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Items: 1 to 50 of 95

1.

Revealing Drug Self-Associations into Nano-Entities.

Dlim MM, Shahout FS, Khabir MK, Labonté PP, LaPlante SR.

ACS Omega. 2019 May 23;4(5):8919-8925. doi: 10.1021/acsomega.9b00667. eCollection 2019 May 31.

2.

Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay.

Ayotte Y, Marando VM, Vaillancourt L, Bouchard P, Heffron G, Coote PW, Larda ST, LaPlante SR.

J Med Chem. 2019 Sep 12;62(17):7885-7896. doi: 10.1021/acs.jmedchem.9b00653. Epub 2019 Sep 3.

PMID:
31422659
3.

Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention: Clinical and Economic Impact of Standard Versus Extended Duration [Internet].

Wells GA, Elliott J, Kelly S, Bai Z, Boucher M, Skidmore B, So D, Laplante S, Lee K.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Mar.

4.

Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity.

Leroy M, Mélin L, LaPlante SR, Medina-Franco JL, Gagnon A.

Bioorg Med Chem Lett. 2019 Mar 15;29(6):826-831. doi: 10.1016/j.bmcl.2019.01.022. Epub 2019 Jan 22.

PMID:
30704813
5.

Composite Resin Versus Amalgam for Dental Restorations: A Health Technology Assessment [Internet].

Khangura SD, Seal K, Esfandiari S, Quiñonez C, Mierzwinski-Urban M, Mulla SM, Laplante S, Tsoi B, Godfrey C, Weeks L, Helis E, Wells C, Pullman D, Basu N.

Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2018 Mar.

6.

Anticosti Island: a hot spot for Neospondylis upiformis (Coleoptera: Cerambycidae) in eastern Canada?

Hébert C, Laplante S, Fréchette M, Jobin L.

Biodivers Data J. 2018 Jul 19;(6):e25553. doi: 10.3897/BDJ.6.e25553. eCollection 2018.

7.

Fragment-Based Phenotypic Lead Discovery: Cell-Based Assay to Target Leishmaniasis.

Ayotte Y, Bilodeau F, Descoteaux A, LaPlante SR.

ChemMedChem. 2018 Jul 18;13(14):1377-1386. doi: 10.1002/cmdc.201800161. Epub 2018 May 30.

PMID:
29722149
8.

Impact of Fluid Choice in Systemic Inflammatory Response Syndrome Patients on Hospital Cost Savings.

Laplante S, Makhija DU, Munson SH, Khangulov VS, Peyerl FW, Paluszkiewicz SM, Ravindranath AJ, Schermer CR.

Pharmacoecon Open. 2018 Sep;2(3):325-335. doi: 10.1007/s41669-017-0055-y.

9.

Remote Monitoring of Automated Peritoneal Dialysis Patients: Assessing Clinical and Economic Value.

Makhija D, Alscher MD, Becker S, D'Alonzo S, Mehrotra R, Wong L, McLeod K, Danek J, Gellens M, Kudelka T, Sloand JA, Laplante S.

Telemed J E Health. 2018 Apr;24(4):315-323. doi: 10.1089/tmj.2017.0046. Epub 2017 Oct 12.

PMID:
29024613
10.

NMR strategies to support medicinal chemistry workflows for primary structure determination.

Oguadinma P, Bilodeau F, LaPlante SR.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):242-247. doi: 10.1016/j.bmcl.2016.11.066. Epub 2016 Nov 24.

PMID:
27913183
11.

Authors' Reply to Gandjour "The Cost Effectiveness of High-Dose Versus Conventional Haemodialysis: A Systematic Review".

Laplante S, Liu FX, Culleton B, Bernardo A, King D, Hudson P.

Appl Health Econ Health Policy. 2016 Dec;14(6):731-732. No abstract available.

PMID:
27744597
12.

Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.

