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Items: 1 to 50 of 76

1.

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.

Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C.

Sci Signal. 2018 Dec 4;11(559). pii: eaar5536. doi: 10.1126/scisignal.aar5536.

PMID:
30514810
2.

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.

Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, Laporte SA.

Sci Signal. 2018 Dec 4;11(559). pii: eaat1631. doi: 10.1126/scisignal.aat1631.

PMID:
30514808
3.

Novel Pathogenesis of Hypertension and Diastolic Dysfunction Caused by M3R (Muscarinic Cholinergic 3 Receptor) Signaling.

Deng AY, deBlois D, Laporte SA, Gelinas D, Tardif JC, Thorin E, Shi Y, Raignault A, Ménard A.

Hypertension. 2018 Sep;72(3):755-764. doi: 10.1161/HYPERTENSIONAHA.118.11385.

PMID:
30354759
4.

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.

Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ.

Sci Signal. 2018 Sep 25;11(549). pii: eaat7650. doi: 10.1126/scisignal.aat7650.

PMID:
30254056
5.

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor.

Chun LS, Vekariya RH, Free RB, Li Y, Lin DT, Su P, Liu F, Namkung Y, Laporte SA, Moritz AE, Aubé J, Frankowski KJ, Sibley DR.

Front Synaptic Neurosci. 2018 Feb 21;10:2. doi: 10.3389/fnsyn.2018.00002. eCollection 2018.

6.

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.

Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M.

Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.

7.

Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2.

Goldberg AA, Joung KB, Mansuri A, Kang Y, Echavarria R, Nikolajev L, Sun Y, Yu JJ, Laporte SA, Schwertani A, Kristof AS.

Oncotarget. 2016 Sep 20;7(38):61152-61165. doi: 10.18632/oncotarget.10748.

8.

Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET.

Namkung Y, Le Gouill C, Lukashova V, Kobayashi H, Hogue M, Khoury E, Song M, Bouvier M, Laporte SA.

Nat Commun. 2016 Jul 11;7:12178. doi: 10.1038/ncomms12178.

9.

Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction.

Bradley SJ, Wiegman CH, Iglesias MM, Kong KC, Butcher AJ, Plouffe B, Goupil E, Bourgognon JM, Macedo-Hatch T, LeGouill C, Russell K, Laporte SA, König GM, Kostenis E, Bouvier M, Chung KF, Amrani Y, Tobin AB.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4524-9. doi: 10.1073/pnas.1521706113. Epub 2016 Apr 8.

10.

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.

Lee MH, Appleton KM, Strungs EG, Kwon JY, Morinelli TA, Peterson YK, Laporte SA, Luttrell LM.

Nature. 2016 Mar 31;531(7596):665-8. doi: 10.1038/nature17154. Epub 2016 Mar 23.

11.

β-Arrestin-mediated Angiotensin II Signaling Controls the Activation of ARF6 Protein and Endocytosis in Migration of Vascular Smooth Muscle Cells.

Charles R, Namkung Y, Cotton M, Laporte SA, Claing A.

J Biol Chem. 2016 Feb 19;291(8):3967-81. doi: 10.1074/jbc.M115.684357. Epub 2015 Dec 24.

12.

The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.

13.

Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F2α receptor.

Boukanoun MK, Hou X, Nikolajev L, Ratni S, Olson D, Claing A, Laporte SA, Chemtob S, Lubell WD.

Org Biomol Chem. 2015 Jul 28;13(28):7750-61. doi: 10.1039/c5ob00962f. Epub 2015 Jun 19.

PMID:
26090777
14.

Quantifying biased signaling in GPCRs using BRET-based biosensors.

Namkung Y, Radresa O, Armando S, Devost D, Beautrait A, Le Gouill C, Laporte SA.

Methods. 2016 Jan 1;92:5-10. doi: 10.1016/j.ymeth.2015.04.010. Epub 2015 Apr 15.

PMID:
25890247
15.

Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells.

Goupil E, Fillion D, Clément S, Luo X, Devost D, Sleno R, Pétrin D, Saragovi HU, Thorin É, Laporte SA, Hébert TE.

J Biol Chem. 2015 Jan 30;290(5):3137-48. doi: 10.1074/jbc.M114.631119. Epub 2014 Dec 15.

16.

Differential regulation of endosomal GPCR/β-arrestin complexes and trafficking by MAPK.

Khoury E, Nikolajev L, Simaan M, Namkung Y, Laporte SA.

J Biol Chem. 2014 Aug 22;289(34):23302-17. doi: 10.1074/jbc.M114.568147. Epub 2014 Jul 11.

17.

