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Items: 1 to 50 of 144

1.

Extravascular coagulation in hematopoietic stem and progenitor cell regulation.

Nguyen TS, Lapidot T, Ruf W.

Blood. 2018 Jul 12;132(2):123-131. doi: 10.1182/blood-2017-12-768986. Epub 2018 Jun 4. Review.

PMID:
29866813
2.

MicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signaling.

Itkin T, Kumari A, Schneider E, Gur-Cohen S, Ludwig C, Brooks R, Kollet O, Golan K, Khatib-Massalha E, Russo CM, Chisholm JD, Rouhi A, Geiger H, Hornstein E, Kerr WG, Kuchenbauer F, Lapidot T.

Leukemia. 2017 May;31(5):1247-1250. doi: 10.1038/leu.2017.50. Epub 2017 Feb 8. No abstract available.

PMID:
28174416
3.

Corrigendum: Age-dependent modulation of vascular niches for haematopoietic stem cells.

Kusumbe AP, Ramasamy SK, Itkin T, Mäe MA, Langen UH, Betsholtz C, Lapidot T, Adams RH.

Nature. 2016 Nov 10;539(7628):314. doi: 10.1038/nature19782. Epub 2016 Sep 14. No abstract available.

PMID:
27626373
4.

Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals.

Ramasamy SK, Kusumbe AP, Itkin T, Gur-Cohen S, Lapidot T, Adams RH.

Annu Rev Cell Dev Biol. 2016 Oct 6;32:649-675. Epub 2016 Aug 17. Review.

PMID:
27576121
5.

Vascular Procr+ stem cells: Finding new branches while looking for the roots.

Gur-Cohen S, Lapidot T.

Cell Res. 2016 Oct;26(10):1071-1072. doi: 10.1038/cr.2016.91. Epub 2016 Aug 2.

6.

Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis.

Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Golan K, Khatib E, Kumari A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T.

Nature. 2016 Oct 13;538(7624):274. doi: 10.1038/nature19088. Epub 2016 Jul 20. No abstract available.

PMID:
27437586
7.

Model for Interpreting Surface Crystallization Using Quartz Crystal Microbalance: Theory and Experiments.

Lapidot T, Sedransk Campbell KL, Heng JY.

Anal Chem. 2016 May 3;88(9):4886-93. doi: 10.1021/acs.analchem.6b00713. Epub 2016 Apr 14.

8.

Distinct bone marrow blood vessels differentially regulate haematopoiesis.

Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T.

Nature. 2016 Apr 21;532(7599):323-8. doi: 10.1038/nature17624. Epub 2016 Apr 13.

PMID:
27074509
9.

Age-dependent modulation of vascular niches for haematopoietic stem cells.

Kusumbe AP, Ramasamy SK, Itkin T, Mäe MA, Langen UH, Betsholtz C, Lapidot T, Adams RH.

Nature. 2016 Apr 21;532(7599):380-4. doi: 10.1038/nature17638. Epub 2016 Apr 13. Erratum in: Nature. 2016 Nov 10;539(7628):314.

10.

Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.

Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T.

Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446b. No abstract available.

PMID:
27050594
11.

Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling.

Gur-Cohen S, Kollet O, Graf C, Esmon CT, Ruf W, Lapidot T.

Ann N Y Acad Sci. 2016 Apr;1370(1):65-81. doi: 10.1111/nyas.13013. Epub 2016 Mar 1. Review.

12.

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.

Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T.

Nat Med. 2015 Nov;21(11):1307-17. doi: 10.1038/nm.3960. Epub 2015 Oct 12. Erratum in: Nat Med. 2016 Apr;22(4):446.

13.

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate.

Maryanovich M, Zaltsman Y, Ruggiero A, Goldman A, Shachnai L, Zaidman SL, Porat Z, Golan K, Lapidot T, Gross A.

Nat Commun. 2015 Jul 29;6:7901. doi: 10.1038/ncomms8901.

PMID:
26219591
14.

Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.

Ben-Chetrit N, Chetrit D, Russell R, Körner C, Mancini M, Abdul-Hai A, Itkin T, Carvalho S, Cohen-Dvashi H, Koestler WJ, Shukla K, Lindzen M, Kedmi M, Lauriola M, Shulman Z, Barr H, Seger D, Ferraro DA, Pareja F, Gil-Henn H, Lapidot T, Alon R, Milanezi F, Symons M, Ben-Hamo R, Efroni S, Schmitt F, Wiemann S, Caldas C, Ehrlich M, Yarden Y.

