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Items: 33


KRAS-Driven Metabolic Rewiring Reveals Novel Actionable Targets in Cancer.

Pupo E, Avanzato D, Middonti E, Bussolino F, Lanzetti L.

Front Oncol. 2019 Aug 30;9:848. doi: 10.3389/fonc.2019.00848. eCollection 2019. Review.


Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites.

Holdgaard SG, Cianfanelli V, Pupo E, Lambrughi M, Lubas M, Nielsen JC, Eibes S, Maiani E, Harder LM, Wesch N, Foged MM, Maeda K, Nazio F, de la Ballina LR, Dötsch V, Brech A, Frankel LB, Jäättelä M, Locatelli F, Barisic M, Andersen JS, Bekker-Jensen S, Lund AH, Rogov VV, Papaleo E, Lanzetti L, De Zio D, Cecconi F.

Nat Commun. 2019 Sep 13;10(1):4176. doi: 10.1038/s41467-019-12094-9.


Kinesin-2 Controls the Motility of RAB5 Endosomes and Their Association with the Spindle in Mitosis.

Pupo E, Avanzato D, Scianna M, Oldani A, Serini G, Lanzetti L.

Int J Mol Sci. 2018 Aug 30;19(9). pii: E2575. doi: 10.3390/ijms19092575.


High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis.

Avanzato D, Pupo E, Ducano N, Isella C, Bertalot G, Luise C, Pece S, Bruna A, Rueda OM, Caldas C, Di Fiore PP, Sapino A, Lanzetti L.

Cancer Res. 2018 Jul 1;78(13):3432-3444. doi: 10.1158/0008-5472.CAN-17-3018. Epub 2018 Apr 24.


Sema4C/PlexinB2 signaling controls breast cancer cell growth, hormonal dependence and tumorigenic potential.

Gurrapu S, Pupo E, Franzolin G, Lanzetti L, Tamagnone L.

Cell Death Differ. 2018 Jul;25(7):1259-1275. doi: 10.1038/s41418-018-0097-4. Epub 2018 Mar 19.


Emerging functions of the EGFR in cancer.

Sigismund S, Avanzato D, Lanzetti L.

Mol Oncol. 2018 Jan;12(1):3-20. doi: 10.1002/1878-0261.12155. Epub 2017 Nov 27. Review.


Behind the Scenes: Endo/Exocytosis in the Acquisition of Metastatic Traits.

Lanzetti L, Di Fiore PP.

Cancer Res. 2017 Apr 15;77(8):1813-1817. doi: 10.1158/0008-5472.CAN-16-3403. Epub 2017 Apr 3. Review.


Deep Sequencing Reveals a Novel miR-22 Regulatory Network with Therapeutic Potential in Rhabdomyosarcoma.

Bersani F, Lingua MF, Morena D, Foglizzo V, Miretti S, Lanzetti L, Carrà G, Morotti A, Ala U, Provero P, Chiarle R, Singer S, Ladanyi M, Tuschl T, Ponzetto C, Taulli R.

Cancer Res. 2016 Oct 15;76(20):6095-6106. Epub 2016 Aug 28.


Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody.

Pupo E, Ducano N, Lupo B, Vigna E, Avanzato D, Perera T, Trusolino L, Lanzetti L, Comoglio PM.

Cancer Res. 2016 Sep 1;76(17):5019-29. doi: 10.1158/0008-5472.CAN-15-3107. Epub 2016 Jun 30.


Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals.

Lupo B, Vialard J, Sassi F, Angibaud P, Puliafito A, Pupo E, Lanzetti L, Comoglio PM, Bertotti A, Trusolino L.

BMC Biol. 2016 Jan 19;14:5. doi: 10.1186/s12915-016-0226-9.


Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration.

Castelli M, De Pascalis C, Distefano G, Ducano N, Oldani A, Lanzetti L, Boletta A.

BMC Cell Biol. 2015 May 7;16:15. doi: 10.1186/s12860-015-0059-3.


TNF-α promotes invasive growth through the MET signaling pathway.

Bigatto V, De Bacco F, Casanova E, Reato G, Lanzetti L, Isella C, Sarotto I, Comoglio PM, Boccaccio C.

Mol Oncol. 2015 Feb;9(2):377-88. doi: 10.1016/j.molonc.2014.09.002. Epub 2014 Sep 26.


The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G.

Dev Cell. 2014 Sep 8;30(5):553-68. doi: 10.1016/j.devcel.2014.08.006.


The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration.

Palamidessi A, Frittoli E, Ducano N, Offenhauser N, Sigismund S, Kajiho H, Parazzoli D, Oldani A, Gobbi M, Serini G, Di Fiore PP, Scita G, Lanzetti L.

Curr Biol. 2013 Dec 2;23(23):2355-64. doi: 10.1016/j.cub.2013.09.060. Epub 2013 Nov 14.


