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The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis.

Mouchiroud M, Camiré É, Aldow M, Caron A, Jubinville É, Turcotte L, Kaci I, Beaulieu MJ, Roy C, Labbé SM, Varin TV, Gélinas Y, Lamothe J, Trottier J, Mitchell PL, Guénard F, Festuccia WT, Joubert P, Rose CF, Karvellas CJ, Barbier O, Morissette MC, Marette A, Laplante M.

Mol Metab. 2019 Dec;30:184-191. doi: 10.1016/j.molmet.2019.09.014. Epub 2019 Oct 4.


The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis.

Mouchiroud M, Camiré É, Aldow M, Caron A, Jubinville É, Turcotte L, Kaci I, Beaulieu MJ, Roy C, Labbé SM, Varin TV, Gélinas Y, Lamothe J, Trottier J, Mitchell PL, Guénard F, Festuccia WT, Joubert P, Rose CF, Karvellas CJ, Barbier O, Morissette MC, Marette A, Laplante M.

JCI Insight. 2019 Aug 8;4(15). pii: 129492. doi: 10.1172/jci.insight.129492. eCollection 2019 Aug 8.


HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide.

Girard R, Darsigny M, Jones C, Maloum-Rami F, Gélinas Y, Carpentier AC, Laplante M, Perreault N, Boudreau F.

Sci Rep. 2019 Mar 12;9(1):4200. doi: 10.1038/s41598-019-41061-z.


PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.

Besse-Patin A, Jeromson S, Levesque-Damphousse P, Secco B, Laplante M, Estall JL.

Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4285-4290. doi: 10.1073/pnas.1815150116. Epub 2019 Feb 15.


Pharmacological activation of liver X receptor during cigarette smoke exposure adversely affects alveolar macrophages and pulmonary surfactant homeostasis.

Jubinville É, Routhier J, Maranda-Robitaille M, Pineault M, Milad N, Talbot M, Beaulieu MJ, Aubin S, Paré MÈ, Laplante M, Morissette MC.

Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1;316(4):L669-L678. doi: 10.1152/ajplung.00482.2018. Epub 2019 Jan 31.


Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung.

Clemenceau A, Boucherat O, Landry-Truchon K, Lamontagne M, Biardel S, Joubert P, Gobeil S, Secco B, Laplante M, Morissette M, Obeidat M, Timens W, Jeannotte L, Bossé Y.

Int J Dev Biol. 2018;62(11-12):857-864. doi: 10.1387/ijdb.180210yb.


Cytokines promote lipolysis in 3T3-L1 adipocytes through induction of NADPH oxidase 3 expression and superoxide production.

Issa N, Lachance G, Bellmann K, Laplante M, Stadler K, Marette A.

J Lipid Res. 2018 Dec;59(12):2321-2328. doi: 10.1194/jlr.M086504. Epub 2018 Oct 12.


DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation.

Wedel J, Bruneau S, Liu K, Kong SW, Sage PT, Sabatini DM, Laplante M, Briscoe DM.

Am J Transplant. 2019 Jan;19(1):77-88. doi: 10.1111/ajt.14995. Epub 2018 Aug 17.


DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.

Caron A, Briscoe DM, Richard D, Laplante M.

Physiol Rev. 2018 Jul 1;98(3):1765-1803. doi: 10.1152/physrev.00064.2017. Review.


Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome.

Wilson AM, Shao Z, Grenier V, Mawambo G, Daudelin JF, Dejda A, Pilon F, Popovic N, Boulet S, Parinot C, Oubaha M, Labrecque N, de Guire V, Laplante M, Lettre G, Sennlaub F, Joyal JS, Meunier M, Sapieha P.

Sci Immunol. 2018 Mar 16;3(21). pii: eaan4626. doi: 10.1126/sciimmunol.aan4626.


Loss of OcaB Prevents Age-Induced Fat Accretion and Insulin Resistance by Altering B-Lymphocyte Transition and Promoting Energy Expenditure.

Carter S, Miard S, Caron A, Sallé-Lefort S, St-Pierre P, Anhê FF, Lavoie-Charland E, Blais-Lecours P, Drolet MC, Lefebvre JS, Lacombe J, Deshaies Y, Couet J, Laplante M, Ferron M, Bossé Y, Marette A, Richard D, Marsolais D, Picard F.

