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Epidemiology and determinants of chronic migraine: A real-world cohort study, with nested case-control analysis, in primary care in Italy.

Marconi E, Pecchioli S, Nica M, Colombo D, Mazzoleni F, De Cesaris F, Geppetti P, Cricelli C, Lapi F.

Cephalalgia. 2019 Nov 19:333102419889351. doi: 10.1177/0333102419889351. [Epub ahead of print]


Impact of risk minimisation measures on the use of strontium ranelate in Europe: a multi-national cohort study in 5 EU countries by the EU-ADR Alliance.

Berencsi K, Sami A, Ali MS, Marinier K, Deltour N, Perez-Guthann S, Pedersen L, Rijnbeek P, Van der Lei J, Lapi F, Simonetti M, Reyes C, Sturkenboom MCJM, Prieto-Alhambra D.

Osteoporos Int. 2019 Nov 6. doi: 10.1007/s00198-019-05181-6. [Epub ahead of print]


Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults.

Alexander M, Loomis AK, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, Pasqua A, Lapi F, Rijnbeek P, Mosseveld M, Avillach P, Egger P, Dhalwani NN, Kendrick S, Celis-Morales C, Waterworth DM, Alazawi W, Sattar N.

BMJ. 2019 Oct 8;367:l5367. doi: 10.1136/bmj.l5367.


Epidemiology of idiopathic pulmonary fibrosis: a population-based study in primary care.

Harari S, Davì M, Biffi A, Caminati A, Ghirardini A, Lovato V, Cricelli C, Lapi F.

Intern Emerg Med. 2019 Sep 20. doi: 10.1007/s11739-019-02195-0. [Epub ahead of print]


STELO: a new tool for family physicians for the correct identification of inherited cancer syndromes.

Mariani C, Carnevali I, Lapi F, Paganini E, Civitelli C, Muzzolon J, Franzetti A, Guerroni A, Tibiletti MG.

Fam Pract. 2019 Sep 19. pii: cmz045. doi: 10.1093/fampra/cmz045. [Epub ahead of print]


Triple inhaled therapy in COPD patients: determinants of prescription in primary care.

Vetrano DL, Zucchelli A, Bianchini E, Cricelli C, Piraino A, Zibellini M, Ricci A, Onder G, Lapi F.

Respir Med. 2019 Jul - Aug;154:12-17. doi: 10.1016/j.rmed.2019.05.022. Epub 2019 May 29.


Epidemiology of non-deferrable medical conditions in primary care in Italy.

Levi M, Marconi E, Simonetti M, Cricelli C, Lapi F.

Health Soc Care Community. 2019 Sep;27(5):e663-e671. doi: 10.1111/hsc.12778. Epub 2019 Jun 3.


Adjuvanted versus nonadjuvanted influenza vaccines and risk of hospitalizations for pneumonia and cerebro/cardiovascular events in the elderly.

Lapi F, Marconi E, Simonetti M, Baldo V, Rossi A, Sessa A, Cricelli C.

Expert Rev Vaccines. 2019 Jun;18(6):663-670. doi: 10.1080/14760584.2019.1622418. Epub 2019 Jun 3.


Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts.

Alexander M, Loomis AK, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, Pasqua A, Lapi F, Rijnbeek P, Mosseveld M, Waterworth DM, Kendrick S, Sattar N, Alazawi W.

BMC Med. 2019 May 20;17(1):95. doi: 10.1186/s12916-019-1321-x.


Gender differences in determinants of iron-deficiency anemia: a population-based study conducted in four European countries.

Levi M, Simonetti M, Marconi E, Brignoli O, Cancian M, Masotti A, Pegoraro V, Heiman F, Cricelli C, Lapi F.

Ann Hematol. 2019 Jul;98(7):1573-1582. doi: 10.1007/s00277-019-03707-w. Epub 2019 May 9.


Bisphosphonates and cardiovascular risk in elderly patients with previous cardiovascular disease: a population-based nested case-control study in Italy.

Kirchmayer U, Sorge C, Sultana J, Lapi F, Onder G, Agabiti N, Cascini S, Roberto G, Corrao G, Vitale C, Lucenteforte E, Mugelli A, Davoli M.