Fader LD, Bailey M, Beaulieu E, Bilodeau F, Bonneau P, Bousquet Y, Carson RJ, Chabot C, Coulombe R, Duan J, Fenwick C, Garneau M, Halmos T, Jakalian A, James C, Kawai SH, Landry S, LaPlante SR, Mason SW, Morin S, Rioux N, Simoneau B, Surprenant S, Thavonekham B, Thibeault C, Trinh T, Tsantrizos Y, Tsoung J, Yoakim C, Wernic D.

ACS Med Chem Lett. 2016 Jun 9;7(8):797-801. doi: 10.1021/acsmedchemlett.6b00194. eCollection 2016 Aug 11.

13.

Comparative Effectiveness of Dialyzers: A Longitudinal, Propensity Score-Matched Study of Incident Hemodialysis Patients.

Sibbel S, Hunt A, Laplante S, Beck W, Gellens M, Brunelli SM.

ASAIO J. 2016 Sep-Oct;62(5):613-22. doi: 10.1097/MAT.0000000000000409.

14.

Remote Monitoring of Chronic Diseases: A Landscape Assessment of Policies in Four European Countries.

Rojahn K, Laplante S, Sloand J, Main C, Ibrahim A, Wild J, Sturt N, Areteou T, Johnson KI.

PLoS One. 2016 May 19;11(5):e0155738. doi: 10.1371/journal.pone.0155738. eCollection 2016.

15.

Optimizing postoperative care protocols in thoracic surgery: best evidence and new technology.

French DG, Dilena M, LaPlante S, Shamji F, Sundaresan S, Villeneuve J, Seely A, Maziak D, Gilbert S.

J Thorac Dis. 2016 Feb;8(Suppl 1):S3-S11. doi: 10.3978/j.issn.2072-1439.2015.10.67. Review.

16.

The Cost Effectiveness of High-Dose versus Conventional Haemodialysis: a Systematic Review.

Laplante S, Liu FX, Culleton B, Bernardo A, King D, Hudson P.

Appl Health Econ Health Policy. 2016 Apr;14(2):185-93. doi: 10.1007/s40258-015-0212-3. Review.

PMID:
26691659
17.

Incorportation of Ethyl Esters of EPA and DHA in Soybean Lecithin Using Rhizomucor miehei Lipase: Effect of Additives and Solvent-Free Conditions.

Marsaoui N, Naghmouchi K, Baah J, Raies A, Laplante S.

Appl Biochem Biotechnol. 2015 Jun;176(3):938-46. doi: 10.1007/s12010-015-1621-3. Epub 2015 Apr 18.

PMID:
25894950
18.

A global overview of renal registries: a systematic review.

Liu FX, Rutherford P, Smoyer-Tomic K, Prichard S, Laplante S.

BMC Nephrol. 2015 Mar 19;16:31. doi: 10.1186/s12882-015-0028-2. Review.

19.

Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.

Beaulieu PL, Bolger G, Deon D, Duplessis M, Fazal G, Gagnon A, Garneau M, LaPlante S, Stammers T, Kukolj G, Duan J.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):1140-5. doi: 10.1016/j.bmcl.2014.12.078. Epub 2015 Jan 3.

PMID:
25599836
20.

Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.

Fader LD, Carson R, Morin S, Bilodeau F, Chabot C, Halmos T, Bailey MD, Kawai SH, Coulombe R, Laplante S, Mekhssian K, Jakalian A, Garneau M, Duan J, Mason SW, Simoneau B, Fenwick C, Tsantrizos Y, Yoakim C.

ACS Med Chem Lett. 2014 Apr 16;5(6):711-6. doi: 10.1021/ml500110j. eCollection 2014 Jun 12.

21.

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.

