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Items: 1 to 50 of 200

1.

Complement and coagulation cascades in trauma.

Satyam A, Graef ER, Lapchak PH, Tsokos MG, Dalle Lucca JJ, Tsokos GC.

Acute Med Surg. 2019 Apr 25;6(4):329-335. doi: 10.1002/ams2.426. eCollection 2019 Oct. Review.

2.

Hyaluronic Acid Synthesis Contributes to Tissue Damage in Systemic Lupus Erythematosus.

Suarez-Fueyo A, Tsokos MG, Kwok SK, Maeda K, Katsuyama E, Lapchak PH, Tsokos GC.

Front Immunol. 2019 Sep 13;10:2172. doi: 10.3389/fimmu.2019.02172. eCollection 2019.

3.

CNB-001 reduces paraplegia in rabbits following spinal cord ischemia.

Lapchak PA, Boitano PD, Bombien R, Chou D, Knight M, Muehle A, Winkel MT, Khoynezhad A.

Neural Regen Res. 2019 Dec;14(12):2192-2198. doi: 10.4103/1673-5374.262598.

4.

Complement Deposition on the Surface of RBC After Trauma Serves A Biomarker of Moderate Trauma Severity: A Prospective Study.

Satyam A, Andreo K, Lapchak PH, Dalle Lucca JJ, Davis RB, Tsokos MG, Shapiro NI, Tsokos GC.

Shock. 2019 Apr 12. doi: 10.1097/SHK.0000000000001348. [Epub ahead of print]

PMID:
30998651
5.

CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys.

Lapchak PA, Boitano PD, Bombien R, Cook DJ, Doyan S, Lara JM, Schubert DR.

Exp Neurol. 2019 Mar;313:98-108. doi: 10.1016/j.expneurol.2018.11.010. Epub 2018 Dec 4.

PMID:
30521790
6.

Intravenous xenogeneic human cardiosphere-derived cell extracellular vesicles (exosomes) improves behavioral function in small-clot embolized rabbits.

Lapchak PA, Boitano PD, de Couto G, Marbán E.

Exp Neurol. 2018 Sep;307:109-117. doi: 10.1016/j.expneurol.2018.06.007. Epub 2018 Jun 14.

PMID:
29908146
7.

C3a Enhances the Formation of Intestinal Organoids through C3aR1.

Matsumoto N, Satyam A, Geha M, Lapchak PH, Dalle Lucca JJ, Tsokos MG, Tsokos GC.

Front Immunol. 2017 Sep 4;8:1046. doi: 10.3389/fimmu.2017.01046. eCollection 2017.

8.

Microglia-dependent synapse loss in type I interferon-mediated lupus.

Bialas AR, Presumey J, Das A, van der Poel CE, Lapchak PH, Mesin L, Victora G, Tsokos GC, Mawrin C, Herbst R, Carroll MC.

Nature. 2017 Jun 22;546(7659):539-543. doi: 10.1038/nature22821. Epub 2017 Jun 14.

PMID:
28614301
9.

Cytoprotective Drug-Tissue Plasminogen Activator Protease Interaction Assays: Screening of Two Novel Cytoprotective Chromones.

Lapchak PA, Lara JM, Boitano PD.

Transl Stroke Res. 2017 Apr 12. doi: 10.1007/s12975-017-0533-7. [Epub ahead of print]

PMID:
28405804
10.

Translational Stroke Research Guideline Projections: The 20/20 Standards.

Lapchak PA, Zhang JH.

Transl Stroke Res. 2018 Feb;9(1):9-12. doi: 10.1007/s12975-017-0534-6. Epub 2017 Apr 6. No abstract available.

PMID:
28386732
11.

Data Standardization and Quality Management.

Lapchak PA, Zhang JH.

Transl Stroke Res. 2018 Feb;9(1):4-8. doi: 10.1007/s12975-017-0531-9. Epub 2017 Mar 10.

PMID:
28283966
12.

Translational Stroke Research Opportunities and a Strategy to Develop Effective Cytoprotection.

Lapchak PA.

Transl Stroke Res. 2017 Aug;8(4):318-321. doi: 10.1007/s12975-017-0529-3. Epub 2017 Mar 8. No abstract available.

PMID:
28271393
13.

Stroke Cytoprotection: Can Repeating History with New Expectations Really Be the Path to Success in Stroke Research?

Lapchak PA, Uteshev VV.

