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Items: 1 to 50 of 126

1.

CareACT - internet-based intervention for enhancing the psychological well-being of elderly caregivers - a study protocol of a controlled trial.

Lappalainen P, Pakkala I, Nikander R.

BMC Geriatr. 2019 Mar 5;19(1):72. doi: 10.1186/s12877-019-1071-9.

2.

Protein modification fine-tunes the cell's force producers.

Lappalainen P.

Nature. 2019 Jan;565(7739):297-298. doi: 10.1038/d41586-018-07882-0. No abstract available.

PMID:
30635662
3.

Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles.

Jiu Y, Kumari R, Fenix AM, Schaible N, Liu X, Varjosalo M, Krishnan R, Burnette DT, Lappalainen P.

Curr Biol. 2019 Jan 7;29(1):81-92.e5. doi: 10.1016/j.cub.2018.11.045. Epub 2018 Dec 20.

4.

Reducing Stress and Enhancing Academic Buoyancy among Adolescents Using a Brief Web-based Program Based on Acceptance and Commitment Therapy: A Randomized Controlled Trial.

Puolakanaho A, Lappalainen R, Lappalainen P, Muotka JS, Hirvonen R, Eklund KM, Ahonen TPS, Kiuru N.

J Youth Adolesc. 2019 Feb;48(2):287-305. doi: 10.1007/s10964-018-0973-8. Epub 2018 Dec 17.

5.

Calponin-3 is critical for coordinated contractility of actin stress fibers.

Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, Iskratsch T, Lappalainen P.

Sci Rep. 2018 Dec 5;8(1):17670. doi: 10.1038/s41598-018-35948-6.

6.

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner.

Tsai FC, Bertin A, Bousquet H, Manzi J, Senju Y, Tsai MC, Picas L, Miserey-Lenkei S, Lappalainen P, Lemichez E, Coudrier E, Bassereau P.

Elife. 2018 Sep 20;7. pii: e37262. doi: 10.7554/eLife.37262.

7.

Regulation of actin dynamics by PI(4,5)P2 in cell migration and endocytosis.

Senju Y, Lappalainen P.

Curr Opin Cell Biol. 2019 Feb;56:7-13. doi: 10.1016/j.ceb.2018.08.003. Epub 2018 Sep 5. Review.

PMID:
30193157
8.

Psychological inflexibility explains distress in parents whose children have chronic conditions.

Sairanen E, Lappalainen P, Hiltunen A.

PLoS One. 2018 Jul 25;13(7):e0201155. doi: 10.1371/journal.pone.0201155. eCollection 2018.

9.

CaMKK2 Regulates Mechanosensitive Assembly of Contractile Actin Stress Fibers.

Tojkander S, Ciuba K, Lappalainen P.

Cell Rep. 2018 Jul 3;24(1):11-19. doi: 10.1016/j.celrep.2018.06.011.

10.

Structural basis of actin monomer re-charging by cyclase-associated protein.

Kotila T, Kogan K, Enkavi G, Guo S, Vattulainen I, Goode BL, Lappalainen P.

Nat Commun. 2018 May 14;9(1):1892. doi: 10.1038/s41467-018-04231-7.

11.

Molecular mechanism for inhibition of twinfilin by phosphoinositides.

Hakala M, Kalimeri M, Enkavi G, Vattulainen I, Lappalainen P.

J Biol Chem. 2018 Mar 30;293(13):4818-4829. doi: 10.1074/jbc.RA117.000484. Epub 2018 Feb 7.

12.

Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides.

Senju Y, Kalimeri M, Koskela EV, Somerharju P, Zhao H, Vattulainen I, Lappalainen P.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8977-E8986. doi: 10.1073/pnas.1705032114. Epub 2017 Oct 9.

13.

UNC-45a promotes myosin folding and stress fiber assembly.

Lehtimäki JI, Fenix AM, Kotila TM, Balistreri G, Paavolainen L, Varjosalo M, Burnette DT, Lappalainen P.

J Cell Biol. 2017 Dec 4;216(12):4053-4072. doi: 10.1083/jcb.201703107. Epub 2017 Oct 20.

14.

The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.

Khan MH, Salomaa SI, Jacquemet G, Butt U, Miihkinen M, Deguchi T, Kremneva E, Lappalainen P, Humphries MJ, Pouwels J.

J Cell Sci. 2017 Sep 15;130(18):3094-3107. doi: 10.1242/jcs.200329. Epub 2017 Aug 3.

