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Items: 25


White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults.

Lao PJ, Vorburger RS, Narkhede A, Gazes Y, Igwe KC, Colón J, Amarante E, Guzman VA, Last BS, Habeck C, Stern Y, Brickman AM.

Front Aging Neurosci. 2019 Dec 10;11:345. doi: 10.3389/fnagi.2019.00345. eCollection 2019.


Tract-defined regional white matter hyperintensities and memory.

Rizvi B, Lao PJ, Colón J, Hale C, Igwe KC, Narkhede A, Budge M, Manly JJ, Schupf N, Brickman AM.

Neuroimage Clin. 2019 Dec 23;25:102143. doi: 10.1016/j.nicl.2019.102143. [Epub ahead of print]


Parental history of dementia is associated with increased small vessel cerebrovascular disease.

Stamm BC, Lao PJ, Rizvi B, Colon J, Igwe K, Chesebro AG, Maas B, Schupf N, Mayeux R, Manly JJ, Brickman AM.

J Gerontol A Biol Sci Med Sci. 2019 Dec 15. pii: glz291. doi: 10.1093/gerona/glz291. [Epub ahead of print]


Leisure Activity, Brain β-amyloid, and Episodic Memory in Adults with Down Syndrome.

Mihaila I, Handen BL, Christian BT, Lao PJ, Cody KA, Klunk WE, Tudorascu DL, Cohen AD, Okonkwo OC, Hartley SL.

Dev Neurobiol. 2019 Jul;79(7):738-749. doi: 10.1002/dneu.22677. Epub 2019 Apr 1.


Multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in Alzheimer's disease progression.

Lao PJ, Brickman AM.

Alzheimers Dement (Amst). 2018 Sep 22;10:638-646. doi: 10.1016/j.dadm.2018.08.007. eCollection 2018.


In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration.

Metzger JM, Moore CF, Boettcher CA, Brunner KG, Fleddermann RA, Matsoff HN, Resnikoff HA, Bondarenko V, Kamp TJ, Hacker TA, Barnhart TE, Lao PJ, Christian BT, Nickles RJ, Gallagher CL, Holden JE, Emborg ME.

NPJ Parkinsons Dis. 2018 Jul 13;4:22. doi: 10.1038/s41531-018-0057-1. eCollection 2018.


The use of Centiloids for applying [11C]PiB classification cutoffs across region-of-interest delineation methods.

Tudorascu DL, Minhas DS, Lao PJ, Betthauser TJ, Yu Z, Laymon CM, Lopresti BJ, Mathis CA, Klunk WE, Handen BL, Christian BT, Cohen AD.

Alzheimers Dement (Amst). 2018 Apr 21;10:332-339. doi: 10.1016/j.dadm.2018.03.006. eCollection 2018.


Letter and Category Fluency Performance Correlates with Distinct Patterns of Cortical Thickness in Older Adults.

Vonk JMJ, Rizvi B, Lao PJ, Budge M, Manly JJ, Mayeux R, Brickman AM.

Cereb Cortex. 2019 Jun 1;29(6):2694-2700. doi: 10.1093/cercor/bhy138.


Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation.

Lao PJ, Handen BL, Betthauser TJ, Cody KA, Cohen AD, Tudorascu DL, Stone CK, Price JC, Johnson SC, Klunk WE, Christian BT.

Brain Imaging Behav. 2019 Apr;13(2):345-353. doi: 10.1007/s11682-018-9888-y.


Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-β Burden in Down Syndrome.

Lao PJ, Handen BL, Betthauser TJ, Mihaila I, Hartley SL, Cohen AD, Tudorascu DL, Bulova PD, Lopresti BJ, Tumuluru RV, Murali D, Mathis CA, Barnhart TE, Stone CK, Price JC, Devenny DA, Johnson SC, Klunk WE, Christian BT.

J Alzheimers Dis. 2018;61(2):631-644. doi: 10.3233/JAD-170720.


Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau.

Betthauser TJ, Ellison PA, Murali D, Lao PJ, Barnhart TE, Furumoto S, Okamura N, Johnson SC, Engle JW, Nickles RJ, Christian BT.

Appl Radiat Isot. 2017 Dec;130:230-237. doi: 10.1016/j.apradiso.2017.10.002. Epub 2017 Oct 4.


Human biodistribution and dosimetry of [18F]nifene, an α4β2* nicotinic acetylcholine receptor PET tracer.

Betthauser TJ, Hillmer AT, Lao PJ, Ehlerding E, Mukherjee J, Stone CK, Christian BT.

Nucl Med Biol. 2017 Dec;55:7-11. doi: 10.1016/j.nucmedbio.2017.08.001. Epub 2017 Aug 17.


