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Abaloparatide increases bone mineral density and bone strength in ovariectomized rabbits with glucocorticoid-induced osteopenia.

Chandler H, Brooks DJ, Hattersley G, Bouxsein ML, Lanske B.

Osteoporos Int. 2019 Aug;30(8):1607-1616. doi: 10.1007/s00198-019-04999-4. Epub 2019 May 3.


Abaloparatide improves cortical geometry and trabecular microarchitecture and increases vertebral and femoral neck strength in a rat model of male osteoporosis.

Besschetnova T, Brooks DJ, Hu D, Nagano K, Nustad J, Ominsky M, Mitlak B, Hattersley G, Bouxsein ML, Baron R, Lanske B.

Bone. 2019 Jul;124:148-157. doi: 10.1016/j.bone.2019.04.025. Epub 2019 Apr 30.


Possible link between FSH and RANKL release from adipocytes in men with impaired gonadal function including Klinefelter syndrome.

Juel Mortensen L, Lorenzen M, Jørgensen N, Andersson AM, Nielsen JE, Petersen LI, Lanske B, Juul A, Hansen JB, Blomberg Jensen M.

Bone. 2019 Jun;123:103-114. doi: 10.1016/j.bone.2019.03.022. Epub 2019 Mar 23.


Abaloparatide, a PTH receptor agonist with homology to PTHrP, enhances callus bridging and biomechanical properties in rats with femoral fracture.

Lanske B, Chandler H, Pierce A, Brown J, Ominsky M, Kostenuik P, Hattersley G.

J Orthop Res. 2019 Apr;37(4):812-820. doi: 10.1002/jor.24254. Epub 2019 Mar 21.


Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton.

Maridas DE, Rendina-Ruedy E, Helderman RC, DeMambro VE, Brooks D, Guntur AR, Lanske B, Bouxsein ML, Rosen CJ.

FASEB J. 2019 Feb;33(2):2885-2898. doi: 10.1096/fj.201800948RR. Epub 2018 Oct 24.


Abaloparatide, a novel osteoanabolic PTHrP analog, increases cortical and trabecular bone mass and architecture in orchiectomized rats by increasing bone formation without increasing bone resorption.

Chandler H, Lanske B, Varela A, Guillot M, Boyer M, Brown J, Pierce A, Ominsky M, Mitlak B, Baron R, Kostenuik P, Hattersley G.

Bone. 2019 Mar;120:148-155. doi: 10.1016/j.bone.2018.10.012. Epub 2018 Oct 19.


In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules.

Ide N, Ye R, Courbebaisse M, Olauson H, Densmore MJ, Larsson TE, Hanai JI, Lanske B.

Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1261-F1270. doi: 10.1152/ajprenal.00650.2017. Epub 2018 Jul 11.


Role of Klotho in bone and implication for CKD.

Komaba H, Lanske B.

Curr Opin Nephrol Hypertens. 2018 Jul;27(4):298-304. doi: 10.1097/MNH.0000000000000423. Review.


Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia.

Fan Y, Liu W, Bi R, Densmore MJ, Sato T, Mannstadt M, Yuan Q, Zhou X, Olauson H, Larsson TE, Toka HR, Pollak MR, Brown EM, Lanske B.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3749-E3758. doi: 10.1073/pnas.1717754115. Epub 2018 Apr 4.


Biology of Fibroblast Growth Factor 23: From Physiology to Pathology.

Courbebaisse M, Lanske B.

Cold Spring Harb Perspect Med. 2018 May 1;8(5). pii: a031260. doi: 10.1101/cshperspect.a031260. Review.


Crosstalk between kidney and bone - Bench to bedside.

Hruska KA, Lanske B, Moe OW.

Bone. 2017 Jul;100:1-3. doi: 10.1016/j.bone.2017.03.046. Epub 2017 Apr 11. No abstract available.


Klotho expression in osteocytes regulates bone metabolism and controls bone formation.

Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B.

Kidney Int. 2017 Sep;92(3):599-611. doi: 10.1016/j.kint.2017.02.014. Epub 2017 Apr 8.