Fader LD, Malenfant E, Parisien M, Carson R, Bilodeau F, Landry S, Pesant M, Brochu C, Morin S, Chabot C, Halmos T, Bousquet Y, Bailey MD, Kawai SH, Coulombe R, LaPlante S, Jakalian A, Bhardwaj PK, Wernic D, Schroeder P, Amad M, Edwards P, Garneau M, Duan J, Cordingley M, Bethell R, Mason SW, Bös M, Bonneau P, Poupart MA, Faucher AM, Simoneau B, Fenwick C, Yoakim C, Tsantrizos Y.

ACS Med Chem Lett. 2014 Jan 22;5(4):422-7. doi: 10.1021/ml500002n. eCollection 2014 Apr 10.

22.

Offering assisted peritoneal dialysis is a cost-effective alternative to the current care pathway in frail elderly Dutch patients.

Laplante S, Krepel H, Simons B, Nijhoff A, van Liere R, Simons M.

Int J Healthc Manag. 2013 Apr;6(1):27-36.

23.

Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor.

Fenwick C, Amad M, Bailey MD, Bethell R, Bös M, Bonneau P, Cordingley M, Coulombe R, Duan J, Edwards P, Fader LD, Faucher AM, Garneau M, Jakalian A, Kawai S, Lamorte L, LaPlante S, Luo L, Mason S, Poupart MA, Rioux N, Schroeder P, Simoneau B, Tremblay S, Tsantrizos Y, Witvrouw M, Yoakim C.

Antimicrob Agents Chemother. 2014 Jun;58(6):3233-44. doi: 10.1128/AAC.02719-13. Epub 2014 Mar 24.

24.

Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.

LaPlante SR, Padyana AK, Abeywardane A, Bonneau P, Cartier M, Coulombe R, Jakalian A, Wildeson-Jones J, Li X, Liang S, McKercher G, White P, Zhang Q, Taylor SJ.

J Med Chem. 2014 Mar 13;57(5):2074-90. doi: 10.1021/jm401432c. Epub 2014 Jan 27.

PMID:
24467709
25.

Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.

Stammers TA, Coulombe R, Duplessis M, Fazal G, Gagnon A, Garneau M, Goulet S, Jakalian A, LaPlante S, Rancourt J, Thavonekham B, Wernic D, Kukolj G, Beaulieu PL.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6879-85. doi: 10.1016/j.bmcl.2013.09.102. Epub 2013 Oct 8.

PMID:
24176401
26.

Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127).

LaPlante SR, Bös M, Brochu C, Chabot C, Coulombe R, Gillard JR, Jakalian A, Poirier M, Rancourt J, Stammers T, Thavonekham B, Beaulieu PL, Kukolj G, Tsantrizos YS.

J Med Chem. 2014 Mar 13;57(5):1845-54. doi: 10.1021/jm4011862. Epub 2013 Nov 11.

PMID:
24159919
27.

Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease.

LaPlante SR, Nar H, Lemke CT, Jakalian A, Aubry N, Kawai SH.

J Med Chem. 2014 Mar 13;57(5):1777-89. doi: 10.1021/jm401338c. Epub 2013 Nov 8.

PMID:
24144444
28.

Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity.

LaPlante SR, Forgione P, Boucher C, Coulombe R, Gillard J, Hucke O, Jakalian A, Joly MA, Kukolj G, Lemke C, McCollum R, Titolo S, Beaulieu PL, Stammers T.

J Med Chem. 2014 Mar 13;57(5):1944-51. doi: 10.1021/jm401202a. Epub 2013 Sep 30.

PMID:
24024973
29.

Monitoring drug self-aggregation and potential for promiscuity in off-target in vitro pharmacology screens by a practical NMR strategy.

LaPlante SR, Aubry N, Bolger G, Bonneau P, Carson R, Coulombe R, Sturino C, Beaulieu PL.

J Med Chem. 2013 Sep 12;56(17):7073-83. doi: 10.1021/jm4008714. Epub 2013 Aug 22.

PMID:
23919803
30.

N- versus O-alkylation: utilizing NMR methods to establish reliable primary structure determinations for drug discovery.

