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Metabo- and mechanoreceptor expression in human heart failure: Relationships with the locomotor muscle afferent influence on exercise responses.

Smith JR, Hart CR, Ramos PA, Akinsanya JG, Lanza IR, Joyner MJ, Curry TB, Olson TP.

Exp Physiol. 2020 Feb 27. doi: 10.1113/EP088353. [Epub ahead of print]


Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice.

Berent TE, Dorschner JM, Meyer T, Craig TA, Wang X, Kunz H, Jatoi A, Lanza IR, Chen H, Kumar R.

PLoS One. 2019 Dec 18;14(12):e0226440. doi: 10.1371/journal.pone.0226440. eCollection 2019.


High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system.

Langley MR, Yoon H, Kim HN, Choi CI, Simon W, Kleppe L, Lanza IR, LeBrasseur NK, Matveyenko A, Scarisbrick IA.

Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165630. doi: 10.1016/j.bbadis.2019.165630. Epub 2019 Dec 6.


Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults.

Hart CR, Ryan ZC, Pfaffenbach KT, Dasari S, Parvizi M, Lalia AZ, Lanza IR.

Aging (Albany NY). 2019 Sep 14;11(18):7587-7604. doi: 10.18632/aging.102273. Epub 2019 Sep 14.


EPA and DHA elicit distinct transcriptional responses to high-fat feeding in skeletal muscle and liver.

Kunz HE, Dasari S, Lanza IR.

Am J Physiol Endocrinol Metab. 2019 Sep 1;317(3):E460-E472. doi: 10.1152/ajpendo.00083.2019. Epub 2019 Jul 2.


Distinct influence of omega-3 fatty acids on the plasma metabolome of healthy older adults.

Xyda SE, Vuckovic I, Petterson XM, Dasari S, Lalia AZ, Parvizi M, Macura SI, Lanza IR.

J Gerontol A Biol Sci Med Sci. 2019 Jun 4. pii: glz141. doi: 10.1093/gerona/glz141. [Epub ahead of print]


A comprehensive protocol for multiplatform metabolomics analysis in patient-derived skin fibroblasts.

Wilkins J, Sakrikar D, Petterson XM, Lanza IR, Trushina E.

Metabolomics. 2019 May 23;15(6):83. doi: 10.1007/s11306-019-1544-z.


TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle.

Koh JH, Johnson ML, Dasari S, LeBrasseur NK, Vuckovic I, Henderson GC, Cooper SA, Manjunatha S, Ruegsegger GN, Shulman GI, Lanza IR, Nair KS.

Diabetes. 2019 Aug;68(8):1552-1564. doi: 10.2337/db19-0088. Epub 2019 May 14.


Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes.

Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS.

FASEB J. 2019 Mar;33(3):4458-4472. doi: 10.1096/fj.201802043R. Epub 2019 Jan 24.


Mitochondrial ADP Sensitivity and Transport: New Insights Into Diet-Induced Mitochondrial Impairments.

Hart CR, Lanza IR.

Diabetes. 2018 Nov;67(11):2152-2153. doi: 10.2337/dbi18-0030. No abstract available.


Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes.

Konopka AR, Esponda RR, Robinson MM, Johnson ML, Carter RE, Schiavon M, Cobelli C, Wondisford FE, Lanza IR, Nair KS.

Cell Rep. 2018 May 22;23(8):2532. doi: 10.1016/j.celrep.2018.05.027. No abstract available.


Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet.

Cheng Y, Song H, Pan X, Xue H, Wan Y, Wang T, Tian Z, Hou E, Lanza IR, Liu P, Liu Y, Laud PW, Usa K, He Y, Liang M.

Theranostics. 2018 Feb 5;8(6):1468-1480. doi: 10.7150/thno.22018. eCollection 2018.


1α,25-dihydroxyvitamin D3 mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells.

Ryan ZC, Craig TA, Wang X, Delmotte P, Salisbury JL, Lanza IR, Sieck GC, Kumar R.

Biochem Biophys Res Commun. 2018 Feb 5;496(2):746-752. doi: 10.1016/j.bbrc.2018.01.092.


Very-long-chain ω-3 fatty acid supplements and adipose tissue functions: a randomized controlled trial.

Hames KC, Morgan-Bathke M, Harteneck DA, Zhou L, Port JD, Lanza IR, Jensen MD.

Am J Clin Nutr. 2017 Jun;105(6):1552-1558. doi: 10.3945/ajcn.116.148114. Epub 2017 Apr 19.


Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults.

Lalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR.

Aging (Albany NY). 2017 Apr;9(4):1096-1129. doi: 10.18632/aging.101210.


Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.

Robinson MM, Dasari S, Konopka AR, Johnson ML, Manjunatha S, Esponda RR, Carter RE, Lanza IR, Nair KS.

Cell Metab. 2017 Mar 7;25(3):581-592. doi: 10.1016/j.cmet.2017.02.009.


Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation?

Lalia AZ, Lanza IR.

Nutrients. 2016 Jun 1;8(6). pii: E329. doi: 10.3390/nu8060329. Review.


Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes.

