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Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation.

Esfahani K, Al-Aubodah TA, Thebault P, Lapointe R, Hudson M, Johnson NA, Baran D, Bhulaiga N, Takano T, Cailhier JF, Piccirillo CA, Miller WH.

Nat Commun. 2019 Oct 17;10(1):4712. doi: 10.1038/s41467-019-12628-1.


Alemtuzumab for Immune-Related Myocarditis Due to PD-1 Therapy.

Esfahani K, Buhlaiga N, Thébault P, Lapointe R, Johnson NA, Miller WH Jr.

N Engl J Med. 2019 Jun 13;380(24):2375-2376. doi: 10.1056/NEJMc1903064. No abstract available.


Advancing the clinical nurse leader model through academic-practice-policy partnership.

Bender M, Baker P, Harris JL, Hites L, LaPointe RJ, Murphy EA, Roussel L, Spiva L, Stanley JM, Thomas PL, Williams M.

Nurs Outlook. 2019 Jul - Aug;67(4):345-353. doi: 10.1016/j.outlook.2019.02.007. Epub 2019 Feb 16.


Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification.

Monette A, Bergeron D, Ben Amor A, Meunier L, Caron C, Mes-Masson AM, Kchir N, Hamzaoui K, Jurisica I, Lapointe R.

J Immunother Cancer. 2019 Mar 28;7(1):86. doi: 10.1186/s40425-019-0544-x.


Failed immune responses across multiple pathologies share pan-tumor and circulating lymphocytic targets.

Monette A, Morou A, Al-Banna NA, Rousseau L, Lattouf JB, Rahmati S, Tokar T, Routy JP, Cailhier JF, Kaufmann DE, Jurisica I, Lapointe R.

J Clin Invest. 2019 Mar 26;129(6):2463-2479. doi: 10.1172/JCI125301.


Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers.

Gruosso T, Gigoux M, Manem VSK, Bertos N, Zuo D, Perlitch I, Saleh SMI, Zhao H, Souleimanova M, Johnson RM, Monette A, Ramos VM, Hallett MT, Stagg J, Lapointe R, Omeroglu A, Meterissian S, Buisseret L, Van den Eynden G, Salgado R, Guiot MC, Haibe-Kains B, Park M.

J Clin Invest. 2019 Apr 1;129(4):1785-1800. doi: 10.1172/JCI96313. Epub 2019 Mar 18.


Portal vein embolization does not affect the long-term survival and risk of cancer recurrence among colorectal liver metastases patients: A prospective cohort study.

Collin Y, Paré A, Belblidia A, Létourneau R, Plasse M, Dagenais M, Turcotte S, Martel G, Roy A, Lapointe R, Vandenbroucke-Menu F.

Int J Surg. 2019 Jan;61:42-47. doi: 10.1016/j.ijsu.2018.11.029. Epub 2018 Dec 8.


An Innovative Approach to Improve Communication and Reduce Physician Stress and Burnout in a University Affiliated Residency Program.

Lapointe R, Bhesania S, Tanner T, Peruri A, Mehta P.

J Med Syst. 2018 May 28;42(7):117. doi: 10.1007/s10916-018-0956-z.


Preliminary Experience in Combined Somatic and Cerebral Oximetry Monitoring in Liver Transplantation.

Hu T, Collin Y, Lapointe R, Carrier FM, Massicotte L, Fortier A, Lambert J, Vandenbroucke-Menu F, Denault AY.

J Cardiothorac Vasc Anesth. 2018 Feb;32(1):73-84. doi: 10.1053/j.jvca.2017.07.019. Epub 2017 Jul 20.


Peripheral and local predictive immune signatures identified in a phase II trial of ipilimumab with carboplatin/paclitaxel in unresectable stage III or stage IV melanoma.

Jamal R, Lapointe R, Cocolakis E, Thébault P, Kazemi S, Friedmann JE, Dionne J, Cailhier JF, Bélanger K, Ayoub JP, Le H, Lambert C, El-Hajjar J, van Kempen LC, Spatz A, Miller WH Jr.

J Immunother Cancer. 2017 Nov 21;5(1):83. doi: 10.1186/s40425-017-0290-x.


Laparoscopic versus open parenchymal preserving liver resections in the posterosuperior segments: a case-matched study.

