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Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability.

Jantos K, Kling A, Mack H, Hornberger W, Moeller A, Nimmrich V, Lao Y, Nijsen M.

Bioorg Med Chem Lett. 2019 May 18. pii: S0960-894X(19)30331-2. doi: 10.1016/j.bmcl.2019.05.034. [Epub ahead of print]


A modular and concise approach to MIDA acylboronates via chemoselective oxidation of unsymmetrical geminal diborylalkanes: unlocking access to a novel class of acylborons.

Lin S, Wang L, Aminoleslami N, Lao Y, Yagel C, Sharma A.

Chem Sci. 2019 Mar 21;10(17):4684-4691. doi: 10.1039/c9sc00378a. eCollection 2019 May 7.


Methanol content in homemade alcohol from a province in North Vietnam.

Lao Y, Pham BD, Le HT, Nguyen Van H, Hovda KE.

Drug Alcohol Rev. 2019 May 16. doi: 10.1111/dar.12937. [Epub ahead of print]


Molecular Analysis of Evolution and Origins of Cultivated Hawthorn (Crataegus spp.) and Related Species in China.

Du X, Zhang X, Bu H, Zhang T, Lao Y, Dong W.

Front Plant Sci. 2019 Apr 9;10:443. doi: 10.3389/fpls.2019.00443. eCollection 2019.


An Accurate Recognition of Infrared Retro-Reflective Markers in Surgical Navigation.

Wu H, Lin Q, Yang R, Zhou Y, Zheng L, Huang Y, Wang Z, Lao Y, Huang J.

J Med Syst. 2019 Apr 24;43(6):153. doi: 10.1007/s10916-019-1257-x.


Activity-based protein profiling approaches for transplantation.

Navarrete M, Wilkins JA, Lao Y, Rush DN, Nickerson PW, Ho J.

Transplantation. 2019 Apr 8. doi: 10.1097/TP.0000000000002752. [Epub ahead of print]


Multimodal Nutritional Management in Primary Lumbar Spine Surgery: A Randomized Controlled Trial.

Xu B, Xu WX, Lao YJ, Ding WG, Lu D, Sheng HF.

Spine (Phila Pa 1976). 2019 Feb 4. doi: 10.1097/BRS.0000000000002992. [Epub ahead of print]


Garsubelone A, the First Dimeric Polycyclic Polyprenylated Acylphloroglucinols with Complicated Heptacyclic Architecture from Garcinia subelliptica.

Wang YL, Ye YS, Fu WW, Wu R, Xiang Q, Lao YZ, Yang JL, Tan HS, Yang XW, Yang BC, Xu HX, Xu G.

Org Lett. 2019 Mar 1;21(5):1534-1537. doi: 10.1021/acs.orglett.9b00388. Epub 2019 Feb 18.


Engineered Mesenchymal Stem Cell/Nanomedicine Spheroid as an Active Drug Delivery Platform for Combinational Glioblastoma Therapy.

Suryaprakash S, Lao YH, Cho HY, Li M, Ji HY, Shao D, Hu H, Quek CH, Huang D, Mintz RL, Bagó JR, Hingtgen SD, Lee KB, Leong KW.

Nano Lett. 2019 Mar 13;19(3):1701-1705. doi: 10.1021/acs.nanolett.8b04697. Epub 2019 Feb 21.


Identification of Genes Involved in Low Temperature-Induced Senescence of Panicle Leaf in Litchi chinensis.

Wang C, Liu H, Yu S, Chen H, Hu F, Zhan H, Pan X, Lao Y, Zhong S, Zhou B.

Genes (Basel). 2019 Feb 1;10(2). pii: E111. doi: 10.3390/genes10020111.


A multifunctional mesoporous silica-gold nanocluster hybrid platform for selective breast cancer cell detection using a catalytic amplification-based colorimetric assay.

Li M, Lao YH, Mintz RL, Chen Z, Shao D, Hu H, Wang HX, Tao Y, Leong KW.

Nanoscale. 2019 Feb 7;11(6):2631-2636. doi: 10.1039/c8nr08337a.


A post-processing method based on interphase motion correction and averaging to improve image quality of 4D magnetic resonance imaging: a clinical feasibility study.

Deng Z, Pang J, Lao Y, Bi X, Wang G, Chen Y, Fenchel M, Tuli R, Li D, Yang W, Fan Z.

Br J Radiol. 2019 Mar;92(1095):20180424. doi: 10.1259/bjr.20180424. Epub 2019 Jan 3.


Prognostic Value of Hemoglobin A1c Levels in Postmenopausal Diabetic Patients Undergoing Percutaneous Coronary Intervention (PCI) for Acute Coronary Syndrome.

