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Items: 1 to 50 of 128

1.

Unique pattern of neutrophil migration and function during tumor progression.

Patel S, Fu S, Mastio J, Dominguez GA, Purohit A, Kossenkov A, Lin C, Alicea-Torres K, Sehgal M, Nefedova Y, Zhou J, Languino LR, Clendenin C, Vonderheide RH, Mulligan C, Nam B, Hockstein N, Masters G, Guarino M, Schug ZT, Altieri DC, Gabrilovich DI.

Nat Immunol. 2018 Nov;19(11):1236-1247. doi: 10.1038/s41590-018-0229-5. Epub 2018 Oct 15.

PMID:
30323345
2.

αvβ3 INTEGRIN MEDIATES RADIORESISTANCE OF PROSTATE CANCER CELLS THROUGH REGULATION OF SURVIVIN.

Wang T, Huang J, Vue M, Alavian MR, Goel HL, Altieri DC, Languino LR, Fitzgerald TJ.

Mol Cancer Res. 2018 Sep 28. pii: molcanres.0544.2018. doi: 10.1158/1541-7786.MCR-18-0544. [Epub ahead of print]

PMID:
30266752
3.

Prostate cancer sheds the αvβ3 integrin in vivo through exosomes.

Krishn SR, Singh A, Bowler N, Duffy AN, Friedman A, Fedele C, Kurtoglu S, Tripathi SK, Wang K, Hawkins A, Sayeed A, Goswami CP, Thakur ML, Iozzo RV, Peiper SC, Kelly WK, Languino LR.

Matrix Biol. 2018 Aug 8. pii: S0945-053X(18)30146-X. doi: 10.1016/j.matbio.2018.08.004. [Epub ahead of print]

PMID:
30098419
4.

Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements.

Seo JH, Agarwal E, Bryant KG, Caino MC, Kim ET, Kossenkov AV, Tang HY, Languino LR, Gabrilovich DI, Cohen AR, Speicher DW, Altieri DC.

Cancer Res. 2018 Aug 1;78(15):4215-4228. doi: 10.1158/0008-5472.CAN-18-0595. Epub 2018 Jun 13.

PMID:
29898993
5.

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer.

Lu H, Bowler N, Harshyne LA, Craig Hooper D, Krishn SR, Kurtoglu S, Fedele C, Liu Q, Tang HY, Kossenkov AV, Kelly WK, Wang K, Kean RB, Weinreb PH, Yu L, Dutta A, Fortina P, Ertel A, Stanczak M, Forsberg F, Gabrilovich DI, Speicher DW, Altieri DC, Languino LR.

Matrix Biol. 2018 Sep;70:20-35. doi: 10.1016/j.matbio.2018.03.009. Epub 2018 Mar 9.

PMID:
29530483
6.

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.

Kumar V, Donthireddy L, Marvel D, Condamine T, Wang F, Lavilla-Alonso S, Hashimoto A, Vonteddu P, Behera R, Goins MA, Mulligan C, Nam B, Hockstein N, Denstman F, Shakamuri S, Speicher DW, Weeraratna AT, Chao T, Vonderheide RH, Languino LR, Ordentlich P, Liu Q, Xu X, Lo A, Puré E, Zhang C, Loboda A, Sepulveda MA, Snyder LA, Gabrilovich DI.

Cancer Cell. 2017 Nov 13;32(5):654-668.e5. doi: 10.1016/j.ccell.2017.10.005.

7.

Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer.

Caino MC, Seo JH, Wang Y, Rivadeneira DB, Gabrilovich DI, Kim ET, Weeraratna AT, Languino LR, Altieri DC.

J Clin Invest. 2017 Oct 2;127(10):3755-3769. doi: 10.1172/JCI93172. Epub 2017 Sep 11.

8.

A neuronal network of mitochondrial dynamics regulates metastasis.

Caino MC, Seo JH, Aguinaldo A, Wait E, Bryant KG, Kossenkov AV, Hayden JE, Vaira V, Morotti A, Ferrero S, Bosari S, Gabrilovich DI, Languino LR, Cohen AR, Altieri DC.

Nat Commun. 2016 Dec 19;7:13730. doi: 10.1038/ncomms13730.

9.

v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1.

Ju X, Jiao X, Ertel A, Casimiro MC, Di Sante G, Deng S, Li Z, Di Rocco A, Zhan T, Hawkins A, Stoyanova T, Andò S, Fatatis A, Lisanti MP, Gomella LG, Languino LR, Pestell RG.