D'Hondt M, Tamby E, Boscart I, Turcotte S, Parmentier I, Pottel H, Lapointe R, Ovaere S, Vansteenkiste F, Vandenbroucke-Menu F.

Surg Endosc. 2018 Mar;32(3):1478-1485. doi: 10.1007/s00464-017-5835-z. Epub 2017 Sep 15.


Long-term outcomes of patients with 10 or more colorectal liver metastases.

Allard MA, Adam R, Giuliante F, Lapointe R, Hubert C, Ijzermans JNM, Mirza DF, Elias D, Laurent C, Gruenberger T, Poston G, Letoublon C, Isoniemi H, Lucidi V, Popescu I, Figueras J.

Br J Cancer. 2017 Aug 22;117(5):604-611. doi: 10.1038/bjc.2017.218. Epub 2017 Jul 20.


Prediction of Hepatocellular Carcinoma Recurrence Beyond Milan Criteria After Resection: Validation of a Clinical Risk Score in an International Cohort.

Zheng J, Chou JF, Gönen M, Vachharajani N, Chapman WC, Majella Doyle MB, Turcotte S, Vandenbroucke-Menu F, Lapointe R, Buettner S, Groot Koerkamp B, Ijzermans JNM, Chan CY, Goh BKP, Teo JY, Kam JH, Jeyaraj PR, Cheow PC, Chung AYF, Chow PKH, Ooi LLPJ, Balachandran VP, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Jarnagin WR, Lee SY.

Ann Surg. 2017 Oct;266(4):693-701. doi: 10.1097/SLA.0000000000002360.


The hemochromatosis protein HFE 20 years later: An emerging role in antigen presentation and in the immune system.

Reuben A, Chung JW, Lapointe R, Santos MM.

Immun Inflamm Dis. 2017 Sep;5(3):218-232. doi: 10.1002/iid3.158. Epub 2017 Apr 19. Review.


Outcomes of parenchyma-preserving hepatectomy and right hepatectomy for solitary small colorectal liver metastasis: A LiverMetSurvey study.

Hosokawa I, Allard MA, Mirza DF, Kaiser G, Barroso E, Lapointe R, Laurent C, Ferrero A, Miyazaki M, Adam R.

Surgery. 2017 Aug;162(2):223-232. doi: 10.1016/j.surg.2017.02.012. Epub 2017 Apr 20.


Resection of colorectal liver metastases after second-line chemotherapy: is it worthwhile? A LiverMetSurvey analysis of 6415 patients.

Adam R, Yi B, Innominato PF, Barroso E, Laurent C, Giuliante F, Capussotti L, Lapointe R, Regimbeau JM, Lopez-Ben S, Isoniemi H, Hubert C, Lin JK, Gruenberger T, Elias D, Skipenko OG, Guglielmi A; LiverMetSurvey International Contributing Centers.

Eur J Cancer. 2017 Jun;78:7-15. doi: 10.1016/j.ejca.2017.03.009. Epub 2017 Apr 10.


Feasibility, safety and efficacy of two-stage hepatectomy for bilobar liver metastases of colorectal cancer: a LiverMetSurvey analysis.

Regimbeau JM, Cosse C, Kaiser G, Hubert C, Laurent C, Lapointe R, Isoniemi H, Adam R.

HPB (Oxford). 2017 May;19(5):396-405. doi: 10.1016/j.hpb.2017.01.008. Epub 2017 Mar 23.


Stereotactic Body Radiotherapy for Inoperable Liver Tumors: Results of a Single Institutional Experience.

Hijazi H, Campeau MP, Roberge D, Donath D, Lapointe R, Vandenbroucke-Menu F, Taussky D, Boudam K, Chan G, Bujold A, Delouya G.

Cureus. 2016 Dec 20;8(12):e935. doi: 10.7759/cureus.935.


Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization.

Tahiri H, Omri S, Yang C, Duhamel F, Samarani S, Ahmad A, Vezina M, Bussières M, Vaucher E, Sapieha P, Hickson G, Hammamji K, Lapointe R, Rodier F, Tremblay S, Royal I, Cailhier JF, Chemtob S, Hardy P.

Sci Rep. 2016 Nov 22;6:37391. doi: 10.1038/srep37391.


Inflammation enhances the vaccination potential of CD40-activated B cells in mice.

Mathieu M, Odagiu L, Gaudot L, Daudelin JF, Melichar HJ, Lapointe R, Labrecque N.