Lao Y, Feng L, Yuan Y, Zhang J, Huang X, Li M, Wu Z.

Med Sci Monit. 2018 Dec 27;24:9399-9405. doi: 10.12659/MSM.912108.


Nuclear actin switch of the INO80 remodeler.

Wu J, Lao Y, Li B.

J Mol Cell Biol. 2019 May 1;11(5):343-344. doi: 10.1093/jmcb/mjy083. No abstract available.


Erratum: In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell: Erratum.

Hu K, Yin F, Yu M, Sun C, Li J, Liang Y, Li W, Xie M, Lao Y, Liang W, Li ZG.

Theranostics. 2018 Nov 10;8(20):5660-5661. doi: 10.7150/thno.31152. eCollection 2018.


Long noncoding RNA ENST00000455974 plays an oncogenic role through up-regulating JAG2 in human DNA mismatch repair-proficient colon cancer.

Lao Y, Li Q, Li N, Liu H, Liu K, Jiang G, Wei N, Wang C, Wang Y, Wu J.

Biochem Biophys Res Commun. 2019 Jan 8;508(2):339-347. doi: 10.1016/j.bbrc.2018.11.088. Epub 2018 Nov 23.


Discriminating lung adenocarcinoma from lung squamous cell carcinoma using respiration-induced tumor shape changes.

Lao Y, David J, Mirhadi A, Lepore N, Sandler H, Wang Y, Tuli R, Yang W.

Phys Med Biol. 2018 Nov 7;63(21):215027. doi: 10.1088/1361-6560/aae7f1.


Profiles of quorum sensing (QS)-related sequences in phycospheric microorganisms during a marine dinoflagellate bloom, as determined by a metagenomic approach.

Huang X, Zhu J, Cai Z, Lao Y, Jin H, Yu K, Zhang B, Zhou J.

Microbiol Res. 2018 Dec;217:1-13. doi: 10.1016/j.micres.2018.08.015. Epub 2018 Aug 30.


Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue.

Qiu Y, Sun Y, Xu D, Yang Y, Liu X, Wei Y, Chen Y, Feng Z, Li S, Reyad-Ul Ferdous M, Zhao Y, Xu H, Lao Y, Ding Q.

EBioMedicine. 2018 Nov;37:344-355. doi: 10.1016/j.ebiom.2018.10.019. Epub 2018 Oct 20.


Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation.

Wu M, Lao YZ, Tan HS, Lu G, Ren Y, Zheng ZQ, Yi J, Fu WW, Shen HM, Xu HX.

Acta Pharmacol Sin. 2018 Oct 17. doi: 10.1038/s41401-018-0167-7. [Epub ahead of print]


Tubeimoside-1, a triterpenoid saponin, induces cytoprotective autophagy in human breast cancer cells in vitro via Akt-mediated pathway.

Jiang SL, Guan YD, Chen XS, Ge P, Wang XL, Lao YZ, Xiao SS, Zhang Y, Yang JM, Xu XJ, Cao DS, Cheng Y.

Acta Pharmacol Sin. 2018 Oct 12. doi: 10.1038/s41401-018-0165-9. [Epub ahead of print]


Antibiofilm activity substances derived from coral symbiotic bacterial extract inhibit biofouling by the model strain Pseudomonas aeruginosa PAO1.

Song Y, Cai ZH, Lao YM, Jin H, Ying KZ, Lin GH, Zhou J.

Microb Biotechnol. 2018 Nov;11(6):1090-1105. doi: 10.1111/1751-7915.13312. Epub 2018 Oct 9.


Targeting Endothelial Erk1/2-Akt Axis as a Regeneration Strategy to Bypass Fibrosis during Chronic Liver Injury in Mice.

Lao Y, Li Y, Zhang P, Shao Q, Lin W, Qiu B, Lv Y, Tang L, Su S, Zhang H, Tian C, Sun A, Wei H, Zhang P, Wu Y, Jiang Y, He F.

Mol Ther. 2018 Dec 5;26(12):2779-2797. doi: 10.1016/j.ymthe.2018.08.016. Epub 2018 Aug 24.


Is metformin still the most efficacious first-line oral hypoglycaemic drug in treating type 2 diabetes? A network meta-analysis of randomized controlled trials.

Jia Y, Lao Y, Zhu H, Li N, Leung SW.

Obes Rev. 2019 Jan;20(1):1-12. doi: 10.1111/obr.12753. Epub 2018 Sep 17. Review.


A rapid UHPLC-HILIC method for algal guanosine 5'-diphosphate 3'-diphosphate (ppGpp) and the potential separation mechanism.