Transl Stroke Res. 2017 Apr;8(2):104-106. doi: 10.1007/s12975-017-0528-4. Epub 2017 Mar 1. No abstract available.

PMID:
28251583
14.

The High Cost of Stroke and Stroke Cytoprotection Research.

Lapchak PA, Zhang JH.

Transl Stroke Res. 2017 Aug;8(4):307-317. doi: 10.1007/s12975-016-0518-y. Epub 2016 Dec 30. Review.

15.

Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage during Mesenteric Ischemia.

Satyam A, Kannan L, Matsumoto N, Geha M, Lapchak PH, Bosse R, Shi GP, Dalle Lucca JJ, Tsokos MG, Tsokos GC.

J Immunol. 2017 Jan 15;198(2):788-797. doi: 10.4049/jimmunol.1502287. Epub 2016 Dec 2.

16.

A novel method to promote behavioral improvement and enhance mitochondrial function following an embolic stroke.

Lapchak PA, Boitano PD.

Brain Res. 2016 Sep 1;1646:125-131. doi: 10.1016/j.brainres.2016.04.039. Epub 2016 May 11.

PMID:
27180104
17.
18.

Transcranial Near-Infrared Laser Therapy for Stroke: How to Recover from Futility in the NEST-3 Clinical Trial.

Lapchak PA, Boitano PD.

Acta Neurochir Suppl. 2016;121:7-12. doi: 10.1007/978-3-319-18497-5_2.

PMID:
26463915
19.

Critical early thrombolytic and endovascular reperfusion therapy for acute ischemic stroke victims: a call for adjunct neuroprotection.

Lapchak PA.

Transl Stroke Res. 2015 Oct;6(5):345-54. doi: 10.1007/s12975-015-0419-5. Epub 2015 Aug 29.

20.

Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer's disease cybrid cells.

Jeong JH, Yum KS, Chang JY, Kim M, Ahn JY, Kim S, Lapchak PA, Han MK.

BMC Neurol. 2015 Jul 31;15:127. doi: 10.1186/s12883-015-0390-5.

21.

Transcranial Near-Infrared Laser Transmission (NILT) Profiles (800 nm): Systematic Comparison in Four Common Research Species.

Lapchak PA, Boitano PD, Butte PV, Fisher DJ, Hölscher T, Ley EJ, Nuño M, Voie AH, Rajput PS.

PLoS One. 2015 Jun 3;10(6):e0127580. doi: 10.1371/journal.pone.0127580. eCollection 2015.

22.

Methodology of motor evoked potentials in a rabbit model.

Waterford SD, Rastegar M, Goodwin E, Lapchak PA, Juan V, Haji F, Bombien R, Khoynezhad A.

Transl Stroke Res. 2015 Oct;6(5):399-406. doi: 10.1007/s12975-015-0406-x. Epub 2015 May 20.

PMID:
25990352
23.

A blinded, randomized study of L-arginine in small clot embolized rabbits.

Lapchak PA, Daley JT, Boitano PD.

Exp Neurol. 2015 Apr;266:143-6. doi: 10.1016/j.expneurol.2015.02.016. Epub 2015 Feb 20.

24.

A cost-effective rabbit embolic stroke bioassay: insight into the development of acute ischemic stroke therapy.

Lapchak PA.

Transl Stroke Res. 2015 Apr;6(2):99-103. doi: 10.1007/s12975-015-0386-x. Epub 2015 Feb 1. No abstract available.

27.

Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance.

Panzhinskiy E, Hua Y, Lapchak PA, Topchiy E, Lehmann TE, Ren J, Nair S.

J Pharmacol Exp Ther. 2014 May;349(2):248-57. doi: 10.1124/jpet.113.208728. Epub 2014 Feb 18.

28.

Fast neuroprotection (fast-NPRX) for acute ischemic stroke victims: the time for treatment is now.

Lapchak PA.

Transl Stroke Res. 2013 Dec;4(6):704-9. doi: 10.1007/s12975-013-0303-0. Epub 2013 Nov 7. No abstract available.

29.
30.

J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox Safety and Genotoxicity Analysis.

Lapchak PA, Bombien R, Rajput PS.

J Neurol Neurophysiol. 2013 Aug;4(3). pii: 158.

31.

Recommendations for preclinical research in hemorrhagic transformation.

Fagan SC, Lapchak PA, Liebeskind DS, Ishrat T, Ergul A.