Eur J Immunol. 2017 Feb;47(2):269-279. doi: 10.1002/eji.201646568. Epub 2016 Dec 27.


Chitosan thermogels for local expansion and delivery of tumor-specific T lymphocytes towards enhanced cancer immunotherapies.

Monette A, Ceccaldi C, Assaad E, Lerouge S, Lapointe R.

Biomaterials. 2016 Jan;75:237-249. doi: 10.1016/j.biomaterials.2015.10.021. Epub 2015 Oct 9.


Comparison of techniques for volumetric analysis of the future liver remnant: implications for major hepatic resections.

Martel G, Cieslak KP, Huang R, van Lienden KP, Wiggers JK, Belblidia A, Dagenais M, Lapointe R, van Gulik TM, Vandenbroucke-Menu F.

HPB (Oxford). 2015 Dec;17(12):1051-7. doi: 10.1111/hpb.12480. Epub 2015 Sep 16.


Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines.

Mukawera E, Chartier S, Williams V, Pagano PJ, Lapointe R, Grandvaux N.

Redox Biol. 2015 Dec;6:9-18. doi: 10.1016/j.redox.2015.06.010. Epub 2015 Jun 23.


Role of neoadjuvant chemotherapy in resectable synchronous colorectal liver metastasis; An international multi-center data analysis using LiverMetSurvey.

Bonney GK, Coldham C, Adam R, Kaiser G, Barroso E, Capussotti L, Laurent C, Verhoef C, Nuzzo G, Elias D, Lapointe R, Hubert C, Lopez-Ben S, Krawczyk M, Mirza DF; LiverMetSurvey International Registry Working Group.

J Surg Oncol. 2015 May;111(6):716-24. doi: 10.1002/jso.23899. Epub 2015 Apr 9.


T lymphocyte-derived TNF and IFN-γ repress HFE expression in cancer cells.

Reuben A, Godin-Ethier J, Santos MM, Lapointe R.

Mol Immunol. 2015 Jun;65(2):259-66. doi: 10.1016/j.molimm.2015.01.029. Epub 2015 Feb 18.


Surgical management of symptomatic hydatid liver disease: experience from a Western centre.

Martel G, Ismail S, Bégin A, Vandenbroucke-Menu F, Lapointe R.

Can J Surg. 2014 Oct;57(5):320-6.


Transarterial embolization therapies for the treatment of hepatocellular carcinoma: CEPO review and clinical recommendations.

Boily G, Villeneuve JP, Lacoursière L, Chaudhury P, Couture F, Ouellet JF, Lapointe R, Goulet S, Gervais N; Comité de l'évolution des pratiques en oncologie.

HPB (Oxford). 2015 Jan;17(1):52-65. doi: 10.1111/hpb.12273. Epub 2014 Jun 24. Review.


Accuracy of preoperative automatic measurement of the liver volume by CT-scan combined to a 3D virtual surgical planning software (3DVSP).

Bégin A, Martel G, Lapointe R, Belblidia A, Lepanto L, Soler L, Mutter D, Marescaux J, Vandenbroucke-Menu F.

Surg Endosc. 2014 Dec;28(12):3408-12. doi: 10.1007/s00464-014-3611-x. Epub 2014 Jun 14.


Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection.

Jenabian MA, Patel M, Kema I, Vyboh K, Kanagaratham C, Radzioch D, Thébault P, Lapointe R, Gilmore N, Ancuta P, Tremblay C, Routy JP.

Clin Exp Immunol. 2014 Oct;178(1):102-11. doi: 10.1111/cei.12396.


Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.

Hanafi LA, Gauchat D, Godin-Ethier J, Possamaï D, Duvignaud JB, Leclerc D, Grandvaux N, Lapointe R.

PLoS One. 2014 Jun 9;9(6):e99211. doi: 10.1371/journal.pone.0099211. eCollection 2014.


The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation.

Reuben A, Phénix M, Santos MM, Lapointe R.

Eur J Immunol. 2014 Jun;44(6):1604-14. doi: 10.1002/eji.201343955. Epub 2014 Mar 20.


Impact of peri-operative bevacizumab on survival in patients with resected colorectal liver metastases: an analysis of the LiverMetSurvey.

Rong Z, Martel G, Vandenbroucke-Menu F, Adam R, Lapointe R.

