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Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential neuroprotectant against ischemic brain injury.

Liao L, Jiang C, Chen J, Shi J, Li X, Wang Y, Wen J, Zhou S, Liang J, Lao Y, Zhang J.

Eur J Med Chem. 2020 Feb 8;190:112114. doi: 10.1016/j.ejmech.2020.112114. [Epub ahead of print]


SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes.

Zhang Y, Yang K, Yang J, Lao Y, Deng L, Deng G, Yi J, Sun X, Wang Q.

Cell Rep. 2020 Feb 11;30(6):1951-1963.e4. doi: 10.1016/j.celrep.2020.01.036.


Screening of the active fractions from the Coreopsis tinctoria Nutt. Flower on diabetic endothelial protection and determination of the underlying mechanism.

Li Y, Huang C, Fu W, Zhang H, Lao Y, Zhou H, Tan H, Xu H.

J Ethnopharmacol. 2020 Feb 8;253:112645. doi: 10.1016/j.jep.2020.112645. [Epub ahead of print]


Separation Orthogonality in Liquid Chromatography-Mass Spectrometry for Proteomic Applications: Comparison of 16 Different Two-Dimensional Combinations.

Yeung D, Mizero B, Gussakovsky D, Klaassen N, Lao Y, Spicer V, Krokhin OV.

Anal Chem. 2020 Feb 14. doi: 10.1021/acs.analchem.9b05407. [Epub ahead of print]


Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi.

Ye YS, Wu M, Jiang NN, Lao YZ, Fu WW, Liu X, Yang XW, Zhang J, Xu HX, Xu G.

Nat Prod Bioprospect. 2020 Feb 4. doi: 10.1007/s13659-019-00229-w. [Epub ahead of print]


CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells.

Mintz RL, Lao YH, Chi CW, He S, Li M, Quek CH, Shao D, Chen B, Han J, Wang S, Leong KW.

Bioeng Transl Med. 2020 Jan 2;5(1):e10152. doi: 10.1002/btm2.10152. eCollection 2020 Jan.


Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes.

Lao YE, Molden E, Kringen MK, Annexstad EJ, Saeverud HA, Jacobsen D, Hovda KE.

Basic Clin Pharmacol Toxicol. 2020 Jan 24. doi: 10.1111/bcpt.13389. [Epub ahead of print]


Boost carbon availability and value in algal cell for economic deployment of biomass.

Sun H, Li X, Ren Y, Zhang H, Mao X, Lao Y, Wang X, Chen F.

Bioresour Technol. 2020 Mar;300:122640. doi: 10.1016/j.biortech.2019.122640. Epub 2019 Dec 19.


Diagnostic accuracy of machine-learning-assisted detection for anterior cruciate ligament injury based on magnetic resonance imaging: Protocol for a systematic review and meta-analysis.

Lao Y, Jia B, Yan P, Pan M, Hui X, Li J, Luo W, Li X, Han J, Yan P, Yao L.

Medicine (Baltimore). 2019 Dec;98(50):e18324. doi: 10.1097/MD.0000000000018324.


Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL-6/pSTAT3 axis in breast cancer.

Sun X, Qu Q, Lao Y, Zhang M, Yin X, Zhu H, Wang Y, Yang J, Yi J, Hao M.

BMC Cancer. 2019 Dec 3;19(1):1180. doi: 10.1186/s12885-019-6333-6.


Value of Galectin-3 in Acute Myocardial Infarction.

Li M, Yuan Y, Guo K, Lao Y, Huang X, Feng L.

Am J Cardiovasc Drugs. 2019 Nov 30. doi: 10.1007/s40256-019-00387-9. [Epub ahead of print] Review.


CXCL9 regulates acetaminophen-induced liver injury via CXCR3.

Song X, Shen Y, Lao Y, Tao Z, Zeng J, Wang J, Wu H.

Exp Ther Med. 2019 Dec;18(6):4845-4851. doi: 10.3892/etm.2019.8122. Epub 2019 Oct 23.


LncRNA SNHG7 is an Oncogenic Biomarker Interacting with MicroRNA-193b in Colon Carcinogenesis.

Liu KL, Wu J, Li WK, Li NS, Li Q, Lao YQ.

Clin Lab. 2019 Nov 1;65(11). doi: 10.7754/Clin.Lab.2019.190501.


