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Dysregulation of histone H3 lysine 27 trimethylation in transforming growth factor-β1-induced gene expression in mesangial cells and diabetic kidney.

Jia Y, Reddy MA, Das S, Oh HJ, Abdollahi M, Yuan H, Zhang E, Lanting L, Wang M, Natarajan R.

J Biol Chem. 2019 Aug 23;294(34):12695-12707. doi: 10.1074/jbc.RA119.007575. Epub 2019 Jul 2.


A Novel Angiotensin II-Induced Long Noncoding RNA Giver Regulates Oxidative Stress, Inflammation, and Proliferation in Vascular Smooth Muscle Cells.

Das S, Zhang E, Senapati P, Amaram V, Reddy MA, Stapleton K, Leung A, Lanting L, Wang M, Chen Z, Kato M, Oh HJ, Guo Q, Zhang X, Zhang B, Zhang H, Zhao Q, Wang W, Wu Y, Natarajan R.

Circ Res. 2018 Dec 7;123(12):1298-1312. doi: 10.1161/CIRCRESAHA.118.313207. Erratum in: Circ Res. 2019 Dec 6;125(12):e112.


Diabetes Mellitus-Induced Long Noncoding RNA Dnm3os Regulates Macrophage Functions and Inflammation via Nuclear Mechanisms.

Das S, Reddy MA, Senapati P, Stapleton K, Lanting L, Wang M, Amaram V, Ganguly R, Zhang L, Devaraj S, Schones DE, Natarajan R.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1806-1820. doi: 10.1161/ATVBAHA.117.310663. Erratum in: Arterioscler Thromb Vasc Biol. 2019 May;39(5):e157.


Reduced Autophagy by a microRNA-mediated Signaling Cascade in Diabetes-induced Renal Glomerular Hypertrophy.

Deshpande S, Abdollahi M, Wang M, Lanting L, Kato M, Natarajan R.

Sci Rep. 2018 May 3;8(1):6954. doi: 10.1038/s41598-018-25295-x.


Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells.

Das S, Senapati P, Chen Z, Reddy MA, Ganguly R, Lanting L, Mandi V, Bansal A, Leung A, Zhang S, Jia Y, Wu X, Schones DE, Natarajan R.

Nat Commun. 2017 Nov 13;8(1):1467. doi: 10.1038/s41467-017-01629-7.


Erratum: Inhibition of the processing of miR-25 by HIPK2-Phosphorylated-MeCP2 induces NOX4 in early diabetic nephropathy.

Oh HJ, Kato M, Deshpande S, Zhang E, Das S, Lanting L, Wang M, Natarajan R.

Sci Rep. 2017 Jan 23;7:40832. doi: 10.1038/srep40832. No abstract available.


Inhibition of the processing of miR-25 by HIPK2-Phosphorylated-MeCP2 induces NOX4 in early diabetic nephropathy.

Oh HJ, Kato M, Deshpande S, Zhang E, Das S, Lanting L, Wang M, Natarajan R.

Sci Rep. 2016 Dec 12;6:38789. doi: 10.1038/srep38789. Erratum in: Sci Rep. 2017 Jan 23;7:40832.


An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy.

Kato M, Wang M, Chen Z, Bhatt K, Oh HJ, Lanting L, Deshpande S, Jia Y, Lai JY, O'Connor CL, Wu Y, Hodgin JB, Nelson RG, Bitzer M, Natarajan R.

Nat Commun. 2016 Sep 30;7:12864. doi: 10.1038/ncomms12864.


Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504.

Reddy MA, Das S, Zhuo C, Jin W, Wang M, Lanting L, Natarajan R.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):864-73. doi: 10.1161/ATVBAHA.115.306770. Epub 2016 Mar 3.


Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of Diabetic Nephropathy.

Bhatt K, Lanting LL, Jia Y, Yadav S, Reddy MA, Magilnick N, Boldin M, Natarajan R.

