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Items: 48

1.

Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma.

Lapadula D, Farias E, Randolph CE, Purwin TJ, McGrath D, Charpentier TH, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner PB, Aplin AE, Aguirre-Ghiso J, Benovic JL.

Mol Cancer Res. 2019 Apr;17(4):963-973. doi: 10.1158/1541-7786.MCR-18-0574. Epub 2018 Dec 19.

PMID:
30567972
2.

A tissue-specific enhancer of the C. elegans nhr-67/tailless gene drives coordinated expression in uterine stem cells and the differentiated anchor cell.

Bodofsky S, Liberatore K, Pioppo L, Lapadula D, Thompson L, Birnbaum S, McClung G, Kartik A, Clever S, Wightman B.

Gene Expr Patterns. 2018 Dec;30:71-81. doi: 10.1016/j.gep.2018.10.003. Epub 2018 Nov 4.

PMID:
30404043
3.

Evaluation of Therapeutics for Advanced-Stage Heart Failure and Other Severely-Debilitating or Life-Threatening Diseases.

Prescott JS, Andrews PA, Baker RW, Bogdanffy MS, Fields FO, Keller DA, Lapadula DM, Mahoney NM, Paul DE, Platz SJ, Reese DM, Stoch SA, DeGeorge JJ.

Clin Pharmacol Ther. 2017 Aug;102(2):219-227. doi: 10.1002/cpt.730. Epub 2017 Jun 21. Review.

PMID:
28474798
4.

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma.

Chua V, Lapadula D, Randolph C, Benovic JL, Wedegaertner PB, Aplin AE.

Mol Cancer Res. 2017 May;15(5):501-506. doi: 10.1158/1541-7786.MCR-17-0007. Epub 2017 Feb 21. Review.

5.

Acute Toxicity of Vildagliptin.

Hoffmann P, Martin L, Keselica M, Gunson D, Skuba E, Lapadula D, Hayes M, Bentley P, Busch S.

Toxicol Pathol. 2017 Jan;45(1):76-83. doi: 10.1177/0192623316672944. Epub 2016 Oct 17.

PMID:
27753637
6.

Vascular origin of vildagliptin-induced skin effects in Cynomolgus monkeys: pathomechanistic role of peripheral sympathetic system and neuropeptide Y.

Hoffmann P, Bentley P, Sahota P, Schoenfeld H, Martin L, Longo L, Spaet R, Moulin P, Pantano S, Dubost V, Lapadula D, Burkey B, Kaushik V, Zhou W, Hayes M, Flavahan N, Chibout SD, Busch S.

Toxicol Pathol. 2014 Jun;42(4):684-95. doi: 10.1177/0192623313516828. Epub 2014 Jan 20.

PMID:
24448599
7.

ICH guidelines: inception, revision, and implications for drug development.

Wang T, Jacobson-Kram D, Pilaro AM, Lapadula D, Jacobs A, Brown P, Lipscomb J, McGuinn WD.

Toxicol Sci. 2010 Dec;118(2):356-67. doi: 10.1093/toxsci/kfq286. Epub 2010 Sep 22. No abstract available.

PMID:
20861066
8.

Neurotoxicity of glycidamide, an acrylamide metabolite, following intraperitoneal injections in rats.

Abou-Donia MB, Ibrahim SM, Corcoran JJ, Lack L, Friedman MA, Lapadula DM.

J Toxicol Environ Health. 1993 Aug;39(4):447-64.

PMID:
8345532
9.

Protein synthesis inhibition blocks maintenance but not induction of epileptogenesis in hippocampal slice.

Jones LS, Grooms SY, Lapadula DM, Lewis DV.

Brain Res. 1992 Dec 25;599(2):338-44.

PMID:
1291037
10.

Anomalous phosphorylated neurofilament aggregations in central and peripheral axons of hens treated with tri-ortho-cresyl phosphate (TOCP).

Jensen KF, Lapadula DM, Anderson JK, Haykal-Coates N, Abou-Donia MB.

J Neurosci Res. 1992 Nov;33(3):455-60.

PMID:
1469747
11.

Ca2+/calmodulin-dependent protein kinase II from hen brain. Purification and characterization.

Gupta RP, Lapadula DM, Abou-Donia MB.

Biochem Pharmacol. 1992 May 8;43(9):1975-88.

PMID:
1317705
12.
13.

