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Intramolecular Diffusion in α-Synuclein: It Depends on How You Measure It.

Woodard J, Srivastava KR, Rahamim G, Grupi A, Hogan S, Witalka DJ, Nawrocki G, Haas E, Feig M, Lapidus LJ.

Biophys J. 2018 Oct 2;115(7):1190-1199. doi: 10.1016/j.bpj.2018.08.023. Epub 2018 Aug 27.


Combined Force Ramp and Equilibrium High-Resolution Investigations Reveal Multipath Heterogeneous Unfolding of Protein G.

Izadi D, Chen Y, Whitmore ML, Slivka JD, Ching K, Lapidus LJ, Comstock MJ.

J Phys Chem B. 2018 Oct 2. doi: 10.1021/acs.jpcb.8b06199. [Epub ahead of print]


Increased mortality among patients with diabetes following first-ever transfemoral amputation.

Sjödin L, Enocson A, Rotzius P, Lapidus LJ.

Diabetes Res Clin Pract. 2018 Sep;143:225-231. doi: 10.1016/j.diabres.2018.07.016. Epub 2018 Jul 29.


Low fasting serum insulin and dementia in nondiabetic women followed for 34 years.

Mehlig K, Lapidus L, Thelle DS, Waern M, Zetterberg H, Björkelund C, Skoog I, Lissner L.

Neurology. 2018 Jul 31;91(5):e427-e435. doi: 10.1212/WNL.0000000000005911. Epub 2018 Jul 11.


Is fast reversal and early surgery (within 24 h) in patients on warfarin medication with trochanteric hip fractures safe? A case-control study.

Mattisson L, Lapidus LJ, Enocson A.

BMC Musculoskelet Disord. 2018 Jun 26;19(1):203. doi: 10.1186/s12891-018-2126-3.


Patient claims in prosthetic hip infections: a comparison of nationwide incidence in Sweden and patient insurance data.

Kasina P, Enocson A, Lindgren V, Lapidus LJ.

Acta Orthop. 2018 Aug;89(4):394-398. doi: 10.1080/17453674.2018.1477708. Epub 2018 May 29.


Single molecule force spectroscopy at high data acquisition: A Bayesian nonparametric analysis.

Sgouralis I, Whitmore M, Lapidus L, Comstock MJ, Pressé S.

J Chem Phys. 2018 Mar 28;148(12):123320. doi: 10.1063/1.5008842.


Protein unfolding mechanisms and their effects on folding experiments.

Lapidus LJ.

F1000Res. 2017 Sep 22;6:1723. doi: 10.12688/f1000research.12070.1. eCollection 2017. Review.


Fluorescent Probe DCVJ Shows High Sensitivity for Characterization of Amyloid β-Peptide Early in the Lag Phase.

Nagarajan S, Lapidus LJ.

Chembiochem. 2017 Nov 16;18(22):2205-2211. doi: 10.1002/cbic.201700387. Epub 2017 Oct 12.


Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.

Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL.

Neurobiol Dis. 2017 Oct;106:191-204. doi: 10.1016/j.nbd.2017.07.007. Epub 2017 Jul 12.


Prion protein dynamics before aggregation.

Srivastava KR, Lapidus LJ.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3572-3577. doi: 10.1073/pnas.1620400114. Epub 2017 Mar 20.


Enzyme-free electrochemical immunosensor based on methylene blue and the electro-oxidation of hydrazine on Pt nanoparticles.

Dutta G, Nagarajan S, Lapidus LJ, Lillehoj PB.

Biosens Bioelectron. 2017 Jun 15;92:372-377. doi: 10.1016/j.bios.2016.10.094. Epub 2016 Nov 3.


Monomer Dynamics of Alzheimer Peptides and Kinetic Control of Early Aggregation in Alzheimer's Disease.

Acharya S, Srivastava KR, Nagarajan S, Lapidus LJ.

Chemphyschem. 2016 Nov 4;17(21):3470-3479. doi: 10.1002/cphc.201600706. Epub 2016 Sep 15.


Intramolecular diffusion controls aggregation of the PAPf39 peptide.

Srivastava KR, French KC, Tzul FO, Makhatadze GI, Lapidus LJ.

Biophys Chem. 2016 Sep;216:37-43. doi: 10.1016/j.bpc.2016.06.004. Epub 2016 Jun 29.


Effects of Mutations on the Reconfiguration Rate of α-Synuclein.

Acharya S, Saha S, Ahmad B, Lapidus LJ.

J Phys Chem B. 2015 Dec 17;119(50):15443-50. doi: 10.1021/acs.jpcb.5b10136. Epub 2015 Dec 4.


Prosthetic joint infection following hip fracture and degenerative hip disorder: a cohort study of three thousand, eight hundred and seven consecutive hip arthroplasties with a minimum follow-up of five years.

Blomfeldt R, Kasina P, Ottosson C, Enocson A, Lapidus LJ.