Konopka AR, Esponda RR, Robinson MM, Johnson ML, Carter RE, Schiavon M, Cobelli C, Wondisford FE, Lanza IR, Nair KS.

Cell Rep. 2016 May 17;15(7):1394-1400. doi: 10.1016/j.celrep.2016.04.024. Epub 2016 May 5. Erratum in: Cell Rep. 2018 May 22;23(8):2532.


Noninvasive Monitoring of the Mitochondrial Function in Mesenchymal Stromal Cells.

Franchi F, Peterson KM, Paulmurugan R, Folmes C, Lanza IR, Lerman A, Rodriguez-Porcel M.

Mol Imaging Biol. 2016 Aug;18(4):510-8. doi: 10.1007/s11307-016-0929-x.


Altered Skeletal Muscle Mitochondrial Proteome As the Basis of Disruption of Mitochondrial Function in Diabetic Mice.

Zabielski P, Lanza IR, Gopala S, Heppelmann CJ, Bergen HR 3rd, Dasari S, Nair KS.

Diabetes. 2016 Mar;65(3):561-73. doi: 10.2337/db15-0823. Epub 2015 Dec 30.


Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans.

Lalia AZ, Dasari S, Johnson ML, Robinson MM, Konopka AR, Distelmaier K, Port JD, Glavin MT, Esponda RR, Nair KS, Lanza IR.

J Clin Endocrinol Metab. 2016 Feb;101(2):626-34. doi: 10.1210/jc.2015-2892. Epub 2015 Dec 28.


1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells.

Ryan ZC, Craig TA, Folmes CD, Wang X, Lanza IR, Schaible NS, Salisbury JL, Nair KS, Terzic A, Sieck GC, Kumar R.

J Biol Chem. 2016 Jan 15;291(3):1514-28. doi: 10.1074/jbc.M115.684399. Epub 2015 Nov 24.


Enhancing the Metabolic Benefits of Bariatric Surgery: Tipping the Scales With Exercise.

Lanza IR.

Diabetes. 2015 Nov;64(11):3656-8. doi: 10.2337/dbi15-0018. No abstract available.


Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults.

Johnson ML, Distelmaier K, Lanza IR, Irving BA, Robinson MM, Konopka AR, Shulman GI, Nair KS.

Diabetes. 2016 Jan;65(1):74-84. doi: 10.2337/db15-0675. Epub 2015 Aug 31.


Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women.

Hebert SL, Marquet-de Rougé P, Lanza IR, McCrady-Spitzer SK, Levine JA, Middha S, Carter RE, Klaus KA, Therneau TM, Highsmith EW, Nair KS.

J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1409-17. doi: 10.1093/gerona/glv086. Epub 2015 Aug 22.


Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice.

Johnson ML, Lalia AZ, Dasari S, Pallauf M, Fitch M, Hellerstein MK, Lanza IR.

Aging Cell. 2015 Oct;14(5):734-43. doi: 10.1111/acel.12352. Epub 2015 May 25.


Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans.

Lalia AZ, Johnson ML, Jensen MD, Hames KC, Port JD, Lanza IR.

Diabetes Care. 2015 Jul;38(7):1228-37. doi: 10.2337/dc14-3101. Epub 2015 Apr 7.


Application of high-resolution mass spectrometry to measure low abundance isotope enrichment in individual muscle proteins.

Hines KM, Ford GC, Klaus KA, Irving BA, Ford BL, Johnson KL, Lanza IR, Nair KS.

Anal Bioanal Chem. 2015 May;407(14):4045-52. doi: 10.1007/s00216-015-8641-2. Epub 2015 Apr 2.


Association of UCP-3 rs1626521 with obesity and stomach functions in humans.

Acosta A, Camilleri M, Shin A, Vazquez-Roque MI, Iturrino J, Lanza IR, Nair KS, Burton D, O'Neill J, Eckert D, Carlson P, Vella A, Zinsmeister AR.

Obesity (Silver Spring). 2015 Apr;23(4):898-906. doi: 10.1002/oby.21039. Epub 2015 Mar 7.


Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training.

Konopka AR, Asante A, Lanza IR, Robinson MM, Johnson ML, Dalla Man C, Cobelli C, Amols MH, Irving BA, Nair KS.

Diabetes. 2015 Jun;64(6):2104-15. doi: 10.2337/db14-1701. Epub 2015 Jan 20.


Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age.

Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS.

J Clin Endocrinol Metab. 2015 Apr;100(4):1654-63. doi: 10.1210/jc.2014-3081. Epub 2015 Jan 19.


Chronically endurance-trained individuals preserve skeletal muscle mitochondrial gene expression with age but differences within age groups remain.

Johnson ML, Lanza IR, Short DK, Asmann YW, Nair KS.

Physiol Rep. 2014 Dec 18;2(12). pii: e12239. doi: 10.14814/phy2.12239. Print 2014 Dec 1.


Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging.

Johnson ML, Irving BA, Lanza IR, Vendelbo MH, Konopka AR, Robinson MM, Henderson GC, Klaus KA, Morse DM, Heppelmann C, Bergen HR 3rd, Dasari S, Schimke JM, Jakaitis DR, Nair KS.