Diabetes. 2018 Jul;67(7):1285-1296. doi: 10.2337/db17-0558. Epub 2018 Mar 1.


Face Perception in Social Anxiety: Visuocortical Dynamics Reveal Propensities for Hypervigilance or Avoidance.

McTeague LM, Laplante MC, Bulls HW, Shumen JR, Lang PJ, Keil A.

Biol Psychiatry. 2018 Apr 1;83(7):618-628. doi: 10.1016/j.biopsych.2017.10.004. Epub 2017 Oct 13.


Functional characterization of the Ucp1-associated oxidative phenotype of human epicardial adipose tissue.

Chechi K, Voisine P, Mathieu P, Laplante M, Bonnet S, Picard F, Joubert P, Richard D.

Sci Rep. 2017 Nov 14;7(1):15566. doi: 10.1038/s41598-017-15501-7.


Loss of hepatic DEPTOR alters the metabolic transition to fasting.

Caron A, Mouchiroud M, Gautier N, Labbé SM, Villot R, Turcotte L, Secco B, Lamoureux G, Shum M, Gélinas Y, Marette A, Richard D, Sabatini DM, Laplante M.

Mol Metab. 2017 Feb 17;6(5):447-458. doi: 10.1016/j.molmet.2017.02.005. eCollection 2017 May.


A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.

Gendron DR, Lecours PB, Lemay AM, Beaulieu MJ, Huppé CA, Lee-Gosselin A, Flamand N, Don AS, Bissonnette É, Blanchet MR, Laplante M, Bourgoin SG, Bossé Y, Marsolais D.

Front Pharmacol. 2017 Feb 21;8:78. doi: 10.3389/fphar.2017.00078. eCollection 2017.


Amplification of Adipogenic Commitment by VSTM2A.

Secco B, Camiré É, Brière MA, Caron A, Billong A, Gélinas Y, Lemay AM, Tharp KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad É, Marsolais D, Bossé Y, Birsoy K, Laplante M.

Cell Rep. 2017 Jan 3;18(1):93-106. doi: 10.1016/j.celrep.2016.12.015.


mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold.

Labbé SM, Mouchiroud M, Caron A, Secco B, Freinkman E, Lamoureux G, Gélinas Y, Lecomte R, Bossé Y, Chimin P, Festuccia WT, Richard D, Laplante M.

Sci Rep. 2016 Nov 23;6:37223. doi: 10.1038/srep37223.


The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.

Carbonneau M, M Gagné L, Lalonde ME, Germain MA, Motorina A, Guiot MC, Secco B, Vincent EE, Tumber A, Hulea L, Bergeman J, Oppermann U, Jones RG, Laplante M, Topisirovic I, Petrecca K, Huot MÉ, Mallette FA.

Nat Commun. 2016 Sep 14;7:12700. doi: 10.1038/ncomms12700.


Metabolic activity of brown, "beige," and white adipose tissues in response to chronic adrenergic stimulation in male mice.

Labbé SM, Caron A, Chechi K, Laplante M, Lecomte R, Richard D.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E260-8. doi: 10.1152/ajpendo.00545.2015. Epub 2016 May 3.


DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance.

Caron A, Labbé SM, Mouchiroud M, Huard R, Lanfray D, Richard D, Laplante M.

Am J Physiol Regul Integr Comp Physiol. 2016 Jun 1;310(11):R1322-31. doi: 10.1152/ajpregu.00549.2015. Epub 2016 Apr 20.


Shoulder Electromyography Measurements During Activities of Daily Living and Routine Rehabilitation Exercises.

Gurney AB, Mermier C, LaPlante M, Majumdar A, O'Neill K, Shewman T, Gurney JG.

J Orthop Sports Phys Ther. 2016 May;46(5):375-83. doi: 10.2519/jospt.2016.6090. Epub 2016 Apr 6.


A Resolving Rash on the Breast.

LaPlante M, Usatine R.

Am Fam Physician. 2016 Feb 15;93(4):297-8. No abstract available.


Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity.

