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Items: 29


Cutting Edge: Check Your Mice-A Point Mutation in the Ncr1 Locus Identified in CD45.1 Congenic Mice with Consequences in Mouse Susceptibility to Infection.

Jang Y, Gerbec ZJ, Won T, Choi B, Podsiad A, B Moore B, Malarkannan S, Laouar Y.

J Immunol. 2018 Mar 15;200(6):1982-1987. doi: 10.4049/jimmunol.1701676. Epub 2018 Feb 9.


Gut symbiotic microbes imprint intestinal immune cells with the innate receptor SLAMF4 which contributes to gut immune protection against enteric pathogens.

Cabinian A, Sinsimer D, Tang M, Jang Y, Choi B, Laouar Y, Laouar A.

Gut. 2018 May;67(5):847-859. doi: 10.1136/gutjnl-2016-313214. Epub 2017 Mar 24.


A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.

Mondanelli G, Bianchi R, Pallotta MT, Orabona C, Albini E, Iacono A, Belladonna ML, Vacca C, Fallarino F, Macchiarulo A, Ugel S, Bronte V, Gevi F, Zolla L, Verhaar A, Peppelenbosch M, Mazza EMC, Bicciato S, Laouar Y, Santambrogio L, Puccetti P, Volpi C, Grohmann U.

Immunity. 2017 Feb 21;46(2):233-244. doi: 10.1016/j.immuni.2017.01.005. Epub 2017 Feb 14.


Transfer of Maternal Immune Cells by Breastfeeding: Maternal Cytotoxic T Lymphocytes Present in Breast Milk Localize in the Peyer's Patches of the Nursed Infant.

Cabinian A, Sinsimer D, Tang M, Zumba O, Mehta H, Toma A, Sant'Angelo D, Laouar Y, Laouar A.

PLoS One. 2016 Jun 10;11(6):e0156762. doi: 10.1371/journal.pone.0156762. eCollection 2016.


Dissecting CD8+ NKT Cell Responses to Listeria Infection Reveals a Component of Innate Resistance.

Seregin SS, Chen GY, Laouar Y.

J Immunol. 2015 Aug 1;195(3):1112-20. doi: 10.4049/jimmunol.1500084. Epub 2015 Jun 26.


Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation.

Domingo-Gonzalez R, Wilke CA, Huang SK, Laouar Y, Brown JP, Freeman CM, Curtis JL, Yanik GA, Moore BB.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L86-95. doi: 10.1152/ajplung.00283.2014. Epub 2014 Oct 31.


CD1d-unrestricted NKT cells are endowed with a hybrid function far superior than that of iNKT cells.

Farr AR, Wu W, Choi B, Cavalcoli JD, Laouar Y.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12841-6. doi: 10.1073/pnas.1323405111. Epub 2014 Aug 20.


TGF-β signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation.

Speck S, Lim J, Shelake S, Matka M, Stoddard J, Farr A, Kuchroo V, Laouar Y.

PLoS One. 2014 Jul 29;9(7):e102390. doi: 10.1371/journal.pone.0102390. eCollection 2014.


γ-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates established murine lung fibrosis.

Ashley SL, Jegal Y, Moore TA, van Dyk LF, Laouar Y, Moore BB.

Am J Physiol Lung Cell Mol Physiol. 2014 Aug 1;307(3):L219-30. doi: 10.1152/ajplung.00300.2013. Epub 2014 May 30.


COX-2 expression is upregulated by DNA hypomethylation after hematopoietic stem cell transplantation.

Domingo-Gonzalez R, Huang SK, Laouar Y, Wilke CA, Moore BB.

J Immunol. 2012 Nov 1;189(9):4528-36. doi: 10.4049/jimmunol.1201116. Epub 2012 Sep 24.


TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy.

Marcoe JP, Lim JR, Schaubert KL, Fodil-Cornu N, Matka M, McCubbrey AL, Farr AR, Vidal SM, Laouar Y.

Nat Immunol. 2012 Sep;13(9):843-50. doi: 10.1038/ni.2388. Epub 2012 Aug 5. Erratum in: Nat Immunol. 2013 Aug;14(8):876.


Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis.