HPB (Oxford). 2014 Apr;16(4):342-9. doi: 10.1111/hpb.12138.


Early recurrence after liver resection for colorectal metastases: risk factors, prognosis, and treatment. A LiverMetSurvey-based study of 6,025 patients.

Viganò L, Capussotti L, Lapointe R, Barroso E, Hubert C, Giuliante F, Ijzermans JN, Mirza DF, Elias D, Adam R.

Ann Surg Oncol. 2014 Apr;21(4):1276-86. doi: 10.1245/s10434-013-3421-8. Epub 2013 Dec 18.


Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers.

Jenabian MA, Patel M, Kema I, Kanagaratham C, Radzioch D, Thébault P, Lapointe R, Tremblay C, Gilmore N, Ancuta P, Routy JP.

PLoS One. 2013 Oct 16;8(10):e78146. doi: 10.1371/journal.pone.0078146. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/11698dd2-0bc1-4fe0-ad92-b161b5594e81.


Comparative genome sequence analysis of Choristoneura occidentalis Freeman and C. rosaceana Harris (Lepidoptera: Tortricidae) alphabaculoviruses.

Thumbi DK, Béliveau C, Cusson M, Lapointe R, Lucarotti CJ.

PLoS One. 2013 Jul 5;8(7):e68968. doi: 10.1371/journal.pone.0068968. Print 2013.


Systematic review and meta-analysis of liver resection for metastatic melanoma.

Aubin JM, Rekman J, Vandenbroucke-Menu F, Lapointe R, Fairfull-Smith RJ, Mimeault R, Balaa FK, Martel G.

Br J Surg. 2013 Aug;100(9):1138-47. doi: 10.1002/bjs.9189. Epub 2013 Jun 17. Review.


Carcinoma of the gallbladder: patterns of presentation, prognostic factors and survival rate. An 11-year single centre experience.

D'Hondt M, Lapointe R, Benamira Z, Pottel H, Plasse M, Letourneau R, Roy A, Dagenais M, Vandenbroucke-Menu F.

Eur J Surg Oncol. 2013 Jun;39(6):548-53. doi: 10.1016/j.ejso.2013.02.010. Epub 2013 Mar 21.


Successful orthotopic liver transplantation after biliopancreatic diversion with duodenal switch.

Auclair M, Martel G, Lapointe R.

Surg Obes Relat Dis. 2013 May-Jun;9(3):e46-8. doi: 10.1016/j.soard.2012.12.005. Epub 2013 Jan 11. No abstract available.


mRNA PCR-based epitope chase method.

Doucet JD, Gauchat D, Lapointe R.

Methods Mol Biol. 2013;969:305-20. doi: 10.1007/978-1-62703-260-5_19. Review.


Heterotopic pancreas presenting as suspicious mass in the gallbladder.

Foucault A, Veilleux H, Martel G, Lapointe R, Vandenbroucke-Menu F.

JOP. 2012 Nov 10;13(6):700-1. doi: 10.6092/1590-8577/1192.


Targeting the MHC Class II antigen presentation pathway in cancer immunotherapy.

Thibodeau J, Bourgeois-Daigneault MC, Lapointe R.

Oncoimmunology. 2012 Sep 1;1(6):908-916.


Cancer classification using the Immunoscore: a worldwide task force.

Galon J, Pagès F, Marincola FM, Angell HK, Thurin M, Lugli A, Zlobec I, Berger A, Bifulco C, Botti G, Tatangelo F, Britten CM, Kreiter S, Chouchane L, Delrio P, Arndt H, Asslaber M, Maio M, Masucci GV, Mihm M, Vidal-Vanaclocha F, Allison JP, Gnjatic S, Hakansson L, Huber C, Singh-Jasuja H, Ottensmeier C, Zwierzina H, Laghi L, Grizzi F, Ohashi PS, Shaw PA, Clarke BA, Wouters BG, Kawakami Y, Hazama S, Okuno K, Wang E, O'Donnell-Tormey J, Lagorce C, Pawelec G, Nishimura MI, Hawkins R, Lapointe R, Lundqvist A, Khleif SN, Ogino S, Gibbs P, Waring P, Sato N, Torigoe T, Itoh K, Patel PS, Shukla SN, Palmqvist R, Nagtegaal ID, Wang Y, D'Arrigo C, Kopetz S, Sinicrope FA, Trinchieri G, Gajewski TF, Ascierto PA, Fox BA.