Sci Signal. 2015 Jan 20;8(360):ra7. doi: 10.1126/scisignal.2005537.

PMID:
25605973
15.

Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment.

Ludin A, Gur-Cohen S, Golan K, Kaufmann KB, Itkin T, Medaglia C, Lu XJ, Ledergor G, Kollet O, Lapidot T.

Antioxid Redox Signal. 2014 Oct 10;21(11):1605-19. doi: 10.1089/ars.2014.5941. Epub 2014 Jun 26. Review.

16.

Dynamic Cross Talk between S1P and CXCL12 Regulates Hematopoietic Stem Cells Migration, Development and Bone Remodeling.

Golan K, Kollet O, Lapidot T.

Pharmaceuticals (Basel). 2013 Sep 23;6(9):1145-69. doi: 10.3390/ph6091145.

17.

Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitors.

Kollet O, Vagima Y, D'Uva G, Golan K, Canaani J, Itkin T, Gur-Cohen S, Kalinkovich A, Caglio G, Medaglia C, Ludin A, Lapid K, Shezen E, Neufeld-Cohen A, Varol D, Chen A, Lapidot T.

Leukemia. 2013 Oct;27(10):2006-15. doi: 10.1038/leu.2013.154. Epub 2013 May 17.

PMID:
23680895
18.

Egress and Mobilization of Hematopoietic Stem and Progenitor Cells: A Dynamic Multi-facet Process.

Lapid K, Glait-Santar C, Gur-Cohen S, Canaani J, Kollet O, Lapidot T.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2012 Dec 10.

19.

Fibroblast growth factor signaling promotes physiological bone remodeling and stem cell self-renewal.

Itkin T, Kaufmann KB, Gur-Cohen S, Ludin A, Lapidot T.

Curr Opin Hematol. 2013 May;20(3):237-44. doi: 10.1097/MOH.0b013e3283606162. Review.

PMID:
23567340
20.

GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement.

Lapid K, Itkin T, D'Uva G, Ovadya Y, Ludin A, Caglio G, Kalinkovich A, Golan K, Porat Z, Zollo M, Lapidot T.

J Clin Invest. 2013 Apr;123(4):1705-17. doi: 10.1172/JCI64149. Epub 2013 Mar 8. Erratum in: J Clin Invest. 2013 Jul 1;123(7):3183.

21.

Cancer stem cell definitions and terminology: the devil is in the details.

Valent P, Bonnet D, De Maria R, Lapidot T, Copland M, Melo JV, Chomienne C, Ishikawa F, Schuringa JJ, Stassi G, Huntly B, Herrmann H, Soulier J, Roesch A, Schuurhuis GJ, Wöhrer S, Arock M, Zuber J, Cerny-Reiterer S, Johnsen HE, Andreeff M, Eaves C.

Nat Rev Cancer. 2012 Nov;12(11):767-75. doi: 10.1038/nrc3368. Epub 2012 Oct 11. Review.

PMID:
23051844
22.

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.

Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S, Lapidot T.

Nat Immunol. 2012 Nov;13(11):1072-82. doi: 10.1038/ni.2408. Epub 2012 Sep 16.

PMID:
22983360
23.

Quantifying hematopoietic stem and progenitor cell mobilization.

Gur-Cohen S, Lapid K, Lapidot T.

Methods Mol Biol. 2012;904:15-35. doi: 10.1007/978-1-61779-943-3_2.

PMID:
22890919
24.

FGF signaling facilitates postinjury recovery of mouse hematopoietic system.

Zhao M, Ross JT, Itkin T, Perry JM, Venkatraman A, Haug JS, Hembree MJ, Deng CX, Lapidot T, He XC, Li L.

Blood. 2012 Aug 30;120(9):1831-42. doi: 10.1182/blood-2011-11-393991. Epub 2012 Jul 16.

25.

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.

Itkin T, Ludin A, Gradus B, Gur-Cohen S, Kalinkovich A, Schajnovitz A, Ovadya Y, Kollet O, Canaani J, Shezen E, Coffin DJ, Enikolopov GN, Berg T, Piacibello W, Hornstein E, Lapidot T.

Blood. 2012 Aug 30;120(9):1843-55. doi: 10.1182/blood-2011-11-394692. Epub 2012 May 29.

26.

The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells.

Maryanovich M, Oberkovitz G, Niv H, Vorobiyov L, Zaltsman Y, Brenner O, Lapidot T, Jung S, Gross A.

Nat Cell Biol. 2012 Mar 25;14(5):535-41. doi: 10.1038/ncb2468.