Ther Adv Drug Saf. 2019 Apr 5;10:2042098619838138. doi: 10.1177/2042098619838138. eCollection 2019.


Prescribing Trends of Codeine-containing Medications and Other Opioids in Primary Care After A Regulatory Decision: An Interrupted Time Series Analysis.

Lombardi N, Vannacci A, Bettiol A, Marconi E, Pecchioli S, Magni A, Cricelli C, Lapi F.

Clin Drug Investig. 2019 May;39(5):455-462. doi: 10.1007/s40261-019-00767-8.


Trends in age-related disease burden and healthcare utilization.

Atella V, Piano Mortari A, Kopinska J, Belotti F, Lapi F, Cricelli C, Fontana L.

Aging Cell. 2019 Feb;18(1):e12861. doi: 10.1111/acel.12861. Epub 2018 Nov 29.


Prescribing patterns of allopurinol and febuxostat according to directives on the reimbursement criteria and clinical guidelines: analysis of a primary care database.

Marconi E, Bettiol A, Lombardi N, Crescioli G, Parretti L, Vannacci A, Medea G, Cricelli C, Lapi F.

Curr Med Res Opin. 2019 Apr;35(4):683-688. doi: 10.1080/03007995.2018.1541315. Epub 2018 Nov 26.


The Role of European Healthcare Databases for Post-Marketing Drug Effectiveness, Safety and Value Evaluation: Where Does Italy Stand?

Trifirò G, Gini R, Barone-Adesi F, Beghi E, Cantarutti A, Capuano A, Carnovale C, Clavenna A, Dellagiovanna M, Ferrajolo C, Franchi M, Ingrasciotta Y, Kirchmayer U, Lapi F, Leone R, Leoni O, Lucenteforte E, Moretti U, Mugelli A, Naldi L, Poluzzi E, Rafaniello C, Rea F, Sultana J, Tettamanti M, Traversa G, Vannacci A, Mantovani L, Corrao G.

Drug Saf. 2019 Mar;42(3):347-363. doi: 10.1007/s40264-018-0732-5. Review.


Overview on the management of diverticular disease by Italian General Practitioners.

Ubaldi E, Grattagliano I, Lapi F, Pecchioli S, Cricelli C.

Dig Liver Dis. 2019 Jan;51(1):63-67. doi: 10.1016/j.dld.2018.07.015. Epub 2018 Jul 31. Review.


Real-world data reveal a diagnostic gap in non-alcoholic fatty liver disease.

Alexander M, Loomis AK, Fairburn-Beech J, van der Lei J, Duarte-Salles T, Prieto-Alhambra D, Ansell D, Pasqua A, Lapi F, Rijnbeek P, Mosseveld M, Avillach P, Egger P, Kendrick S, Waterworth DM, Sattar N, Alazawi W.

BMC Med. 2018 Aug 13;16(1):130. doi: 10.1186/s12916-018-1103-x.


Epidemiology of acromegaly in Italy: analysis from a large longitudinal primary care database.

Gatto F, Trifirò G, Lapi F, Cocchiara F, Campana C, Dell'Aquila C, Ferrajolo C, Arvigo M, Cricelli C, Giusti M, Ferone D.

Endocrine. 2018 Sep;61(3):533-541. doi: 10.1007/s12020-018-1630-4. Epub 2018 May 24.


Deterministic and Probabilistic Record Linkage: an Application to Primary Care Data.

Carreras G, Simonetti M, Cricelli C, Lapi F.

J Med Syst. 2018 Mar 22;42(5):82. doi: 10.1007/s10916-018-0944-3. No abstract available.


NSAIDs utilization for musculoskeletal indications in elderly patients with cerebro/cardiovascular disease.

Roberto G, Bartolini C, Rea F, Onder G, Vitale C, Trifirò G, Kirchmayer U, Chinellato A, Lucenteforte E, Corrao G, Mugelli A, Lapi F, Gini R; Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE).

Eur J Clin Pharmacol. 2018 May;74(5):637-643. doi: 10.1007/s00228-018-2411-y. Epub 2018 Jan 30.


Monitoring compliance with standards of care for chronic diseases using healthcare administrative databases in Italy: Strengths and limitations.

