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Items: 48


Bioactivity-Guided Isolation of Totarane-Derived Diterpenes from Podocarpus neriifolius and Structure Revision of 3-Deoxy-2α-hydroxynagilactone E.

Benatrehina PA, Chen WL, Czarnecki AA, Kurina S, Chai HB, Lantvit DD, Ninh TN, Zhang X, Soejarto DD, Burdette JE, Kinghorn AD, Rakotondraibe LH.

Nat Prod Bioprospect. 2019 Apr;9(2):157-163. doi: 10.1007/s13659-019-0198-x. Epub 2019 Feb 19.


Exposure of the extracellular matrix and colonization of the ovary in metastasis of fallopian-tube-derived cancer.

Dean M, Jin V, Russo A, Lantvit DD, Burdette JE.

Carcinogenesis. 2019 Mar 12;40(1):41-51. doi: 10.1093/carcin/bgy170.


Evidence for Chemopreventive and Resilience Activity of Licorice: Glycyrrhiza Glabra and G. Inflata Extracts Modulate Estrogen Metabolism in ACI Rats.

Wang S, Dunlap TL, Huang L, Liu Y, Simmler C, Lantvit DD, Crosby J, Howell CE, Dong H, Chen SN, Pauli GF, van Breemen RB, Dietz BM, Bolton JL.

Cancer Prev Res (Phila). 2018 Dec;11(12):819-830. doi: 10.1158/1940-6207.CAPR-18-0178. Epub 2018 Oct 4.


Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition.

Young AN, Herrera D, Huntsman AC, Korkmaz MA, Lantvit DD, Mazumder S, Kolli S, Coss CC, King S, Wang H, Swanson SM, Kinghorn AD, Zhang X, Phelps MA, Aldrich LN, Fuchs JR, Burdette JE.

Mol Cancer Ther. 2018 Oct;17(10):2123-2135. doi: 10.1158/1535-7163.MCT-17-1195. Epub 2018 Jul 17.


Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model.

Karthikeyan S, Russo A, Dean M, Lantvit DD, Endsley M, Burdette JE.

Cancer Lett. 2018 Oct 1;433:221-231. doi: 10.1016/j.canlet.2018.07.003. Epub 2018 Jul 5.


The Flavonoid Apigenin Is a Progesterone Receptor Modulator with In Vivo Activity in the Uterus.

Dean M, Austin J, Jinhong R, Johnson ME, Lantvit DD, Burdette JE.

Horm Cancer. 2018 Aug;9(4):265-277. doi: 10.1007/s12672-018-0333-x. Epub 2018 May 7.


PTEN loss in the fallopian tube induces hyperplasia and ovarian tumor formation.

Russo A, Czarnecki AA, Dean M, Modi DA, Lantvit DD, Hardy L, Baligod S, Davis DA, Wei JJ, Burdette JE.

Oncogene. 2018 Apr;37(15):1976-1990. doi: 10.1038/s41388-017-0097-8. Epub 2018 Jan 25.


Merocyclophanes C and D from the Cultured Freshwater Cyanobacterium Nostoc sp. (UIC 10110).

May DS, Chen WL, Lantvit DD, Zhang X, Krunic A, Burdette JE, Eustaquio A, Orjala J.

J Nat Prod. 2017 Apr 28;80(4):1073-1080. doi: 10.1021/acs.jnatprod.6b01175. Epub 2017 Mar 2.


PAX2 function, regulation and targeting in fallopian tube-derived high-grade serous ovarian cancer.

Modi DA, Tagare RD, Karthikeyan S, Russo A, Dean M, Davis DA, Lantvit DD, Burdette JE.

Oncogene. 2017 May 25;36(21):3015-3024. doi: 10.1038/onc.2016.455. Epub 2016 Dec 19.


Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity.

Ren Y, Chen WL, Lantvit DD, Sass EJ, Shriwas P, Ninh TN, Chai HB, Zhang X, Soejarto DD, Chen X, Lucas DM, Swanson SM, Burdette JE, Kinghorn AD.

J Nat Prod. 2017 Mar 24;80(3):648-658. doi: 10.1021/acs.jnatprod.6b00924. Epub 2016 Dec 16.


Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface.

Karthikeyan S, Lantvit DD, Chae DH, Burdette JE.

Oncotarget. 2016 Oct 25;7(43):69871-69882. doi: 10.18632/oncotarget.11499.


Carnosic acid promotes degradation of the androgen receptor and is regulated by the unfolded protein response pathway in vitro and in vivo.

Petiwala SM, Li G, Bosland MC, Lantvit DD, Petukhov PA, Johnson JJ.

Carcinogenesis. 2016 Aug;37(8):827-838. doi: 10.1093/carcin/bgw052. Epub 2016 Jun 7.


Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.

Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SN, Nikolić D, Pauli GF, van Breemen RB, Dietz BM, Bolton JL.

Chem Res Toxicol. 2015 Nov 16;28(11):2130-41. doi: 10.1021/acs.chemrestox.5b00310. Epub 2015 Nov 5.


Spontaneous Transformation of Murine Oviductal Epithelial Cells: A Model System to Investigate the Onset of Fallopian-Derived Tumors.

Endsley MP, Moyle-Heyrman G, Karthikeyan S, Lantvit DD, Davis DA, Wei JJ, Burdette JE.

Front Oncol. 2015 Jul 17;5:154. doi: 10.3389/fonc.2015.00154. eCollection 2015.


In vivo tumor growth of high-grade serous ovarian cancer cell lines.

Mitra AK, Davis DA, Tomar S, Roy L, Gurler H, Xie J, Lantvit DD, Cardenas H, Fang F, Liu Y, Loughran E, Yang J, Sharon Stack M, Emerson RE, Cowden Dahl KD, V Barbolina M, Nephew KP, Matei D, Burdette JE.

Gynecol Oncol. 2015 Aug;138(2):372-7. doi: 10.1016/j.ygyno.2015.05.040. Epub 2015 Jun 5.


Tumorigenesis and peritoneal colonization from fallopian tube epithelium.

Eddie SL, Quartuccio SM, Ó hAinmhir E, Moyle-Heyrman G, Lantvit DD, Wei JJ, Vanderhyden BC, Burdette JE.

Oncotarget. 2015 Aug 21;6(24):20500-12.


Mutant p53 expression in fallopian tube epithelium drives cell migration.

Quartuccio SM, Karthikeyan S, Eddie SL, Lantvit DD, Ó hAinmhire E, Modi DA, Wei JJ, Burdette JE.

Int J Cancer. 2015 Oct 1;137(7):1528-38. doi: 10.1002/ijc.29528. Epub 2015 Apr 11.


Elevated GH/IGF-I promotes mammary tumors in high-fat, but not low-fat, fed mice.

Gahete MD, Córdoba-Chacón J, Lantvit DD, Ortega-Salas R, Sanchez-Sanchez R, Pérez-Jiménez F, López-Miranda J, Swanson SM, Castaño JP, Luque RM, Kineman RD.

Carcinogenesis. 2014 Nov;35(11):2467-73. doi: 10.1093/carcin/bgu161. Epub 2014 Aug 1.


Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei.

Ren Y, Lantvit DD, Deng Y, Kanagasabai R, Gallucci JC, Ninh TN, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Swanson SM, Kinghorn AD.

J Nat Prod. 2014 Jun 27;77(6):1494-504. doi: 10.1021/np5002785. Epub 2014 Jun 12.


Targeting of follicle stimulating hormone peptide-conjugated dendrimers to ovarian cancer cells.

Modi DA, Sunoqrot S, Bugno J, Lantvit DD, Hong S, Burdette JE.

Nanoscale. 2014 Mar 7;6(5):2812-20. doi: 10.1039/c3nr05042d. Epub 2014 Jan 27.


Kaempferol Exhibits Progestogenic Effects in Ovariectomized Rats.

Toh MF, Mendonca E, Eddie SL, Endsley MP, Lantvit DD, Petukhov PA, Burdette JE.

J Steroids Horm Sci. 2014;5(3):136.


Bioactive constituents of Indigofera spicata.