15.

Twinfilin 2a regulates platelet reactivity and turnover in mice.

Stritt S, Beck S, Becker IC, Vögtle T, Hakala M, Heinze KG, Du X, Bender M, Braun A, Lappalainen P, Nieswandt B.

Blood. 2017 Oct 12;130(15):1746-1756. doi: 10.1182/blood-2017-02-770768. Epub 2017 Jul 25.

PMID:
28743718
16.

Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation.

Stefani C, Gonzalez-Rodriguez D, Senju Y, Doye A, Efimova N, Janel S, Lipuma J, Tsai MC, Hamaoui D, Maddugoda MP, Cochet-Escartin O, Prévost C, Lafont F, Svitkina T, Lappalainen P, Bassereau P, Lemichez E.

Nat Commun. 2017 Jun 23;8:15839. doi: 10.1038/ncomms15839.

17.

ADF/Cofilin Accelerates Actin Dynamics by Severing Filaments and Promoting Their Depolymerization at Both Ends.

Wioland H, Guichard B, Senju Y, Myram S, Lappalainen P, Jégou A, Romet-Lemonne G.

Curr Biol. 2017 Jul 10;27(13):1956-1967.e7. doi: 10.1016/j.cub.2017.05.048. Epub 2017 Jun 15.

18.

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.

Pfisterer SG, Gateva G, Horvath P, Pirhonen J, Salo VT, Karhinen L, Varjosalo M, Ryhänen SJ, Lappalainen P, Ikonen E.

Nat Commun. 2017 Mar 31;8:14858. doi: 10.1038/ncomms14858.

19.

Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro.

Gateva G, Kremneva E, Reindl T, Kotila T, Kogan K, Gressin L, Gunning PW, Manstein DJ, Michelot A, Lappalainen P.

Curr Biol. 2017 Mar 6;27(5):705-713. doi: 10.1016/j.cub.2017.01.018. Epub 2017 Feb 16.

20.

Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA.

Jiu Y, Peränen J, Schaible N, Cheng F, Eriksson JE, Krishnan R, Lappalainen P.

J Cell Sci. 2017 Mar 1;130(5):892-902. doi: 10.1242/jcs.196881. Epub 2017 Jan 17.

21.

Actin-binding proteins: the long road to understanding the dynamic landscape of cellular actin networks.

Lappalainen P.

Mol Biol Cell. 2016 Aug 15;27(16):2519-22. doi: 10.1091/mbc.E15-10-0728.

22.

Actin Filament Structures in Migrating Cells.

Lehtimäki J, Hakala M, Lappalainen P.

Handb Exp Pharmacol. 2017;235:123-152. doi: 10.1007/164_2016_28. Review.

PMID:
27469496
23.

Usage and Dose Response of a Mobile Acceptance and Commitment Therapy App: Secondary Analysis of the Intervention Arm of a Randomized Controlled Trial.

Mattila E, Lappalainen R, Välkkynen P, Sairanen E, Lappalainen P, Karhunen L, Peuhkuri K, Korpela R, Kolehmainen M, Ermes M.

JMIR Mhealth Uhealth. 2016 Jul 28;4(3):e90. doi: 10.2196/mhealth.5241.

24.

An online guided ACT intervention for enhancing the psychological wellbeing of university students: A randomized controlled clinical trial.

Räsänen P, Lappalainen P, Muotka J, Tolvanen A, Lappalainen R.

Behav Res Ther. 2016 Mar;78:30-42. doi: 10.1016/j.brat.2016.01.001. Epub 2016 Jan 26.

PMID:
26848517
25.

Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly.

Tojkander S, Gateva G, Husain A, Krishnan R, Lappalainen P.

Elife. 2015 Dec 10;4:e06126. doi: 10.7554/eLife.06126.

26.

IRSp53 senses negative membrane curvature and phase separates along membrane tubules.

Prévost C, Zhao H, Manzi J, Lemichez E, Lappalainen P, Callan-Jones A, Bassereau P.

Nat Commun. 2015 Oct 15;6:8529. doi: 10.1038/ncomms9529.

27.

How Leiomodin and Tropomodulin use a common fold for different actin assembly functions.

Boczkowska M, Rebowski G, Kremneva E, Lappalainen P, Dominguez R.

Nat Commun. 2015 Sep 15;6:8314. doi: 10.1038/ncomms9314.

28.