Int Orthop. 2015 Nov;39(11):2091-6. doi: 10.1007/s00264-015-2989-y. Epub 2015 Sep 18.


Complex pathways in folding of protein G explored by simulation and experiment.

Lapidus LJ, Acharya S, Schwantes CR, Wu L, Shukla D, King M, DeCamp SJ, Pande VS.

Biophys J. 2014 Aug 19;107(4):947-55. doi: 10.1016/j.bpj.2014.06.037.


Physical activity, weight status, diabetes and dementia: a 34-year follow-up of the population study of women in Gothenburg.

Mehlig K, Skoog I, Waern M, Miao Jonasson J, Lapidus L, Björkelund C, Ostling S, Lissner L.

Neuroepidemiology. 2014;42(4):252-9. doi: 10.1159/000362201. Epub 2014 Jun 7.


[Acute pulmonary embolism with hemodynamic compromise. Management and treatment].

Svennerholm K, Lapidus L, Malm CJ, Redfors B, Stigendal L, Jönsson KZ, Rylander C.

Lakartidningen. 2014 Apr 9-15;111(15):669-72. Review. Swedish. No abstract available.


Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.

Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner FG, Schrader T, Loo JA, Bitan G, Lapidus LJ.

J Biol Chem. 2014 Apr 11;289(15):10727-37. doi: 10.1074/jbc.M113.524520. Epub 2014 Feb 24.


Sub-millisecond chain collapse of the Escherichia coli globin ApoHmpH.

Zhu L, Kurt N, Choi J, Lapidus LJ, Cavagnero S.

J Phys Chem B. 2013 Jul 3;117(26):7868-77. doi: 10.1021/jp400174e. Epub 2013 Jun 24.


Symptomatic venous thromboembolism and mortality in orthopaedic surgery - an observational study of 45 968 consecutive procedures.

Lapidus LJ, Ponzer S, Pettersson H, de Bri E.

BMC Musculoskelet Disord. 2013 Jun 4;14:177. doi: 10.1186/1471-2474-14-177.


Combining ultrarapid mixing with photochemical oxidation to probe protein folding.

Wu L, Lapidus LJ.

Anal Chem. 2013 May 21;85(10):4920-4. doi: 10.1021/ac3033646. Epub 2013 May 2.


Tourniquet time affects postoperative complications after knee arthroplasty.

Olivecrona C, Lapidus LJ, Benson L, Blomfeldt R.

Int Orthop. 2013 May;37(5):827-32. doi: 10.1007/s00264-013-1826-4. Epub 2013 Feb 16.


Internal fixation of garden I and II femoral neck fractures: posterior tilt did not influence the reoperation rate in 382 consecutive hips followed for a minimum of 5 years.

Lapidus LJ, Charalampidis A, Rundgren J, Enocson A.

J Orthop Trauma. 2013 Jul;27(7):386-90; discussion 390-1. doi: 10.1097/BOT.0b013e318281da6e.


Exploring the top of the protein folding funnel by experiment.

Lapidus LJ.

Curr Opin Struct Biol. 2013 Feb;23(1):30-5. doi: 10.1016/ Epub 2012 Oct 30. Review.


Understanding protein aggregation from the view of monomer dynamics.

Lapidus LJ.

Mol Biosyst. 2013 Jan 27;9(1):29-35. doi: 10.1039/c2mb25334h. Epub 2012 Oct 26. Review.


Exploring the energy landscape of nucleic acid hairpins using laser temperature-jump and microfluidic mixing.

Narayanan R, Zhu L, Velmurugu Y, Roca J, Kuznetsov SV, Prehna G, Lapidus LJ, Ansari A.

J Am Chem Soc. 2012 Nov 21;134(46):18952-63. doi: 10.1021/ja301218e. Epub 2012 Nov 7.


[Anticoagulants in delayed diagnosis of deep venous thrombosis can cause compartment syndrome. Cases of misjudged calf pain described].

Sandberg D, Jakobsson J, Liu J, Lapidus L.

Lakartidningen. 2012 Aug 22-Sep 4;109(34-35):1471-3. Swedish. No abstract available.


Main causes of death among Swedish women born 1914 and 1918: 32-year follow-up of the Population Study of Women in Gothenburg.

Hange D, Sigurdsson JA, Björkelund C, Lapidus L, Bengtsson C.

Int J Gen Med. 2012;5:597-601. doi: 10.2147/IJGM.S31748. Epub 2012 Jul 12.


Slow unfolded-state structuring in Acyl-CoA binding protein folding revealed by simulation and experiment.

Voelz VA, Jäger M, Yao S, Chen Y, Zhu L, Waldauer SA, Bowman GR, Friedrichs M, Bakajin O, Lapidus LJ, Weiss S, Pande VS.

J Am Chem Soc. 2012 Aug 1;134(30):12565-77. doi: 10.1021/ja302528z. Epub 2012 Jul 19.