Allosteric and biased g protein-coupled receptor signaling regulation: potentials for new therapeutics.

Khoury E, Clément S, Laporte SA.

Front Endocrinol (Lausanne). 2014 May 8;5:68. doi: 10.3389/fendo.2014.00068. eCollection 2014. Review.

18.

A simple method to detect allostery in GPCR dimers.

Goupil E, Laporte SA, Hébert TE.

Methods Cell Biol. 2013;117:165-79. doi: 10.1016/B978-0-12-408143-7.00009-8.

PMID:
24143977
19.

T cell-induced airway smooth muscle cell proliferation via the epidermal growth factor receptor.

Al Heialy S, Risse PA, Zeroual MA, Roman HN, Tsuchiya K, Siddiqui S, Laporte SA, Martin JG.

Am J Respir Cell Mol Biol. 2013 Oct;49(4):563-70. doi: 10.1165/rcmb.2012-0356OC.

PMID:
23656597
20.

GPCR heterodimers: asymmetries in ligand binding and signalling output offer new targets for drug discovery.

Goupil E, Laporte SA, Hébert TE.

Br J Pharmacol. 2013 Mar;168(5):1101-3. doi: 10.1111/bph.12040.

21.

Functional selectivity in GPCR signaling: understanding the full spectrum of receptor conformations.

Goupil E, Laporte SA, Hébert TE.

Mini Rev Med Chem. 2012 Aug;12(9):817-30. Review.

PMID:
22681252
22.

Biasing the prostaglandin F2α receptor responses toward EGFR-dependent transactivation of MAPK.

Goupil E, Wisehart V, Khoury E, Zimmerman B, Jaffal S, Hébert TE, Laporte SA.

Mol Endocrinol. 2012 Jul;26(7):1189-202. doi: 10.1210/me.2011-1245. Epub 2012 May 25.

23.

Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs.

Zimmerman B, Beautrait A, Aguila B, Charles R, Escher E, Claing A, Bouvier M, Laporte SA.

Sci Signal. 2012 Apr 24;5(221):ra33. doi: 10.1126/scisignal.2002522.

24.

Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: implications for ERK1/2 activation in human myometrial cells.

Wrzal PK, Goupil E, Laporte SA, Hébert TE, Zingg HH.

Cell Signal. 2012 Jan;24(1):333-41. doi: 10.1016/j.cellsig.2011.09.019. Epub 2011 Sep 22.

PMID:
21964067
25.

Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization.

Wrzal PK, Devost D, Pétrin D, Goupil E, Iorio-Morin C, Laporte SA, Zingg HH, Hébert TE.

Cell Signal. 2012 Jan;24(1):342-50. doi: 10.1016/j.cellsig.2011.09.020. Epub 2011 Sep 22.

PMID:
21963428
26.

Study of G protein-coupled receptor/β-arrestin interactions within endosomes using FRAP.

Aguila B, Simaan M, Laporte SA.

Methods Mol Biol. 2011;756:371-80. doi: 10.1007/978-1-61779-160-4_23.

PMID:
21870240
27.

Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics.

Bourguet CB, Goupil E, Tassy D, Hou X, Thouin E, Polyak F, Hébert TE, Claing A, Laporte SA, Chemtob S, Lubell WD.

J Med Chem. 2011 Sep 8;54(17):6085-97. doi: 10.1021/jm200608k. Epub 2011 Aug 9.

PMID:
21774512
28.

Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality.

Béliveau F, Brulé C, Désilets A, Zimmerman B, Laporte SA, Lavoie CL, Leduc R.

J Biol Chem. 2011 Aug 19;286(33):29035-43. doi: 10.1074/jbc.M111.223461. Epub 2011 Jul 1.

29.

Role of ßarrestins in bradykinin B2 receptor-mediated signalling.

Zimmerman B, Simaan M, Akoume MY, Houri N, Chevallier S, Séguéla P, Laporte SA.

Cell Signal. 2011 Apr;23(4):648-59. doi: 10.1016/j.cellsig.2010.11.016. Epub 2010 Dec 8.

PMID:
21145390
30.

An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production.

Mathurin K, Gallant MA, Germain P, Allard-Chamard H, Brisson J, Iorio-Morin C, de Brum Fernandes A, Caron MG, Laporte SA, Parent JL.

J Biol Chem. 2011 Jan 28;286(4):2696-706. doi: 10.1074/jbc.M110.178277. Epub 2010 Nov 26.

31.

A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway.

Goupil E, Tassy D, Bourguet C, Quiniou C, Wisehart V, Pétrin D, Le Gouill C, Devost D, Zingg HH, Bouvier M, Saragovi HU, Chemtob S, Lubell WD, Claing A, Hébert TE, Laporte SA.