Jin H, Lao YM, Zhou J, Zhang HJ, Cai ZH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Oct 1;1096:143-153. doi: 10.1016/j.jchromb.2018.08.009. Epub 2018 Aug 17.


A Novel Hydrolytic Activity of Tri-Functional Geranylgeranyl Pyrophosphate Synthase in Haematococcus pluvialis.

Lao YM, Jin H, Zhou J, Zhang HJ, Zhu XS, Cai ZH.

Plant Cell Physiol. 2018 Dec 1;59(12):2536-2548. doi: 10.1093/pcp/pcy173.


SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation.

Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q.

Nat Commun. 2018 Aug 8;9(1):3157. doi: 10.1038/s41467-018-05676-6.


Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors.

Amberg W, Lange UEW, Ochse M, Pohlki F, Behl B, Relo AL, Hornberger W, Hoft C, Mezler M, Sydor J, Wang Y, Zhao H, Brewer JT, Dietrich J, Li H, Akritopoulou-Zanze I, Lao Y, Hannick SM, Ku YY, Vasudevan A.

J Med Chem. 2018 Sep 13;61(17):7503-7524. doi: 10.1021/acs.jmedchem.8b00300. Epub 2018 Aug 27.


HPV Oncogene Manipulation Using Nonvirally Delivered CRISPR/Cas9 or Natronobacterium gregoryi Argonaute.

Lao YH, Li M, Gao MA, Shao D, Chi CW, Huang D, Chakraborty S, Ho TC, Jiang W, Wang HX, Wang S, Leong KW.

Adv Sci (Weinh). 2018 May 18;5(7):1700540. doi: 10.1002/advs.201700540. eCollection 2018 Jul.


De Novo Design, Synthesis, and Biological Evaluation of 3,4-Disubstituted Pyrrolidine Sulfonamides as Potent and Selective Glycine Transporter 1 Competitive Inhibitors.

Wang Y, Zhao H, Brewer JT, Li H, Lao Y, Amberg W, Behl B, Akritopoulou-Zanze I, Dietrich J, Lange UEW, Pohlki F, Hoft C, Hornberger W, Djuric SW, Sydor J, Mezler M, Relo AL, Vasudevan A.

J Med Chem. 2018 Sep 13;61(17):7486-7502. doi: 10.1021/acs.jmedchem.8b00295. Epub 2018 Jul 17.


Bioinspired Diselenide-Bridged Mesoporous Silica Nanoparticles for Dual-Responsive Protein Delivery.

Shao D, Li M, Wang Z, Zheng X, Lao YH, Chang Z, Zhang F, Lu M, Yue J, Hu H, Yan H, Chen L, Dong WF, Leong KW.

Adv Mater. 2018 May 28:e1801198. doi: 10.1002/adma.201801198. [Epub ahead of print]


Anti-infective biomaterials with surface-decorated tachyplesin I.

Xue Q, Liu XB, Lao YH, Wu LP, Wang D, Zuo ZQ, Chen JY, Hou J, Bei YY, Wu XF, Leong KW, Xiang H, Han J.

Biomaterials. 2018 Sep;178:351-362. doi: 10.1016/j.biomaterials.2018.05.008. Epub 2018 May 9.


Natural compound Oblongifolin C confers gemcitabine resistance in pancreatic cancer by downregulating Src/MAPK/ERK pathways.

Li Y, Xi Z, Chen X, Cai S, Liang C, Wang Z, Li Y, Tan H, Lao Y, Xu H.

Cell Death Dis. 2018 May 1;9(5):538. doi: 10.1038/s41419-018-0574-1.


Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide.

Wang HX, Song Z, Lao YH, Xu X, Gong J, Cheng D, Chakraborty S, Park JS, Li M, Huang D, Yin L, Cheng J, Leong KW.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):4903-4908. doi: 10.1073/pnas.1712963115. Epub 2018 Apr 23.


Mitigating the Metabolic Liability of Carbonyl Reduction: Novel Calpain Inhibitors with P1' Extension.

Kling A, Jantos K, Mack H, Hornberger W, Backfisch G, Lao Y, Nijsen M, Rendenbach-Mueller B, Moeller A.

ACS Med Chem Lett. 2018 Feb 4;9(3):221-226. doi: 10.1021/acsmedchemlett.7b00494. eCollection 2018 Mar 8.


[Tumor-induced osteomalacia: a case report].

Luo C, Zhang YB, Lao YJ, Xu TT, Jin HT, Ji WF, Xiao LW, Tong PJ.

