degradation, resulting in the accumulation of its substrate PTEN. ...
LAPTM5 causes BCR internalization, resulting in decreased phosphorylation of SYK and ERK. In addition, LAPTM5 targets the E3 u …
Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages.
Zhao L, Wang S, Xu M, He Y, Zhang X, Xiong Y, Sun H, Ding H, Geng W, Shang H, Liang G. Zhao L, et al. Nat Commun. 2021 Jun 17;12(1):3691. doi: 10.1038/s41467-021-24087-8. Nat Commun. 2021. PMID: 34140527 Free PMC article.
Vpr counteracts the restrictive effects of LAPTM5 by triggering its degradation via DCAF1. In the absence of Vpr, the silencing of LAPTM5 precisely phenocopied the effect of Vpr on HIV-1 infection. In contrast, Vpr did not enhance HIV-1 infection in the absence of …
Vpr counteracts the restrictive effects of LAPTM5 by triggering its degradation via DCAF1. In the absence of Vpr, the silencing of …
c-Myc inhibits LAPTM5 expression in B-cell lymphomas.
Zhang Y, Zhang X, Zhang Y, Xu H, Wei Z, Wang X, Li Y, Guo J, Wu F, Fang X, Pang L, Deng B, Yu D. Zhang Y, et al. Ann Hematol. 2023 Dec;102(12):3499-3513. doi: 10.1007/s00277-023-05434-9. Epub 2023 Sep 15. Ann Hematol. 2023. PMID: 37713124
Here, we found that Myc trans-represses the expression of murine LAPTM5, a gene coding a lysosome-associated protein, by binding to two E-boxes in the LAPTM5 promoter. ...Moreover, Myc trans-activated miR-17-3p, which promoted tumor growth. Strikingly, LAPTM5 …
Here, we found that Myc trans-represses the expression of murine LAPTM5, a gene coding a lysosome-associated protein, by binding to t …
LAPTM5-CD40 Crosstalk in Glioblastoma Invasion and Temozolomide Resistance.
Berberich A, Bartels F, Tang Z, Knoll M, Pusch S, Hucke N, Kessler T, Dong Z, Wiestler B, Winkler F, Platten M, Wick W, Abdollahi A, Lemke D. Berberich A, et al. Front Oncol. 2020 Jun 5;10:747. doi: 10.3389/fonc.2020.00747. eCollection 2020. Front Oncol. 2020. PMID: 32582531 Free PMC article.
CD40 knockdown and overexpression were induced to investigate a potential crosstalk of LAPTM5 and CD40. LAPTM5 and CD40 were correlated with the clinical outcome of glioma patients. ...Hence, LAPTM5 may provide a potential biomarker for sensitivity to temozol …
CD40 knockdown and overexpression were induced to investigate a potential crosstalk of LAPTM5 and CD40. LAPTM5 and CD40 were c …
Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.
Jiang B, Zhao X, Chen W, Diao W, Ding M, Qin H, Li B, Cao W, Chen W, Fu Y, He K, Gao J, Chen M, Lin T, Deng Y, Yan C, Guo H. Jiang B, et al. Nat Commun. 2022 Jul 16;13(1):4141. doi: 10.1038/s41467-022-31783-6. Nat Commun. 2022. PMID: 35842443 Free PMC article.
Organotropism during cancer metastasis occurs frequently but the underlying mechanism remains poorly understood. Here, we show that lysosomal protein transmembrane 5 (LAPTM5) promotes lung-specific metastasis in renal cancer. LAPTM5 sustains self-renewal and cancer …
Organotropism during cancer metastasis occurs frequently but the underlying mechanism remains poorly understood. Here, we show that lysosoma …
LAPTM5 is transactivated by RUNX2 and involved in RANKL trafficking in osteoblastic cells.
Geng YM, Liu CX, Lu WY, Liu P, Yuan PY, Liu WL, Xu PP, Shen XQ. Geng YM, et al. Mol Med Rep. 2019 Nov;20(5):4193-4201. doi: 10.3892/mmr.2019.10688. Epub 2019 Sep 16. Mol Med Rep. 2019. PMID: 31545469 Free PMC article.
Chromatin immunoprecipitation analysis identified the binding of RUNX2 to the LAPTM5 promoter at the -1176 to -1171 position. Dual-luciferase reporter assays confirmed that RUNX2 directly activated the LAPTM5 gene. ...The present study indicated that expression of …
Chromatin immunoprecipitation analysis identified the binding of RUNX2 to the LAPTM5 promoter at the -1176 to -1171 position. Dual-lu …
Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.
Jiang L, Zhao J, Yang Q, Li M, Liu H, Xiao X, Tian S, Hu S, Liu Z, Yang P, Chen M, Ye P, Xia J. Jiang L, et al. Nat Commun. 2023 May 8;14(1):2654. doi: 10.1038/s41467-023-37908-9. Nat Commun. 2023. PMID: 37156795 Free PMC article.
The protein level of LAPTM5 bears a negative correlation with NAS score. Moreover, LAPTM5 degradation is mediated through its ubiquitination modification by the E3 ubquitin ligase NEDD4L. Discovered by experiments conducted on male mice, hepatocyte-specific depletio …
The protein level of LAPTM5 bears a negative correlation with NAS score. Moreover, LAPTM5 degradation is mediated through its …
LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/beta-catenin pathway.
Han S, Jin X, Hu T, Chi F. Han S, et al. Oncol Rep. 2023 Mar;49(3):60. doi: 10.3892/or.2023.8497. Epub 2023 Feb 17. Oncol Rep. 2023. PMID: 36799186 Free PMC article.
However, the biological functions and mechanism of LAPTM5 in breast cancer remain unclear. In the present study, the potential tumor-promoting effect of LAPTM5 was predicted by bioinformatics analysis. LAPTM5 was highly expressed in breast cancer clinical spe …
However, the biological functions and mechanism of LAPTM5 in breast cancer remain unclear. In the present study, the potential tumor- …
116 results