Cancer Res. 2016 Nov 15;76(22):6723-6734. doi: 10.1158/0008-5472.CAN-15-3327. Epub 2016 Sep 15.

10.

Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.

Lisanti S, Garlick DS, Bryant KG, Tavecchio M, Mills GB, Lu Y, Kossenkov AV, Showe LC, Languino LR, Altieri DC.

J Biol Chem. 2016 Nov 25;291(48):25247-25254. Epub 2016 Oct 17.

11.

A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice.

Farina NH, Zingiryan A, Akech JA, Callahan CJ, Lu H, Stein JL, Languino LR, Stein GS, Lian JB.

Oncotarget. 2016 Oct 25;7(43):70462-70474. doi: 10.18632/oncotarget.11992.

12.

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.

Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, Locatelli M, Bryant KG, Ghosh JC, Lisanti S, Ku B, Bosari S, Languino LR, Speicher DW, Altieri DC.

Cancer Cell. 2016 Aug 8;30(2):257-272. doi: 10.1016/j.ccell.2016.07.004.

13.

αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor.

Lu H, Wang T, Li J, Fedele C, Liu Q, Zhang J, Jiang Z, Jain D, Iozzo RV, Violette SM, Weinreb PH, Davis RJ, Gioeli D, FitzGerald TJ, Altieri DC, Languino LR.

Cancer Res. 2016 Sep 1;76(17):5163-74. doi: 10.1158/0008-5472.CAN-16-0543. Epub 2016 Jul 22.

14.

Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype.

Singh A, Fedele C, Lu H, Nevalainen MT, Keen JH, Languino LR.

Mol Cancer Res. 2016 Nov;14(11):1136-1146. Epub 2016 Jul 20.

15.

β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation.

Sayeed A, Lu H, Liu Q, Deming D 2nd, Duffy A, McCue P, Dicker AP, Davis RJ, Gabrilovich D, Rodeck U, Altieri DC, Languino LR.

Oncotarget. 2016 Aug 16;7(33):52618-52630. doi: 10.18632/oncotarget.10522.

16.

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.

Seo JH, Rivadeneira DB, Caino MC, Chae YC, Speicher DW, Tang HY, Vaira V, Bosari S, Palleschi A, Rampini P, Kossenkov AV, Languino LR, Altieri DC.

PLoS Biol. 2016 Jul 7;14(7):e1002507. doi: 10.1371/journal.pbio.1002507. eCollection 2016 Jul.

17.

Exosome-mediated transfer from the tumor microenvironment increases TGFβ signaling in squamous cell carcinoma.

Languino LR, Singh A, Prisco M, Inman GJ, Luginbuhl A, Curry JM, South AP.

Am J Transl Res. 2016 May 15;8(5):2432-7. eCollection 2016.

18.

c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.

DeRita RM, Zerlanko B, Singh A, Lu H, Iozzo RV, Benovic JL, Languino LR.

J Cell Biochem. 2017 Jan;118(1):66-73. doi: 10.1002/jcb.25611. Epub 2016 Jul 12.

19.

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation.

Kumar V, Cheng P, Condamine T, Mony S, Languino LR, McCaffrey JC, Hockstein N, Guarino M, Masters G, Penman E, Denstman F, Xu X, Altieri DC, Du H, Yan C, Gabrilovich DI.

Immunity. 2016 Feb 16;44(2):303-15. doi: 10.1016/j.immuni.2016.01.014.

20.

Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose Metabolism.

Tavecchio M, Lisanti S, Bennett MJ, Languino LR, Altieri DC.

Sci Rep. 2015 Oct 30;5:15981. doi: 10.1038/srep15981.

21.

Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts.

Trerotola M, Ganguly KK, Fazli L, Fedele C, Lu H, Dutta A, Liu Q, De Angelis T, Riddell LW, Riobo NA, Gleave ME, Zoubeidi A, Pestell RG, Altieri DC, Languino LR.

Oncotarget. 2015 Oct 20;6(32):34038. doi: 10.18632/oncotarget.6187. No abstract available.

22.

Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion.

Rivadeneira DB, Caino MC, Seo JH, Angelin A, Wallace DC, Languino LR, Altieri DC.

Sci Signal. 2015 Aug 11;8(389):ra80. doi: 10.1126/scisignal.aab1624.

23.

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.

Caino MC, Ghosh JC, Chae YC, Vaira V, Rivadeneira DB, Faversani A, Rampini P, Kossenkov AV, Aird KM, Zhang R, Webster MR, Weeraratna AT, Bosari S, Languino LR, Altieri DC.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8638-43. doi: 10.1073/pnas.1500722112. Epub 2015 Jun 29.