LaPlante SR, Bilodeau F, Aubry N, Gillard JR, O'Meara J, Coulombe R.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4663-8. doi: 10.1016/j.bmcl.2013.06.007. Epub 2013 Jun 12.

PMID:
23809849
31.

Incorporation of omega-3 polyunsaturated fatty acids into soybean lecithin: effect of amines and divalent cations on transesterification by lipases.

Marsaoui N, Laplante S, Raies A, Naghmouchi K.

World J Microbiol Biotechnol. 2013 Dec;29(12):2233-8. doi: 10.1007/s11274-013-1388-z. Epub 2013 Jun 9.

PMID:
23749246
32.

Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists.

LaPlante SR, Carson R, Gillard J, Aubry N, Coulombe R, Bordeleau S, Bonneau P, Little M, O'Meara J, Beaulieu PL.

J Med Chem. 2013 Jun 27;56(12):5142-50. doi: 10.1021/jm400535b. Epub 2013 Jun 13.

PMID:
23730910
33.

Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors.

Tremblay M, Bethell RC, Cordingley MG, DeRoy P, Duan J, Duplessis M, Edwards PJ, Faucher AM, Halmos T, James CA, Kuhn C, Lacoste JÉ, Lamorte L, LaPlante SR, Malenfant E, Minville J, Morency L, Morin S, Rajotte D, Salois P, Simoneau B, Tremblay S, Sturino CF.

Bioorg Med Chem Lett. 2013 May 1;23(9):2775-80. doi: 10.1016/j.bmcl.2013.02.042. Epub 2013 Feb 16.

PMID:
23511023
34.

Discovery of the first thumb pocket 1 NS5B polymerase inhibitor (BILB 1941) with demonstrated antiviral activity in patients chronically infected with genotype 1 hepatitis C virus (HCV).

Beaulieu PL, Bös M, Cordingley MG, Chabot C, Fazal G, Garneau M, Gillard JR, Jolicoeur E, LaPlante S, McKercher G, Poirier M, Poupart MA, Tsantrizos YS, Duan J, Kukolj G.

J Med Chem. 2012 Sep 13;55(17):7650-66. doi: 10.1021/jm3006788. Epub 2012 Aug 16.

PMID:
22849725
35.

Assessing atropisomer axial chirality in drug discovery and development.

Laplante SR, D Fader L, Fandrick KR, Fandrick DR, Hucke O, Kemper R, Miller SP, Edwards PJ.

J Med Chem. 2011 Oct 27;54(20):7005-22. doi: 10.1021/jm200584g. Epub 2011 Sep 15. Review. No abstract available.

PMID:
21848318
36.

Preparation of counterion stabilized concentrated silver sols.

LaPlante S, Halaciuga I, Goia DV.

J Colloid Interface Sci. 2011 Jul 1;359(1):121-5. doi: 10.1016/j.jcis.2011.03.080. Epub 2011 Mar 30.

PMID:
21497824
37.

The effect of the P1 side chain on the binding of optimized carboxylate and activated carbonyl inhibitors of the hepatitis C virus NS3 protease.

Kawai SH, LaPlante SR, Llinàs-Brunet M, Hucke O.

Future Med Chem. 2010 Jul;2(7):1073-81. doi: 10.4155/fmc.10.198.

PMID:
21426157
38.

Revealing atropisomer axial chirality in drug discovery.

LaPlante SR, Edwards PJ, Fader LD, Jakalian A, Hucke O.

ChemMedChem. 2011 Mar 7;6(3):505-13. doi: 10.1002/cmdc.201000485. Epub 2011 Jan 5.

PMID:
21360821
39.

Precipitation of dispersed silver particles using acetone as reducing agent.

Halaciuga I, Laplante S, Goia DV.

J Colloid Interface Sci. 2011 Feb 15;354(2):620-3. doi: 10.1016/j.jcis.2010.11.014. Epub 2010 Nov 13.

PMID:
21134680
40.

Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.