Zhongguo Gu Shang. 2017 Oct 25;30(10):968-971. doi: 10.3969/j.issn.1003-0034.2017.10.018. Chinese. No abstract available.


Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth.

Xu L, Meng X, Xu N, Fu W, Tan H, Zhang L, Zhou Q, Qian J, Tu S, Li X, Lao Y, Xu H.

Cell Death Dis. 2018 Feb 15;9(3):262. doi: 10.1038/s41419-018-0314-6.


Distribution Patterns of Microbial Community Structure Along a 7000-Mile Latitudinal Transect from the Mediterranean Sea Across the Atlantic Ocean to the Brazilian Coastal Sea.

Zhou J, Song X, Zhang CY, Chen GF, Lao YM, Jin H, Cai ZH.

Microb Ecol. 2018 Oct;76(3):592-609. doi: 10.1007/s00248-018-1150-z. Epub 2018 Feb 14.


Accumulated Spinal Axial Biomechanical Loading Induces Degeneration in Intervertebral Disc of Mice Lumbar Spine.

Lao YJ, Xu TT, Jin HT, Ruan HF, Wang JT, Zhou L, Wang PE, Wang J, Ying J, Zhang YB, Luo C, Fu FD, Tong PJ, Xiao LW, Wu CL.

Orthop Surg. 2018 Feb;10(1):56-63. doi: 10.1111/os.12365. Epub 2018 Feb 12.


DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages.

Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ETH, Yang J, Yi J.

J Biol Chem. 2018 Mar 16;293(11):3965-3980. doi: 10.1074/jbc.M117.816769. Epub 2018 Jan 19.


In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell.

Hu K, Yin F, Yu M, Sun C, Li J, Liang Y, Li W, Xie M, Lao Y, Liang W, Li ZG.

Theranostics. 2017 Oct 13;7(18):4566-4576. doi: 10.7150/thno.19840. eCollection 2017. Erratum in: Theranostics. 2018 Nov 10;8(20):5660-5661.


Proteomic Analysis Reveals Dab2 Mediated Receptor Endocytosis Promotes Liver Sinusoidal Endothelial Cell Dedifferentiation.

Lao Y, Li Y, Hou Y, Chen H, Qiu B, Lin W, Sun A, Wei H, Jiang Y, He F.

Sci Rep. 2017 Oct 18;7(1):13456. doi: 10.1038/s41598-017-13917-9.


Administration of erythropoietin prevents bone loss in osteonecrosis of the femoral head in mice.

Xu T, Jin H, Lao Y, Wang P, Zhang S, Ruan H, Mao Q, Zhou L, Xiao L, Tong P, Wu C.

Mol Med Rep. 2017 Dec;16(6):8755-8762. doi: 10.3892/mmr.2017.7735. Epub 2017 Oct 6.


How well can we quantify dust deposition to the ocean?

Anderson RF, Cheng H, Edwards RL, Fleisher MQ, Hayes CT, Huang KF, Kadko D, Lam PJ, Landing WM, Lao Y, Lu Y, Measures CI, Moran SB, Morton PL, Ohnemus DC, Robinson LF, Shelley RU.

Philos Trans A Math Phys Eng Sci. 2016 Nov 28;374(2081). pii: 20150285. doi: 10.1098/rsta.2015.0285.


Functional Characterization of a Missing Branch Component in Haematococcus pluvialis for Control of Algal Carotenoid Biosynthesis.

Lao YM, Jin H, Zhou J, Zhang HJ, Cai ZH.

Front Plant Sci. 2017 Aug 2;8:1341. doi: 10.3389/fpls.2017.01341. eCollection 2017.


Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.

Kling A, Jantos K, Mack H, Hornberger W, Drescher K, Nimmrich V, Relo A, Wicke K, Hutchins CW, Lao Y, Marsh K, Moeller A.

J Med Chem. 2017 Aug 24;60(16):7123-7138. doi: 10.1021/acs.jmedchem.7b00731. Epub 2017 Aug 15.


Synthetic Cyclic Peptomers as Type III Secretion System Inhibitors.

Lam H, Schwochert J, Lao Y, Lau T, Lloyd C, Luu J, Kooner O, Morgan J, Lokey S, Auerbuch V.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00060-17. doi: 10.1128/AAC.00060-17. Print 2017 Sep.


Ventricular shape and relative position abnormalities in preterm neonates.

Paquette N, Shi J, Wang Y, Lao Y, Ceschin R, Nelson MD, Panigrahy A, Lepore N.

Neuroimage Clin. 2017 May 28;15:483-493. doi: 10.1016/j.nicl.2017.05.025. eCollection 2017.

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