24.

Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression.

Forno I, Ferrero S, Russo MV, Gazzano G, Giangiobbe S, Montanari E, Del Nero A, Rocco B, Albo G, Languino LR, Altieri DC, Vaira V, Bosari S.

PLoS One. 2015 Jun 24;10(6):e0130060. doi: 10.1371/journal.pone.0130060. eCollection 2015.

25.

Corrigendum: Landscape of the mitochondrial Hsp90 metabolome in tumours.

Chae YC, Angelin A, Lisanti S, Kossenkov AV, Speicher KD, Wang H, Powers JF, Tischler AS, Pacak K, Fliedner S, Michalek RD, Karoly ED, Wallace DC, Languino LR, Speicher DW, Altieri DC.

Nat Commun. 2015 Jun 18;6:7605. doi: 10.1038/ncomms8605. No abstract available.

26.

Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts.

Trerotola M, Ganguly KK, Fazli L, Fedele C, Lu H, Dutta A, Liu Q, De Angelis T, Riddell LW, Riobo NA, Gleave ME, Zoubeidi A, Pestell RG, Altieri DC, Languino LR.

Oncotarget. 2015 Jun 10;6(16):14318-28. Erratum in: Oncotarget. 2015 Oct 20;6(32):34038.

27.

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1.

Zhang X, Wu H, Dobson JR, Browne G, Hong D, Akech J, Languino LR, Stein GS, Lian JB.

J Cell Biochem. 2015 Sep;116(9):2098-108. doi: 10.1002/jcb.25167.

28.

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC.

J Natl Cancer Inst. 2015 Feb 3;107(3). pii: dju502. doi: 10.1093/jnci/dju502. Print 2015 Mar.

29.

The αvβ6 integrin is transferred intercellularly via exosomes.

Fedele C, Singh A, Zerlanko BJ, Iozzo RV, Languino LR.

J Biol Chem. 2015 Feb 20;290(8):4545-51. doi: 10.1074/jbc.C114.617662. Epub 2015 Jan 7.

30.

αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression.

Dutta A, Li J, Fedele C, Sayeed A, Singh A, Violette SM, Manes TD, Languino LR.

Biochem J. 2015 Mar 15;466(3):525-36. doi: 10.1042/BJ20140698.

31.

Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks.

Lisanti S, Tavecchio M, Chae YC, Liu Q, Brice AK, Thakur ML, Languino LR, Altieri DC.

Cell Rep. 2014 Aug 7;8(3):671-7. doi: 10.1016/j.celrep.2014.06.061. Epub 2014 Jul 31.

32.

Integrin αvβ6 promotes an osteolytic program in cancer cells by upregulating MMP2.

Dutta A, Li J, Lu H, Akech J, Pratap J, Wang T, Zerlanko BJ, FitzGerald TJ, Jiang Z, Birbe R, Wixted J, Violette SM, Stein JL, Stein GS, Lian JB, Languino LR.

Cancer Res. 2014 Mar 1;74(5):1598-608. doi: 10.1158/0008-5472.CAN-13-1796. Epub 2014 Jan 2.

33.

IGF-IR promotes prostate cancer growth by stabilizing α5β1 integrin protein levels.

Sayeed A, Fedele C, Trerotola M, Ganguly KK, Languino LR.

PLoS One. 2013 Oct 9;8(10):e76513. doi: 10.1371/journal.pone.0076513. eCollection 2013.

34.

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells.

Caino MC, Chae YC, Vaira V, Ferrero S, Nosotti M, Martin NM, Weeraratna A, O'Connell M, Jernigan D, Fatatis A, Languino LR, Bosari S, Altieri DC.

J Clin Invest. 2013 Jul;123(7):2907-20. doi: 10.1172/JCI67841. Epub 2013 Jun 10.

35.

Landscape of the mitochondrial Hsp90 metabolome in tumours.

Chae YC, Angelin A, Lisanti S, Kossenkov AV, Speicher KD, Wang H, Powers JF, Tischler AS, Pacak K, Fliedner S, Michalek RD, Karoly ED, Wallace DC, Languino LR, Speicher DW, Altieri DC.

Nat Commun. 2013;4:2139. doi: 10.1038/ncomms3139. Erratum in: Nat Commun. 2015;6:7605.

36.

Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions.