Parathyroid hormone controls paracellular Ca2+ transport in the thick ascending limb by regulating the tight-junction protein Claudin14.

Sato T, Courbebaisse M, Ide N, Fan Y, Hanai JI, Kaludjerovic J, Densmore MJ, Yuan Q, Toka HR, Pollak MR, Hou J, Lanske B.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3344-E3353. doi: 10.1073/pnas.1616733114. Epub 2017 Apr 3.


Bone Marrow Adipose Tissue: The First 40 Years.

Lanske B, Rosen C.

J Bone Miner Res. 2017 Jun;32(6):1153-1156. doi: 10.1002/jbmr.3140. Epub 2017 Apr 14. No abstract available.


Reproductive endocrinology of vitamin D.

Lorenzen M, Boisen IM, Mortensen LJ, Lanske B, Juul A, Blomberg Jensen M.

Mol Cell Endocrinol. 2017 Sep 15;453:103-112. doi: 10.1016/j.mce.2017.03.023. Epub 2017 Mar 22. Review.


Effects of klotho deletion from bone during chronic kidney disease.

Kaludjerovic J, Komaba H, Lanske B.

Bone. 2017 Jul;100:50-55. doi: 10.1016/j.bone.2017.02.006. Epub 2017 Feb 20. Review.


Klotho expression in long bones regulates FGF23 production during renal failure.

Kaludjerovic J, Komaba H, Sato T, Erben RG, Baron R, Olauson H, Larsson TE, Lanske B.

FASEB J. 2017 May;31(5):2050-2064. doi: 10.1096/fj.201601036R. Epub 2017 Feb 9.


Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.

Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Bilezikian JP, Dempster DW, Rosen CJ, Lanske B.

Cell Metab. 2017 Mar 7;25(3):661-672. doi: 10.1016/j.cmet.2017.01.001. Epub 2017 Feb 2.


Selection of High-Quality Spermatozoa May Be Promoted by Activated Vitamin D in the Woman.

Bøllehuus Hansen L, Rehfeld A, de Neergaard R, Nielsen JE, Iversen LH, Boisen IM, Mortensen LJ, Lanske B, Almstrup K, Carlsen E, Berg AH, Jørgensen N, Andersen AN, Juul A, Blomberg Jensen M.

J Clin Endocrinol Metab. 2017 Mar 1;102(3):950-961. doi: 10.1210/jc.2016-3008.


FGF23 Is Not Required to Regulate Fetal Phosphorus Metabolism but Exerts Effects Within 12 Hours After Birth.

Ma Y, Kirby BJ, Fairbridge NA, Karaplis AC, Lanske B, Kovacs CS.

Endocrinology. 2017 Feb 1;158(2):252-263. doi: 10.1210/en.2016-1369.


Possible influence of vitamin D on male reproduction.

Boisen IM, Bøllehuus Hansen L, Mortensen LJ, Lanske B, Juul A, Blomberg Jensen M.

J Steroid Biochem Mol Biol. 2017 Oct;173:215-222. doi: 10.1016/j.jsbmb.2016.09.023. Epub 2016 Sep 28. Review.


Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men.

Blomberg Jensen M, Gerner Lawaetz J, Andersson AM, Petersen JH, Nordkap L, Bang AK, Ekbom P, Joensen UN, Prætorius L, Lundstrøm P, Boujida VH, Lanske B, Juul A, Jørgensen N.

Hum Reprod. 2016 Aug;31(8):1875-85. doi: 10.1093/humrep/dew152. Epub 2016 Jun 19.


In vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling.

Ide N, Olauson H, Sato T, Densmore MJ, Wang H, Hanai JI, Larsson TE, Lanske B.

Kidney Int. 2016 Aug;90(2):348-362. doi: 10.1016/j.kint.2016.04.009. Epub 2016 Jun 9.


PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.

Kir S, Komaba H, Garcia AP, Economopoulos KP, Liu W, Lanske B, Hodin RA, Spiegelman BM.

Cell Metab. 2016 Feb 9;23(2):315-23. doi: 10.1016/j.cmet.2015.11.003. Epub 2015 Dec 6.


Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones.

Amano K, Densmore M, Fan Y, Lanske B.

Bone. 2016 Feb;83:256-266. doi: 10.1016/j.bone.2015.11.017. Epub 2015 Nov 24.


Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis.

Fan Y, Bi R, Densmore MJ, Sato T, Kobayashi T, Yuan Q, Zhou X, Erben RG, Lanske B.

FASEB J. 2016 Jan;30(1):428-40. doi: 10.1096/fj.15-278184. Epub 2015 Oct 1.


Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.

Amano K, Densmore MJ, Lanske B.

J Bone Miner Res. 2015 Dec;30(12):2262-72. doi: 10.1002/jbmr.2582. Epub 2015 Jul 29.


FGF23 neutralization improves bone quality and osseointegration of titanium implants in chronic kidney disease mice.

Sun N, Guo Y, Liu W, Densmore M, Shalhoub V, Erben RG, Ye L, Lanske B, Yuan Q.

Sci Rep. 2015 Feb 10;5:8304. doi: 10.1038/srep08304.


Molecular interactions of FGF23 and PTH in phosphate regulation.

Lanske B, Razzaque MS.

Kidney Int. 2014 Dec;86(6):1072-4. doi: 10.1038/ki.2014.316.


FGF23 deficiency leads to mixed hearing loss and middle ear malformation in mice.

Lysaght AC, Yuan Q, Fan Y, Kalwani N, Caruso P, Cunnane M, Lanske B, Stanković KM.

PLoS One. 2014 Sep 22;9(9):e107681. doi: 10.1371/journal.pone.0107681. eCollection 2014.


Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2/Smads interactions.

Amano K, Densmore M, Nishimura R, Lanske B.

J Biol Chem. 2014 Sep 5;289(36):24898-910. doi: 10.1074/jbc.M114.570507. Epub 2014 Jul 15.


The kidney is the principal organ mediating klotho effects.

Lindberg K, Amin R, Moe OW, Hu MC, Erben RG, Östman Wernerson A, Lanske B, Olauson H, Larsson TE.

J Am Soc Nephrol. 2014 Oct;25(10):2169-75. doi: 10.1681/ASN.2013111209. Epub 2014 May 22.


FGF23 regulates renal sodium handling and blood pressure.

Andrukhova O, Slavic S, Smorodchenko A, Zeitz U, Shalhoub V, Lanske B, Pohl EE, Erben RG.

EMBO Mol Med. 2014 Jun;6(6):744-59. doi: 10.1002/emmm.201303716. Epub 2014 Apr 6.


Vitamin D supplementation enhances the fixation of titanium implants in chronic kidney disease mice.

Liu W, Zhang S, Zhao D, Zou H, Sun N, Liang X, Dard M, Lanske B, Yuan Q.

PLoS One. 2014 Apr 21;9(4):e95689. doi: 10.1371/journal.pone.0095689. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e99972.


Vitamin D endocrine system and osteocytes.

Lanske B, Densmore MJ, Erben RG.

Bonekey Rep. 2014 Feb 5;3:494. doi: 10.1038/bonekey.2013.228. eCollection 2014.


Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization.

Ma Y, Samaraweera M, Cooke-Hubley S, Kirby BJ, Karaplis AC, Lanske B, Kovacs CS.

Endocrinology. 2014 May;155(5):1596-605. doi: 10.1210/en.2013-2061. Epub 2014 Mar 6.


Fibroblast growth factor-23 and cardiac structure and function.

Agarwal I, Ide N, Ix JH, Kestenbaum B, Lanske B, Schiller NB, Whooley MA, Mukamal KJ.

J Am Heart Assoc. 2014 Feb 13;3(1):e000584. doi: 10.1161/JAHA.113.000584.


FGF-23 is a negative regulator of prenatal and postnatal erythropoiesis.

Coe LM, Madathil SV, Casu C, Lanske B, Rivella S, Sitara D.

J Biol Chem. 2014 Apr 4;289(14):9795-810. doi: 10.1074/jbc.M113.527150. Epub 2014 Feb 7.