Human brain imaging of nicotinic acetylcholine α4β2* receptors using [18 F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways.

Mukherjee J, Lao PJ, Betthauser TJ, Samra GK, Pan ML, Patel IH, Liang C, Metherate R, Christian BT.

J Comp Neurol. 2018 Jan 1;526(1):80-95. doi: 10.1002/cne.24320. Epub 2017 Sep 19.


Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome.

Hartley SL, Handen BL, Devenny D, Mihaila I, Hardison R, Lao PJ, Klunk WE, Bulova P, Johnson SC, Christian BT.

Neurobiol Aging. 2017 Oct;58:68-76. doi: 10.1016/j.neurobiolaging.2017.05.019. Epub 2017 Jun 2.


Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population.

Lao PJ, Handen BL, Betthauser TJ, Mihaila I, Hartley SL, Cohen AD, Tudorascu DL, Bulova PD, Lopresti BJ, Tumuluru RV, Murali D, Mathis CA, Barnhart TE, Stone CK, Price JC, Devenny DA, Mailick MR, Klunk WE, Johnson SC, Christian BT.

Alzheimers Dement (Amst). 2017 May 23;9:1-9. doi: 10.1016/j.dadm.2017.05.001. eCollection 2017.


[18 F]Nifene test-retest reproducibility in first-in-human imaging of α4β2* nicotinic acetylcholine receptors.

Lao PJ, Betthauser TJ, Tudorascu DL, Barnhart TE, Hillmer AT, Stone CK, Mukherjee J, Christian BT.

Synapse. 2017 Aug;71(8). doi: 10.1002/syn.21981. Epub 2017 Apr 26.


Leisure Activity and Caregiver Involvement in Middle-Aged and Older Adults With Down Syndrome.

Mihaila I, Hartley SL, Handen BL, Bulova PD, Tumuluru RV, Devenny DA, Johnson SC, Lao PJ, Christian BT.

Intellect Dev Disabil. 2017 Apr;55(2):97-109. doi: 10.1352/1934-9556-55.2.97.


In Vivo Comparison of Tau Radioligands 18F-THK-5351 and 18F-THK-5317.

Betthauser TJ, Lao PJ, Murali D, Barnhart TE, Furumoto S, Okamura N, Stone CK, Johnson SC, Christian BT.

J Nucl Med. 2017 Jun;58(6):996-1002. doi: 10.2967/jnumed.116.182980. Epub 2016 Nov 10.


The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B.

Lao PJ, Betthauser TJ, Hillmer AT, Price JC, Klunk WE, Mihaila I, Higgins AT, Bulova PD, Hartley SL, Hardison R, Tumuluru RV, Murali D, Mathis CA, Cohen AD, Barnhart TE, Devenny DA, Mailick MR, Johnson SC, Handen BL, Christian BT.

Alzheimers Dement. 2016 Apr;12(4):380-90. doi: 10.1016/j.jalz.2015.05.013. Epub 2015 Jun 13.


First-in-human evaluation of 18F-mefway, a PET radioligand specific to serotonin-1A receptors.

Hillmer AT, Wooten DW, Bajwa AK, Higgins AT, Lao PJ, Betthauser TJ, Barnhart TE, Rowley HA, Stone CK, Johnson SC, Mukherjee J, Christian BT.

J Nucl Med. 2014 Dec;55(12):1973-9. doi: 10.2967/jnumed.114.145151. Epub 2014 Nov 13.


Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer.

Peng Y, Li M, Clarkson BD, Pehar M, Lao PJ, Hillmer AT, Barnhart TE, Christian BT, Mitchell HA, Bendlin BB, Sandor M, Puglielli L.

J Neurosci. 2014 May 14;34(20):6772-89. doi: 10.1523/JNEUROSCI.0077-14.2014.


Changes in the α4β2* nicotinic acetylcholine system during chronic controlled alcohol exposure in nonhuman primates.

Hillmer AT, Tudorascu DL, Wooten DW, Lao PJ, Barnhart TE, Ahlers EO, Resch LM, Larson JA, Converse AK, Moore CF, Schneider ML, Christian BT.

Drug Alcohol Depend. 2014 May 1;138:216-9. doi: 10.1016/j.drugalcdep.2014.01.027. Epub 2014 Feb 15.


PET imaging of acetylcholinesterase inhibitor-induced effects on α4β2 nicotinic acetylcholine receptor binding.

Hillmer AT, Wooten DW, Farhoud M, Higgins AT, Lao PJ, Barnhart TE, Mukherjee J, Christian BT.

Synapse. 2013 Dec;67(12):882-6. doi: 10.1002/syn.21698. Epub 2013 Aug 30.


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