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Items: 1 to 50 of 63

1.

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.

Kostich W, Hamman BD, Li YW, Naidu S, Dandapani K, Feng J, Easton A, Bourin C, Baker K, Allen J, Savelieva K, Louis JV, Dokania M, Elavazhagan S, Vattikundala P, Sharma V, Das ML, Shankar G, Kumar A, Holenarsipur VK, Gulianello M, Molski T, Brown JM, Lewis M, Huang Y, Lu Y, Pieschl R, O'Malley K, Lippy J, Nouraldeen A, Lanthorn TH, Ye G, Wilson A, Balakrishnan A, Denton R, Grace JE, Lentz KA, Santone KS, Bi Y, Main A, Swaffield J, Carson K, Mandlekar S, Vikramadithyan RK, Nara SJ, Dzierba C, Bronson J, Macor JE, Zaczek R, Westphal R, Kiss L, Bristow L, Conway CM, Zambrowicz B, Albright CF.

J Pharmacol Exp Ther. 2016 Sep;358(3):371-86. doi: 10.1124/jpet.116.235333. Epub 2016 Jul 13.

2.

Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice.

Powell DR, Gay JP, Wilganowski N, Doree D, Savelieva KV, Lanthorn TH, Read R, Vogel P, Hansen GM, Brommage R, Ding ZM, Desai U, Zambrowicz B.

Front Endocrinol (Lausanne). 2015 Jun 2;6:86. doi: 10.3389/fendo.2015.00086. eCollection 2015.

3.

Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders.

Zipp GG, Barbosa J, Green MA, Terranova KM, Fink C, Yu XC, Nouraldeen A, Wilson A, Savelieva K, Lanthorn TH, David Kimball S.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3886-90. doi: 10.1016/j.bmcl.2014.06.049. Epub 2014 Jul 1.

PMID:
25037917
4.

Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit.

Ye GL, Savelieva KV, Vogel P, Baker KB, Mason S, Lanthorn TH, Rajan I.

Behav Brain Res. 2015 Jan 1;276:99-110. doi: 10.1016/j.bbr.2014.04.039. Epub 2014 Apr 29.

PMID:
24786331
5.

Characterization of PTPRG in knockdown and phosphatase-inactive mutant mice and substrate trapping analysis of PTPRG in mammalian cells.

Zhang W, Savelieva KV, Tran DT, Pogorelov VM, Cullinan EB, Baker KB, Platt KA, Hu S, Rajan I, Xu N, Lanthorn TH.

PLoS One. 2012;7(9):e45500. doi: 10.1371/journal.pone.0045500. Epub 2012 Sep 20.

6.

A high-throughput screen for receptor protein tyrosine phosphatase-gamma selective inhibitors.

Appiah KK, Kostich WA, Gerritz SW, Huang Y, Hamman BD, Allen J, Zhang W, Lanthorn TH, Albright CF, Westphal R, Banks MN, O'Connell JC.

J Biomol Screen. 2011 Jun;16(5):476-85. doi: 10.1177/1087057111399336. Epub 2011 Mar 15.

PMID:
21406618
7.

Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.

Zhang W, Savelieva KV, Suwanichkul A, Small DL, Kirkpatrick LL, Xu N, Lanthorn TH, Ye GL.

PLoS One. 2010 Jun 22;5(6):e11261. doi: 10.1371/journal.pone.0011261.

8.

Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments.

Baker KB, Wray SP, Ritter R, Mason S, Lanthorn TH, Savelieva KV.

Genes Brain Behav. 2010 Aug;9(6):562-74. doi: 10.1111/j.1601-183X.2010.00585.x. Epub 2010 Apr 6.

9.

Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development.

Rajan I, Savelieva KV, Ye GL, Wang CY, Malbari MM, Friddle C, Lanthorn TH, Zhang W.

PLoS One. 2009 Aug 12;4(8):e6612. doi: 10.1371/journal.pone.0006612.

10.

Discovery and characterization of potent small molecule inhibitors of the high affinity proline transporter.

Yu XC, Zhang W, Oldham A, Buxton E, Patel S, Nghi N, Tran D, Lanthorn TH, Bomont C, Shi ZC, Liu Q.

Neurosci Lett. 2009 Feb 27;451(3):212-6. doi: 10.1016/j.neulet.2009.01.018. Epub 2009 Jan 13.

PMID:
19159658
11.

Differential sensitivity to SSRI and tricyclic antidepressants in juvenile and adult mice of three strains.

Mason SS, Baker KB, Davis KW, Pogorelov VM, Malbari MM, Ritter R, Wray SP, Gerhardt B, Lanthorn TH, Savelieva KV.