J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1386-93. doi: 10.1093/gerona/glu221. Epub 2014 Dec 10.


Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice.

Zabielski P, Blachnio-Zabielska A, Lanza IR, Gopala S, Manjunatha S, Jakaitis DR, Persson XM, Gransee J, Klaus KA, Schimke JM, Jensen MD, Nair KS.

Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E529-42. doi: 10.1152/ajpendo.00610.2012. Epub 2013 Dec 24.


Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size.

Yin X, Lanza IR, Swain JM, Sarr MG, Nair KS, Jensen MD.

J Clin Endocrinol Metab. 2014 Feb;99(2):E209-16. doi: 10.1210/jc.2013-3042. Epub 2013 Nov 25.


Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance.

Bhattacharyya S, Saha S, Giri K, Lanza IR, Nair KS, Jennings NB, Rodriguez-Aguayo C, Lopez-Berestein G, Basal E, Weaver AL, Visscher DW, Cliby W, Sood AK, Bhattacharya R, Mukherjee P.

PLoS One. 2013 Nov 13;8(11):e79167. doi: 10.1371/journal.pone.0079167. eCollection 2013.


Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet.

Lanza IR, Blachnio-Zabielska A, Johnson ML, Schimke JM, Jakaitis DR, Lebrasseur NK, Jensen MD, Sreekumaran Nair K, Zabielski P.

Am J Physiol Endocrinol Metab. 2013 Jun 15;304(12):E1391-403. doi: 10.1152/ajpendo.00584.2012. Epub 2013 Apr 30. Erratum in: Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E1048.


Methods for assessing mitochondrial function in diabetes.

Perry CG, Kane DA, Lanza IR, Neufer PD.

Diabetes. 2013 Apr;62(4):1041-53. doi: 10.2337/db12-1219. Review.


A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.

Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, Leinwand LA, Spiegelman BM.

Cell. 2012 Dec 7;151(6):1319-31. doi: 10.1016/j.cell.2012.10.050.


Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis.

Lanza IR, Zabielski P, Klaus KA, Morse DM, Heppelmann CJ, Bergen HR 3rd, Dasari S, Walrand S, Short KR, Johnson ML, Robinson MM, Schimke JM, Jakaitis DR, Asmann YW, Sun Z, Nair KS.

Cell Metab. 2012 Dec 5;16(6):777-88. doi: 10.1016/j.cmet.2012.11.003.


Measurement of human skeletal muscle oxidative capacity by 31P-MR spectroscopy: a cross-validation with in vitro measurements.

Lanza IR, Bhagra S, Nair KS, Port JD.

J Magn Reson Imaging. 2011 Nov;34(5):1143-50. doi: 10.1002/jmri.22733.


The impact of old age on skeletal muscle energetics: supply and demand.

Russ DW, Lanza IR.

Curr Aging Sci. 2011 Dec;4(3):234-47. Review.


Can dietary nitrates enhance the efficiency of mitochondria?

Nair KS, Irving BA, Lanza IR.

Cell Metab. 2011 Feb 2;13(2):117-8. doi: 10.1016/j.cmet.2011.01.013.


Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction.

Rostambeigi N, Lanza IR, Dzeja PP, Deeds MC, Irving BA, Reddi HV, Madde P, Zhang S, Asmann YW, Anderson JM, Schimke JM, Nair KS, Eberhardt NL, Kudva YC.

Transplantation. 2011 Mar 27;91(6):615-23. doi: 10.1097/TP.0b013e3182094a33.


Intracellular energetics and critical PO2 in resting ischemic human skeletal muscle in vivo.

Lanza IR, Tevald MA, Befroy DE, Kent-Braun JA.

Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1415-22. doi: 10.1152/ajpregu.00225.2010. Epub 2010 Sep 1.


Mitochondrial metabolic function assessed in vivo and in vitro.

Lanza IR, Nair KS.

Curr Opin Clin Nutr Metab Care. 2010 Sep;13(5):511-7. doi: 10.1097/MCO.0b013e32833cc93d. Review.


Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes.

Lanza IR, Zhang S, Ward LE, Karakelides H, Raftery D, Nair KS.

PLoS One. 2010 May 10;5(5):e10538. doi: 10.1371/journal.pone.0010538.


Regulation of skeletal muscle mitochondrial function: genes to proteins.

Lanza IR, Sreekumaran Nair K.

Acta Physiol (Oxf). 2010 Aug;199(4):529-47. doi: 10.1111/j.1748-1716.2010.02124.x. Epub 2010 Mar 25. Review.


Mitochondrial DNA alterations and reduced mitochondrial function in aging.

Hebert SL, Lanza IR, Nair KS.

Mech Ageing Dev. 2010 Jul-Aug;131(7-8):451-62. doi: 10.1016/j.mad.2010.03.007. Epub 2010 Mar 20. Review.


Lower energy cost of skeletal muscle contractions in older humans.

Tevald MA, Foulis SA, Lanza IR, Kent-Braun JA.

Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R729-39. doi: 10.1152/ajpregu.00713.2009. Epub 2009 Dec 23.

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