Web-based acceptance and commitment therapy for depressive symptoms with minimal support: a randomized controlled trial.

Lappalainen P, Langrial S, Oinas-Kukkonen H, Tolvanen A, Lappalainen R.

Behav Modif. 2015 Nov;39(6):805-34. doi: 10.1177/0145445515598142. Epub 2015 Aug 6.

PMID:
26253644
29.

Tropomyosin - master regulator of actin filament function in the cytoskeleton.

Gunning PW, Hardeman EC, Lappalainen P, Mulvihill DP.

J Cell Sci. 2015 Aug 15;128(16):2965-74. doi: 10.1242/jcs.172502. Epub 2015 Aug 3. Review.

30.

MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation.

Saarikangas J, Kourdougli N, Senju Y, Chazal G, Segerstråle M, Minkeviciene R, Kuurne J, Mattila PK, Garrett L, Hölter SM, Becker L, Racz I, Hans W, Klopstock T, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, von Ossowski L, Taira T, Lappalainen P, Rivera C, Hotulainen P.

Dev Cell. 2015 Jun 22;33(6):644-59. doi: 10.1016/j.devcel.2015.04.014. Epub 2015 Jun 4.

31.

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers.

Jiu Y, Lehtimäki J, Tojkander S, Cheng F, Jäälinoja H, Liu X, Varjosalo M, Eriksson JE, Lappalainen P.

Cell Rep. 2015 Jun 16;11(10):1511-8. doi: 10.1016/j.celrep.2015.05.008. Epub 2015 May 28.

32.

Cofilin-2 controls actin filament length in muscle sarcomeres.

Kremneva E, Makkonen MH, Skwarek-Maruszewska A, Gateva G, Michelot A, Dominguez R, Lappalainen P.

Dev Cell. 2014 Oct 27;31(2):215-26. doi: 10.1016/j.devcel.2014.09.002.

33.

GMF promotes leading-edge dynamics and collective cell migration in vivo.

Poukkula M, Hakala M, Pentinmikko N, Sweeney MO, Jansen S, Mattila J, Hietakangas V, Goode BL, Lappalainen P.

Curr Biol. 2014 Nov 3;24(21):2533-40. doi: 10.1016/j.cub.2014.08.066. Epub 2014 Oct 9.

34.

Direct interaction of actin filaments with F-BAR protein pacsin2.

Kostan J, Salzer U, Orlova A, Törö I, Hodnik V, Senju Y, Zou J, Schreiner C, Steiner J, Meriläinen J, Nikki M, Virtanen I, Carugo O, Rappsilber J, Lappalainen P, Lehto VP, Anderluh G, Egelman EH, Djinović-Carugo K.

EMBO Rep. 2014 Nov;15(11):1154-62. doi: 10.15252/embr.201439267. Epub 2014 Sep 12.

35.

ACT Internet-based vs face-to-face? A randomized controlled trial of two ways to deliver Acceptance and Commitment Therapy for depressive symptoms: an 18-month follow-up.

Lappalainen P, Granlund A, Siltanen S, Ahonen S, Vitikainen M, Tolvanen A, Lappalainen R.

Behav Res Ther. 2014 Oct;61:43-54. doi: 10.1016/j.brat.2014.07.006. Epub 2014 Jul 28.

PMID:
25127179
36.

MTSS1 is a metastasis driver in a subset of human melanomas.

Mertz KD, Pathria G, Wagner C, Saarikangas J, Sboner A, Romanov J, Gschaider M, Lenz F, Neumann F, Schreiner W, Nemethova M, Glassmann A, Lappalainen P, Stingl G, Small JV, Fink D, Chin L, Wagner SN.

Nat Commun. 2014 Mar 17;5:3465. doi: 10.1038/ncomms4465.

PMID:
24632752
37.

Palladin promotes assembly of non-contractile dorsal stress fibers through VASP recruitment.

Gateva G, Tojkander S, Koho S, Carpen O, Lappalainen P.

J Cell Sci. 2014 May 1;127(Pt 9):1887-98. doi: 10.1242/jcs.135780. Epub 2014 Feb 4.

38.

Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.

Talman V, Gateva G, Ahti M, Ekokoski E, Lappalainen P, Tuominen RK.

Eur J Pharm Sci. 2014 May 13;55:46-57. doi: 10.1016/j.ejps.2014.01.002. Epub 2014 Jan 29.

PMID:
24486483
39.