J Am Soc Nephrol. 2016 Aug;27(8):2277-88. doi: 10.1681/ASN.2015010111. Epub 2015 Dec 8.


Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy.

Yuan H, Reddy MA, Deshpande S, Jia Y, Park JT, Lanting LL, Jin W, Kato M, Xu ZG, Das S, Natarajan R.

Antioxid Redox Signal. 2016 Mar 1;24(7):361-75. doi: 10.1089/ars.2015.6372. Epub 2015 Nov 30.


Repression of let-7 by transforming growth factor-β1-induced Lin28 upregulates collagen expression in glomerular mesangial cells under diabetic conditions.

Park JT, Kato M, Lanting L, Castro N, Nam BY, Wang M, Kang SW, Natarajan R.

Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1390-403. doi: 10.1152/ajprenal.00458.2014. Epub 2014 Oct 29.


Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA.

Reddy MA, Chen Z, Park JT, Wang M, Lanting L, Zhang Q, Bhatt K, Leung A, Wu X, Putta S, Sætrom P, Devaraj S, Natarajan R.

Diabetes. 2014 Dec;63(12):4249-61. doi: 10.2337/db14-0298. Epub 2014 Jul 9.


Losartan reverses permissive epigenetic changes in renal glomeruli of diabetic db/db mice.

Reddy MA, Sumanth P, Lanting L, Yuan H, Wang M, Mar D, Alpers CE, Bomsztyk K, Natarajan R.

Kidney Int. 2014 Feb;85(2):362-73. doi: 10.1038/ki.2013.387. Epub 2013 Oct 2.


FOG2 protein down-regulation by transforming growth factor-β1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy.

Park JT, Kato M, Yuan H, Castro N, Lanting L, Wang M, Natarajan R.

J Biol Chem. 2013 Aug 2;288(31):22469-80. doi: 10.1074/jbc.M113.453043. Epub 2013 Jun 20.


TGF-β induces acetylation of chromatin and of Ets-1 to alleviate repression of miR-192 in diabetic nephropathy.

Kato M, Dang V, Wang M, Park JT, Deshpande S, Kadam S, Mardiros A, Zhan Y, Oettgen P, Putta S, Yuan H, Lanting L, Natarajan R.

Sci Signal. 2013 Jun 4;6(278):ra43. doi: 10.1126/scisignal.2003389.


Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells.

Leung A, Trac C, Jin W, Lanting L, Akbany A, Sætrom P, Schones DE, Natarajan R.

Circ Res. 2013 Jul 19;113(3):266-78. doi: 10.1161/CIRCRESAHA.112.300849. Epub 2013 May 22.


Transforming growth factor-β-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy.

Deshpande SD, Putta S, Wang M, Lai JY, Bitzer M, Nelson RG, Lanting LL, Kato M, Natarajan R.

Diabetes. 2013 Sep;62(9):3151-62. doi: 10.2337/db13-0305. Epub 2013 May 6.


Involvement of p300/CBP and epigenetic histone acetylation in TGF-β1-mediated gene transcription in mesangial cells.

Yuan H, Reddy MA, Sun G, Lanting L, Wang M, Kato M, Natarajan R.

Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F601-13. doi: 10.1152/ajprenal.00523.2012. Epub 2012 Dec 12.


Small RNA sequencing reveals microRNAs that modulate angiotensin II effects in vascular smooth muscle cells.

Jin W, Reddy MA, Chen Z, Putta S, Lanting L, Kato M, Park JT, Chandra M, Wang C, Tangirala RK, Natarajan R.

J Biol Chem. 2012 May 4;287(19):15672-83. doi: 10.1074/jbc.M111.322669. Epub 2012 Mar 19.


Pro-inflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice.

Reddy MA, Jin W, Villeneuve L, Wang M, Lanting L, Todorov I, Kato M, Natarajan R.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):721-9. doi: 10.1161/ATVBAHA.111.241109. Epub 2012 Jan 12.


Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy.

Putta S, Lanting L, Sun G, Lawson G, Kato M, Natarajan R.

J Am Soc Nephrol. 2012 Mar;23(3):458-69. doi: 10.1681/ASN.2011050485. Epub 2012 Jan 5.


A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells.

Kato M, Arce L, Wang M, Putta S, Lanting L, Natarajan R.

Kidney Int. 2011 Aug;80(4):358-68. doi: 10.1038/ki.2011.43. Epub 2011 Mar 9.


Epigenetic histone methylation modulates fibrotic gene expression.

Sun G, Reddy MA, Yuan H, Lanting L, Kato M, Natarajan R.

J Am Soc Nephrol. 2010 Dec;21(12):2069-80. doi: 10.1681/ASN.2010060633. Epub 2010 Oct 7.


Towards evidence-based, quality-controlled health promotion: the Dutch recognition system for health promotion interventions.

Brug J, van Dale D, Lanting L, Kremers S, Veenhof C, Leurs M, van Yperen T, Kok G.

Health Educ Res. 2010 Dec;25(6):1100-6. doi: 10.1093/her/cyq046. Epub 2010 Sep 13.


Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells.

Kato M, Wang L, Putta S, Wang M, Yuan H, Sun G, Lanting L, Todorov I, Rossi JJ, Natarajan R.

J Biol Chem. 2010 Oct 29;285(44):34004-15. doi: 10.1074/jbc.M110.165027. Epub 2010 Aug 16.


Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1.

Villeneuve LM, Kato M, Reddy MA, Wang M, Lanting L, Natarajan R.

Diabetes. 2010 Nov;59(11):2904-15. doi: 10.2337/db10-0208. Epub 2010 Aug 10.


Diabetic conditions promote binding of monocytes to vascular smooth muscle cells and their subsequent differentiation.

Meng L, Park J, Cai Q, Lanting L, Reddy MA, Natarajan R.

Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H736-45. doi: 10.1152/ajpheart.00935.2009. Epub 2009 Dec 11.


TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN.

Kato M, Putta S, Wang M, Yuan H, Lanting L, Nair I, Gunn A, Nakagawa Y, Shimano H, Todorov I, Rossi JJ, Natarajan R.

Nat Cell Biol. 2009 Jul;11(7):881-9. doi: 10.1038/ncb1897. Epub 2009 Jun 21.


Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells.

Reddy MA, Sahar S, Villeneuve LM, Lanting L, Natarajan R.

Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):387-93. doi: 10.1161/ATVBAHA.108.179150. Epub 2008 Dec 18.


Ethnic differences in internal medicine referrals and diagnosis in the Netherlands.

Lanting LC, Bootsma AH, Lamberts SW, Mackenbach JP, Joung IM.

BMC Public Health. 2008 Aug 14;8:287. doi: 10.1186/1471-2458-8-287.


Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice.

Reddy MA, Villeneuve LM, Wang M, Lanting L, Natarajan R.

Circ Res. 2008 Sep 12;103(6):615-23. doi: 10.1161/CIRCRESAHA.108.175190. Epub 2008 Aug 7. Retraction in: Circ Res. 2009 Sep 11;105(6):e9.


Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes.

Villeneuve LM, Reddy MA, Lanting LL, Wang M, Meng L, Natarajan R.

Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9047-52. doi: 10.1073/pnas.0803623105. Epub 2008 Jun 25.


Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes.

Yuan H, Lanting L, Xu ZG, Li SL, Swiderski P, Putta S, Jonnalagadda M, Kato M, Natarajan R.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F605-17. doi: 10.1152/ajprenal.90268.2008. Epub 2008 Jun 18.


Ethnic differences in outcomes of diabetes care and the role of self-management behavior.

Lanting LC, Joung IM, Vogel I, Bootsma AH, Lamberts SW, Mackenbach JP.