Lievens D, Habets KL, Robertson AK, Laouar Y, Winkels H, Rademakers T, Beckers L, Wijnands E, Boon L, Mosaheb M, Ait-Oufella H, Mallat Z, Flavell RA, Rudling M, Binder CJ, Gerdes N, Biessen EA, Weber C, Daemen MJ, Kuiper J, Lutgens E.

Eur Heart J. 2013 Dec;34(48):3717-27. doi: 10.1093/eurheartj/ehs106. Epub 2012 May 21.


Severe gammaherpesvirus-induced pneumonitis and fibrosis in syngeneic bone marrow transplant mice is related to effects of transforming growth factor-β.

Coomes SM, Farmen S, Wilke CA, Laouar Y, Moore BB.

Am J Pathol. 2011 Nov;179(5):2382-96. doi: 10.1016/j.ajpath.2011.08.002. Epub 2011 Sep 13.


Role of T cell TGFbeta signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection.

Faust SM, Lu G, Marini BL, Zou W, Gordon D, Iwakura Y, Laouar Y, Bishop DK.

J Immunol. 2009 Dec 1;183(11):7297-306. doi: 10.4049/jimmunol.0902446. Epub 2009 Nov 16.


Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, Duyckaerts C, Flavell RA, Hirsch EC, Hunot S.

J Clin Invest. 2009 Jan;119(1):182-92. doi: 10.1172/JCI36470. Epub 2008 Dec 22.


Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789.

Craig DH, Gayer CP, Schaubert KL, Wei Y, Li J, Laouar Y, Basson MD.

Am J Physiol Cell Physiol. 2009 Jan;296(1):C193-204. doi: 10.1152/ajpcell.00355.2008. Epub 2008 Nov 12.


TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis.

Laouar Y, Town T, Jeng D, Tran E, Wan Y, Kuchroo VK, Flavell RA.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10865-70. doi: 10.1073/pnas.0805058105. Epub 2008 Jul 31.


Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.

Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA.

Nat Med. 2008 Jun;14(6):681-7. doi: 10.1038/nm1781. Epub 2008 Jun 1.


IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells.

Temann UA, Laouar Y, Eynon EE, Homer R, Flavell RA.

Int Immunol. 2007 Jan;19(1):1-10. Epub 2006 Nov 13.


Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity.

Querec T, Bennouna S, Alkan S, Laouar Y, Gorden K, Flavell R, Akira S, Ahmed R, Pulendran B.

J Exp Med. 2006 Feb 20;203(2):413-24. Epub 2006 Feb 6.


TGFbeta-mediated immunoregulation.

Peng Y, Gorelik L, Laouar Y, Li MO, Flavell RA.

Ernst Schering Res Found Workshop. 2006;(56):155-60.


Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma.

Laouar Y, Sutterwala FS, Gorelik L, Flavell RA.

Nat Immunol. 2005 Jun;6(6):600-7. Epub 2005 Apr 24.


TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes.

Peng Y, Laouar Y, Li MO, Green EA, Flavell RA.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4572-7. Epub 2004 Mar 18.


STAT3 is required for Flt3L-dependent dendritic cell differentiation.

Laouar Y, Welte T, Fu XY, Flavell RA.

Immunity. 2003 Dec;19(6):903-12.


Overexpression of IL-7R alpha provides a competitive advantage during early T-cell development.

Laouar Y, Crispe IN, Flavell RA.

Blood. 2004 Mar 15;103(6):1985-94. Epub 2003 Oct 30.


Selective involvement of the Fas (CD95)/Fas ligand pathway in bone marrow B cell progenitors.

Laouar Y, Vasseur F, Moreau G, Garcia C, Pasqualetto V, Waché AC, Ezine S.

Eur J Immunol. 2000 May;30(5):1402-9.


Involvement of the Fas (CD95) system in peripheral cell death and lymphoid organ development.

Laouar Y, Sarukhan A, Pasqualetto V, Garcia C, Ezine S.

Eur J Immunol. 1998 Mar;28(3):1078-88.


In vivo CD4+ lymph node T cells from lpr mice generate CD4-CD8-B220+TCR-beta low cells.

Laouar Y, Ezine S.

J Immunol. 1994 Nov 1;153(9):3948-55.


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