Eur J Pharmacol. 2009 Jan 14;602(2-3):306-15. doi: 10.1016/j.ejphar.2008.11.010. Epub 2008 Nov 12.

PMID:
19038246
12.

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.

Savelieva KV, Zhao S, Pogorelov VM, Rajan I, Yang Q, Cullinan E, Lanthorn TH.

PLoS One. 2008;3(10):e3301. doi: 10.1371/journal.pone.0003301. Epub 2008 Oct 15.

13.

Learning and memory impairment in Eph receptor A6 knockout mice.

Savelieva KV, Rajan I, Baker KB, Vogel P, Jarman W, Allen M, Lanthorn TH.

Neurosci Lett. 2008 Jun 20;438(2):205-9. doi: 10.1016/j.neulet.2008.04.013. Epub 2008 Apr 10.

PMID:
18450376
14.

Netrin-G2 and netrin-G2 ligand are both required for normal auditory responsiveness.

Zhang W, Rajan I, Savelieva KV, Wang CY, Vogel P, Kelly M, Xu N, Hasson B, Jarman W, Lanthorn TH.

Genes Brain Behav. 2008 Jun;7(4):385-92. Epub 2007 Oct 31.

15.

Use of a platform in an automated open-field to enhance assessment of anxiety-like behaviors in mice.

Pogorelov VM, Lanthorn TH, Savelieva KV.

J Neurosci Methods. 2007 May 15;162(1-2):222-8. Epub 2007 Jan 26.

PMID:
17331587
16.

Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice.

Zhao S, Edwards J, Carroll J, Wiedholz L, Millstein RA, Jaing C, Murphy DL, Lanthorn TH, Holmes A.

Neuroscience. 2006 Jun 19;140(1):321-34. Epub 2006 Mar 20.

PMID:
16542782
17.

Structural modifications to an N-methyl-D-aspartate receptor antagonist result in large differences in trapping block.

Mealing GA, Lanthorn TH, Small DL, Murray RJ, Mattes KC, Comas TM, Morley P.

J Pharmacol Exp Ther. 2001 Jun;297(3):906-14.

PMID:
11356910
18.

Differences in degree of trapping between AR-R15896 and other uncompetitive NMDA receptor antagonists.

Lanthorn TH, Mealing GA, Morley P.

Amino Acids. 2000;19(1):173-5.

PMID:
11026486
19.

Uncompetitive NMDA receptor antagonists--is low affinity better?

Danysz W, Lanthorn TH.

Amino Acids. 2000;19(1):131-2. No abstract available.

PMID:
11026481
20.

Distinct ATP-activated currents in different types of neurons dissociated from rat dorsal root ganglion.

Li C, Peoples RW, Lanthorn TH, Li ZW, Weight FF.

Neurosci Lett. 1999 Mar 19;263(1):57-60.

PMID:
10218910
21.

Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block.

Mealing GA, Lanthorn TH, Murray CL, Small DL, Morley P.

J Pharmacol Exp Ther. 1999 Jan;288(1):204-10.

PMID:
9862772
22.
23.

Antagonism of N-methyl-D-aspartate-evoked currents in rat cortical cultures by ARL 15896AR.

Mealing GA, Lanthorn TH, Small DL, Black MA, Laferriere NB, Morley P.

J Pharmacol Exp Ther. 1997 Apr;281(1):376-83.

PMID:
9103520
24.
25.

D-Cycloserine: Agonist turned antagonist.

Lanthorn TH.

Amino Acids. 1994 Oct;6(3):247-60. doi: 10.1007/BF00813745.

PMID:
24189733
26.
27.

Comparison of neuronal responses to experimental ischemia in gerbil and rat hippocampal slices.

Stittsworth JD Jr, Lanthorn TH.

Brain Res. 1994 Jun 27;649(1-2):353-6.

PMID:
7953652
28.

Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention.

Quartermain D, Mower J, Rafferty MF, Herting RL, Lanthorn TH.

Eur J Pharmacol. 1994 May 12;257(1-2):7-12.

PMID:
8082709
29.

D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats.

Baxter MG, Lanthorn TH, Frick KM, Golski S, Wan RQ, Olton DS.

Neurobiol Aging. 1994 Mar-Apr;15(2):207-13.

PMID:
7838293
30.

Resistance to epileptic, but not anoxic, depolarization in the gerbil hippocampal slice preparation.

Stittsworth JD Jr, Lanthorn TH.

Neurosci Lett. 1994 Feb 28;168(1-2):8-10.

PMID:
8028797
31.

Lactate mimics only some effects of D-glucose on epileptic depolarization and long-term synaptic failure.

Stittsworth JD Jr, Lanthorn TH.

Brain Res. 1993 Dec 10;630(1-2):21-7.