Patient Educ Couns. 2008 Jul;72(1):146-54. doi: 10.1016/j.pec.2008.03.008. Epub 2008 May 1.


Products of 12/15-lipoxygenase upregulate the angiotensin II receptor.

Xu ZG, Yuan H, Lanting L, Li SL, Wang M, Shanmugam N, Kato M, Adler SG, Reddy MA, Natarajan R.

J Am Soc Nephrol. 2008 Mar;19(3):559-69. doi: 10.1681/ASN.2007080939. Epub 2008 Jan 30.


Viral vector-mediated 12/15-lipoxygenase overexpression in vascular smooth muscle cells enhances inflammatory gene expression and migration.

Dwarakanath RS, Sahar S, Lanting L, Wang N, Stemerman MB, Natarajan R, Reddy MA.

J Vasc Res. 2008;45(2):132-42. Epub 2007 Oct 17.


Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes.

Guha M, Xu ZG, Tung D, Lanting L, Natarajan R.

FASEB J. 2007 Oct;21(12):3355-68. Epub 2007 Jun 6.


MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.

Kato M, Zhang J, Wang M, Lanting L, Yuan H, Rossi JJ, Natarajan R.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3432-7. Epub 2007 Feb 20.


Role of the Akt/FoxO3a pathway in TGF-beta1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease.

Kato M, Yuan H, Xu ZG, Lanting L, Li SL, Wang M, Hu MC, Reddy MA, Natarajan R.

J Am Soc Nephrol. 2006 Dec;17(12):3325-35. Epub 2006 Nov 2.


Enhanced proatherogenic responses in macrophages and vascular smooth muscle cells derived from diabetic db/db mice.

Li SL, Reddy MA, Cai Q, Meng L, Yuan H, Lanting L, Natarajan R.

Diabetes. 2006 Sep;55(9):2611-9.


Key role of Src kinase in S100B-induced activation of the receptor for advanced glycation end products in vascular smooth muscle cells.

Reddy MA, Li SL, Sahar S, Kim YS, Xu ZG, Lanting L, Natarajan R.

J Biol Chem. 2006 May 12;281(19):13685-93. Epub 2006 Mar 21.


Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy.

Xu ZG, Li SL, Lanting L, Kim YS, Shanmugam N, Reddy MA, Natarajan R.

Kidney Int. 2006 Feb;69(3):512-9.


Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17.

Miao F, Li S, Chavez V, Lanting L, Natarajan R.

Mol Endocrinol. 2006 Jul;20(7):1562-73. Epub 2006 Feb 23.


Ethnic differences in mortality, end-stage complications, and quality of care among diabetic patients: a review.

Lanting LC, Joung IM, Mackenbach JP, Lamberts SW, Bootsma AH.

Diabetes Care. 2005 Sep;28(9):2280-8. Review.


Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis.

Sahar S, Dwarakanath RS, Reddy MA, Lanting L, Todorov I, Natarajan R.

Circ Res. 2005 May 27;96(10):1064-71. Epub 2005 Apr 28.


Novel interactions between TGF-{beta}1 actions and the 12/15-lipoxygenase pathway in mesangial cells.

Kim YS, Xu ZG, Reddy MA, Li SL, Lanting L, Sharma K, Adler SG, Natarajan R.

J Am Soc Nephrol. 2005 Feb;16(2):352-62. Epub 2004 Dec 22.


12/15-lipoxygenase inhibitors in diabetic nephropathy in the rat.

Ma J, Natarajan R, LaPage J, Lanting L, Kim N, Becerra D, Clemmons B, Nast CC, Surya Prakash GK, Mandal M, Adler SG.

Prostaglandins Leukot Essent Fatty Acids. 2005 Jan;72(1):13-20.


Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.

Li SL, Dwarakanath RS, Cai Q, Lanting L, Natarajan R.

J Lipid Res. 2005 Feb;46(2):220-9. Epub 2004 Dec 1.

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