J Transl Med. 2012 Oct 3;10:205. doi: 10.1186/1479-5876-10-205. Review.


Stimulation of Wnt/ß-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype.

Forget MA, Huon Y, Reuben A, Grange C, Liberman M, Martin J, Mes-Masson AM, Arbour N, Lapointe R.

PLoS One. 2012;7(7):e41074. doi: 10.1371/journal.pone.0041074. Epub 2012 Jul 30.


Transfusion rate for 500 consecutive liver transplantations: experience of one liver transplantation center.

Massicotte L, Denault AY, Beaulieu D, Thibeault L, Hevesi Z, Nozza A, Lapointe R, Roy A.

Transplantation. 2012 Jun 27;93(12):1276-81. doi: 10.1097/TP.0b013e318250fc25.


MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression.

Galbas T, Steimle V, Lapointe R, Ishido S, Thibodeau J.

Cytokine. 2012 Jul;59(1):27-30. doi: 10.1016/j.cyto.2012.03.015. Epub 2012 Apr 12.


Improvement of the PapMV nanoparticle adjuvant property through an increased of its avidity for the antigen [influenza NP].

Savard C, Laliberté-Gagné MÈ, Babin C, Bolduc M, Guérin A, Drouin K, Forget MA, Majeau N, Lapointe R, Leclerc D.

Vaccine. 2012 Mar 28;30(15):2535-42. doi: 10.1016/j.vaccine.2012.01.085. Epub 2012 Feb 8.


CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells.

Mathieu M, Cotta-Grand N, Daudelin JF, Boulet S, Lapointe R, Labrecque N.

PLoS One. 2012;7(1):e30139. doi: 10.1371/journal.pone.0030139. Epub 2012 Jan 23.


Defining the critical hurdles in cancer immunotherapy.

Fox BA, Schendel DJ, Butterfield LH, Aamdal S, Allison JP, Ascierto PA, Atkins MB, Bartunkova J, Bergmann L, Berinstein N, Bonorino CC, Borden E, Bramson JL, Britten CM, Cao X, Carson WE, Chang AE, Characiejus D, Choudhury AR, Coukos G, de Gruijl T, Dillman RO, Dolstra H, Dranoff G, Durrant LG, Finke JH, Galon J, Gollob JA, Gouttefangeas C, Grizzi F, Guida M, Håkansson L, Hege K, Herberman RB, Hodi FS, Hoos A, Huber C, Hwu P, Imai K, Jaffee EM, Janetzki S, June CH, Kalinski P, Kaufman HL, Kawakami K, Kawakami Y, Keilholtz U, Khleif SN, Kiessling R, Kotlan B, Kroemer G, Lapointe R, Levitsky HI, Lotze MT, Maccalli C, Maio M, Marschner JP, Mastrangelo MJ, Masucci G, Melero I, Melief C, Murphy WJ, Nelson B, Nicolini A, Nishimura MI, Odunsi K, Ohashi PS, O'Donnell-Tormey J, Old LJ, Ottensmeier C, Papamichail M, Parmiani G, Pawelec G, Proietti E, Qin S, Rees R, Ribas A, Ridolfi R, Ritter G, Rivoltini L, Romero PJ, Salem ML, Scheper RJ, Seliger B, Sharma P, Shiku H, Singh-Jasuja H, Song W, Straten PT, Tahara H, Tian Z, van Der Burg SH, von Hoegen P, Wang E, Welters MJ, Winter H, Withington T, Wolchok JD, Xiao W, Zitvogel L, Zwierzina H, Marincola FM, Gajewski TF, Wigginton JM, Disis ML.

J Transl Med. 2011 Dec 14;9:214. doi: 10.1186/1479-5876-9-214.


Complete sequence, analysis and organization of the Orgyia leucostigma nucleopolyhedrovirus genome.

Thumbi DK, Eveleigh RJ, Lucarotti CJ, Lapointe R, Graham RI, Pavlik L, Lauzon HA, Arif BM.

Viruses. 2011 Nov;3(11):2301-27. doi: 10.3390/v3112301. Epub 2011 Nov 15.


Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives.

Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R.

Clin Cancer Res. 2011 Nov 15;17(22):6985-91. doi: 10.1158/1078-0432.CCR-11-1331. Epub 2011 Nov 8. Review.

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