Neuropilin-1-dependent regulation of EGF-receptor signaling.

Rizzolio S, Rabinowicz N, Rainero E, Lanzetti L, Serini G, Norman J, Neufeld G, Tamagnone L.

Cancer Res. 2012 Nov 15;72(22):5801-11. doi: 10.1158/0008-5472.CAN-12-0995. Epub 2012 Sep 17.


The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling.

Sandri C, Caccavari F, Valdembri D, Camillo C, Veltel S, Santambrogio M, Lanzetti L, Bussolino F, Ivaska J, Serini G.

Cell Res. 2012 Oct;22(10):1479-501. doi: 10.1038/cr.2012.110. Epub 2012 Jul 24.


A novel function of Rab5 in mitosis.

Lanzetti L.

Small GTPases. 2012 Jul-Sep;3(3):168-72. doi: 10.4161/sgtp.19987. Epub 2012 Jun 14.


Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores.

Serio G, Margaria V, Jensen S, Oldani A, Bartek J, Bussolino F, Lanzetti L.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17337-42. doi: 10.1073/pnas.1103516108. Epub 2011 Oct 10.


Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth.

Burgo A, Sotirakis E, Simmler MC, Verraes A, Chamot C, Simpson JC, Lanzetti L, Proux-Gillardeaux V, Galli T.

EMBO Rep. 2009 Oct;10(10):1117-24. doi: 10.1038/embor.2009.186. Epub 2009 Sep 11.


Endocytosis and cancer: an 'insider' network with dangerous liaisons.

Lanzetti L, Di Fiore PP.

Traffic. 2008 Dec;9(12):2011-21. doi: 10.1111/j.1600-0854.2008.00816.x. Epub 2008 Aug 14. Review.


Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.

Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P, Rückle T, Rommel C, Backer JM, Forni G, Wymann MP, Hirsch E.

Sci Signal. 2008 Sep 9;1(36):ra3. doi: 10.1126/scisignal.1161577.


Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration.

Palamidessi A, Frittoli E, Garré M, Faretta M, Mione M, Testa I, Diaspro A, Lanzetti L, Scita G, Di Fiore PP.

Cell. 2008 Jul 11;134(1):135-47. doi: 10.1016/j.cell.2008.05.034.


Met-driven invasive growth involves transcriptional regulation of Arhgap12.

Gentile A, D'Alessandro L, Lazzari L, Martinoglio B, Bertotti A, Mira A, Lanzetti L, Comoglio PM, Medico E.

Oncogene. 2008 Sep 18;27(42):5590-8. doi: 10.1038/onc.2008.173. Epub 2008 May 26.


The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway.

Frittoli E, Palamidessi A, Pizzigoni A, Lanzetti L, Garrè M, Troglio F, Troilo A, Fukuda M, Di Fiore PP, Scita G, Confalonieri S.

Mol Biol Cell. 2008 Apr;19(4):1304-16. doi: 10.1091/mbc.E07-06-0594. Epub 2008 Jan 16.


Actin in membrane trafficking.

Lanzetti L.

Curr Opin Cell Biol. 2007 Aug;19(4):453-8. Epub 2007 Jul 5. Review.


Regulation of the Rab5 GTPase-activating protein RN-tre by the dual specificity phosphatase Cdc14A in human cells.

Lanzetti L, Margaria V, Melander F, Virgili L, Lee MH, Bartek J, Jensen S.

J Biol Chem. 2007 May 18;282(20):15258-70. Epub 2007 Mar 19.


Src triggers circular ruffling and macropinocytosis at the apical surface of polarized MDCK cells.

Mettlen M, Platek A, Van Der Smissen P, Carpentier S, Amyere M, Lanzetti L, de Diesbach P, Tyteca D, Courtoy PJ.

Traffic. 2006 May;7(5):589-603.


Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases.

Lanzetti L, Palamidessi A, Areces L, Scita G, Di Fiore PP.

Nature. 2004 May 20;429(6989):309-14.


Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase.

Vieira OV, Bucci C, Harrison RE, Trimble WS, Lanzetti L, Gruenberg J, Schreiber AD, Stahl PD, Grinstein S.

Mol Cell Biol. 2003 Apr;23(7):2501-14.


Pathways linking endocytosis and actin cytoskeleton in mammalian cells.

Lanzetti L, Di Fiore PP, Scita G.

Exp Cell Res. 2001 Nov 15;271(1):45-56. Review. No abstract available.


The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.

Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP.

Nature. 2000 Nov 16;408(6810):374-7.


A novel SH3-containing human gene family preferentially expressed in the central nervous system.

Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N.

Genomics. 1997 May 1;41(3):427-34.


In the budding yeast Kluyveromyces marxianus, adenylate cyclase is regulated by Ras protein(s) in vitro.

Verzotti E, Geymonat M, Valetti F, Lanzetti L, Giunta C.

Yeast. 1994 Aug;10(8):993-1001.


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