Bueno Pérez L, Li J, Lantvit DD, Pan L, Ninh TN, Chai HB, Soejarto DD, Swanson SM, Lucas DM, Kinghorn AD.

J Nat Prod. 2013 Aug 23;76(8):1498-504. doi: 10.1021/np400567c. Epub 2013 Jul 30.


Conditional inactivation of p53 in mouse ovarian surface epithelium does not alter MIS driven Smad2-dominant negative epithelium-lined inclusion cysts or teratomas.

Quartuccio SM, Lantvit DD, Bosland MC, Burdette JE.

PLoS One. 2013 May 31;8(5):e65067. doi: 10.1371/journal.pone.0065067. Print 2013.


Goyazensolide Induces Apoptosis in Cancer Cells in vitro and in vivo.

Acuña UM, Shen Q, Ren Y, Lantvit DD, Wittwer JA, Kinghorn AD, Swanson SM, de Blanco EJ.

Int J Cancer Res. 2013;9(2):36-53.


Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi.

Pearce CJ, Lantvit DD, Shen Q, Jarjoura D, Zhang X, Oberlies NH, Kroll DJ, Wani MC, Orjala J, Soejarto DD, Farnsworth NR, de Blanco EJ, Fuchs JR, Kinghorn AD, Swanson SM.

Methods Mol Biol. 2012;944:267-77. doi: 10.1007/978-1-62703-122-6_20.


Isolation, structure elucidation, and biological evaluation of 16,23-epoxycucurbitacin constituents from Eleaocarpus chinensis.

Pan L, Yong Y, Deng Y, Lantvit DD, Ninh TN, Chai H, Carcache de Blanco EJ, Soejarto DD, Swanson SM, Kinghorn AD.

J Nat Prod. 2012 Mar 23;75(3):444-52. doi: 10.1021/np200879p. Epub 2012 Jan 12.


Lyngbyaureidamides A and B, two anabaenopeptins from the cultured freshwater cyanobacterium Lyngbya sp. (SAG 36.91).

Zi J, Lantvit DD, Swanson SM, Orjala J.

Phytochemistry. 2012 Feb;74:173-7. doi: 10.1016/j.phytochem.2011.09.017. Epub 2011 Dec 5.


Bioassay-guided isolation of constituents of Piper sarmentosum using a mitochondrial transmembrane potential assay.

Pan L, Matthew S, Lantvit DD, Zhang X, Ninh TN, Chai H, Carcache de Blanco EJ, Soejarto DD, Swanson SM, Kinghorn AD.

J Nat Prod. 2011 Oct 28;74(10):2193-9. doi: 10.1021/np200557e. Epub 2011 Oct 5.


Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.

Ren Y, Matthew S, Lantvit DD, Ninh TN, Chai H, Fuchs JR, Soejarto DD, de Blanco EJ, Swanson SM, Kinghorn AD.

J Nat Prod. 2011 May 27;74(5):1117-25. doi: 10.1021/np200051j. Epub 2011 Mar 23.


Scytonemides A and B, cyclic peptides with 20S proteasome inhibitory activity from the cultured cyanobacterium Scytonema hofmanii.

Krunic A, Vallat A, Mo S, Lantvit DD, Swanson SM, Orjala J.

J Nat Prod. 2010 Nov 29;73(11):1927-32. doi: 10.1021/np100600z. Epub 2010 Nov 8.


Cylindrocyclophanes with proteasome inhibitory activity from the Cyanobacterium Nostoc sp.

Chlipala GE, Sturdy M, Krunic A, Lantvit DD, Shen Q, Porter K, Swanson SM, Orjala J.

J Nat Prod. 2010 Sep 24;73(9):1529-37. doi: 10.1021/np100352e.


Proteasome-inhibitory and cytotoxic constituents of Garcinia lateriflora: absolute configuration of caged xanthones.

Ren Y, Lantvit DD, Carcache de Blanco EJ, Kardono LB, Riswan S, Chai H, Cottrell CE, Farnsworth NR, Swanson SM, Ding Y, Li XC, Marais JP, Ferreira D, Kinghorn AD.

Tetrahedron. 2010 Jul 17;66(29):5311-5320.


Bioactivity-guided isolation of cytotoxic sesquiterpenes of Rolandra fruticosa.