LaPlante SR, Gillard JR, Jakalian A, Aubry N, Coulombe R, Brochu C, Tsantrizos YS, Poirier M, Kukolj G, Beaulieu PL.

J Am Chem Soc. 2010 Nov 3;132(43):15204-12. doi: 10.1021/ja101358s.

PMID:
20942454
41.

Recovery and characterization of a serine collagenolytic extract from snow crab (Chionoecetes opilio) by-products.

Souchet N, Laplante S.

Appl Biochem Biotechnol. 2011 Mar;163(6):765-79. doi: 10.1007/s12010-010-9081-2. Epub 2010 Sep 20.

PMID:
20853161
42.

Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: improved drug-like properties through C-2 SAR in three sub-series.

Beaulieu PL, Dansereau N, Duan J, Garneau M, Gillard J, McKercher G, LaPlante S, Lagacée L, Thauvette L, Kukolj G.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1825-9. doi: 10.1016/j.bmcl.2010.02.003. Epub 2010 Feb 6.

PMID:
20185309
43.

N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.

Beaulieu PL, Jolicoeur E, Gillard J, Brochu C, Coulombe R, Dansereau N, Duan J, Garneau M, Jakalian A, Kühn P, Lagacé L, LaPlante S, McKercher G, Perrault S, Poirier M, Poupart MA, Stammers T, Thauvette L, Thavonekham B, Kukolj G.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):857-61. doi: 10.1016/j.bmcl.2009.12.101. Epub 2010 Jan 4.

PMID:
20074949
44.

Dimethylthiazolidine carboxylic acid as a rigid p3 unit in inhibitors of serine proteases: application to two targets.

Kawai SH, Aubry N, Duceppe JS, Llinàs-Brunet M, LaPlante SR.

Chem Biol Drug Des. 2009 Nov;74(5):517-22. doi: 10.1111/j.1747-0285.2009.00870.x. Epub 2009 Sep 22.

PMID:
19780760
45.

The challenge of atropisomerism in drug discovery.

Clayden J, Moran WJ, Edwards PJ, LaPlante SR.

Angew Chem Int Ed Engl. 2009;48(35):6398-401. doi: 10.1002/anie.200901719. Review. No abstract available.

PMID:
19637174
46.

The use of chemical double-mutant cycles in biomolecular recognition studies: application to HCV NS3 protease inhibitors.

Kawai SH, Bailey MD, Halmos T, Forgione P, Laplante SR, Llinàs-Brunet M, Naud J, Goudreau N.

ChemMedChem. 2008 Nov;3(11):1654-7. doi: 10.1002/cmdc.200800214. No abstract available.

PMID:
18942693
47.

Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

O'Meara JA, Jakalian A, LaPlante S, Bonneau PR, Coulombe R, Faucher AM, Guse I, Landry S, Racine J, Simoneau B, Thavonekham B, Yoakim C.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3362-6. Epub 2007 Apr 5.

PMID:
17451954
48.

Seasonal and geographical variations of sterol composition in snow crab hepatopancreas and pelagic fish viscera from Eastern Quebec.

Souchet N, Laplante S.

Comp Biochem Physiol B Biochem Mol Biol. 2007 Jul;147(3):378-86. Epub 2007 Feb 12.

PMID:
17374564
49.

Quantifying trifluoroacetic acid as a counterion in drug discovery by 19F NMR and capillary electrophoresis.

Little MJ, Aubry N, Beaudoin ME, Goudreau N, LaPlante SR.

J Pharm Biomed Anal. 2007 Mar 12;43(4):1324-30. Epub 2006 Dec 4.

PMID:
17145157
50.

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.

Beaulieu PL, Gillard J, Bykowski D, Brochu C, Dansereau N, Duceppe JS, Haché B, Jakalian A, Lagacé L, LaPlante S, McKercher G, Moreau E, Perreault S, Stammers T, Thauvette L, Warrington J, Kukolj G.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):4987-93.

PMID:
16908138

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