FGF23 promotes renal calcium reabsorption through the TRPV5 channel.

Andrukhova O, Smorodchenko A, Egerbacher M, Streicher C, Zeitz U, Goetz R, Shalhoub V, Mohammadi M, Pohl EE, Lanske B, Erben RG.

EMBO J. 2014 Feb 3;33(3):229-46. doi: 10.1002/embj.201284188. Epub 2014 Jan 16.


Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice.

Zhou J, Chen Q, Lanske B, Fleming BC, Terek R, Wei X, Zhang G, Wang S, Li K, Wei L.

Arthritis Res Ther. 2014 Jan 15;16(1):R11. doi: 10.1186/ar4437.


Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion.

Olauson H, Lindberg K, Amin R, Sato T, Jia T, Goetz R, Mohammadi M, Andersson G, Lanske B, Larsson TE.

PLoS Genet. 2013;9(12):e1003975. doi: 10.1371/journal.pgen.1003975. Epub 2013 Dec 12.


Increased osteopontin contributes to inhibition of bone mineralization in FGF23-deficient mice.

Yuan Q, Jiang Y, Zhao X, Sato T, Densmore M, Schüler C, Erben RG, McKee MD, Lanske B.

J Bone Miner Res. 2014 Mar;29(3):693-704. doi: 10.1002/jbmr.2079.


Effect of chronic kidney disease on the healing of titanium implants.

Zou H, Zhao X, Sun N, Zhang S, Sato T, Yu H, Chen Q, Weber HP, Dard M, Yuan Q, Lanske B.

Bone. 2013 Oct;56(2):410-5. doi: 10.1016/j.bone.2013.07.014. Epub 2013 Jul 19.


Indian hedgehog controls proliferation and differentiation in skin tumorigenesis and protects against malignant progression.

Kakanj P, Reuter K, Séquaris G, Wodtke C, Schettina P, Frances D, Zouboulis CC, Lanske B, Niemann C.

Cell Rep. 2013 Jul 25;4(2):340-51. doi: 10.1016/j.celrep.2013.06.037. Epub 2013 Jul 18.


FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway.

Andrukhova O, Zeitz U, Goetz R, Mohammadi M, Lanske B, Erben RG.

Bone. 2012 Sep;51(3):621-8. doi: 10.1016/j.bone.2012.05.015. Epub 2012 May 27.


Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice.

Yuan Q, Sato T, Densmore M, Saito H, Schüler C, Erben RG, Lanske B.

PLoS Genet. 2012;8(5):e1002726. doi: 10.1371/journal.pgen.1002726. Epub 2012 May 17.


Long-term Fgf23 deficiency does not influence aging, glucose homeostasis, or fat metabolism in mice with a nonfunctioning vitamin D receptor.

Streicher C, Zeitz U, Andrukhova O, Rupprecht A, Pohl E, Larsson TE, Windisch W, Lanske B, Erben RG.

Endocrinology. 2012 Apr;153(4):1795-805. doi: 10.1210/en.2011-1878. Epub 2012 Jan 31.


Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells.

Takei Y, Yamamoto H, Sato T, Otani A, Kozai M, Masuda M, Taketani Y, Muto-Sato K, Lanske B, Takeda E.

Bone. 2012 Apr;50(4):998-1005. doi: 10.1016/j.bone.2012.01.006. Epub 2012 Jan 21.


PTH ablation ameliorates the anomalies of Fgf23-deficient mice by suppressing the elevated vitamin D and calcium levels.

Yuan Q, Sitara D, Sato T, Densmore M, Saito H, Schüler C, Erben RG, Lanske B.

Endocrinology. 2011 Nov;152(11):4053-61. doi: 10.1210/en.2011-1113. Epub 2011 Sep 6.


Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia.

Seriwatanachai D, Densmore MJ, Sato T, Correa D, Neff L, Baron R, Lanske B.

FASEB J. 2011 Sep;25(9):3057-67. doi: 10.1096/fj.11-183277. Epub 2011 Jun 3.

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