Pan L, Lantvit DD, Riswan S, Kardono LB, Chai HB, de Blanco EJ, Farnsworth NR, Soejarto DD, Swanson SM, Kinghorn AD.

Phytochemistry. 2010 Apr;71(5-6):635-40. doi: 10.1016/j.phytochem.2010.01.012. Epub 2010 Feb 25.


Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen).

Han AR, Kim JA, Lantvit DD, Kardono LB, Riswan S, Chai H, Carcache de Blanco EJ, Farnsworth NR, Swanson SM, Kinghorn AD.

J Nat Prod. 2009 Nov;72(11):2028-31. doi: 10.1021/np900517h.


Bioactive 5,6-dihydro-alpha-pyrone derivatives from Hyptis brevipes.

Deng Y, Balunas MJ, Kim JA, Lantvit DD, Chin YW, Chai H, Sugiarso S, Kardono LB, Fong HH, Pezzuto JM, Swanson SM, de Blanco EJ, Kinghorn AD.

J Nat Prod. 2009 Jun;72(6):1165-9. doi: 10.1021/np9001724.


Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators.

Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR.

Drug Metab Dispos. 2009 Jan;37(1):161-9. doi: 10.1124/dmd.108.023408. Epub 2008 Oct 20.


In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.

Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL.

Chem Biol Interact. 2008 Oct 22;176(1):30-9. doi: 10.1016/j.cbi.2008.06.005. Epub 2008 Jun 20.


Disruption of growth hormone signaling retards prostate carcinogenesis in the Probasin/TAg rat.

Wang Z, Luque RM, Kineman RD, Ray VH, Christov KT, Lantvit DD, Shirai T, Hedayat S, Unterman TG, Bosland MC, Prins GS, Swanson SM.

Endocrinology. 2008 Mar;149(3):1366-76. Epub 2007 Dec 13.


Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.

Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR.

Mol Cancer Ther. 2007 Sep;6(9):2418-28.


Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene.

Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, Bolton JL, Thatcher GR.

ChemMedChem. 2007 Oct;2(10):1520-6.


Advanced rat mammary cancers are growth hormone dependent.

Shen Q, Lantvit DD, Lin Q, Li Y, Christov K, Wang Z, Unterman TG, Mehta RG, Swanson SM.

Endocrinology. 2007 Oct;148(10):4536-44. Epub 2007 Jun 21.


Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling.

Zhang X, Mehta RG, Lantvit DD, Coschigano KT, Kopchick JJ, Green JE, Hedayat S, Christov KT, Ray VH, Unterman TG, Swanson SM.

Carcinogenesis. 2007 Jan;28(1):143-50. Epub 2006 Aug 17.


Effect of deguelin on UVB-induced skin carcinogenesis.

Gills JJ, Kosmeder J 2nd, Moon RC, Lantvit DD, Pezzuto JM.

J Chemother. 2005 Jun;17(3):297-301.


Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion.

Gills JJ, Jeffery EH, Matusheski NV, Moon RC, Lantvit DD, Pezzuto JM.

Cancer Lett. 2006 May 8;236(1):72-9. Epub 2005 Jul 1. Review.


Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies.

Christov KT, Moon RC, Lantvit DD, Boone CW, Kelloff GJ, Steele VE, Lubet RA, Pezzuto JM.

Eur J Cancer. 2004 Jun;40(9):1404-11.


Multiple myeloma regression mediated by bruceantin.

Cuendet M, Christov K, Lantvit DD, Deng Y, Hedayat S, Helson L, McChesney JD, Pezzuto JM.

Clin Cancer Res. 2004 Feb 1;10(3):1170-9.


9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats.

Christov KT, Moon RC, Lantvit DD, Boone CW, Steele VE, Lubet RA, Kelloff GJ, Pezzuto JM.

Cancer Res. 2002 Sep 15;62(18):5178-82.


Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry.

Park EJ, Lee D, Shin YG, Lantvit DD, van Breemen RB, Kinghorn AD, Pezzuto JM.

J Chromatogr B Biomed Sci Appl. 2001 Apr 25;754(2):327-32.


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