Triphenyl phosphite-induced ultrastructural changes in bovine adrenomedullary chromaffin cells.

Knoth-Anderson J, Veronesi B, Jones K, Lapadula DM, Abou-Donia MB.

Toxicol Appl Pharmacol. 1992 Jan;112(1):110-9.

PMID:
1733042
14.

Persistent alterations of calmodulin kinase II activity in chickens after an oral dose of tri-o-cresyl phosphate.

Lapadula ES, Lapadula DM, Abou-Donia MB.

Biochem Pharmacol. 1991 Jun 21;42(1):171-80.

PMID:
1648921
15.

Mechanisms of joint neurotoxicity of n-hexane, methyl isobutyl ketone and O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens.

Abou-Donia MB, Hu ZH, Lapadula DM, Gupta RP.

J Pharmacol Exp Ther. 1991 Apr;257(1):282-9.

PMID:
2019992
16.

Induction of cytochrome P450 isozymes by simultaneous inhalation exposure of hens to n-hexane and methyl iso-butyl ketone (MiBK).

Lapadula DM, Habig C, Gupta RP, Abou-Donia MB.

Biochem Pharmacol. 1991 Mar 15-Apr 1;41(6-7):877-83.

PMID:
2009082
17.

In vivo binding of [(14)C]acrylamide to proteins in the mouse nervous system.

Carrington CD, Lapadula DM, Dulak L, Friedman M, Abou-Donia MB.

Neurochem Int. 1991;18(2):191-7.

PMID:
20504693
18.

Light and electron microscopic evidence of tri-o-cresyl phosphate (TOCP)-mediated testicular toxicity in Fischer 344 rats.

Somkuti SG, Lapadula DM, Chapin RE, Abou-Donia MB.

Toxicol Appl Pharmacol. 1991 Jan;107(1):35-46.

PMID:
1987658
19.

Purification and characterization of cytochrome P450 isozymes from beta-naphthoflavone-induced adult hen liver.

Gupta RP, Lapadula DM, Abou-Donia MB.

Arch Biochem Biophys. 1990 Oct;282(1):170-82.

PMID:
2171427
20.

Effects of diisopropyl phosphorofluoridate (DFP) on CA3 and CA1 responses in rat hippocampus.

Jones LS, Lapadula DM, Lewis DV, Abou-Donia MB.

Mol Chem Neuropathol. 1990 Aug-Oct;13(1-2):1-16.

PMID:
2095778
21.

Assessment of the delayed neurotoxicity of tributyl phosphate, tributoxyethyl phosphate, and dibutylphenyl phosphate.

Carrington CD, Lapadula DM, Othman M, Farr C, Nair RS, Johannsen F, Abou-Donia MB.

Toxicol Ind Health. 1990 May-Jul;6(3-4):415-23.

PMID:
2237927
22.

Mechanisms of organophosphorus ester-induced delayed neurotoxicity: type I and type II.

Abou-Donia MB, Lapadula DM.

Annu Rev Pharmacol Toxicol. 1990;30:405-40. Review.

PMID:
2188574
23.

Absence of delayed neurotoxicity and increased plasma butyrylcholinesterase activity in triallate-treated hens.

Lapadula DM, Johannsen F, Abou-Donia MB.

Fundam Appl Toxicol. 1990 Jan;14(1):191-8.

PMID:
2155148
24.

Purification and characterization of cytochrome P-450 isozymes from phenobarbital-induced adult hen liver.

Gupta RP, Lapadula DM, Abou-Donia MB.

Comp Biochem Physiol C. 1990;96(1):163-76.

PMID:
1980873
25.

In vitro binding of [14C]acrylamide to neurofilament and microtubule proteins of rats.

Lapadula DM, Bowe M, Carrington CD, Dulak L, Friedman M, Abou-Donia MB.

Brain Res. 1989 Feb 27;481(1):157-61.

PMID:
2495837
26.

Acceleration of anterograde axonal transport in cat sciatic nerve by diisopropyl phosphorofluoridate.

Carrington CD, Lapadula DM, Abou-Donia MB.

Brain Res. 1989 Jan 2;476(1):179-82.

PMID:
2464416
27.

Evidence for multiple mechanisms responsible for 2,5-hexanedione-induced neuropathy.

Lapadula DM, Suwita E, Abou-Donia MB.

Brain Res. 1988 Aug 16;458(1):123-31.