PMID:
8118687
32.

SC-46275: a potent and highly selective agonist at the EP3 receptor.

Savage MA, Moummi C, Karabatsos PJ, Lanthorn TH.

Prostaglandins Leukot Essent Fatty Acids. 1993 Dec;49(6):939-43.

PMID:
8140121
33.
34.

Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor.

Flood JF, Morley JE, Lanthorn TH.

Eur J Pharmacol. 1992 Oct 20;221(2-3):249-54.

PMID:
1330624
35.

Polyamine spider toxins are potent un-competitive antagonists of rat cortex excitatory amino acid receptors.

Davies MS, Baganoff MP, Grishin EV, Lanthorn TH, Volkova TM, Watson GB, Wiegand RC.

Eur J Pharmacol. 1992 Sep 1;227(1):51-6.

PMID:
1385187
36.

Characterization of indole-2-carboxylate derivatives as antagonists of N-methyl-D-aspartate receptor activity at the associated glycine recognition site.

Hood WF, Gray NM, Dappen MS, Watson GB, Compton RP, Cordi AA, Lanthorn TH, Monahan JB.

J Pharmacol Exp Ther. 1992 Aug;262(2):654-60.

PMID:
1386886
37.

BMY-14802 protects against ischemia-induced neuronal damage in the gerbil.

Contreras PC, Gray NM, Ragan DM, Lanthorn TH.

Life Sci. 1992;51(14):1145-9.

PMID:
1518377
38.

Synthesis, absolute configuration and activity at N-methyl-D-aspartic acid (NMDA) receptor of the four D-2-amino-4,5-methano-adipate diastereoisomers.

Pellicciari R, Natalini B, Marinozzi M, Sadeghpour BM, Cordi AA, Lanthorn TH, Hood WF, Monahan JB.

Farmaco. 1991 Nov;46(11):1243-64.

PMID:
1667358
39.

Evaluation of U-50,488H analogs for neuroprotective activity in the gerbil.

Contreras PC, Ragan DM, Bremer ME, Lanthorn TH, Gray NM, Iyengar S, Jacobson AE, Rice KC, de Costa BR.

Brain Res. 1991 Apr 12;546(1):79-82.

PMID:
1649669
40.

Opipramol, a potent sigma ligand, is an anti-ischemic agent: neurochemical evidence for an interaction with the N-methyl-D-aspartate receptor complex in vivo by cerebellar cGMP measurements.

Rao TS, Cler JA, Mick SJ, Ragan DM, Lanthorn TH, Contreras PC, Iyengar S, Wood PL.

Neuropharmacology. 1990 Dec;29(12):1199-204.

PMID:
1963477
41.
42.

Cis-2,4-methanoglutamate is a potent and selective N-methyl-D-aspartate receptor agonist.

Lanthorn TH, Hood WF, Watson GB, Compton RP, Rader RK, Gaoni Y, Monahan JB.

Eur J Pharmacol. 1990 Jul 17;182(3):397-404.

PMID:
2146136
43.

Differential modulation of the associated glycine recognition site by competitive N-methyl-D-aspartate receptor antagonists.

Monahan JB, Biesterfeldt JP, Hood WF, Compton RP, Cordi AA, Vazquez MI, Lanthorn TH, Wood PL.

Mol Pharmacol. 1990 Jun;37(6):780-4.

PMID:
2163012
44.

NMDA receptor antagonists attenuate a portion of the penicillin-induced epileptiform burst.

Watson GB, Lanthorn TH.

Brain Res Bull. 1990 Jun;24(6):765-8.

PMID:
1973626
45.

Selective activation of oscillatory currents by trans-ACPD in rat brain mRNA-injected Xenopus oocytes and their blockade by NMDA.

Watson GB, Monaghan DT, Lanthorn TH.

Eur J Pharmacol. 1990 Apr 25;179(3):479-81. No abstract available.

PMID:
1694771
46.

D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes.

Watson GB, Bolanowski MA, Baganoff MP, Deppeler CL, Lanthorn TH.

Brain Res. 1990 Feb 26;510(1):158-60.

PMID:
2157524
47.
48.

Glycine antagonist action of 1-aminocyclobutane-1-carboxylate (ACBC) in Xenopus oocytes injected with rat brain mRNA.

Watson GB, Bolanowski MA, Baganoff MP, Deppeler CL, Lanthorn TH.

Eur J Pharmacol. 1989 Aug 22;167(2):291-4.

PMID:
2556287
49.
50.

Gostatin blocks physiological actions and binding of acidic amino acids in rat brain.

Lanthorn TH, Fagg GE.

Neuropharmacology. 1989 Apr;28(4):429-32.

PMID:
2546088

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