Aberrant DNA Hypermethylation Silenced LncRNA Expression in Gastric Cancer.

Tsai KW, Tsai CY, Chou NH, Wang KC, Kang CH, Li SC, Lao YH, Chang HT.

Anticancer Res. 2019 Oct;39(10):5381-5391. doi: 10.21873/anticanres.13732.


Tandem mass tag-based quantitative proteomic analysis reveal the inhibition mechanism of thyme essential oil against flagellum of Listeria monocytogenes.

Sarengaowa, Hu W, Feng K, Xiu Z, Jiang A, Lao Y.

Food Res Int. 2019 Nov;125:108508. doi: 10.1016/j.foodres.2019.108508. Epub 2019 Jun 22.


hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy.

Xu R, Yu S, Zhu D, Huang X, Xu Y, Lao Y, Tian Y, Zhang J, Tang Z, Zhang Z, Yi J, Zhu HH, Zheng X.

Nat Commun. 2019 Aug 23;10(1):3812. doi: 10.1038/s41467-019-11795-5.


Efficacy and safety of siponimod for multiple sclerosis: Protocol for a systematic review and meta-analysis.

Song Y, Lao Y, Liang F, Li J, Jia B, Wang Z, Hui X, Lu Z, Zhou B, Luo W, Song B.

Medicine (Baltimore). 2019 Aug;98(34):e15415. doi: 10.1097/MD.0000000000015415.


SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLC.

Yuan M, Xu LF, Zhang J, Kong SY, Wu M, Lao YZ, Zhou H, Zhang L, Xu H.

Front Oncol. 2019 Jul 30;9:586. doi: 10.3389/fonc.2019.00586. eCollection 2019.


Engineering Cell Membrane-Based Nanotherapeutics to Target Inflammation.

Yan H, Shao D, Lao YH, Li M, Hu H, Leong KW.

Adv Sci (Weinh). 2019 May 22;6(15):1900605. doi: 10.1002/advs.201900605. eCollection 2019 Aug 7. Review.


Novel association of five HLA alleles with HIV-1 progression in Spanish long-term non progressor patients.

Ramírez de Arellano E, Díez-Fuertes F, Aguilar F, de la Torre Tarazona HE, Sánchez-Lara S, Lao Y, Vicario JL, García F, González-Garcia J, Pulido F, Gutierrez-Rodero F, Moreno S, Iribarren JA, Viciana P, Vilches C, Ramos M, Capa L, Alcamí J, Del Val M.

PLoS One. 2019 Aug 8;14(8):e0220459. doi: 10.1371/journal.pone.0220459. eCollection 2019.


The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45α.

Zheng Z, Wu M, Zhang J, Fu W, Xu N, Lao Y, Lin L, Xu H.

Front Oncol. 2019 Jul 17;9:654. doi: 10.3389/fonc.2019.00654. eCollection 2019.


A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3.

Liu K, Guo C, Lao Y, Yang J, Chen F, Zhao Y, Yang Y, Yang J, Yi J.

Autophagy. 2019 Aug 2:1-16. doi: 10.1080/15548627.2019.1647944. [Epub ahead of print]


Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-β1 signaling pathways.

Wang J, Wu M, Zheng D, Zhang H, Lv Y, Zhang L, Tan HS, Zhou H, Lao YZ, Xu HX.

Acta Pharmacol Sin. 2020 Jan;41(1):82-92. doi: 10.1038/s41401-019-0271-3. Epub 2019 Aug 1.


The natural compound neobractatin inhibits tumor metastasis by upregulating the RNA-binding-protein MBNL2.

Zhang J, Zheng Z, Wu M, Zhang L, Wang J, Fu W, Xu N, Zhao Z, Lao Y, Xu H.

Cell Death Dis. 2019 Jul 18;10(8):554. doi: 10.1038/s41419-019-1789-5.


Effect of Sweet Corn Residue on Micronutrient Fortification in Baked Cakes.

Lao YX, Yu YY, Li GK, Chen SY, Li W, Xing XP, Wang XM, Hu JG, Guo XB.

Foods. 2019 Jul 16;8(7). pii: E260. doi: 10.3390/foods8070260.


Uncariitannin, a polyphenolic polymer from Uncaria gambier, attenuates Staphylococcus aureus virulence through an MgrA-mediated regulation of α-hemolysin.