J Biol Chem. 2010 Aug 13;285(33):25624-36. doi: 10.1074/jbc.M110.115196. Epub 2010 Jun 15.

32.

Cellular signalling: Peptide hormones and growth factors.

Posner BI, Laporte SA.

Prog Brain Res. 2010;181:1-16. doi: 10.1016/S0079-6123(08)81001-1. Review.

PMID:
20478429
33.

Gbetagamma is a negative regulator of AP-1 mediated transcription.

Robitaille M, Gora S, Wang Y, Goupil E, Pétrin D, Del Duca D, Villeneuve LR, Allen BG, Laporte SA, Bernard DJ, Hébert TE.

Cell Signal. 2010 Aug;22(8):1254-66. doi: 10.1016/j.cellsig.2010.04.005. Epub 2010 Apr 18.

PMID:
20403427
34.

Cross-talk between signaling pathways can generate robust oscillations in calcium and cAMP.

Siso-Nadal F, Fox JJ, Laporte SA, Hébert TE, Swain PS.

PLoS One. 2009 Oct 21;4(10):e7189. doi: 10.1371/journal.pone.0007189.

35.

TGFbeta-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration.

Guo J, Chen H, Ho J, Mancini J, Sontag T, Laporte SA, Richard DE, Lebrun JJ.

Cell Signal. 2009 Jun;21(6):899-905.

PMID:
19385060
36.

c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway.

Zimmerman B, Simaan M, Lee MH, Luttrell LM, Laporte SA.

Cell Signal. 2009 Jan;21(1):103-10. doi: 10.1016/j.cellsig.2008.09.013. Epub 2008 Oct 1.

PMID:
18938240
37.

Inferring the lifetime of endosomal protein complexes by fluorescence recovery after photobleaching.

Gousseva V, Simaan M, Laporte SA, Swain PS.

Biophys J. 2008 Jan 15;94(2):679-87. Epub 2007 Sep 7.

38.

ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin.

Poupart ME, Fessart D, Cotton M, Laporte SA, Claing A.

Cell Signal. 2007 Nov;19(11):2370-8. Epub 2007 Jul 31.

PMID:
17719203
39.

Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2.

Hamdan FF, Rochdi MD, Breton B, Fessart D, Michaud DE, Charest PG, Laporte SA, Bouvier M.

J Biol Chem. 2007 Oct 5;282(40):29089-100. Epub 2007 Aug 3.

40.

Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.

Fessart D, Simaan M, Zimmerman B, Comeau J, Hamdan FF, Wiseman PW, Bouvier M, Laporte SA.

J Cell Sci. 2007 May 15;120(Pt 10):1723-32. Epub 2007 Apr 24.

41.

Novel roles for arrestins in G protein-coupled receptor biology and drug discovery.

Claing A, Laporte SA.

Curr Opin Drug Discov Devel. 2005 Sep;8(5):585-9. Review.

PMID:
16159020
42.

The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction.

Ho J, Cocolakis E, Dumas VM, Posner BI, Laporte SA, Lebrun JJ.

EMBO J. 2005 Sep 21;24(18):3247-58. Epub 2005 Aug 25.

43.

Dissociation of beta-arrestin from internalized bradykinin B2 receptor is necessary for receptor recycling and resensitization.

Simaan M, Bédard-Goulet S, Fessart D, Gratton JP, Laporte SA.

Cell Signal. 2005 Sep;17(9):1074-83. Epub 2005 Jan 18.

PMID:
15993749
44.
45.

C5L2 is a functional receptor for acylation-stimulating protein.

Kalant D, MacLaren R, Cui W, Samanta R, Monk PN, Laporte SA, Cianflone K.

J Biol Chem. 2005 Jun 24;280(25):23936-44. Epub 2005 Apr 14.

46.
47.
48.

Involvement of a cytoplasmic-tail serine cluster in urotensin II receptor internalization.

Proulx CD, Simaan M, Escher E, Laporte SA, Guillemette G, Leduc R.

Biochem J. 2005 Jan 1;385(Pt 1):115-23.

49.

Real-time detection of interactions between the human oxytocin receptor and G protein-coupled receptor kinase-2.

Hasbi A, Devost D, Laporte SA, Zingg HH.

Mol Endocrinol. 2004 May;18(5):1277-86. Epub 2004 Feb 19.

PMID:
14976224
50.

Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates.

Barak LS, Zhang J, Ferguson SS, Laporte SA, Caron MG.

Methods Enzymol. 1999;302:153-71. No abstract available.

PMID:
12876769

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