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Items: 34


Macropinocytosis drives T cell growth by sustaining the activation of mTORC1.

Charpentier JC, Chen D, Lapinski PE, Turner J, Grigorova I, Swanson JA, King PD.

Nat Commun. 2020 Jan 10;11(1):180. doi: 10.1038/s41467-019-13997-3.


RASA1-dependent cellular export of collagen IV controls blood and lymphatic vascular development.

Chen D, Teng JM, North PE, Lapinski PE, King PD.

J Clin Invest. 2019 Jun 11;130:3545-3561. doi: 10.1172/JCI124917.


Somatic second hit mutation of RASA1 in vascular endothelial cells in capillary malformation-arteriovenous malformation.

Lapinski PE, Doosti A, Salato V, North P, Burrows PE, King PD.

Eur J Med Genet. 2018 Jan;61(1):11-16. doi: 10.1016/j.ejmg.2017.10.004. Epub 2017 Oct 9.


RASA1 regulates the function of lymphatic vessel valves in mice.

Lapinski PE, Lubeck BA, Chen D, Doosti A, Zawieja SD, Davis MJ, King PD.

J Clin Invest. 2017 Jun 30;127(7):2569-2585. doi: 10.1172/JCI89607. Epub 2017 May 22.


A novel mutation in CELSR1 is associated with hereditary lymphedema.

Gonzalez-Garay ML, Aldrich MB, Rasmussen JC, Guilliod R, Lapinski PE, King PD, Sevick-Muraca EM.

Vasc Cell. 2016 Feb 5;8:1. doi: 10.1186/s13221-016-0035-5. eCollection 2016.


Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.

Lubeck BA, Lapinski PE, Oliver JA, Ksionda O, Parada LF, Zhu Y, Maillard I, Chiang M, Roose J, King PD.

J Immunol. 2015 Jul 1;195(1):31-5. doi: 10.4049/jimmunol.1402639. Epub 2015 May 22.


Blood vascular abnormalities in Rasa1(R780Q) knockin mice: implications for the pathogenesis of capillary malformation-arteriovenous malformation.

Lubeck BA, Lapinski PE, Bauler TJ, Oliver JA, Hughes ED, Saunders TL, King PD.

Am J Pathol. 2014 Dec;184(12):3163-9. doi: 10.1016/j.ajpath.2014.08.018. Epub 2014 Oct 3.


Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.

Mleczko-Sanecka K, Roche F, da Silva AR, Call D, D'Alessio F, Ragab A, Lapinski PE, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro LA, Klingmüller U, King PD, Boutros M, Hentze MW, Muckenthaler MU.

Blood. 2014 Mar 6;123(10):1574-85. doi: 10.1182/blood-2013-07-515957. Epub 2014 Jan 2.


The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease.

He S, Xie F, Liu Y, Tong Q, Mochizuki K, Lapinski PE, Mani RS, Reddy P, Mochizuki I, Chinnaiyan AM, Mineishi S, King PD, Zhang Y.

Blood. 2013 Dec 12;122(25):4119-28. doi: 10.1182/blood-2013-05-505180. Epub 2013 Oct 18.


The transition from stem cell to progenitor spermatogonia and male fertility requires the SHP2 protein tyrosine phosphatase.

Puri P, Phillips BT, Suzuki H, Orwig KE, Rajkovic A, Lapinski PE, King PD, Feng GS, Walker WH.

Stem Cells. 2014 Mar;32(3):741-53. doi: 10.1002/stem.1572.


Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice.

Lapinski PE, Meyer MF, Feng GS, Kamiya N, King PD.

Dis Model Mech. 2013 Nov;6(6):1448-58. doi: 10.1242/dmm.012849. Epub 2013 Sep 25.


Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man.

Burrows PE, Gonzalez-Garay ML, Rasmussen JC, Aldrich MB, Guilliod R, Maus EA, Fife CE, Kwon S, Lapinski PE, King PD, Sevick-Muraca EM.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8621-6. doi: 10.1073/pnas.1222722110. Epub 2013 May 6.


The Ras GTPase-activating protein neurofibromin 1 promotes the positive selection of thymocytes.

Oliver JA, Lapinski PE, Lubeck BA, Turner JS, Parada LF, Zhu Y, King PD.

