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Items: 12


Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.

Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J.

J Clin Invest. 2017 Aug 1;127(8):3189-3200. doi: 10.1172/JCI94310. Epub 2017 Jul 24.


Lmo7 is dispensable for skeletal muscle and cardiac function.

Lao DH, Esparza MC, Bremner SN, Banerjee I, Zhang J, Veevers J, Bradford WH, Gu Y, Dalton ND, Knowlton KU, Peterson KL, Lieber RL, Chen J.

Am J Physiol Cell Physiol. 2015 Oct 1;309(7):C470-9. doi: 10.1152/ajpcell.00177.2015. Epub 2015 Jul 8.


Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.

Pereira L, Rehmann H, Lao DH, Erickson JR, Bossuyt J, Chen J, Bers DM.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):3991-6. doi: 10.1073/pnas.1416163112. Epub 2015 Mar 17.


Development of a enterovirus diagnostic assay system for diagnosis of viral myocarditis in humans.

Lim BK, Ju ES, Lao DH, Yun SH, Lee YJ, Kim DK, Jeon ES.

Microbiol Immunol. 2013 Apr;57(4):281-7. doi: 10.1111/1348-0421.12028.


Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM.

Circulation. 2013 Feb 26;127(8):913-22. doi: 10.1161/CIRCULATIONAHA.12.148619. Epub 2013 Jan 30.


Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.

Manso AM, Li R, Monkley SJ, Cruz NM, Ong S, Lao DH, Koshman YE, Gu Y, Peterson KL, Chen J, Abel ED, Samarel AM, Critchley DR, Ross RS.

J Biol Chem. 2013 Feb 8;288(6):4252-64. doi: 10.1074/jbc.M112.427484. Epub 2012 Dec 24.


Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1.

Yan J, Mei FC, Cheng H, Lao DH, Hu Y, Wei J, Patrikeev I, Hao D, Stutz SJ, Dineley KT, Motamedi M, Hommel JD, Cunningham KA, Chen J, Cheng X.

Mol Cell Biol. 2013 Mar;33(5):918-26. doi: 10.1128/MCB.01227-12. Epub 2012 Dec 21.


Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

Chandramouli S, Yu CY, Yusoff P, Lao DH, Leong HF, Mizuno K, Guy GR.

J Biol Chem. 2008 Jan 18;283(3):1679-91. Epub 2007 Nov 1.


Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation.

Lao DH, Yusoff P, Chandramouli S, Philp RJ, Fong CW, Jackson RA, Saw TY, Yu CY, Guy GR.

J Biol Chem. 2007 Mar 23;282(12):9117-26. Epub 2007 Jan 25.


A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation.

Lao DH, Chandramouli S, Yusoff P, Fong CW, Saw TY, Tai LP, Yu CY, Leong HF, Guy GR.

J Biol Chem. 2006 Oct 6;281(40):29993-30000. Epub 2006 Aug 7.


Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf.

Yusoff P, Lao DH, Ong SH, Wong ES, Lim J, Lo TL, Leong HF, Fong CW, Guy GR.

J Biol Chem. 2002 Feb 1;277(5):3195-201. Epub 2001 Nov 6.

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