Hip arthroplasty after failed fixation of trochanteric and subtrochanteric fractures.

Enocson A, Mattisson L, Ottosson C, Lapidus LJ.

Acta Orthop. 2012 Oct;83(5):493-8. doi: 10.3109/17453674.2012.688724. Epub 2012 May 10.


Microfluidic mixers for studying protein folding.

Waldauer SA, Wu L, Yao S, Bakajin O, Lapidus LJ.

J Vis Exp. 2012 Apr 10;(62). pii: 3976. doi: 10.3791/3976.


Medial Achilles tendon island flap--a novel technique to treat reruptures and neglected ruptures of the Achilles tendon.

Lapidus LJ, Ray BA, Hamberg P.

Int Orthop. 2012 Aug;36(8):1629-34. doi: 10.1007/s00264-012-1521-x. Epub 2012 Mar 17.


Aggregation of α-synuclein is kinetically controlled by intramolecular diffusion.

Ahmad B, Chen Y, Lapidus LJ.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2336-41. doi: 10.1073/pnas.1109526109. Epub 2012 Jan 27.


Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate.

Ahmad B, Lapidus LJ.

J Biol Chem. 2012 Mar 16;287(12):9193-9. doi: 10.1074/jbc.M111.325548. Epub 2012 Jan 20.


Evidence of multiple folding pathways for the villin headpiece subdomain.

Zhu L, Ghosh K, King M, Cellmer T, Bakajin O, Lapidus LJ.

J Phys Chem B. 2011 Nov 3;115(43):12632-7. doi: 10.1021/jp206238y. Epub 2011 Oct 12.


Unipolar versus bipolar Exeter hip hemiarthroplasty: a prospective cohort study on 830 consecutive hips in patients with femoral neck fractures.

Enocson A, Hedbeck CJ, Törnkvist H, Tidermark J, Lapidus LJ.

Int Orthop. 2012 Apr;36(4):711-7. doi: 10.1007/s00264-011-1326-3. Epub 2011 Jul 26.


Deep venous thrombosis after surgery for Achilles tendon rupture: a provoked transient event with minor long-term sequelae.

Persson LM, Lapidus LJ, Lärfars G, Rosfors S.

J Thromb Haemost. 2011 Aug;9(8):1493-9. doi: 10.1111/j.1538-7836.2011.04376.x.


A general polymer model of unfolded proteins under folding conditions.

Chen Y, Wedemeyer WJ, Lapidus LJ.

J Phys Chem B. 2010 Dec 9;114(48):15969-75. doi: 10.1021/jp104746g. Epub 2010 Nov 15.


A follow-up study of the fate of small asymptomatic deep venous thromboses.

Rosfors S, Persson LM, Lärfars G, Lapidus LJ.

Thromb J. 2010 Feb 12;8:4. doi: 10.1186/1477-9560-8-4.


Extremely slow intramolecular diffusion in unfolded protein L.

Waldauer SA, Bakajin O, Lapidus LJ.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13713-7. doi: 10.1073/pnas.1005415107. Epub 2010 Jul 19.


Thirty-six-year secular trends in sleep duration and sleep satisfaction, and associations with mental stress and socioeconomic factors--results of the Population Study of Women in Gothenburg, Sweden.

Rowshan Ravan A, Bengtsson C, Lissner L, Lapidus L, Björkelund C.

J Sleep Res. 2010 Sep;19(3):496-503. doi: 10.1111/j.1365-2869.2009.00815.x. Epub 2010 Apr 30.


Unfolded-state dynamics and structure of protein L characterized by simulation and experiment.

Voelz VA, Singh VR, Wedemeyer WJ, Lapidus LJ, Pande VS.

J Am Chem Soc. 2010 Apr 7;132(13):4702-9. doi: 10.1021/ja908369h.


Direction of hip arthroplasty dislocation in patients with femoral neck fractures.

Enocson A, Lapidus G, Törnkvist H, Tidermark J, Lapidus LJ.

Int Orthop. 2010 Jun;34(5):641-7. doi: 10.1007/s00264-009-0943-6. Epub 2010 Jan 22.


Conformational properties of unfolded HypF-N.

Chen Y, Parrini C, Taddei N, Lapidus LJ.

J Phys Chem B. 2009 Dec 17;113(50):16209-13. doi: 10.1021/jp904189b.


Direct observation of downhill folding of lambda-repressor in a microfluidic mixer.

DeCamp SJ, Naganathan AN, Waldauer SA, Bakajin O, Lapidus LJ.

Biophys J. 2009 Sep 16;97(6):1772-7. doi: 10.1016/j.bpj.2009.07.003.


[Time to stop basing the risk on BMI].

Bengtsson C, Lapidus L, Lissner L, Björkelund C, Lindqvist P, Sigurdsson JA.

Lakartidningen. 2009 Jun 24-Jul 7;106(26-27):1752-3. Swedish. No abstract available.


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