Gini R, Schuemie MJ, Pasqua A, Carlini E, Profili F, Cricelli I, Dazzi P, Barletta V, Francesconi P, Lapi F, Donatini A, Dal Co G, Visca M, Bellentani M, Sturkenboom M, Klazinga N.

PLoS One. 2017 Dec 12;12(12):e0188377. doi: 10.1371/journal.pone.0188377. eCollection 2017.


Factors Associated with Type 2 Diabetes Mellitus Treatment Choice Across Four European Countries.

Heintjes EM, Overbeek JA, Hall GC, Prieto-Alhambra D, Lapi F, Hammar N, Bezemer ID.

Clin Ther. 2017 Nov;39(11):2296-2310.e14. doi: 10.1016/j.clinthera.2017.09.016. Epub 2017 Nov 4.


Inappropriate pharmacological treatment in older adults affected by cardiovascular disease and other chronic comorbidities: a systematic literature review to identify potentially inappropriate prescription indicators.

Lucenteforte E, Lombardi N, Vetrano DL, La Carpia D, Mitrova Z, Kirchmayer U, Corrao G, Lapi F, Mugelli A, Vannacci A.

Clin Interv Aging. 2017 Oct 19;12:1761-1778. doi: 10.2147/CIA.S137403. eCollection 2017. Review.


Drug interactions in users of tablet vs. oral liquid levothyroxine formulations: a real-world evidence study in primary care.

Guglielmi V, Bellia A, Bianchini E, Medea G, Cricelli I, Sbraccia P, Lauro D, Cricelli C, Lapi F.

Endocrine. 2018 Mar;59(3):585-592. doi: 10.1007/s12020-017-1412-4. Epub 2017 Sep 14.


Poor adherence to chronic obstructive pulmonary disease medications in primary care: Role of age, disease burden and polypharmacy.

Vetrano DL, Bianchini E, Onder G, Cricelli I, Cricelli C, Bernabei R, Bettoncelli G, Lapi F.

Geriatr Gerontol Int. 2017 Dec;17(12):2500-2506. doi: 10.1111/ggi.13115. Epub 2017 Jun 28.


Cardiovascular and cerebrovascular risk with nonsteroidal anti-inflammatory drugs and cyclooxygenase 2 inhibitors: latest evidence and clinical implications.

Fanelli A, Ghisi D, Aprile PL, Lapi F.

Ther Adv Drug Saf. 2017 Jun;8(6):173-182. doi: 10.1177/2042098617690485. Epub 2017 Feb 10. Review.


Effectiveness of adherence to lipid lowering therapy on LDL-cholesterol in patients with very high cardiovascular risk: A real-world evidence study in primary care.

Guglielmi V, Bellia A, Pecchioli S, Della-Morte D, Parretti D, Cricelli I, Medea G, Sbraccia P, Lauro D, Cricelli C, Lapi F.

Atherosclerosis. 2017 Aug;263:36-41. doi: 10.1016/j.atherosclerosis.2017.05.018. Epub 2017 May 20.


Prescription Appropriateness of Cyproterone Acetate/Ethinylestradiol in Primary Care: A Population-Based Study in Italy.

Lapi F, Simonetti M, Cricelli I, Cricelli C, Cassano N, Vena GA.

Clin Drug Investig. 2017 Aug;37(8):755-762. doi: 10.1007/s40261-017-0529-9.


Type 2 Diabetes Mellitus Treatment Patterns Across Europe: A Population-based Multi-database Study.

Overbeek JA, Heintjes EM, Prieto-Alhambra D, Blin P, Lassalle R, Hall GC, Lapi F, Bianchini E, Hammar N, Bezemer ID, Herings RMC.

Clin Ther. 2017 Apr;39(4):759-770. doi: 10.1016/j.clinthera.2017.02.008. Epub 2017 Mar 23.


The Burden of Chronic Heart Failure in Primary Care in Italy.

Piccinni C, Antonazzo IC, Simonetti M, Mennuni MG, Parretti D, Cricelli C, Colombo D, Nica M, Cricelli I, Lapi F.

High Blood Press Cardiovasc Prev. 2017 Jun;24(2):171-178. doi: 10.1007/s40292-017-0193-4. Epub 2017 Mar 21.


Regular use of acetaminophen or acetaminophen-codeine combinations and prescription of rescue therapy with non-steroidal anti-inflammatory drugs: a population-based study in primary care.