Transl Stroke Res. 2013 Jun;4(3):322-7. doi: 10.1007/s12975-012-0222-5. Review.

32.
33.

RIGOR guidelines: escalating STAIR and STEPS for effective translational research.

Lapchak PA, Zhang JH, Noble-Haeusslein LJ.

Transl Stroke Res. 2013 Jun;4(3):279-85. doi: 10.1007/s12975-012-0209-2. Epub 2012 Sep 5.

34.

Development of transcranial sonothrombolysis as an alternative stroke therapy: incremental scientific advances toward overcoming substantial barriers.

Lapchak PA, Kikuchi K, Butte P, Hölscher T.

Expert Rev Med Devices. 2013 Mar;10(2):201-13. doi: 10.1586/erd.12.88. Review.

PMID:
23480089
35.

Recommendations and practices to optimize stroke therapy: developing effective translational research programs.

Lapchak PA.

Stroke. 2013 Mar;44(3):841-3. doi: 10.1161/STROKEAHA.112.680439. Epub 2013 Feb 7. No abstract available.

PMID:
23391768
36.

Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke.

Kikuchi K, Miura N, Kawahara KI, Murai Y, Morioka M, Lapchak PA, Tanaka E.

Biomed Rep. 2013 Jan;1(1):7-12. Epub 2012 Aug 29. Review.

37.

Sisyphus and translational stroke research.

Lyden P, Lapchak P.

Sci Transl Med. 2012 Oct 17;4(156):156ps20. doi: 10.1126/scitranslmed.3005083.

PMID:
23076354
38.

The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury.

Lapchak PH, Ioannou A, Rani P, Lieberman LA, Yoshiya K, Kannan L, Dalle Lucca JJ, Kowalska MA, Tsokos GC.

PLoS One. 2012;7(7):e39934. doi: 10.1371/journal.pone.0039934. Epub 2012 Jul 6.

39.

A series of novel neuroprotective blood brain barrier penetrating flavonoid drugs to treat acute ischemic stroke.

Lapchak PA.

Curr Pharm Des. 2012;18(25):3694-703. Review. Erratum in: Curr Pharm Des. 2013;19(3):527.

PMID:
22574983
40.

Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury.

Lapchak PH, Kannan L, Rani P, Pamuk ON, Ioannou A, Dalle Lucca JJ, Pine P, Tsokos GC.

Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1416-22. doi: 10.1152/ajpgi.00026.2012. Epub 2012 Apr 5.

41.

Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury.

Lapchak PH, Ioannou A, Kannan L, Rani P, Dalle Lucca JJ, Tsokos GC.

PLoS One. 2012;7(2):e32260. doi: 10.1371/journal.pone.0032260. Epub 2012 Feb 27.

42.

Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion.

Lapchak PH, Kannan L, Ioannou A, Rani P, Karian P, Dalle Lucca JJ, Tsokos GC.

Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G888-97. doi: 10.1152/ajpgi.00499.2011. Epub 2012 Feb 2.

43.
44.
45.

De-Risking of Stilbazulenyl Nitrone (STAZN), a Lipophilic Nitrone to Treat Stroke Using a Unique Panel of In Vitro Assays.

Lapchak PA, Schubert DR, Maher PA.

Transl Stroke Res. 2011 Jun;2(2):209-17. doi: 10.1007/s12975-011-0071-7.

46.

Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury.

Yoshiya K, Lapchak PH, Thai TH, Kannan L, Rani P, Dalle Lucca JJ, Tsokos GC.

Am J Physiol Gastrointest Liver Physiol. 2011 Dec;301(6):G1020-30. doi: 10.1152/ajpgi.00239.2011. Epub 2011 Sep 8.

47.

Emerging Therapies: Pleiotropic Multi-target Drugs to Treat Stroke Victims.

Lapchak PA.

Transl Stroke Res. 2011 Jun 1;2(2):129-35. doi: 10.1007/s12975-011-0074-4. No abstract available.

48.

Resolving the negative data publication dilemma in translational stroke research.

Lapchak PA, Zhang JH.

Transl Stroke Res. 2011 Mar 1;2(1):1-6. doi: 10.1007/s12975-010-0057-x. No abstract available.

49.

Continuous monitoring of changes in plasma nitrite following cerebral ischemia in a rabbit embolic stroke model.

Silver JH, Lapchak PA.

Transl Stroke Res. 2011 Jun;2(2):218-26. doi: 10.1007/s12975-011-0073-5.

50.

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