Mol Immunol. 2013 Oct;55(3-4):292-302. doi: 10.1016/j.molimm.2013.03.005. Epub 2013 Mar 20.


Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.

King PD, Lubeck BA, Lapinski PE.

Sci Signal. 2013 Feb 26;6(264):re1. doi: 10.1126/scisignal.2003669. Review.


Regulation of Ras signal transduction during T cell development and activation.

Lapinski PE, King PD.

Am J Clin Exp Immunol. 2012;1(2):147-153.


Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

Qiao Y, Zhu L, Sofi H, Lapinski PE, Horai R, Mueller K, Stritesky GL, He X, Teh HS, Wiest DL, Kappes DJ, King PD, Hogquist KA, Schwartzberg PL, Sant'Angelo DB, Chang CH.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16264-9. doi: 10.1073/pnas.1207528109. Epub 2012 Sep 17.


RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice.

Lapinski PE, Kwon S, Lubeck BA, Wilkinson JE, Srinivasan RS, Sevick-Muraca E, King PD.

J Clin Invest. 2012 Feb;122(2):733-47. doi: 10.1172/JCI46116. Epub 2012 Jan 9.


A role for p120 RasGAP in thymocyte positive selection and survival of naive T cells.

Lapinski PE, Qiao Y, Chang CH, King PD.

J Immunol. 2011 Jul 1;187(1):151-63. doi: 10.4049/jimmunol.1100178. Epub 2011 Jun 6.


Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.

Bauler TJ, Kamiya N, Lapinski PE, Langewisch E, Mishina Y, Wilkinson JE, Feng GS, King PD.

Dis Model Mech. 2011 Mar;4(2):228-39. doi: 10.1242/dmm.006130. Epub 2010 Nov 10.


MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis.

Anand S, Majeti BK, Acevedo LM, Murphy EA, Mukthavaram R, Scheppke L, Huang M, Shields DJ, Lindquist JN, Lapinski PE, King PD, Weis SM, Cheresh DA.

Nat Med. 2010 Aug;16(8):909-14. doi: 10.1038/nm.2186. Epub 2010 Aug 1.


The T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B.

Lapinski PE, Oliver JA, Bodie JN, Marti F, King PD.

Immunol Rev. 2009 Nov;232(1):240-54. doi: 10.1111/j.1600-065X.2009.00829.x. Review.


Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein.

Lapinski PE, Bauler TJ, Brown EJ, Hughes ED, Saunders TL, King PD.

Genesis. 2007 Dec;45(12):762-7.


Catalytic site modifications of TAP1 and TAP2 and their functional consequences.

Perria CL, Rajamanickam V, Lapinski PE, Raghavan M.

J Biol Chem. 2006 Dec 29;281(52):39839-51. Epub 2006 Oct 26.


The T cell-specific adapter protein functions as a regulator of peripheral but not central immunological tolerance.

Lapinski PE, MacGregor JN, Marti F, King PD.

Adv Exp Med Biol. 2006;584:73-87. Review. No abstract available.


Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells.

Marti F, Garcia GG, Lapinski PE, MacGregor JN, King PD.

J Exp Med. 2006 Feb 20;203(2):281-7. Epub 2006 Jan 30. Erratum in: J Exp Med. 2006 Feb 20;203(2):479.


The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man.

Marti F, Lapinski PE, King PD.

Immunol Lett. 2005 Mar 15;97(2):165-70. Epub 2004 Nov 18. Review.


Nucleotide interactions with membrane-bound transporter associated with antigen processing proteins.

Lapinski PE, Raghuraman G, Raghavan M.

J Biol Chem. 2003 Mar 7;278(10):8229-37. Epub 2002 Dec 25.


Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes.

Raghuraman G, Lapinski PE, Raghavan M.

J Biol Chem. 2002 Nov 1;277(44):41786-94. Epub 2002 Sep 3.


Calreticulin recognizes misfolded HLA-A2 heavy chains.

Mancino L, Rizvi SM, Lapinski PE, Raghavan M.

Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5931-6.


Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.

Lapinski PE, Neubig RR, Raghavan M.

J Biol Chem. 2001 Mar 9;276(10):7526-33. Epub 2000 Nov 30.


Pairing of the nucleotide binding domains of the transporter associated with antigen processing.

Lapinski PE, Miller GG, Tampé R, Raghavan M.

J Biol Chem. 2000 Mar 10;275(10):6831-40.

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