Vannacci A, Lombardi N, Simonetti M, Fornasari D, Fanelli A, Cricelli I, Cricelli C, Lora Aprile P, Lapi F.

Curr Med Res Opin. 2017 Jun;33(6):1141-1148. doi: 10.1080/03007995.2017.1308920. Epub 2017 Apr 21.


Erratum to: Assessing risk of osteoporotic fractures in primary care: development and validation of the FRA-HS algorithm.

Lapi F, Bianchini E, Michieli R, Pasqua A, Cricelli I, Mazzaglia G, Frediani B, Prieto-Alhambra D, Brandi ML, Cricelli C.

Calcif Tissue Int. 2017 Jun;100(6):550. doi: 10.1007/s00223-017-0262-7. No abstract available.


Automatic identification of type 2 diabetes, hypertension, ischaemic heart disease, heart failure and their levels of severity from Italian General Practitioners' electronic medical records: a validation study.

Gini R, Schuemie MJ, Mazzaglia G, Lapi F, Francesconi P, Pasqua A, Bianchini E, Montalbano C, Roberto G, Barletta V, Cricelli I, Cricelli C, Dal Co G, Bellentani M, Sturkenboom M, Klazinga N.

BMJ Open. 2016 Dec 9;6(12):e012413. doi: 10.1136/bmjopen-2016-012413.


Hepatitis C virus infection: opportunities for an earlier detection in primary care.

Lapi F, Capogrosso Sansone A, Mantarro S, Simonetti M, Tuccori M, Blandizzi C, Rossi A, Corti G, Bartoloni A, Bellia A, Baiocchi L, Cricelli I, Cricelli C.

Eur J Gastroenterol Hepatol. 2017 Mar;29(3):271-276. doi: 10.1097/MEG.0000000000000785.


Prevalence and Control of Hypertension in Different Macro-Areas in Italy: Analysis of a Large Database by the General Practice.

Tocci G, Nati G, Cricelli C, Parretti D, Lapi F, Ferrucci A, Borghi C, Volpe M.

High Blood Press Cardiovasc Prev. 2016 Dec;23(4):387-393. doi: 10.1007/s40292-016-0173-0. Epub 2016 Oct 8.


Prevalence and control of hypertension in the general practice in Italy: updated analysis of a large database.

Tocci G, Nati G, Cricelli C, Parretti D, Lapi F, Ferrucci A, Borghi C, Volpe M.

J Hum Hypertens. 2017 Apr;31(4):258-262. doi: 10.1038/jhh.2016.71. Epub 2016 Sep 15.


A probabilistic bias analysis for misclassified categorical exposures, with application to oral anti-hyperglycaemic drugs.

Arfè A, Nicotra F, Ghirardi A, Simonetti M, Lapi F, Sturkenboom M, Corrao G.

Pharmacoepidemiol Drug Saf. 2016 Dec;25(12):1443-1450. doi: 10.1002/pds.4093. Epub 2016 Sep 4.


Identifying Cases of Type 2 Diabetes in Heterogeneous Data Sources: Strategy from the EMIF Project.

Roberto G, Leal I, Sattar N, Loomis AK, Avillach P, Egger P, van Wijngaarden R, Ansell D, Reisberg S, Tammesoo ML, Alavere H, Pasqua A, Pedersen L, Cunningham J, Tramontan L, Mayer MA, Herings R, Coloma P, Lapi F, Sturkenboom M, van der Lei J, Schuemie MJ, Rijnbeek P, Gini R.

PLoS One. 2016 Aug 31;11(8):e0160648. doi: 10.1371/journal.pone.0160648. eCollection 2016.


How to early recognize mood disorders in primary care: A nationwide, population-based, cohort study.

Castellini G, Pecchioli S, Cricelli I, Mazzoleni F, Cricelli C, Ricca V, Hudziak JJ, Brignoli O, Lapi F.

Eur Psychiatry. 2016 Sep;37:63-9. doi: 10.1016/j.eurpsy.2016.04.003.


What is the actual epidemiology of familial hypercholesterolemia in Italy? Evidence from a National Primary Care Database.