Caron A, Labbé SM, Lanfray D, Blanchard PG, Villot R, Roy C, Sabatini DM, Richard D, Laplante M.

Mol Metab. 2015 Dec 8;5(2):102-112. doi: 10.1016/j.molmet.2015.11.005. eCollection 2016 Feb.


Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice.

Lanfray D, Caron A, Roy MC, Laplante M, Morin F, Leprince J, Tonon MC, Richard D.

Elife. 2016 Feb 15;5. pii: e11742. doi: 10.7554/eLife.11742.


The Roles of mTOR Complexes in Lipid Metabolism.

Caron A, Richard D, Laplante M.

Annu Rev Nutr. 2015;35:321-48. doi: 10.1146/annurev-nutr-071714-034355. Review.


Acute onset of polyarthralgia and skin plaques.

LaPlante M, Usatine R.

Am Fam Physician. 2015 May 15;91(10):723-4. No abstract available.


In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis.

Labbé SM, Caron A, Bakan I, Laplante M, Carpentier AC, Lecomte R, Richard D.

FASEB J. 2015 May;29(5):2046-58. doi: 10.1096/fj.14-266247. Epub 2015 Feb 13.


A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.

Sood A, Jeyaraju DV, Prudent J, Caron A, Lemieux P, McBride HM, Laplante M, Tóth K, Pellegrini L.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16017-22. doi: 10.1073/pnas.1408061111. Epub 2014 Oct 28.


Early development of calcific aortic valve disease and left ventricular hypertrophy in a mouse model of combined dyslipidemia and type 2 diabetes mellitus.

Le Quang K, Bouchareb R, Lachance D, Laplante MA, El Husseini D, Boulanger MC, Fournier D, Fang XP, Avramoglu RK, Pibarot P, Deshaies Y, Sweeney G, Mathieu P, Marette A.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2283-91. doi: 10.1161/ATVBAHA.114.304205. Epub 2014 Aug 14.


DEP domain-containing mTOR-interacting protein in the rat brain: distribution of expression and potential implication.

Caron A, Baraboi ED, Laplante M, Richard D.

J Comp Neurol. 2015 Jan 1;523(1):93-107. doi: 10.1002/cne.23668. Epub 2014 Sep 22.


Interrelationships between ghrelin, insulin and glucose homeostasis: Physiological relevance.

Chabot F, Caron A, Laplante M, St-Pierre DH.

World J Diabetes. 2014 Jun 15;5(3):328-41. doi: 10.4239/wjd.v5.i3.328. Review.


Developmental gene expression provides clues to relationships between sponge and eumetazoan body plans.

Leininger S, Adamski M, Bergum B, Guder C, Liu J, Laplante M, Bråte J, Hoffmann F, Fortunato S, Jordal S, Rapp HT, Adamska M.

Nat Commun. 2014 May 20;5:3905. doi: 10.1038/ncomms4905.


Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide.

Festuccia WT, Pouliot P, Bakan I, Sabatini DM, Laplante M.

PLoS One. 2014 Apr 16;9(4):e95432. doi: 10.1371/journal.pone.0095432. eCollection 2014.


The genetic and metabolic determinants of cardiovascular complications in type 2 diabetes: recent insights from animal models and clinical investigations.

Kohen Avramoglu R, Laplante MA, Le Quang K, Deshaies Y, Després JP, Larose E, Mathieu P, Poirier P, Pérusse L, Vohl MC, Sweeney G, Ylä-Herttuala S, Laakso M, Uusitupa M, Marette A.

Can J Diabetes. 2013 Oct;37(5):351-8. doi: 10.1016/j.jcjd.2013.08.262. Review.


Key goals and indicators for successful aging of adults with early-onset disability.

LaPlante MP.

Disabil Health J. 2014 Jan;7(1 Suppl):S44-50. doi: 10.1016/j.dhjo.2013.08.005. Epub 2013 Oct 2.


AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes.