Zhang H, Jiang JM, Han L, Lao YZ, Zheng D, Chen YY, Wan SJ, Zheng CW, Tan HS, Li ZG, Xu HX.

Pharmacol Res. 2019 Sep;147:104328. doi: 10.1016/j.phrs.2019.104328. Epub 2019 Jul 6.


Association between alcohol consumption and mild cognitive impairment: A protocol of dose-response meta-analysis.

Hui X, Li J, Lao Y, Jia B, Hou L, Lu Z, Gu Q, Niu J, Bao H, Yan P, Yao L.

Medicine (Baltimore). 2019 Jul;98(27):e16098. doi: 10.1097/MD.0000000000016098.


Alcohol consumption and risk of dementia: A dose-response meta-analysis.

Li J, Hui X, Gu Q, Lao Y, Lu Z, Hou L, Jia B, Niu J, Yao L, Yan P.

Medicine (Baltimore). 2019 Jun;98(26):e16099. doi: 10.1097/MD.0000000000016099.


Delayed angioplasty is superior to an emergency strategy in ST-segment elevation myocardial infarction patients who present late and with infarct artery spontaneous reperfusion before intervention.

Li M, Wu Z, Yuan Y, Feng L, Lao Y, Guo Z.

Cardiovasc J Afr. 2019 May/Jun 23;30(3):162-167. doi: 10.5830/CVJA-2019-009. Epub 2019 May 16.


Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability.

Jantos K, Kling A, Mack H, Hornberger W, Moeller A, Nimmrich V, Lao Y, Nijsen M.

Bioorg Med Chem Lett. 2019 Aug 1;29(15):1968-1973. doi: 10.1016/j.bmcl.2019.05.034. Epub 2019 May 18.


A modular and concise approach to MIDA acylboronates via chemoselective oxidation of unsymmetrical geminal diborylalkanes: unlocking access to a novel class of acylborons.

Lin S, Wang L, Aminoleslami N, Lao Y, Yagel C, Sharma A.

Chem Sci. 2019 Mar 21;10(17):4684-4691. doi: 10.1039/c9sc00378a. eCollection 2019 May 7.


Methanol content in homemade alcohol from a province in North Vietnam.

Lao Y, Pham BD, Le HT, Nguyen Van H, Hovda KE.

Drug Alcohol Rev. 2019 Jul;38(5):537-542. doi: 10.1111/dar.12937. Epub 2019 May 16.


Molecular Analysis of Evolution and Origins of Cultivated Hawthorn (Crataegus spp.) and Related Species in China.

Du X, Zhang X, Bu H, Zhang T, Lao Y, Dong W.

Front Plant Sci. 2019 Apr 9;10:443. doi: 10.3389/fpls.2019.00443. eCollection 2019.


An Accurate Recognition of Infrared Retro-Reflective Markers in Surgical Navigation.

Wu H, Lin Q, Yang R, Zhou Y, Zheng L, Huang Y, Wang Z, Lao Y, Huang J.

J Med Syst. 2019 Apr 24;43(6):153. doi: 10.1007/s10916-019-1257-x.


Activity-based Protein Profiling Approaches for Transplantation.

Navarrete M, Wilkins JA, Lao Y, Rush DN, Nickerson PW, Ho J.

Transplantation. 2019 Sep;103(9):1790-1798. doi: 10.1097/TP.0000000000002752.


Multimodal Nutritional Management in Primary Lumbar Spine Surgery: A Randomized Controlled Trial.

Xu B, Xu WX, Lao YJ, Ding WG, Lu D, Sheng HF.

Spine (Phila Pa 1976). 2019 Jul 15;44(14):967-974. doi: 10.1097/BRS.0000000000002992.


Garsubelone A, the First Dimeric Polycyclic Polyprenylated Acylphloroglucinols with Complicated Heptacyclic Architecture from Garcinia subelliptica.

Wang YL, Ye YS, Fu WW, Wu R, Xiang Q, Lao YZ, Yang JL, Tan HS, Yang XW, Yang BC, Xu HX, Xu G.

Org Lett. 2019 Mar 1;21(5):1534-1537. doi: 10.1021/acs.orglett.9b00388. Epub 2019 Feb 18.


Engineered Mesenchymal Stem Cell/Nanomedicine Spheroid as an Active Drug Delivery Platform for Combinational Glioblastoma Therapy.