Guglielmi V, Bellia A, Pecchioli S, Medea G, Parretti D, Lauro D, Sbraccia P, Federici M, Cricelli I, Cricelli C, Lapi F.

Int J Cardiol. 2016 Nov 15;223:701-705. doi: 10.1016/j.ijcard.2016.08.269. Epub 2016 Aug 17.


Epidemiology of Parkinson's Disease: A Population-Based Study in Primary Care in Italy.

Pupillo E, Cricelli C, Mazzoleni F, Cricelli I, Pasqua A, Pecchioli S, Lapi F, Beghi E.

Neuroepidemiology. 2016;47(1):38-45. doi: 10.1159/000448402. Epub 2016 Aug 10.


Medication patterns in chronic spontaneous urticaria: results from a nationwide investigation in the primary care setting in Italy.

Vena GA, Cassano N, Pegoraro V, Cataldo N, Heiman F, Cricelli I, Colombo D, Zagni E, Cricelli C, Lapi F.

G Ital Dermatol Venereol. 2018 Feb;153(1):39-42. doi: 10.23736/S0392-0488.16.05387-6. Epub 2016 Jun 1.


Paracetamol: a probably still safe drug.

Battaggia A, Lora Aprile P, Cricelli I, Fornasari D, Fanelli A, Cricelli C, Lapi F.

Ann Rheum Dis. 2016 Sep;75(9):e57. doi: 10.1136/annrheumdis-2016-209713. Epub 2016 May 10. No abstract available.


Epidemiology of iron deficiency anaemia in four European countries: a population-based study in primary care.

Levi M, Rosselli M, Simonetti M, Brignoli O, Cancian M, Masotti A, Pegoraro V, Cataldo N, Heiman F, Chelo M, Cricelli I, Cricelli C, Lapi F.

Eur J Haematol. 2016 Dec;97(6):583-593. doi: 10.1111/ejh.12776. Epub 2016 Jun 8.


Patient Adherence to Olmesartan/Amlodipine Combinations: Fixed Versus Extemporaneous Combinations.

Levi M, Pasqua A, Cricelli I, Cricelli C, Piccinni C, Parretti D, Lapi F.

J Manag Care Spec Pharm. 2016 Mar;22(3):255-62. doi: 10.18553/jmcp.2016.22.3.255.


Risk of prostate cancer in low-dose aspirin users: A retrospective cohort study.

Lapi F, Levi M, Simonetti M, Cancian M, Parretti D, Cricelli I, Sobrero A, Cricelli C.

Int J Cancer. 2016 Jul 1;139(1):205-11. doi: 10.1002/ijc.30061. Epub 2016 Mar 15.


Epidemiology of chronic spontaneous urticaria: results from a nationwide, population-based study in Italy.

Lapi F, Cassano N, Pegoraro V, Cataldo N, Heiman F, Cricelli I, Levi M, Colombo D, Zagni E, Cricelli C, Vena GA.

Br J Dermatol. 2016 May;174(5):996-1004. doi: 10.1111/bjd.14470. Epub 2016 Mar 15.


Risk of Acute Cerebrovascular and Cardiovascular Events Among Users of Acetaminophen or an Acetaminophen-Codeine Combination in a Cohort of Patients with Osteoarthritis: A Nested Case-Control Study.

Roberto G, Simonetti M, Piccinni C, Lora Aprile P, Cricelli I, Fanelli A, Cricelli C, Lapi F.

Pharmacotherapy. 2015 Oct;35(10):899-909. doi: 10.1002/phar.1646.


Development and Validation of a Score for Adjusting Health Care Costs in General Practice.

Lapi F, Bianchini E, Cricelli I, Trifirò G, Mazzaglia G, Cricelli C.

Value Health. 2015 Sep;18(6):884-95. doi: 10.1016/j.jval.2015.05.004. Epub 2015 Jul 17.


Concurrent Use of Low-Dose Aspirin and Omega-3 Fatty Acids and Risk of Upper Gastrointestinal Complications: A Cohort Study with Nested Case-Control Analysis.

Roberto G, Simonetti M, Cricelli C, Cricelli I, Giustini SE, Parretti D, Lapi F.

Basic Clin Pharmacol Toxicol. 2016 Feb;118(2):136-42. doi: 10.1111/bcpt.12454. Epub 2015 Sep 11.

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