Jenkins Y, Sun TQ, Markovtsov V, Foretz M, Li W, Nguyen H, Li Y, Pan A, Uy G, Gross L, Baltgalvis K, Yung SL, Gururaja T, Kinoshita T, Owyang A, Smith IJ, McCaughey K, White K, Godinez G, Alcantara R, Choy C, Ren H, Basile R, Sweeny DJ, Xu X, Issakani SD, Carroll DC, Goff DA, Shaw SJ, Singh R, Boros LG, Laplante MA, Marcotte B, Kohen R, Viollet B, Marette A, Payan DG, Kinsella TM, Hitoshi Y.

PLoS One. 2013 Dec 5;8(12):e81870. doi: 10.1371/journal.pone.0081870. eCollection 2013.


Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.

Laplante MA, Charbonneau A, Avramoglu RK, Pelletier P, Fang X, Bachelard H, Ylä-Herttuala S, Laakso M, Després JP, Deshaies Y, Sweeney G, Mathieu P, Marette A.

Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E573-84. doi: 10.1152/ajpendo.00122.2013. Epub 2013 Jul 2.


A comparative perspective on lipid storage in animals.

Birsoy K, Festuccia WT, Laplante M.

J Cell Sci. 2013 Apr 1;126(Pt 7):1541-52. doi: 10.1242/jcs.104992.


Regulation of mTORC1 and its impact on gene expression at a glance.

Laplante M, Sabatini DM.

J Cell Sci. 2013 Apr 15;126(Pt 8):1713-9. doi: 10.1242/jcs.125773. Epub 2013 May 2. Review.


The woodwork effect in medicaid long-term services and supports.

LaPlante MP.

J Aging Soc Policy. 2013;25(2):161-80. doi: 10.1080/08959420.2013.766072.


DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM.

Cell Metab. 2012 Aug 8;16(2):202-12. doi: 10.1016/j.cmet.2012.07.008.


mTOR signaling in growth control and disease.

Laplante M, Sabatini DM.

Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017. Review.


Medicaid home- and community-based services: impact of the affordable care act.

Harrington C, Ng T, Laplante M, Kaye HS.

J Aging Soc Policy. 2012;24(2):169-87. doi: 10.1080/08959420.2012.659118.


Connecting mTORC1 signaling to SREBP-1 activation.

Bakan I, Laplante M.

Curr Opin Lipidol. 2012 Jun;23(3):226-34. doi: 10.1097/MOL.0b013e328352dd03. Review.


Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway.

Li Z, Miard S, Laplante M, Sonenberg N, Picard F.

Mol Cell Endocrinol. 2012 Jul 6;358(1):63-8. doi: 10.1016/j.mce.2012.02.022. Epub 2012 Mar 3.


Defensive mobilization in specific phobia: fear specificity, negative affectivity, and diagnostic prominence.

McTeague LM, Lang PJ, Wangelin BC, Laplante MC, Bradley MM.

Biol Psychiatry. 2012 Jul 1;72(1):8-18. doi: 10.1016/j.biopsych.2012.01.012. Epub 2012 Mar 3.


mTOR Signaling.

Laplante M, Sabatini DM.

Cold Spring Harb Perspect Biol. 2012 Feb 1;4(2). pii: a011593. doi: 10.1101/cshperspect.a011593. Review. No abstract available.


A randomised controlled pilot study of standardised counselling and cost-free pharmacotherapy for smoking cessation among stroke and TIA patients.

Papadakis S, Aitken D, Gocan S, Riley D, Laplante MA, Bhatnagar-Bost A, Cousineau D, Simpson D, Edjoc R, Pipe AL, Sharma M, Reid RD.

BMJ Open. 2011 Nov 28;1(2):e000366. doi: 10.1136/bmjopen-2011-000366. Print 2011.


Cyclo-oxygenase-2 knockout genotype in mice is associated with blunted angiotensin II-induced oxidative stress and hypertension.

Wu R, Duchemin S, Laplante MA, De Champlain J, Girouard H.

Am J Hypertens. 2011 Nov;24(11):1239-44. doi: 10.1038/ajh.2011.137. Epub 2011 Aug 11.


Aversive imagery in panic disorder: agoraphobia severity, comorbidity, and defensive physiology.

McTeague LM, Lang PJ, Laplante MC, Bradley MM.

Biol Psychiatry. 2011 Sep 1;70(5):415-24. doi: 10.1016/j.biopsych.2011.03.005. Epub 2011 May 8.

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