PMID:
3145093
28.

Cytoskeletal proteins as targets for organophosphorus compound and aliphatic hexacarbon-induced neurotoxicity.

Abou-Donia MB, Lapadula DM, Suwita E.

Toxicology. 1988 May;49(2-3):469-77.

PMID:
2836976
29.

Lack of delayed neurotoxic effect after tri-o-cresyl phosphate treatment in male Fischer 344 rats: biochemical, neurobehavioral, and neuropathological studies.

Somkuti SG, Tilson HA, Brown HR, Campbell GA, Lapadula DM, Abou-Donia MB.

Fundam Appl Toxicol. 1988 Feb;10(2):199-205.

PMID:
3356306
30.

Testicular toxicity following oral administration of tri-o-cresyl phosphate (TOCP) in roosters.

Somkuti SG, Lapadula DM, Chapin RE, Lamb JC 4th, Abou-Donia MB.

Toxicol Lett. 1987 Aug;37(3):279-90.

PMID:
3617103
31.

Time course of the tri-o-cresyl phosphate-induced testicular lesion in F-344 rats: enzymatic, hormonal, and sperm parameter studies.

Somkuti SG, Lapadula DM, Chapin RE, Lamb JC 4th, Abou-Donia MB.

Toxicol Appl Pharmacol. 1987 Jun 15;89(1):64-72.

PMID:
3590189
32.

Reproductive tract lesions resulting from subchronic administration (63 days) of tri-o-cresyl phosphate in male rats.

Somkuti SG, Lapadula DM, Chapin RE, Lamb JC 4th, Abou-Donia MB.

Toxicol Appl Pharmacol. 1987 Jun 15;89(1):49-63.

PMID:
3590188
33.

Neurotoxic effects of combined treatment of 2,5-hexanedione and triethyllead chloride.

Lapadula DM, Tilson HA, Campbell G, Abou-Donia MB.

J Toxicol Environ Health. 1987;21(4):483-92.

PMID:
3599091
34.
36.

Cross-linking of neurofilament proteins of rat spinal cord in vivo after administration of 2,5-hexanedione.

Lapadula DM, Irwin RD, Suwita E, Abou-Donia MB.

J Neurochem. 1986 Jun;46(6):1843-50.

PMID:
3084709
37.
38.

Electromyographic, neuropathologic, and functional correlates in the cat as the result of tri-o-cresyl phosphate delayed neurotoxicity.

Abou-Donia MB, Trofatter LP, Graham DG, Lapadula DM.

Toxicol Appl Pharmacol. 1986 Mar 30;83(1):126-41.

PMID:
3952742
39.

Changes in in vitro brain and spinal cord protein phosphorylation after a single oral administration of tri-o-cresyl phosphate to hens.

Patton SE, Lapadula DM, O'Callaghan JP, Miller DB, Abou-Donia MB.

J Neurochem. 1985 Nov;45(5):1567-77.

PMID:
4045464
40.
41.

Characterization of delayed neurotoxicity in the mouse following chronic oral administration of tri-o-cresyl phosphate.

Lapadula DM, Patton SE, Campbell GA, Abou-Donia MB.

Toxicol Appl Pharmacol. 1985 Jun 15;79(1):83-90.

PMID:
4049409
42.
43.

Partial characterization of endogenous phosphorylation conditions for hen brain cytosolic and membrane proteins.

Patton SE, Lapadula DM, Abou-Donia MB.

Brain Res. 1985 Feb 25;328(1):1-14.

PMID:
3971166
46.

Neurologic manifestations of tri-O-cresyl phosphate delayed neurotoxicity in cats.

Abou-Donia MB, Jensen DN, Lapadula DM.

Neurobehav Toxicol Teratol. 1983 Jul-Aug;5(4):431-42.

PMID:
6646317
47.

Monosynaptic reflex depression in cats with organophosphorus neuropathy: effects of tri-o-cresyl phosphate.

Lapadula DM, Kinnes CG, Somjen GG, Abou-Donia MB.

Neurotoxicology. 1982 Nov;3(3):51-61.

PMID:
6891759
48.

A new in vivo method for quantitatively evaluating local anesthetics.

Lieeman FM, Brown D, Friedman P, Klinger G, Lapadula D.

Eur J Pharmacol. 1978 Oct 15;51(4):337-44.

PMID:
710509

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