PMID:
22446738
27.

Regulatory cross talks of bone cells, hematopoietic stem cells and the nervous system maintain hematopoiesis.

Kollet O, Canaani J, Kalinkovich A, Lapidot T.

Inflamm Allergy Drug Targets. 2012 Jun;11(3):170-80. Review.

PMID:
22280241
28.

S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release.

Golan K, Vagima Y, Ludin A, Itkin T, Cohen-Gur S, Kalinkovich A, Kollet O, Kim C, Schajnovitz A, Ovadya Y, Lapid K, Shivtiel S, Morris AJ, Ratajczak MZ, Lapidot T.

Blood. 2012 Mar 15;119(11):2478-88. doi: 10.1182/blood-2011-06-358614. Epub 2012 Jan 25.

29.

CD45 regulates homing and engraftment of immature normal and leukemic human cells in transplanted immunodeficient mice.

Shivtiel S, Lapid K, Kalchenko V, Avigdor A, Goichberg P, Kalinkovich A, Nagler A, Kollet O, Lapidot T.

Exp Hematol. 2011 Dec;39(12):1161-1170.e1. doi: 10.1016/j.exphem.2011.08.012. Epub 2011 Sep 10.

PMID:
21911094
30.

Insights into the mechanism of enhanced mobilization of hematopoietic progenitor cells and release of CXCL12 by a combination of AMD3100 and aminoglycoside-polyarginine conjugates.

Berchanski A, Kalinkovich A, Ludin A, Lapidot T, Lapidot A.

FEBS J. 2011 Nov;278(21):4150-65. doi: 10.1111/j.1742-4658.2011.08348.x. Epub 2011 Oct 4.

31.

MT1-MMP and RECK: opposite and essential roles in hematopoietic stem and progenitor cell retention and migration.

Golan K, Vagima Y, Goichberg P, Gur-Cohen S, Lapidot T.

J Mol Med (Berl). 2011 Dec;89(12):1167-74. doi: 10.1007/s00109-011-0792-9. Epub 2011 Aug 13. Review.

PMID:
21842347
32.

Chronic B cell deficiency from birth prevents age-related alterations in the B lineage.

Keren Z, Averbuch D, Shahaf G, Zisman-Rozen S, Golan K, Itkin T, Lapidot T, Mehr R, Melamed D.

J Immunol. 2011 Sep 1;187(5):2140-7. doi: 10.4049/jimmunol.1100999. Epub 2011 Aug 1.

33.

Neural regulation of bone, marrow, and the microenvironment.

Canaani J, Kollet O, Lapidot T.

Front Biosci (Schol Ed). 2011 Jun 1;3:1021-31. Review.

PMID:
21622251
34.

Pathways implicated in stem cell migration: the SDF-1/CXCR4 axis.

Vagima Y, Lapid K, Kollet O, Goichberg P, Alon R, Lapidot T.

Methods Mol Biol. 2011;750:277-89. doi: 10.1007/978-1-61779-145-1_19.

PMID:
21618098
35.

Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications.

Staal FJ, Baum C, Cowan C, Dzierzak E, Hacein-Bey-Abina S, Karlsson S, Lapidot T, Lemischka I, Mendez-Ferrer S, Mikkers H, Moore K, Moreno E, Mummery CL, Robin C, Suda T, Van Pel M, Vanden Brink G, Zwaginga JJ, Fibbe WE.

Leukemia. 2011 Jul;25(7):1095-102. doi: 10.1038/leu.2011.52. Epub 2011 Apr 29. Review.

PMID:
21527933
36.

Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.

Orlovsky K, Kalinkovich A, Rozovskaia T, Shezen E, Itkin T, Alder H, Ozer HG, Carramusa L, Avigdor A, Volinia S, Buchberg A, Mazo A, Kollet O, Largman C, Croce CM, Nakamura T, Lapidot T, Canaani E.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7956-61. doi: 10.1073/pnas.1103154108. Epub 2011 Apr 25.

37.

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells.

Dar A, Schajnovitz A, Lapid K, Kalinkovich A, Itkin T, Ludin A, Kao WM, Battista M, Tesio M, Kollet O, Cohen NN, Margalit R, Buss EC, Baleux F, Oishi S, Fujii N, Larochelle A, Dunbar CE, Broxmeyer HE, Frenette PS, Lapidot T.

Leukemia. 2011 Aug;25(8):1286-1296. doi: 10.1038/leu.2011.62. Epub 2011 Apr 15. Erratum in: Leukemia. 2011 Aug;25(8):1378.