Suryaprakash S, Lao YH, Cho HY, Li M, Ji HY, Shao D, Hu H, Quek CH, Huang D, Mintz RL, Bagó JR, Hingtgen SD, Lee KB, Leong KW.

Nano Lett. 2019 Mar 13;19(3):1701-1705. doi: 10.1021/acs.nanolett.8b04697. Epub 2019 Feb 21.


Identification of Genes Involved in Low Temperature-Induced Senescence of Panicle Leaf in Litchi chinensis.

Wang C, Liu H, Yu S, Chen H, Hu F, Zhan H, Pan X, Lao Y, Zhong S, Zhou B.

Genes (Basel). 2019 Feb 1;10(2). pii: E111. doi: 10.3390/genes10020111.


A multifunctional mesoporous silica-gold nanocluster hybrid platform for selective breast cancer cell detection using a catalytic amplification-based colorimetric assay.

Li M, Lao YH, Mintz RL, Chen Z, Shao D, Hu H, Wang HX, Tao Y, Leong KW.

Nanoscale. 2019 Feb 7;11(6):2631-2636. doi: 10.1039/c8nr08337a.


A post-processing method based on interphase motion correction and averaging to improve image quality of 4D magnetic resonance imaging: a clinical feasibility study.

Deng Z, Pang J, Lao Y, Bi X, Wang G, Chen Y, Fenchel M, Tuli R, Li D, Yang W, Fan Z.

Br J Radiol. 2019 Mar;92(1095):20180424. doi: 10.1259/bjr.20180424. Epub 2019 Jan 3.


Prognostic Value of Hemoglobin A1c Levels in Postmenopausal Diabetic Patients Undergoing Percutaneous Coronary Intervention (PCI) for Acute Coronary Syndrome.

Lao Y, Feng L, Yuan Y, Zhang J, Huang X, Li M, Wu Z.

Med Sci Monit. 2018 Dec 27;24:9399-9405. doi: 10.12659/MSM.912108.


Nuclear actin switch of the INO80 remodeler.

Wu J, Lao Y, Li B.

J Mol Cell Biol. 2019 May 1;11(5):343-344. doi: 10.1093/jmcb/mjy083. No abstract available.


Erratum: In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell: Erratum.

Hu K, Yin F, Yu M, Sun C, Li J, Liang Y, Li W, Xie M, Lao Y, Liang W, Li ZG.

Theranostics. 2018 Nov 10;8(20):5660-5661. doi: 10.7150/thno.31152. eCollection 2018.


Long noncoding RNA ENST00000455974 plays an oncogenic role through up-regulating JAG2 in human DNA mismatch repair-proficient colon cancer.

Lao Y, Li Q, Li N, Liu H, Liu K, Jiang G, Wei N, Wang C, Wang Y, Wu J.

Biochem Biophys Res Commun. 2019 Jan 8;508(2):339-347. doi: 10.1016/j.bbrc.2018.11.088. Epub 2018 Nov 23.


Discriminating lung adenocarcinoma from lung squamous cell carcinoma using respiration-induced tumor shape changes.

Lao Y, David J, Mirhadi A, Lepore N, Sandler H, Wang Y, Tuli R, Yang W.

Phys Med Biol. 2018 Nov 7;63(21):215027. doi: 10.1088/1361-6560/aae7f1.


Profiles of quorum sensing (QS)-related sequences in phycospheric microorganisms during a marine dinoflagellate bloom, as determined by a metagenomic approach.

Huang X, Zhu J, Cai Z, Lao Y, Jin H, Yu K, Zhang B, Zhou J.

Microbiol Res. 2018 Dec;217:1-13. doi: 10.1016/j.micres.2018.08.015. Epub 2018 Aug 30.


Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue.

Qiu Y, Sun Y, Xu D, Yang Y, Liu X, Wei Y, Chen Y, Feng Z, Li S, Reyad-Ul Ferdous M, Zhao Y, Xu H, Lao Y, Ding Q.

EBioMedicine. 2018 Nov;37:344-355. doi: 10.1016/j.ebiom.2018.10.019. Epub 2018 Oct 20.


Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation.

Wu M, Lao YZ, Tan HS, Lu G, Ren Y, Zheng ZQ, Yi J, Fu WW, Shen HM, Xu HX.

Acta Pharmacol Sin. 2019 Jul;40(7):929-937. doi: 10.1038/s41401-018-0167-7. Epub 2018 Oct 17.


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