Trerotola M, Jernigan DL, Liu Q, Siddiqui J, Fatatis A, Languino LR.

Cancer Res. 2013 May 15;73(10):3155-67. doi: 10.1158/0008-5472.CAN-12-3266. Epub 2013 Mar 27.

37.

β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1.

Goel HL, Sayeed A, Breen M, Zarif MJ, Garlick DS, Leav I, Davis RJ, Fitzgerald TJ, Morrione A, Hsieh CC, Liu Q, Dicker AP, Altieri DC, Languino LR.

J Cell Physiol. 2013 Jul;228(7):1601-9. doi: 10.1002/jcp.24323.

38.

Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s.

Chae YC, Caino MC, Lisanti S, Ghosh JC, Dohi T, Danial NN, Villanueva J, Ferrero S, Vaira V, Santambrogio L, Bosari S, Languino LR, Herlyn M, Altieri DC.

Cancer Cell. 2012 Sep 11;22(3):331-44. doi: 10.1016/j.ccr.2012.07.015.

39.

α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma.

Garlick DS, Li J, Sansoucy B, Wang T, Griffith L, Fitzgerald T, Butterfield J, Charbonneau B, Violette SM, Weinreb PH, Ratliff TL, Liao CP, Roy-Burman P, Vietri M, Lian JB, Stein GS, Altieri DC, Languino LR.

Am J Transl Res. 2012;4(2):165-74. Epub 2012 Apr 10.

40.

Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis.

Trerotola M, Li J, Alberti S, Languino LR.

J Cell Physiol. 2012 Nov;227(11):3670-7. doi: 10.1002/jcp.24074.

41.

PSA regulates androgen receptor expression in prostate cancer cells.

Saxena P, Trerotola M, Wang T, Li J, Sayeed A, Vanoudenhove J, Adams DS, Fitzgerald TJ, Altieri DC, Languino LR.

Prostate. 2012 May 15;72(7):769-76. doi: 10.1002/pros.21482. Epub 2011 Sep 28.

42.

The search for a better prostate cancer biomarker.

Laskiewicz L, Jiang Z, Altieri DC, Languino LR.

J Urol. 2011 Nov;186(5):1758-9. doi: 10.1016/j.juro.2011.08.019. Epub 2011 Sep 25. No abstract available.

PMID:
21944983
43.

TRAP-1, the mitochondrial Hsp90.

Altieri DC, Stein GS, Lian JB, Languino LR.

Biochim Biophys Acta. 2012 Mar;1823(3):767-73. doi: 10.1016/j.bbamcr.2011.08.007. Epub 2011 Aug 22. Review.

44.

Insulin-like growth factor 1 stimulation of androgen receptor activity requires β(1A) integrins.

Sayeed A, Alam N, Trerotola M, Languino LR.

J Cell Physiol. 2012 Feb;227(2):751-8. doi: 10.1002/jcp.22784.

45.

Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease.

Kang BH, Tavecchio M, Goel HL, Hsieh CC, Garlick DS, Raskett CM, Lian JB, Stein GS, Languino LR, Altieri DC.

Br J Cancer. 2011 Feb 15;104(4):629-34. doi: 10.1038/bjc.2011.9. Epub 2011 Feb 1.

46.

Molecular targets for radiation oncology in prostate cancer.

Wang T, Languino LR, Lian J, Stein G, Blute M, Fitzgerald TJ.

Front Oncol. 2011 Jul 13;1:17. doi: 10.3389/fonc.2011.00017. eCollection 2011.

47.

Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer.

Kang BH, Siegelin MD, Plescia J, Raskett CM, Garlick DS, Dohi T, Lian JB, Stein GS, Languino LR, Altieri DC.

Clin Cancer Res. 2010 Oct 1;16(19):4779-88. doi: 10.1158/1078-0432.CCR-10-1818. Epub 2010 Sep 28.

48.

CD133, Trop-2 and alpha2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells.

Trerotola M, Rathore S, Goel HL, Li J, Alberti S, Piantelli M, Adams D, Jiang Z, Languino LR.

Am J Transl Res. 2010 Mar 15;2(2):135-44.

49.

Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1.

Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR.

J Cell Physiol. 2010 Jul;224(1):210-7. doi: 10.1002/jcp.22116.

50.

Protein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer.

Biswas MH, Du C, Zhang C, Straubhaar J, Languino LR, Balaji KC.

Cancer Res. 2010 Mar 1;70(5):2095-104. doi: 10.1158/0008-5472.CAN-09-4155. Epub 2010 Feb 16.

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