38.

CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions.

Schajnovitz A, Itkin T, D'Uva G, Kalinkovich A, Golan K, Ludin A, Cohen D, Shulman Z, Avigdor A, Nagler A, Kollet O, Seger R, Lapidot T.

Nat Immunol. 2011 May;12(5):391-8. doi: 10.1038/ni.2017. Epub 2011 Mar 27.

PMID:
21441933
39.

The brain-bone-blood triad: traffic lights for stem-cell homing and mobilization.

Lapidot T, Kollet O.

Hematology Am Soc Hematol Educ Program. 2010;2010:1-6. doi: 10.1182/asheducation-2010.1.1. Review.

PMID:
21239763
40.

SDF-1 keeps HSC quiescent at home.

Itkin T, Lapidot T.

Blood. 2011 Jan 13;117(2):373-4. doi: 10.1182/blood-2010-09-307843. No abstract available.

41.

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging.

Keren Z, Naor S, Nussbaum S, Golan K, Itkin T, Sasaki Y, Schmidt-Supprian M, Lapidot T, Melamed D.

Blood. 2011 Mar 17;117(11):3104-12. doi: 10.1182/blood-2010-09-307983. Epub 2011 Jan 12.

42.

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling.

Tesio M, Golan K, Corso S, Giordano S, Schajnovitz A, Vagima Y, Shivtiel S, Kalinkovich A, Caione L, Gammaitoni L, Laurenti E, Buss EC, Shezen E, Itkin T, Kollet O, Petit I, Trumpp A, Christensen J, Aglietta M, Piacibello W, Lapidot T.

Blood. 2011 Jan 13;117(2):419-28. doi: 10.1182/blood-2009-06-230359. Epub 2010 Jun 28.

43.

Blood-forming stem cells are nervous: direct and indirect regulation of immature human CD34+ cells by the nervous system.

Kalinkovich A, Spiegel A, Shivtiel S, Kollet O, Jordaney N, Piacibello W, Lapidot T.

Brain Behav Immun. 2009 Nov;23(8):1059-65. doi: 10.1016/j.bbi.2009.03.008. Epub 2009 Mar 31. Review.

PMID:
19341792
44.

MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.

Vagima Y, Avigdor A, Goichberg P, Shivtiel S, Tesio M, Kalinkovich A, Golan K, Dar A, Kollet O, Petit I, Perl O, Rosenthal E, Resnick I, Hardan I, Gellman YN, Naor D, Nagler A, Lapidot T.

J Clin Invest. 2009 Mar;119(3):492-503. doi: 10.1172/JCI36541. Epub 2009 Feb 9.

45.

Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment.

Spiegel A, Kalinkovich A, Shivtiel S, Kollet O, Lapidot T.

Cell Stem Cell. 2008 Nov 6;3(5):484-92. doi: 10.1016/j.stem.2008.10.006. Review.

46.

The endosteum region keeps human leukemic stem cells alive.

Lapidot T, Goichberg P, Lapid K, Avigdor A, Kollet O.

Cell Stem Cell. 2007 Nov;1(5):483-4. No abstract available.

47.

CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules.

Shivtiel S, Kollet O, Lapid K, Schajnovitz A, Goichberg P, Kalinkovich A, Shezen E, Tesio M, Netzer N, Petit I, Sharir A, Lapidot T.

J Exp Med. 2008 Sep 29;205(10):2381-95. doi: 10.1084/jem.20080072. Epub 2008 Sep 8.

48.

The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche.

Aicher A, Kollet O, Heeschen C, Liebner S, Urbich C, Ihling C, Orlandi A, Lapidot T, Zeiher AM, Dimmeler S.

Circ Res. 2008 Oct 10;103(8):796-803. doi: 10.1161/CIRCRESAHA.107.172718. Epub 2008 Sep 5.

PMID:
18776043
49.

A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells.

Hartmann TN, Grabovsky V, Pasvolsky R, Shulman Z, Buss EC, Spiegel A, Nagler A, Lapidot T, Thelen M, Alon R.

J Leukoc Biol. 2008 Oct;84(4):1130-40. doi: 10.1189/jlb.0208088. Epub 2008 Jul 24.

PMID:
18653785
50.

NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity.

Lapidot A, Peled A, Berchanski A, Pal B, Kollet O, Lapidot T, Borkow G.

Biochim Biophys Acta. 2008 Jun;1780(6):914-20. doi: 10.1016/j.bbagen.2008.03.011. Epub 2008 Mar 21.

PMID:
18410746

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