The inverse BAR domain protein IBARa drives membrane remodeling to control osmoregulation, phagocytosis and cytokinesis.

Linkner J, Witte G, Zhao H, Junemann A, Nordholz B, Runge-Wollmann P, Lappalainen P, Faix J.

J Cell Sci. 2014 Mar 15;127(Pt 6):1279-92. doi: 10.1242/jcs.140756. Epub 2014 Jan 24.

40.

LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route.

Kanerva K, Uronen RL, Blom T, Li S, Bittman R, Lappalainen P, Peränen J, Raposo G, Ikonen E.

Dev Cell. 2013 Nov 11;27(3):249-62. doi: 10.1016/j.devcel.2013.09.016. Epub 2013 Oct 24.

41.

Membrane-sculpting BAR domains generate stable lipid microdomains.

Zhao H, Michelot A, Koskela EV, Tkach V, Stamou D, Drubin DG, Lappalainen P.

Cell Rep. 2013 Sep 26;4(6):1213-23. doi: 10.1016/j.celrep.2013.08.024. Epub 2013 Sep 19.

42.

Feasibility of a personal health technology-based psychological intervention for men with stress and mood problems: randomized controlled pilot trial.

Lappalainen P, Kaipainen K, Lappalainen R, Hoffrén H, Myllymäki T, Kinnunen ML, Mattila E, Happonen AP, Rusko H, Korhonen I.

JMIR Res Protoc. 2013 Jan 9;2(1):e1. doi: 10.2196/resprot.2389.

43.

Effects of actin-binding proteins on the thermal stability of monomeric actin.

Pivovarova AV, Chebotareva NA, Kremneva EV, Lappalainen P, Levitsky DI.

Biochemistry. 2013 Jan 8;52(1):152-60. doi: 10.1021/bi3012884. Epub 2012 Dec 24.

PMID:
23231323
44.

A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p membrane interactions.

Weber-Boyvat M, Zhao H, Aro N, Yuan Q, Chernov K, Peränen J, Lappalainen P, Jäntti J.

Mol Biol Cell. 2013 Feb;24(3):331-41. doi: 10.1091/mbc.E12-05-0415. Epub 2012 Nov 28.

45.

Mammalian and malaria parasite cyclase-associated proteins catalyze nucleotide exchange on G-actin through a conserved mechanism.

Makkonen M, Bertling E, Chebotareva NA, Baum J, Lappalainen P.

J Biol Chem. 2013 Jan 11;288(2):984-94. doi: 10.1074/jbc.M112.435719. Epub 2012 Nov 26.

46.

Segregation of a missense variant in enteric smooth muscle actin γ-2 with autosomal dominant familial visceral myopathy.

Lehtonen HJ, Sipponen T, Tojkander S, Karikoski R, Järvinen H, Laing NG, Lappalainen P, Aaltonen LA, Tuupanen S.

Gastroenterology. 2012 Dec;143(6):1482-1491.e3. doi: 10.1053/j.gastro.2012.08.045. Epub 2012 Sep 6.

PMID:
22960657
47.

A simple guide to biochemical approaches for analyzing protein-lipid interactions.

Zhao H, Lappalainen P.

Mol Biol Cell. 2012 Aug;23(15):2823-30. doi: 10.1091/mbc.E11-07-0645. Review.

48.

Actin stress fibers--assembly, dynamics and biological roles.

Tojkander S, Gateva G, Lappalainen P.

J Cell Sci. 2012 Apr 15;125(Pt 8):1855-64. doi: 10.1242/jcs.098087. Epub 2012 Apr 29.

49.

Identification of new surfaces of cofilin that link mitochondrial function to the control of multi-drug resistance.

Kotiadis VN, Leadsham JE, Bastow EL, Gheeraert A, Whybrew JM, Bard M, Lappalainen P, Gourlay CW.

J Cell Sci. 2012 May 1;125(Pt 9):2288-99. doi: 10.1242/jcs.099390. Epub 2012 Feb 17.

50.

cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization.

Maddugoda MP, Stefani C, Gonzalez-Rodriguez D, Saarikangas J, Torrino S, Janel S, Munro P, Doye A, Prodon F, Aurrand-Lions M, Goossens PL, Lafont F, Bassereau P, Lappalainen P, Brochard F, Lemichez E.

Cell Host Microbe. 2011 Nov 17;10(5):464-74. doi: 10.1016/j.chom.2011.09.014.

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